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Ageing, age-related diseases and oxidative stress: What to do next?
Open accessAbstract
Among other mechanisms, oxidative stress has been postulated to play an important role in the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential components in pathological pathways which are thought to drive multiple age-related diseases. Nonetheless, results from studies testing the hypothesis of oxidative stress in ageing and diseases showed controversial results. While observational studies mainly found detrimental effects of high oxidative stress levels on disease status, randomized clinical trials examining the effect of antioxidant supplementation on disease status generally showed null effects. However, re-evaluations of these counterinitiative observations are required considering the lack of reliability and specificity of traditionally used biomarkers for measuring oxidative stress. To facilitate these re-evaluations, this review summarizes the basic knowledge of oxidative stress and the present findings regarding the role of oxidative damage in ageing and age-related diseases. Meanwhile, two approaches are highlighted, namely proper participants selection, together with the development of reliable biomarkers. We propose that oxidized vitamin E metabolites may be used to accurately monitor individual functional antioxidant level, which might serve as promising key solutions for future elucidating the impact of oxidative stress on ageing and age-related diseases.
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“Based on many published studies and some facts outlined above, it is clear that aging and age-related diseases have a multifactorial and multilayered origin (Luo et al. 2020), however, one of the key factors is certainly oxidative damage.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Luo et al. 2020
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BackgroundAçaì (Euterpe oleracea) Extract Protects Human Erythrocytes from Age-Related Oxidative Stress
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BackgroundSirtuin 3 Plays a Critical Role in the Antidepressant- and Anxiolytic-like Effects of Kaempferol
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Metadata
- Authors
- Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D.
- Affiliations
- Leiden University Medical Center (NL)
- Great Ormond Street Hospital (GB)
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 57
- Pages
- 100982
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2985538915
- Cited by
- 581
- References
- 237
- Citations by year
- 2026: 53 · 2025: 90 · 2024: 109 · 2023: 115 · 2022: 105 · 2021: 79 · 2020: 29
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Velux Stiftung (1156)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- oxidative stress, aging, age-related diseases, oxidative damage, antioxidant supplementation, oxidative stress biomarkers
- MeSH terms
- Aging, Animals, Antioxidants, Humans, Sensitivity and Specificity, Reproducibility of Results, Biomarkers, Oxidative Stress
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