Cited by 583Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesGenetics, Aging, and Longevity in Model Organisms

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Ageing, age-related diseases and oxidative stress: What to do next?

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Luo, Jiao, Mills, Kevin, le Cessie, Saskia, Noordam, Raymond, van Heemst, Diana·2020·Ageing Research Reviews

DOI 10.1016/j.arr.2019.100982

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Abstract

Among other mechanisms, oxidative stress has been postulated to play an important role in the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential components in pathological pathways which are thought to drive multiple age-related diseases. Nonetheless, results from studies testing the hypothesis of oxidative stress in ageing and diseases showed controversial results. While observational studies mainly found detrimental effects of high oxidative stress levels on disease status, randomized clinical trials examining the effect of antioxidant supplementation on disease status generally showed null effects. However, re-evaluations of these counterinitiative observations are required considering the lack of reliability and specificity of traditionally used biomarkers for measuring oxidative stress. To facilitate these re-evaluations, this review summarizes the basic knowledge of oxidative stress and the present findings regarding the role of oxidative damage in ageing and age-related diseases. Meanwhile, two approaches are highlighted, namely proper participants selection, together with the development of reliable biomarkers. We propose that oxidized vitamin E metabolites may be used to accurately monitor individual functional antioxidant level, which might serve as promising key solutions for future elucidating the impact of oxidative stress on ageing and age-related diseases.

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Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease
Jiang, T., Sun, Q., & Chen, S. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.005 · Cited by 605 · cited 1×
“related proteins including α-Synuclein, Parkin, DJ-1, PINK1, LRRK2 and HTRA2 were associated with mitochondrial dysfunction as well (Jiang et al., 2016; Lin and Beal, 2006).”
Background
Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance
Dalleau, S., Baradat, M., Guéraud, F., & Huc, L. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.138 · Cited by 580
The GH/IGF-1 axis in ageing and longevity
Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.67 · Cited by 574 · cited 2×
“Mice with antioxidant overexpression, for example, catalase (Dai et al., 2017), or with modifications in other signaling pathway components, such as p66sch-/- (Migliaccio et al., 1999), Igf1r+/− (Junnila et al., 2013) are generally considered to have increased longevity.”
Background
Oxy radicals, lipid peroxidation and DNA damage
Marnett, L. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00448-1 · Cited by 563 · cited 1×
“In addition, adducts to DNA can be formed by reaction of deoxyguanosine (M(1)G) and deoxyadenosine with other macromolecular modifications trigged by ROS, such as reactive aldehyde products generated during the lipid peroxidation (Marnett, 2002).”
Background
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
Coskun, P. E., Beal, M. F., & Wallace, D. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403649101 · Cited by 556
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534
Calorie restriction in humans: An update
Most, J., Tosti, V., Redman, L. M., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.005 · Cited by 530
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
Fornai, F., Schlüter, O. M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., Lazzeri, G., Busceti, C. L., Pontarelli, F., Battaglia, G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409713102 · Cited by 526 · cited 1×
“…(MPTP), and rotenone, both of which are mitochondrial complex I inhibitors, have been demonstrated to result in clinical PD phenotype by producing pathological degeneration of dopaminergic neurons of the substantia nigra (Betarbet et al., 2000; Fornai et al., 2005).”
Background
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513 · cited 1×
“A series of reviews regarding sirtuins on mitochondrial and oxidative regulation have been published before (Grabowska et al., 2017; Guarente, 2008, 2011a; Guarente, 2011b; Imai and Guarente, 2016; Sack and Finkel, 2012; Westphal et al., 2007).”
Background
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000361 · Cited by 511
Sirtuins, Aging, and Medicine
Guarente, L. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100831 · Cited by 510 · cited 3×
“It plays an important role in mitochondrial bioenergetics (Guarente, 2011a; Imai and Guarente, 2016; Sack and Finkel, 2012; Westphal et al., 2007), as well as promote resistance to oxidative stress by reducing ROS via magnesium SOD deacetylation and activation (Guarente, 2011a; Sack and Finkel,…”
Background
Mitochondrial Dysfunction and Reactive Oxygen Species in Excitotoxicity and Apoptosis: Implications for the Pathogenesis of Neurodegenerative Diseases
Rego, A. C., & Oliveira, C. R. (2003) · Neurochemical Research · doi:10.1023/a:1025682611389 · Cited by 476 · cited 1×
“lower rate of cellular renewal, membrane PUFA levels, as well as less active oxidative defense mechanisms (Rego and Oliveira, 2003).”
Background
Sirtuins, a promising target in slowing down the ageing process
Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · cited 1×
“A series of reviews regarding sirtuins on mitochondrial and oxidative regulation have been published before (Grabowska et al., 2017; Guarente, 2008, 2011a; Guarente, 2011b; Imai and Guarente, 2016; Sack and Finkel, 2012; Westphal et al., 2007).”
Background
Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Myung, S.-K., Ju, W., Cho, B., Oh, S.-W., Park, S. M., Koo, B.-K., Park, B.-J., & for the Korean Meta-Analysis (KORMA) Study Group (2013) · BMJ · doi:10.1136/bmj.f10 · Cited by 467 · cited 2×
“the prevention or treatment of various age-related diseases (Bjelakovic et al., 2007; Farina et al., 2017; Klein et al., 2011; Miller et al., 2005; Myung et al., 2013; Wang et al., 2014).”
Background
Vitamin E: Emerging aspects and new directions
Galli, F., Azzi, A., Birringer, M., Cook‐Mills, J. M., Eggersdorfer, M. L., Frank, J., Cruciani, G., Lorkowski, S., & Özer, N. K. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.017 · Cited by 467
Calorie restriction and sirtuins revisited
Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464 · cited 2×
“1α), leading to a slower rate of aging-related decline and extended lifespan (Guarente, 2013; LópezLluch and Navas, 2016; Zullo et al., 2018).”
Background
Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence
von Zglinicki, T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06639.x · Cited by 452 · cited 1×
“For example, telomeres are highly sensitive to oxidative damage and their repair capacity is less well than other parts of the chromosome (von Zglinicki, 2000; von Zglinicki, 2002).”
Background
Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?
Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 451 · cited 1×
“With respect to induced genetic alternations, antioxidants-related transgenic lower models have been frequently used, which have altered antioxidant capacity or a disrupted oxidative-related signaling pathway, leading to either a reduced or extended lifespan (Chen et al., 2010; Liang et al., 2003; Liao and Kennedy, 20…”
Background
SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism
Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445
Why Have Antioxidants Failed in Clinical Trials?
Steinhubl, S. R. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.003 · Cited by 428 · cited 1×
“Several potential reasons for this failure have been discussed extensively (Brewer, 2010; Murphy, 2014; Robinson et al., 2006; Steinhubl, 2008).”
Background
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D. J., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub5 · Cited by 424 · cited 4×
“the prevention or treatment of various age-related diseases (Bjelakovic et al., 2007; Farina et al., 2017; Klein et al., 2011; Miller et al., 2005; Myung et al., 2013; Wang et al., 2014).”
BackgroundInfluential
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
Doonan, R., McElwee, J. J., Matthijssens, F., Walker, G. A., Houthoofd, K., Back, P., Matscheski, A., Vanfleteren, J. R., & Gems, D. (2008) · Genes & Development · doi:10.1101/gad.504808 · Cited by 423
Antioxidant Vitamin Intake and Risk of Alzheimer Disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.203 · Cited by 414
Vitamin E: action, metabolism and perspectives
Herrera, E., & Barbas, C. (2001) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179812 · Cited by 413
It takes two to tango: NAD(+) and sirtuins in aging/longevity control
Imai, S.-I., & Guarente, L. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.17 · Cited by 394
Mitochondrial decay in aging
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00024-x · Cited by 391 · cited 2×
“much higher in mtDNA than in nuclear DNA (Ames et al., 1995; Cui et al., 2012).”
Background
Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.
Halliwell, B. B. (1989) · PubMed Central · Cited by 366
The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans
Yee, C., Yang, W., & Hekimi, S. (2014) · Cell · doi:10.1016/j.cell.2014.02.055 · Cited by 356 · cited 1×
“…some studies even found a large extension of lifespan with elevated oxidative stress level (Doonan et al., 2008; Hwang et al., 2014; Oberacker et al., 2018; Reveillaud et al., 1994; Uno and Nishida, 2016; Van Raamsdonk and Hekimi, 2009; Yang and Hekimi, 2010; Yang et al., 2007; Yee et al., 2014).”
Background
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353 · cited 8×
“Once generated, it could be catalyzed spontaneously by SOD into H2O2.”
Influential
Vaccines, new opportunities for a new society
Rappuoli, R., Pizza, M., Giudice, G. D., & Gregorio, E. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402981111 · Cited by 352 · cited 1×
“result of improved medical care, vaccination and hygiene (Eggleston and Fuchs, 2012; Rappuoli et al., 2014).”
Background
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
Daiber, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.032 · Cited by 347 · cited 11×
“Here we will discuss the harmful consequences of oxidative stress, mainly oxidative damage which are more closely related to accelerated ageing and multiple age-related diseases, with a special focus on ageing and lifespan, cardiovascular diseases (CVD) and neurodegenerative diseases (NNDs).”
BackgroundInfluential
A mitochondrial bioenergetic etiology of disease
Wallace, D. C. (2013) · Journal of Clinical Investigation · doi:10.1172/jci61398 · Cited by 342 · cited 1×
“All these modifications are the driving force for further mitochondrial dysfunction and loss of integrity, which will affect cell viability and cellular function (Lin and Beal, Jo rn al Pr epr oo f 2006; Wallace, 2013).”
Background
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization
Yang, W., Nagasawa, K., Münch, C., Xu, Y., Satterstrom, F. K., Jeong, S., Hayes, S., Jedrychowski, M. P., Vyas, F. S., Zaganjor, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.016 · Cited by 341 · cited 1×
“In addition, these mitochondrial sirtuins work in concert and present complicated interaction profiles (Yang et al., 2016), for example, SIRT3 and SIRT4 may function together to protect cells from stress and DNA damage (Jeong et al.”
Background
Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease
Morris, M. C., Beckett, L. A., Scherr, P. A., Hebert, L. E., Bennett, D. A., Field, T. S., & Evans, D. A. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00001 · Cited by 332
Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases
Trpković, A., Resanović, I., Stanimirović, J., Radak, D. J., Mousa, S. A., Cenic-Milosevic, D., Jevremović, D., & Isenović, E. R. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.992063 · Cited by 326 · cited 1×
“low-density lipoprotein (oxLDL) derived from oxidative modification (Trpkovic et al., 2015), and nitrotyrosine resulting from tyrosine oxidation (Bartesaghi et al.”
Background
F 2 -Isoprostanes as markers of oxidative stress in vivo : An overview
Milne, G. L., Musiek, E. S., & Morrow, J. D. (2005) · Biomarkers · doi:10.1080/13547500500216546 · Cited by 323 · cited 3×
“These are prostaglandin-like compounds initially formed in-situ esterified to phospholipids and subsequently released in free form by phospholipases (Milne et al., 2005).”
Background
Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta‐analysis
da Silva, S. L., Vellas, B. J., Elemans, S., Luchsinger, J. A., Kamphuis, P. J. G. H., Yaffe, K. S., Sijben, J., Groenendijk, M., & Stijnen, T. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1771 · Cited by 313
Effect of Antioxidants Supplementation on Aging and Longevity
Sadowska‐Bartosz, I., & Bartosz, G. (2014) · BioMed Research International · doi:10.1155/2014/404680 · Cited by 307 · cited 1×
“The inconsistence was also found in experiments with dietary antioxidants supplementation (Sadowska-Bartosz and Bartosz, 2014).”
Background
Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆
Butterfield, D. A., Lange, M. L. B., & Rukhsana Sultana, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.005 · Cited by 302
Calorie restriction as an intervention in ageing
López‐Lluch, G., & Navas, P. (2015) · The Journal of Physiology · doi:10.1113/jp270543 · Cited by 301
Haptoglobin: Basic and Clinical Aspects
Levy, A. P., Asleh, R., Blum, S., Levy, N. S., Miller‐Lotan, R., Kalet-Litman, S., Anbinder, Y., Lache, O., Nakhoul, F. M., Asaf, R., et al. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2793 · Cited by 297
Association of mitochondrial DNA copy number with cardiovascular disease
Ashar, F. N., Zhang, Y., Longchamps, R. J., Lane, J., Moes, A., Grove, M. L., Mychaleckyj, J. C., Taylor, K. D., Coresh, J., Rotter, J. I., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.3683 · Cited by 295
Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease
Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybyłowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G., & Channon, K. M. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000196651.64776.51 · Cited by 278
Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease
Mecocci, P., & Polidori, M. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.006 · Cited by 277 · cited 1×
“A series of seminal papers on antioxidant therapy as well as the challenges in AD have been reviewed thoroughly (Mecocci et al., 2018; Mecocci and Polidori, 2012; Polidori and Nelles, 2014).”
Background
Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function
Daiber, A., Lisa, F. D., Oelze, M. W., Kröller‐Schön, S., Steven, S., Schulz, E., & Münzel, T. F. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13403 · Cited by 274
The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis
Spickett, C. M. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.007 · Cited by 269 · cited 1×
“…due to the high reactivity of these aldehydes, for example they can react with proteins through the Michael addition reaction or with DNA to form adducts (Il'yasova et al., 2012; Spickett, 2013), it is difficult to accurately measure their free concentrations as valid oxidative damage levels.”
Background
Oxidative Stress Signaling to Chromatin in Health and Disease
Kreuz, S., & Fischle, W. (2016) · Epigenomics · doi:10.2217/epi-2016-0002 · Cited by 265
The relationship between dose of vitamin E and suppression of oxidative stress in humans
Roberts, L. J., Oates, J. A., Linton, M. F., Fazio, S., Meador, B. P., Gross, M., Shyr, Y., & Morrow, J. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.019 · Cited by 260 · cited 1×
“However, the dose for vitamin E to suppress plasma F2-isoprostane concentration is 1600 IU or 3200 IU without observing any adverse effect after 16 weeks of supplementation, while the suppression of isoprostane were 35% and 49% respectively (Roberts et al., 2007).”
Background
A Long Journey into Aging, Brain Aging, and Alzheimer’s Disease Following the Oxidative Stress Tracks
Mecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., & Baroni, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170732 · Cited by 259 · cited 1×
“A series of seminal papers on antioxidant therapy as well as the challenges in AD have been reviewed thoroughly (Mecocci et al., 2018; Mecocci and Polidori, 2012; Polidori and Nelles, 2014).”
Background
Urinary biomarkers of oxidative status
Il’yasova, D., Scarbrough, P. M., & Spasojević, I. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.06.012 · Cited by 253 · cited 3×
“However, due to the high reactivity of these aldehydes, for example they can react with proteins through the Michael addition reaction or with DNA to form adducts (Il'yasova et al., 2012; Spickett, 2013), it is difficult to accurately measure their free concentrations as valid”
BackgroundInfluential
Mitochondrial DNA repair pathways
Croteau, D. L., Stierum, R. H., & Bohr, V. A. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00025-7 · Cited by 245 · cited 1×
“Though base excision repair, mismatch repair as well as recombination or nonhomologous end joining repair mechanisms do exist in mtDNA, nucleotide excision repair is still absent, and the specific roles of each pathway, as well as proteins involved in repair processes remain to be fully elucidated (Croteau et al., 199…”
Background
Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk
Zhang, S., Hernán, M. Á., Chen, H., Spiegelman, D. L., Willett, W. C., & Ascherio, A. (2002) · Neurology · doi:10.1212/01.wnl.0000028688.75881.12 · Cited by 243
Mitochondrial Metabolism, Sirtuins, and AgingPreprint
Sack, M. N., & Finkel, T. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013102 · Cited by 242 · cited 3×
“mitochondrial bioenergetics (Guarente, 2011a; Imai and Guarente, 2016; Sack and Finkel, 2012; Westphal et al., 2007), as well as promote resistance to oxidative stress by reducing ROS via magnesium SOD deacetylation and activation (Guarente, 2011a; Sack and Finkel, 2012).”
Background
Genetic mouse models of extended lifespan
Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A., & Richardson, A. G. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.019 · Cited by 239 · cited 1×
“With respect to induced genetic alternations, antioxidants-related transgenic lower models have been frequently used, which have altered antioxidant capacity or a disrupted oxidative-related signaling pathway, leading to either a reduced or extended lifespan (Chen et al., 2010; Liang et al., 2003; Liao and Kennedy, 20…”
Background
Reduced risk of colon cancer with high intake of vitamin E : the Iowa Women's Health Study.
Bostick, Potter, J. D., McKenzie, M., & Sellers (1993) · Cancer Research · Cited by 234
Mitochondrial DNA repair in aging and disease
Druzhyna, N., Wilson, G. L., & LeDoux, S. P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.002 · Cited by 225 · cited 2×
“Though base excision repair, mismatch repair as well as recombination or nonhomologous end joining repair mechanisms do exist in mtDNA, nucleotide excision repair is still absent, and the specific roles of each pathway, as well as proteins involved in repair processes remain to be fully elucidated (Croteau et al., 199…”
Background
Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension
Fessel, J. P., Porter, N. A., Moore, K. P., Sheller, J. R., & Roberts, L. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252649099 · Cited by 219
Antioxidant and prooxidant activity of alpha-tocopherol in human plasma and low density lipoprotein.
Kontush, A., Finckh, B., Karten, B., Kohlschütter, A., & Beisiegel†, U. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39128-8 · Cited by 216
Sirtuins, Aging, and MetabolismPreprint
Guarente, L. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010629 · Cited by 213 · cited 3×
“It plays an important role in mitochondrial bioenergetics (Guarente, 2011a; Imai and Guarente, 2016; Sack and Finkel, 2012; Westphal et al., 2007), as well as promote resistance to oxidative stress by reducing ROS via magnesium SOD deacetylation and activation (Guarente, 2011a; Sack and Finkel,…”
Background
Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice
Jang, Y. C., Pérez, V., Song, W. J., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A. R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp100 · Cited by 205
Many tocopherols, one vitamin E
Azzi, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.004 · Cited by 204 · cited 2×
““vitamin E” given its proved ability to avoid vitamin E deficiency (Azzi, 2018).”
Background
DNA damage in neurodegenerative diseases
Coppedè, F., & Migliore, L. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.11.010 · Cited by 202
Lifespan-regulating genes in C. elegans
Uno, M., & Nishida, E. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.10 · Cited by 202 · cited 1×
“…some studies even found a large extension of lifespan with elevated oxidative stress level (Doonan et al., 2008; Hwang et al., 2014; Oberacker et al., 2018; Reveillaud et al., 1994; Uno and Nishida, 2016; Van Raamsdonk and Hekimi, 2009; Yang and Hekimi, 2010; Yang et al., 2007; Yee et al., 2014).”
Background
The brain, sirtuins, and ageing
Satoh, A., Imai, S., & Guarente, L. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.42 · Cited by 197 · cited 1×
“3) are also associated with neuron fates, being either neuroprotective or neurotoxic (Sansone et al., 2013; Satoh et al., 2017; Westphal et al., 2007).”
Background
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
Hwang, A. B., Ryu, E.-A., Artan, M., Chang, H., Kabir, M. H., Nam, H.-J., Lee, D.-Y., Yang, J., Kim, S., Mair, W. B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411199111 · Cited by 196
Antioxidants: Scientific Literature Landscape Analysis
Yeung, A. W. K., Tzvetkov, N. T., El-Tawil, O. S., BUNGAU, S. G., Abdel‐Daim, M. M., & Atanasov, A. G. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8278454 · Cited by 193 · cited 1×
“Conversely, the annual publication count of antioxidant articles steadily increased since the 1990s, and more than 30,000 papers have been published in 2018 alone about this research topic (Yeung et al., 2019).”
Background
Dietary Intakes of Vitamin E, Vitamin C, and β-Carotene and Risk of Alzheimer's Disease: A Meta-Analysis
Li, F.-J., Shen, L., & Ji, H. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120349 · Cited by 184 · cited 1×
“Although lower disease risks in individuals with higher vitamin E concentration have been found in many observational studies (Bostick et al., 1993; Li et al., 2012; Mayer-Davis et al., 2002; Rimm et al., 1993; Stampfer et al., 1993; Wright et al., 2006), as well as Jo ur na l P epr oo f protective…”
Background
Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study.
Bostick, R. M., Potter, J. D., McKenzie, D. R., Sellers, T. A., Kushi, L. H., Steinmetz, K. A., & Folsom, A. R. (1993) · PubMed · Cited by 180
Classifying oxidative stress by F2-isoprostane levels across human diseases: A meta-analysis
Erve, T. J. V. ‘., Kadiiska, M. B., London, S. J., & Mason, R. P. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.024 · Cited by 174
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity
Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J. W., Epstein, C., Richardson, A., et al. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp132 · Cited by 172 · cited 10×
“Once generated, it could be catalyzed spontaneously by SOD into H2O2.”
BackgroundInfluential
Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds
Sousa, B. C., Pitt, A. R., & Spickett, C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.003 · Cited by 172 · cited 2×
“Furthermore, lipid radicals generated during oxidation processes can form a myriad of deleterious end products, including reactive aldehydes, alkanes and alkenes (Sousa et al., 2017).”
Background
Haptoglobin
Andersen, C. B. F., Stødkilde, K., Sæderup, K. L., Kuhlee, A., Raunser, S., Graversen, J. H., & Moestrup, S. K. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6793 · Cited by 172
A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans
Yang, W., Li, J., & Hekimi, S. (2007) · Genetics · doi:10.1534/genetics.107.080788 · Cited by 171 · cited 1×
“…some studies even found a large extension of lifespan with elevated oxidative stress level (Doonan et al., 2008; Hwang et al., 2014; Oberacker et al., 2018; Reveillaud et al., 1994; Uno and Nishida, 2016; Van Raamsdonk and Hekimi, 2009; Yang and Hekimi, 2010; Yang et al., 2007; Yee et al., 2014).”
Background
Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models
Gugliandolo, A., Bramanti, P., & Mazzon, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122504 · Cited by 170
Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases
Bartoli, M. L. E., Novelli, F., Costa, F., Malagrinò, L., Melosini, L., Bacci, E., Cianchetti, S., Dente, F. L., Franco, A. D., Vagaggini, B., et al. (2011) · Mediators of Inflammation · doi:10.1155/2011/891752 · Cited by 168 · cited 1×
“have been identified in experimental and population-based studies (Bartoli et al., 2011; Dalleau et al., 2013; Strobel et al., 2011; van't Erve et al., 2017), together with the potential associations with ageing”
A therapeutic role for sirtuins in diseases of aging?
Westphal, C. H., Dipp, M., & Guarente, L. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.09.008 · Cited by 168 · cited 3×
“mitochondrial bioenergetics (Guarente, 2011a; Imai and Guarente, 2016; Sack and Finkel, 2012; Westphal et al., 2007), as well as promote resistance to oxidative stress by reducing ROS via magnesium SOD deacetylation and activation (Guarente, 2011a; Sack and Finkel, 2012).”
Background
Dietary supplements and risk of cause-specific death, cardiovascular disease, and cancer: a systematic review and meta-analysis of primary prevention trials
Schwingshackl, L., Boeing, H., Stelmach-Mardas, M., Gottschald, M., Dietrich, S., Hoffmann, G., & Chaimani, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013516 · Cited by 165
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Rutjes, A. W., Denton, D. A., Di Nisio, M., Chong, L.-Y., Abraham, R. P., Al-Assaf, A. S., Anderson, J. L., Malik, M. A., Vernooij, R. W., Martínez, G., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011906.pub2 · Cited by 164 · cited 1×
“Meta-analyses also suggested that there is no evidence of vitamin supplementation for prevention of cognitive decline or dementia in cognitively healthy adults (Rutjes et al., 2018), or for prevention of progression from mild cognitive impairment (MCI) to dementia, or for treatment of MCI, or for improvement of cognit…”
Background
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment
McCleery, J., Abraham, R. P., Denton, D. A., Rutjes, A. W., Chong, L.-Y., Al-Assaf, A. S., Griffith, D. J., Rafeeq, S., Yaman, H., Malik, M. A., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011905.pub2 · Cited by 162
Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity
Testa, G., Biasi, F., Poli, G., & Chiarpotto, E. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660699 · Cited by 153
Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
Wright, M. E., Lawson, K. A., Weinstein, S. J., Pietinen, P., Taylor, P. R., Virtamo, J. R. K., & Albanes, D. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1200 · Cited by 150
Impact of antioxidants, zinc, and copper on cognition in the elderly
Age-Related Eye Disease Study Research Group (2004) · Neurology · doi:10.1212/01.wnl.0000142969.19465.8f · Cited by 149
Antioxidants as therapies: can we improve on nature?
Murphy, M. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.010 · Cited by 148 · cited 3×
“Several potential reasons for this failure have been discussed extensively (Brewer, 2010; Murphy, 2014; Robinson et al., 2006; Steinhubl, 2008).”
Background
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C. C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.12.001 · Cited by 146
Self-citation
Anti‐atherosclerotic effects of vitamin E – myth or reality?
Vlad, A., Zingg, J.-M., & Azzi, A. (2004) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2004.tb00260.x · Cited by 145 · cited 1×
“tocopherol levels could only increase less than 2-3 times no matter the amount or duration of supplementation (Munteanu et al., 2004).”
Background
Oxidative stress biomarkers as predictors of cardiovascular disease
Strobel, N., Fassett, R. G., Marsh, S. A., & Coombes, J. S. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.08.008 · Cited by 145 · cited 1×
“have been identified in experimental and population-based studies (Bartoli et al., 2011; Dalleau et al., 2013; Strobel et al., 2011; van't Erve et al., 2017), together with the potential associations with ageing”
Lower brain and blood nutrient status in Alzheimer's disease: Results from meta‐analyses
de Wilde, M. C., Vellas, B. J., Girault, E. M., Cetinyurek‐Yavuz, A., & Sijben, J. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.06.002 · Cited by 144
A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus
Olsson, L. M., Johansson, Å. C. M., Gullstrand, B., Jönsen, A., Saevarsdóttir, S., Rönnblom, L., Leonard, D., Wetterö, J., Sjöwall, C., Svenungsson, E., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211287 · Cited by 142 · cited 1×
“Similarly, the Ncf1-339 T allele, related to reduced extracellular ROS production in neutrophils and increased type 1 interferon-regulated genes expression, was found enriched in systemic lupus erythematosus patients compared to healthy controls (Olsson et al., 2017).”
Background
Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature
Kelkka, T., Kienhöfer, D., Hoffmann, M. H., Linja, M., Wing, K., Sareila, O., Hultqvist, M. H., Laajala, E., Chen, Z. J., Vasconcelos, J. H. L., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5828 · Cited by 138 · cited 1×
“ROS level, were more susceptible to develop chronic granulomatous disease (Kelkka et al., 2014).”
Background
Synthetic as compared with natural vitamin E is preferentially excreted as α‐CEHC in human urine: studies using deuterated α‐tocopheryl acetates
Traber, M. G., Elsner, A., & Brigelius‐Flohé, R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01210-1 · Cited by 138 · cited 1×
“characterizing by preferentially non-oxidation metabolites in urine (Traber et al., 1998).”
Background
Biological ageing and cardiovascular disease
Samani, N. J., & van der Harst, P. (2008) · Heart · doi:10.1136/hrt.2007.136010 · Cited by 136
Protein tyrosine nitration in hydrophilic and hydrophobic environments
Bartesaghi, S., Ferrer‐Sueta, G., Peluffo, G., Valez, V., Zhang, H., Kalyanaraman, B., & Radí, R. (2006) · Amino Acids · doi:10.1007/s00726-006-0425-8 · Cited by 133 · cited 1×
“, 2015), and nitrotyrosine resulting from tyrosine oxidation (Bartesaghi et al., 2007).”
Background
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span
Salmon, A. B., Pérez, V., Bokov, A. F., Jernigan, A., Kim, G., Zhao, H., Levine, R. L., & Richardson, A. (2009) · The FASEB Journal · doi:10.1096/fj.08-127415 · Cited by 131 · cited 2×
“…SOD (Jang et al., 2009; Perez et al., 2009; Van Remmen et al., 2003; Zhang et al., 2009), thioredoxin (Cunningham et al., 2018; Perez et al., 2011), or methionine sulfoxide reductase A (MsrA−/−) that function to protect against protein oxidation (Moskovitz et al., 2001; Salmon et al., 2009).”
Background
Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies
Ye, Z., & Song, H. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f11f95 · Cited by 131 · cited 1×
“associated with lower CVD risk, such as coronary heart disease, ischemic stroke as well as CVD mortality (Siti et al., 2015; Ye and Song, 2008).”
Background
Pathophysiological importance of aggregated damaged proteins
Höhn, A., Jung, T., & Grune, T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.028 · Cited by 130
Oxidative stress and endothelial dysfunction: Therapeutic implications
Gori, T., & Münzel, T. F. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.543920 · Cited by 126
Calorie restriction in rodents: Caveats to consider
Ingram, D. K., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.008 · Cited by 123
Peripheral artery disease, redox signaling, oxidative stress – Basic and clinical aspects
Steven, S., Daiber, A., Dopheide, J. F., Münzel, T. F., & Espinola–Klein, C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.017 · Cited by 115
Evidence for beneficial effects of vitamin E
Niki, E. (2015) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2015.30.5.571 · Cited by 112 · cited 1×
“In addition to these potential explanations for the lack of significant findings of vitamin E supplementation, some opinions argued that oxidative damage could merely play a role in the pathophysiology instead of being a direct cause of diseases (Kim et al., 2015; Murphy, 2014; Niki, 2015).”
Background
Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan?
Sanz, A. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.03.018 · Cited by 111 · cited 2×
“mitochondria play a critical role in the ageing process, but it remains unclear whether it is a cause or consequence (Sanz, 2016).”
Background
Plasma and Dietary Vitamin E in Relation to Incidence of Type 2 Diabetes
Mayer‐Davis, E. J., Costacou, T., King, I. B., Zaccaro, D. J., & Bell, R. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2172 · Cited by 109
A Mitochondrial Etiology of Neurodegenerative Diseases: Evidence from Parkinson's Disease
Хуснутдинова, Э. К., Gilyazova, I. R., Ruiz‐Pesini, E., Derbeneva, O. A., Khusainova, R. I., Khidiyatova, I. M., Magzhanov, R. V., & Wallace, D. C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.001 · Cited by 108
Coexistence of Oxidized Lipids and α-Tocopherol in All Lipoprotein Density Fractions Isolated From Advanced Human Atherosclerotic Plaques
Niu, X., Zammit, V. C., Upston, J. M., Dean, R. T., & Stocker, R. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.7.1708 · Cited by 105 · cited 1×
“A level of about 3% to 11% of α-tocopherol as oxidized form of α-TQ was found in all lipoprotein density fractions prepared from advanced human atherosclerotic plaque (Niu et al., 1999).”
Background
DNA mismatch repair (MMR) mediates 6-thioguanine genotoxicity by introducing single-strand breaks to signal a G2-M arrest in MMR-proficient RKO cells.
Yan, T., Berry, S. E., Desai, A. B., & Kinsella, T. J. (2003) · PubMed · Cited by 104
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub4 · Cited by 104
Vitamin E: absorption, plasma transport and cell uptake
Hacquebard, M., & Carpentier, Y. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200503000-00005 · Cited by 102
Vitamin E in Humans: An Explanation of Clinical Trial Failure
Robinson, I., de Serna, D. G., Gutierrez, A., & Schade, D. S. (2006) · Endocrine Practice · doi:10.4158/ep.12.5.576 · Cited by 101
Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans
Desjardins, D., Cacho‐Valadez, B., Liu, J., Wang, Y., Yee, C. S., Bernard, K., Khaki, A., Breton, L., & Hekimi, S. (2016) · Aging Cell · doi:10.1111/acel.12528 · Cited by 101 · cited 1×
“In addition, antioxidants would have this similar dose-response manner since the change of antioxidant levels are mostly inversely associated with oxidants, for example, in C elegans, an inverted U-shaped dose-response relationship between antioxidants and lifespan was observed (Desjardins et al., 2017).”
Background
Structure of a hydroxyl radical-induced DNA-protein crosslink involving thymine and tyrosine in nucleohistone
Dizdaroğlu, M., Gajewski, E., Reddy, P., & Margolis, S. A. (1989) · Biochemistry · doi:10.1021/bi00434a071 · Cited by 99 · cited 1×
“DNA-protein cross-links involving thymine and tyrosine in the nucleoprotein complex of histones and DNA (nucleo-histone) can also be induced by the hydroxyl radicals (Dizdaroglu et al., 1989).”
Background
Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial , , ,
Wang, L., Sesso, H. D., Glynn, R. J., Christen, W. G., Bubes, V. Y., Manson, J. E., Buring, J. E., & Gaziano, J. M. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.085480 · Cited by 99 · cited 1×
“the prevention or treatment of various age-related diseases (Bjelakovic et al., 2007; Farina et al., 2017; Klein et al., 2011; Miller et al., 2005; Myung et al., 2013; Wang et al., 2014).”
Background
Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection
Vardi, M., Levy, N. S., & Levy, A. P. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r026641 · Cited by 98 · cited 1×
“Vitamin E supplementation provided cardiovascular-protective effects only in discriminatingly selected subgroup of individuals with both diabetes and Hp2-2 genotype (Hochberg et al., 2017; Seferovic et al., 2018; Vardi et al., 2013), who had high levels of oxidative stress and inferior antioxidant protection, in whom…”
Background
The New Demographic Transition: Most Gains in Life Expectancy Now Realized Late in Life
Eggleston, K. N., & Fuchs, V. R. (2012) · Journal of Economic Perspectives · doi:10.1257/jep.26.3.137 · Cited by 95 · cited 1×
“result of improved medical care, vaccination and hygiene (Eggleston and Fuchs, 2012; Rappuoli et al., 2014).”
The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials
Zhu, Z., Sun, M.-X., Zhang, W., Wang, W., Jin, Y.-M., & Xie, C. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2757-9 · Cited by 88 · cited 1×
“Similar results were partly observed for PD (Negida et al., 2016; Zhu et al., 2017).”
Result
The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial
El‐Aal, A. A., Abdelghffar, E. A. R., Ghali, A. S. A., Zughbur, M. R., & Sirdah, M. M. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.03.013 · Cited by 85 · cited 1×
“metformin treatment alone, indicating that antioxidants use might be an adjuvant therapy in the management in type 2 diabetic patients (El-Aal et al., 2018).”
Background
Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice
Pérez, V., Cortez, L. A., Lew, C. M., Rodriguez, M., Webb, C. R., Remmen, H. V., Chaudhuri, A. R., Qi, W., Lee, S., Bokov, A., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr125 · Cited by 84 · cited 1×
“, 2009), thioredoxin (Cunningham et al., 2018; Perez et al., 2011), or methionine sulfoxide reductase A (MsrA) that function to protect against protein oxidation (Moskovitz et al.”
Background
Measurement of plasma F2-isoprostanes as an index of lipid peroxidation does not appear to be confounded by diet
Gopaul, N. K., Halliwell, B. B., & Änggård, E. (2000) · Free Radical Research · doi:10.1080/10715760000300671 · Cited by 83 · cited 2×
“C, B12, B6 and folic acid, on CVD risk, especially in atherosclerosis (Gori and Munzel, 2011; Siti et al., 2015).”
Background
Coenzyme Q10 for Patients with Parkinson';s Disease: A Systematic Review and Meta-Analysis
Negida, A., Menshawy, A., Ashal, G. E., Elfouly, Y., Hani, Y., Hegazy, Y., ghonimy, S. E., Fouda, S., & Rashad, Y. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150821103306 · Cited by 77 · cited 1×
“Similar results were partly observed for PD (Negida et al., 2016; Zhu et al., 2017).”
Result
Mammalian models of extended healthy lifespan
Selman, C., & Withers, D. J. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0243 · Cited by 75
Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease
Boccardi, V., Baroni, M., Mangialasche, F., & Mecocci, P. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.08.002 · Cited by 73 · cited 1×
“Plasma vitamin E levels are associated with better cognitive performance (Boccardi et al., 2016), and patients with AD were found to have a lower nutrient status of vitamin E, C, B12 in blood and”
Background
Antioxidant Clinical Trials in Mild Cognitive Impairment and Alzheimer’s disease – Challenges and Perspectives
Polidori, M., & Nelles, G. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660706 · Cited by 69 · cited 1×
“A series of seminal papers on antioxidant therapy as well as the challenges in AD have been reviewed thoroughly (Mecocci et al., 2018; Mecocci and Polidori, 2012; Polidori and Nelles, 2014).”
Background
Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle
Zullo, A., Simone, E., Grimaldi, M., Musto, V., & Mancini, F. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040928 · Cited by 67 · cited 1×
“1α), leading to a slower rate of aging-related decline and extended lifespan (Guarente, 2013; LópezLluch and Navas, 2016; Zullo et al., 2018).”
Background
Mitochondrial-Targeted Catalase
Dai, D., Chiao, Y. A., Martin, G. M., Marcinek, D. J., Basisty, N., Quarles, E. K., & Rabinovitch, P. S. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.015 · Cited by 65 · cited 1×
“Mice with antioxidant overexpression, for example, catalase (Dai et al., 2017), or with modifications in other signaling pathway components, such as p66 (Migliaccio et al.”
Background
Inter- and intra-individual variation in plasma and red blood cell vitamin E after supplementation
Roxborough, H. E., Burton, G. W., & Kelly, F. J. (2000) · Free Radical Research · doi:10.1080/10715760000300971 · Cited by 64 · cited 1×
“variations in the regulation of vitamin E uptake and metabolism between subjects, such as genetic factors, particularly apolipoprotein polymorphism (Roxborough et al., 2000).”
Background
Enhanced expression of thioredoxin‐interacting‐protein regulates oxidative DNA damage and aging
Oberacker, T., Bajorat, J., Ziola, S., Schroeder, A., Röth, D., Kastl, L., Edgar, B. A., Wagner, W., Gülow, K., & Krammer, P. H. (2018) · FEBS Letters · doi:10.1002/1873-3468.13156 · Cited by 63
Circulating vitamin E levels and Alzheimer's disease: a Mendelian randomization study
Liu, G., Zhao, Y., Jin, S., Hu, Y., Wang, T., Tian, R., Han, Z., Xu, D., & Jiang, Q. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.08.008 · Cited by 62 · cited 2×
“In European-ancestry individuals, there is no causal association between circulating vitamin E levels (Liu et al., 2018), as well as ascorbate, β-carotene, retinol (Williams et al.”
Background

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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Oxidative Stress and Inflammation in Osteoarthritis Pathogenesis: Role of Polyphenols
Ansari, M. Y., Ahmad, N., & Haqqi, T. (2020) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2020.110452 · Cited by 665
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“Aging is also related to the occurrence of various age-related diseases such as diabetes, cancer, and neurodegenerative and cardiovascular disorders [7].”
Background
Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update
Cordiano, R., Gioacchino, M. D., Mangifesta, R., Panzera, C., Gangemi, S., & Minciullo, P. L. (2023) · Molecules · doi:10.3390/molecules28165979 · Cited by 490

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Authors: Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D.
Affiliations: Leiden University Medical Center (NL)
Great Ormond Street Hospital (GB)
ORCID: Luo, Jiao
Mills, Kevin
Noordam, Raymond
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2020-01
Volume: 57
Pages: 100982
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2019.100982
OpenAlex: W2985538915
Cited by: 581
References: 237
Citations by year: 2026: 53 · 2025: 90 · 2024: 109 · 2023: 115 · 2022: 105 · 2021: 79 · 2020: 29
FWCI: 5.16
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Leiden Repository (Leiden University) (submittedVersion, cc-by)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
UCL Discovery (University College London) (submittedVersion)
Funders: Velux Stiftung (1156)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: oxidative stress, aging, age-related diseases, oxidative damage, antioxidant supplementation, oxidative stress biomarkers
MeSH terms: Aging, Animals, Antioxidants, Humans, Sensitivity and Specificity, Reproducibility of Results, Biomarkers, Oxidative Stress

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Ageing, age-related diseases and oxidative stress: What to do next?

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