The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota
Abstract
In the past decade, numerous studies have demonstrated the close relationship between gut microbiota and the occurrence and development of Alzheimer's disease (AD). However, the specific mechanism is still unclear. Both the neuroinflammation and systemic inflammation serve as the key hubs to accelerate the process of AD by promoting pathology and damaging neuron. What's more, the gut microbiota is also crucial for the regulation of inflammation. Therefore, this review focused on the role of gut microbiota in AD through inflammatory pathways. Firstly, this review summarized the relationship and interaction among gut microbiota, inflammation, and AD. Secondly, the direct and indirect regulatory effects of gut microbiota on AD through inflammatory pathways were described. These effects were mainly mediated by the component of the gut microbiota (lipopolysaccharides (LPS) and amyloid peptides), the metabolites of bacteria (short-chain fatty acids, branched amino acids, and neurotransmitters) and functional by-products (bile acids). In addition, potential treatments (fecal microbiota transplantation, antibiotics, probiotics, prebiotics, and dietary interventions) for AD were also discussed through these mechanisms. Finally, according to the current research status, the key problems to be solved in the future studies were proposed.
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“This hypothesis posits that various pathological factors, such as Aβ plaques, pro-inflammatory cytokines, and oxidative stress, activate microglia, the central nervous system’s innate immune cells. Upon activation, microglia undergo morphological changes and initiate a variety of inflammatory responses, which can lead to the release of pro-inflammatory mediators that exacerbate neurotoxicity.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [16]
In the citing paper
“The inflammatory hypothesis suggests that chronic neuroinflammation plays a significant role in the pathogenesis of AD.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [16]
In the citing paper
“The persistent activation of microglia may result in a failure to resolve inflammation, contributing to neuronal damage and the cognitive decline associated with AD [15,16].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [16]
Citations
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Cited by
Sorted by citations
Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343
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“The persistent activation of microglia may result in a failure to resolve inflammation, contributing to neuronal damage and the cognitive decline associated with AD [15,16].”
BackgroundZhao, Q., Chen, J., Wu, M., Yin, X., Jiang, Q., Gao, H., & Zheng, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110638 · Cited by 49
The endocannabinoid system: a bridge between alzheimer’s disease and gut microbiota
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Metadata
- Authors
- Qian, X.-H., Song, X.-X., Liu, X.-L., Chen, S.-D., & Tang, H.-D.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 68
- Pages
- 101317
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W3134448216
- Cited by
- 153
- References
- 209
- Citations by year
- 2026: 12 · 2025: 31 · 2024: 35 · 2023: 40 · 2022: 28 · 2021: 7
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, gut microbiota, neuroinflammation, systemic inflammation, lipopolysaccharide, amyloid peptides, short-chain fatty acids, branched-chain amino acids, neurotransmitters, bile acids, fecal microbiota transplantation, probiotics, prebiotics, dietary intervention, antibiotics
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Alzheimer Disease, Amyloid, Humans, Probiotics
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