Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota

The sequence of the human genome

Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

2016 Alzheimer's disease facts and figures

Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

The role of short-chain fatty acids in microbiota–gut–brain communication

Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179

TREM2 Variants in Alzheimer's Disease

Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020

A framework for human microbiome research

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11209 · Cited by 2,650

2019 Alzheimer’s disease facts and figures.

Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461

The role of short chain fatty acids in health and disease

Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190

Gut microbiome alterations in Alzheimer’s disease

Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137

Immune attack: the role of inflammation in Alzheimer disease

Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754

Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed

Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748

Neuroinflammation in Alzheimer's disease: current evidence and future directions

Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678

Neurotransmitter modulation by the gut microbiota

Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., et al. (2018) · Science · doi:10.1126/science.aan5931 · Cited by 1,508

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., et al. (2019) · Nature · doi:10.1038/s41586-019-1769-z · Cited by 1,487

Bile acid metabolites control TH17 and Treg cell differentiation

Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1785-z · Cited by 1,457

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382

Regulation of immune cell function by short‐chain fatty acids

Corrêa‐Oliveira, R., Fachi, J. L., Vieira, A., Sato, F. T., & Vinolo, M. A. R. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.17 · Cited by 1,346

Synergy between amyloid-β and tau in Alzheimer’s disease

Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242

The blood-brain barrier in systemic inflammation

Varatharaj, A., & Galea, I. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.03.010 · Cited by 1,172

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144

Systemic inflammation and disease progression in Alzheimer disease

Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bb95 · Cited by 1,139

The metabolic syndrome, inflammation, and risk of cognitive decline

Yaffe, K. (2004) · JAMA · doi:10.1001/jama.292.18.2237 · Cited by 1,025

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Venegas, C., Kumar, S., Franklin, B. S., Dierkes, T., Brinkschulte, R., Tejera, D., Vieira-Saecker, A., Schwartz, S., Santarelli, F., Kummer, M. P., et al. (2017) · Nature · doi:10.1038/nature25158 · Cited by 983

Astrocytes: Key Regulators of Neuroinflammation

Colombo, E., & Farina, C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.06.006 · Cited by 936

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901

Microglia-mediated neuroinflammation in neurodegenerative diseases

Subhramanyam, C. S., Wang, C., Hu, Q., & Dheen, S. T. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.004 · Cited by 897

Acetylcholine beyond neurons: the non‐neuronal cholinergic system in humans

Wessler, I. K., & Kirkpatrick, C. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.185 · Cited by 872

The Gut Microbiota and Alzheimer’s Disease

Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808

Microglia Heterogeneity in the Single-Cell Era

Masuda, T., Sankowski, R., Staszewski, O., & Prinz, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.010 · Cited by 784

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1434-3 · Cited by 767

The human microbiome: Our second genome

Grice, E. A., & Segre, J. A. (2012) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090711-163814 · Cited by 759

The cost of Alzheimer's disease in China and re‐estimation of costs worldwide

Jia, J., Wei, C., Chen, S., Li, F., Tang, Y., Qin, W., Zhao, L., Jin, H., Xu, H., Wang, F., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.12.006 · Cited by 752

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

Kilgore, M., Miller, C. A., Fass, D. M., Hennig, K. M., Haggarty, S. J., Sweatt, J. D., & Rumbaugh, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.197 · Cited by 727

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Olah, M., Menon, V., Habib, N., Taga, M. F., Ma, Y., Yung, C. J., Cimpean, M., Khairallah, A., Coronas-Samano, G., Sankowski, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19737-2 · Cited by 722

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., Louie, G., Kueider‐Paisley, A., Moseley, M. A., Thompson, J. W., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.217 · Cited by 706

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., et al. (2016) · Scientific Reports · doi:10.1038/srep30028 · Cited by 655

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

Nagpal, R., Neth, B. J., Wang, S., Craft, S., & Yadav, H. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.032 · Cited by 653

Lipopolysaccharide-induced blood-brain barrier disruption: Roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

Banks, W. A., Gray, A. M., Erickson, M. A., Salameh, T. S., Damodarasamy, M., Sheibani, N., Meabon, J. S., Wing, E. E., Morofuji, Y., Cook, D. G., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0434-1 · Cited by 636

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Kim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

Shi, Y., & Holtzman, D. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0051-1 · Cited by 595

The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review

Sochocka, M., Donskow-Łysoniewska, K., Diniz, B. S., Kurpas, D., Brzozowska, E., & Leszek, J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1188-4 · Cited by 584

World Alzheimer Report 2018: The state of the art of dementia research: New frontiers

Patterson, C. (2018) · Cited by 581

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 541

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

Heneka, M. T., Nadrigny, F., Regen, T., Martinez-Hernandez, A., Dumitrescu‐Ozimek, L., Terwel, D., Jardanhazi‐Kurutz, D., Walter, J., Kirchhoff, F., Hanisch, U., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909586107 · Cited by 532

Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

Newcombe, E. A., Camats-Perna, J., Silva, M. L., Valmas, N., Huat, T. J., & Medeiros, R. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1313-3 · Cited by 532

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

Sun, J., Xu, J., Ling, Y., Wang, F., Gong, T., Yang, C., Ye, S., Ye, K., Wei, D., Song, Z., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0525-3 · Cited by 532

Gram-negative bacterial molecules associate with Alzheimer disease pathology

Zhan, X., Stamova, B., Jin, L.-W., DeCarli, C., Phinney, B., & Sharp, F. R. (2016) · Neurology · doi:10.1212/wnl.0000000000003391 · Cited by 521

Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

Gill, P. A., van Zelm, M. C., Muir, J. G., & Gibson, P. R. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14689 · Cited by 520

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

Cruz Hernández, J. C., Bracko, O., Kersbergen, C. J., Muse, V., Haft-Javaherian, M., Berg, M., Park, L., Vinarcsik, L. K., Ivasyk, I., Rivera, D. A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0329-4 · Cited by 508

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 484

Metabolic network failures in Alzheimer's disease: A biochemical road map

Toledo, J. B., Arnold, M., Kastenmüller, G., Chang, R. R., Baillie, R., Han, X., Thambisetty, M., Tenenbaum, J. D., Suhre, K., Thompson, J. W., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.01.020 · Cited by 463

The endotoxin hypothesis of neurodegeneration

Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism

Yoon, M. (2016) · Nutrients · doi:10.3390/nu8070405 · Cited by 455

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453

Mapping microglia states in the human brain through the integration of high-dimensional techniques

Sankowski, R., Böttcher, C., Masuda, T., Geirsdottir, L., Sagar, Sindram, E., Seredenina, T., Muhs, A., Scheiwe, C., Shah, M. J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0532-y · Cited by 449

An early and late peak in microglial activation in Alzheimer’s disease trajectory

Fan, Z., Brooks, D. J., Okello, A., & Edison, P. (2017) · Brain · doi:10.1093/brain/aww349 · Cited by 438

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

Lai, K. S. P., Liu, C. S., Rau, A., Lanctôt, K. L., Köhler, C. A., Pakosh, M., Carvalho, A. F., & Herrmann, N. (2017) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316201 · Cited by 433

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

Shao, W., Zhang, S., Tang, M., Zhang, X., Zhou, Z., Yin, Y., Zhou, Q., Huang, Y., Liu, Y., Wawrousek, E. F., et al. (2012) · Nature · doi:10.1038/nature11748 · Cited by 418

Glial contributions to neurodegeneration in tauopathies

Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

Yang, X., Yu, D., Xue, L., Li, H., & Du, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.07.001 · Cited by 407

Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression

Govindarajan, N., Agis-Balboa, R. C., Walter, J., Sananbenesi, F., & Fischer, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110080 · Cited by 405

The role of microbial amyloid in neurodegeneration

Friedland, R. P., & Chapman, M. R. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006654 · Cited by 398

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

Hur, J.-Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., Barros, M., Li, T., Nie, P., Zhai, Y., et al. (2020) · Nature · doi:10.1038/s41586-020-2681-2 · Cited by 382

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

Cox, M. A., Jackson, J., Stanton, M., Rojas-Triana, A., Bober, L., Laverty, M., Yang, X., Zhu, F., Liu, J., Wang, S., et al. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5549 · Cited by 377

Regulatory T cells delay disease progression in Alzheimer-like pathology

Dansokho, C., Ahmed, D. A., Aïd, S., Toly‐Ndour, C., Chaigneau, T., Calle, V., Cagnard, N., Holzenberger, M., Piaggio, E., Aucouturier, P., et al. (2016) · Brain · doi:10.1093/brain/awv408 · Cited by 375

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

Zhan, X., Stamova, B. S., & Sharp, F. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 361

Review: Systemic inflammation andAlzheimer's disease

Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

Tejera, D., Mercan, D., Sanchez‐Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & Heneka, M. T. (2019) · The EMBO Journal · doi:10.15252/embj.2018101064 · Cited by 351

The histaminergic network in the brain: basic organization and role in disease

Panula, P., & Nuutinen, S. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3526 · Cited by 346

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

Nho, K., Kueider‐Paisley, A., MahmoudianDehkordi, S., Arnold, M., Risacher, S. L., Louie, G., Blach, C., Baillie, R., Han, X., Kastenmüller, G., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.08.012 · Cited by 343

Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis

Baj, A., Moro, E., Bistoletti, M., Orlandi, V. T., Crema, F., & Giaroni, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061482 · Cited by 339

Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338

Immune Signaling in Neurodegeneration

Hammond, T. R., Marsh, S. E., & Stevens, B. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.016 · Cited by 336

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

Arranz, A. M., & De Strooper, B. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30490-3 · Cited by 334

Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A., & Johnson, R. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01832 · Cited by 330

Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells

Wenzel, T. J., Gates, E. J., Ranger, A. L., & Klegeris, A. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103493 · Cited by 320

Alzheimer’s disease

Hodson, R. (2018) · Nature · doi:10.1038/d41586-018-05717-6 · Cited by 320

Branched-Chain Amino Acids and Immunity ,

Calder, P. C. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.288s · Cited by 318

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

Morris, G., Berk, M., Carvalho, A. F., Caso, J. R., Sanz, Y., Walder, K. R., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0004-2 · Cited by 318

Stimulation of Microglial Metabotropic Glutamate Receptor mGlu2 Triggers Tumor Necrosis Factor α-Induced Neurotoxicity in Concert with Microglial-Derived Fas Ligand

Taylor, D. L., Jones, F., Kubota, E. S. F. C. S., & Pocock, J. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4456-04.2005 · Cited by 308

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

Stanciu, G. D., Luca, A., Rusu, R.-N., Bild, V., Chiriac, S. I. B., Solcan, C., Bild, W., & Ababei, D. C. (2019) · Biomolecules · doi:10.3390/biom10010040 · Cited by 307

Effect of Clostridium butyricum against Microglia‐Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate

Sun, J., Xu, J., Yang, B., Chen, K., Kong, Y., Fang, N., Gong, T., Wang, F., Ling, Z., & Liu, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900636 · Cited by 302

The Histamine H4 Receptor Mediates Allergic Airway Inflammation by Regulating the Activation of CD4+ T Cells

Dunford, P. J., O'Donnell, N., Riley, J. P., Williams, K. N., Karlsson, L., & Thurmond, R. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.7062 · Cited by 294

Microglia actions in Alzheimer's disease

Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291

Neuroinflammation in psychiatric disorders: PET imaging and promising new targets

Meyer, J. H., Červenka, S., Kim, M.-J., Kreisl, W. C., Henter, I. D., & Innis, R. B. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30255-8 · Cited by 287

Feeding the immune system

Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283

SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

Bonfili, L., Cecarini, V., Cuccioloni, M., Angeletti, M., Berardi, S., Scarpona, S., Rossi, G., & Eleuteri, A. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0973-4 · Cited by 282

Association of branched‐chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Tynkkynen, J., Chouraki, V. A., van der Lee, S. J., Hernesniemi, J. A., Yang, Q., Li, S., Beiser, A., Larson, M. G., Sääksjärvi, K., Shipley, M. J., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.01.003 · Cited by 277

Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis

Bradburn, S., Murgatroyd, C., & Ray, N. J. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.002 · Cited by 277

Microglial activation correlates in vivo with both tau and amyloid in Alzheimer’s disease

Dani, M., Wood, M., Mizoguchi, R., Fan, Z., Walker, Z., Morgan, R., Hinz, R., Biju, M., Kuruvilla, T., Brooks, D. J., et al. (2018) · Brain · doi:10.1093/brain/awy188 · Cited by 270

Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1–42) injected rats

Azm, S. A. N., Djazayeri, A., Safa, M., Azami, K., Ahmadvand, B., Sabbaghziarani, F., Sharifzadeh, M. S., & Vafa, M. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0648 · Cited by 262

Understanding the Role of Systemic Inflammation in Alzheimer’s Disease

Walker, K. A., Ficek, B. N., & Westbrook, R. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00333 · Cited by 259

Biological significance of short-chain fatty acid metabolism by the intestinal microbiome

Puertollano, E., Kolida, S., & Yaqoob, P. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000025 · Cited by 242

Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease

Giau, V. V., Wu, S., Jamerlan, A., An, S. S. A., Kim, S., & Hulme, J. (2018) · Nutrients · doi:10.3390/nu10111765 · Cited by 239

Histamine H4 Receptor Stimulation Suppresses IL-12p70 Production and Mediates Chemotaxis in Human Monocyte-Derived Dendritic Cells

Gutzmer, R., Diestel, C., Mommert, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5224 · Cited by 232

Behavioral Characterization of Mice Lacking Histamine H3 Receptors

Toyota, H., Dugovic, C., Koehl, M., Laposky, A. D., Weber, C., Ngo, K., Wu, Y., Lee, D. H., Yanai, K., Sakurai, E., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.2.389 · Cited by 226

TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti‐Inflammatory Effects in Microglial Cells

Yanguas‐Casás, N., Barreda‐Manso, M. A., Nieto‐Sampedro, M., & Romero‐Ramírez, L. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25742 · Cited by 223

Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages

MILLARD, A. L., MERTES, P. M., ITTELET, D., VILLARD, F., JEANNESSON, P., & BERNARD, J. (2002) · Clinical and Experimental Immunology · doi:10.1046/j.0009-9104.2002.01977.x · Cited by 220

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

Cunningham, C., & Hennessy, E. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0117-2 · Cited by 211

The role of gut microbiota in pathogenesis of Alzheimer's disease

Bostancıklıoğlu, M. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14264 · Cited by 210

APOε4 is associated with enhanced in vivo innate immune responses in human subjects

Gale, S. C., Gao, L., Mikacenic, C., Coyle, S. M., Rafaels, N., Murray Dudenkov, T., Madenspacher, J. H., Draper, D. W., Ge, W., Aloor, J. J., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.01.032 · Cited by 202

Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease

Parbo, P., Ismail, R., Hansen, K. V., Amidi, A., Mårup, F. H., Gottrup, H., Brændgaard, H., Eriksson, B. O., Eskildsen, S. F., Lund, T. E., et al. (2017) · Brain · doi:10.1093/brain/awx120 · Cited by 199

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

Nunes, A. F., Amaral, J. D., Lo, A. C., Fonseca, M. B., Viana, R. J. S., Callaerts-Vegh, Z., D’Hooge, R., & Rodrigues, C. M. P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8256-y · Cited by 192

Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias

King, E., O'Brien, J. T., Donaghy, P. C., Morris, C. M., Barnett, N. A., Olsen, K., Martin-Ruiz, C. M., Taylor, J., & Thomas, A. J. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317134 · Cited by 187

Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice

Jang, H.-M., Lee, H.-J., Jang, S.-E., Han, M. J., & Kim, D.-H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0042-3 · Cited by 181

Gut microbiota, the pharmabiotics they produce and host health

Patterson, E., Cryan, J. F., Fitzgerald, G. F., Ross, R. P., Dinan, T. G., & Stanton, C. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114001426 · Cited by 174

Microbial-generated amyloids and Alzheimer's disease (AD)

Hill, J. M., & Lukiw, W. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00009 · Cited by 173

Pathogenic microbes, the microbiome, and Alzheimer’s disease (AD)

Hill, J. M., Clément, C., Pogue, A. I., Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00127 · Cited by 170

Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice

Lee, H.-J., Lee, K.-E., Kim, J.-K., & Kim, D.-H. (2019) · Scientific Reports · doi:10.1038/s41598-019-48342-7 · Cited by 164

Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer’s Disease Transgenic Mouse Model at an Early Disease Stage

Fernando, W. M. A. D. B., Martins, I. J., Morici, M., Bharadwaj, P., Rainey-Smith, S. R., Lim, W. L. F., & Martins, R. N. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-190120 · Cited by 164

Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer’s disease

Marksteiner, J., Blasko, I., Kemmler, G., Koal, T., & Humpel, C. (2017) · Metabolomics · doi:10.1007/s11306-017-1297-5 · Cited by 161

Time to test antibacterial therapy in Alzheimer’s disease

Panza, F., Lozupone, M., Solfrizzi, V., Watling, M., & Imbimbo, B. P. (2019) · Brain · doi:10.1093/brain/awz244 · Cited by 161

Fungal Infection in Patients with Alzheimer's Disease

Alonso, R., Pisa, D., Marina, A., Morato, E., Rábano, A., & Carrasco, L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132681 · Cited by 156

Profound degeneration of wake‐promoting neurons in Alzheimer's disease

Oh, J. Y., Eser, R. A., Ehrenberg, A. J., Morales, D. O., Petersen, C., Kudlacek, J., Dunlop, S. R., Theofilas, P., Resende, E. D. P. F., Cosme, C. G., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.06.3916 · Cited by 156

Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation

Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019) · Aging Cell · doi:10.1111/acel.13037 · Cited by 156

Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a d-galactose-induced accelerated aging mouse model

Woo, J.-Y., Gu, W., Kim, K., Jang, S., Han, M. J., & Kim, D. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.03.003 · Cited by 155

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

Sheppard, O., Coleman, M. P., & Durrant, C. S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1490-8 · Cited by 152

Microbiota, Inflammation and Obesity

Sanz, Y., & Moya-Pérez, Á. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_14 · Cited by 151

Histamine Induces Upregulated Expression of Histamine Receptors and Increases Release of Inflammatory Mediators from Microglia

Dong, H., Zhang, W., Zeng, X., Hu, G., Zhang, H., He, S., & Zhang, S. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8697-6 · Cited by 151

Probiotic treatment improves the impaired spatial cognitive performance and restores synaptic plasticity in an animal model of Alzheimer's disease

Rezaeiasl, Z., Sepehri, G., & Salami, M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112183 · Cited by 150

2017 Alzheimers Disease Facts and Figures

Alzheimers Association (2017) · Issue Lab (Candid) · Cited by 150

Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

Nizami, S., Hall‐Roberts, H., Warrier, S., Cowley, S. A., & Di Daniel, E. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14618 · Cited by 147

Histamine-secreting microbes are increased in the gut of adult asthma patients

Barcik, W., Pugin, B., Westermann, P., Perez, N. R., Ferstl, R., Wawrzyniak, M., Smolinska, S., Jutel, M., Hessel, E. M., Michalovich, D., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.049 · Cited by 142

Gut microbiota manipulation through probiotics oral administration restores glucose homeostasis in a mouse model of Alzheimer's disease

Bonfili, L., Cecarini, V., Gogoi, O., Berardi, S., Scarpona, S., Angeletti, M., Rossi, G., & Eleuteri, A. M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.11.004 · Cited by 140

Immune regulation by histamine and histamine-secreting bacteria

Barcik, W., Wawrzyniak, M., Akdiş, C. A., & O’Mahony, L. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.08.011 · Cited by 137

Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals

Simone, R. D., Vissicchio, F., Mingarelli, C., Nuccio, C. D., Visentin, S., Ajmone‐Cat, M. A., & Minghetti, L. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.001 · Cited by 135

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity

Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

Kong, Y., Ruan, L., Qian, L., Liu, X., & Le, Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2985-10.2010 · Cited by 128

Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset

Dionísio, P. A., Amaral, J. D., Ribeiro, M. F., Lo, A. C., D'Hooge, R., & Rodrigues, C. M. P. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.034 · Cited by 127

Fatty acids as modulators of neutrophil recruitment, function and survival

Rodrigues, H. G., Takeo Sato, F., Curi, R., & Vinolo, M. A. R. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.098 · Cited by 124

Histamine modulates microglia function

Ferreira, R., Santos, T., Gonçalves, J., Baltazar, G., Ferreira, L., Agasse, F., & Bernardino, L. I. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-90 · Cited by 124

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

Rocha, S. M., Saraiva, T., Cristóvão, A. C., Ferreira, R., Santos, T., Esteves, M., Saraiva, C., Je, G., Cortes, L., Valero, J., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0600-0 · Cited by 124

Protein kinase Cα: disease regulator and therapeutic target

Konopatskaya, O., & Poole, A. W. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.10.006 · Cited by 121

Gut microbiota of mice putatively modifies amino acid metabolism in the host brain

Kawase, T., Nagasawa, M., Ikeda, H., Yasuo, S., Koga, Y., & Furuse, M. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517000678 · Cited by 119

Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior

Gonzalez-Santana, A., & Diaz Heijtz, R. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.05.003 · Cited by 118

Infection, systemic inflammation, and Alzheimer's disease

Lim, S., Rodríguez‐Ortiz, C. J., & Kitazawa, M. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.04.004 · Cited by 117

Polymicrobial Infections In Brain Tissue From Alzheimer’s Disease Patients

Pisa, D., Alonso, R., Fernández-Fernández, A. M., Rábano, A., & Carrasco, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-05903-y · Cited by 114

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease

Ramalho, R. M., Viana, R. J. S., Low, W. C., Steer, C. J., & Rodrigues, C. M. P. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.001 · Cited by 107

Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels

Ruiz, H. H., Chi, T., Shin, A. C., Lindtner, C., Hsieh, W., Ehrlich, M. E., Gandy, S., & Buettner, C. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.01.008 · Cited by 107

Chemoproteomic Profiling of Bile Acid Interacting Proteins

Zhuang, S., Li, Q., Cai, L., Wang, C., & Lei, X. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00134 · Cited by 106

Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

Yanguas-Casás, N., Barreda-Manso, M. A., Nieto-Sampedro, M., & Romero-Ramírez, L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-50 · Cited by 103

Neuroprotective effects of INT-777 against Aβ1–42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice

Wu, X. G., Lv, Y., Du, Y., Chen, F., Reed, M. N., Hu, M. Y., Suppiramaniam, V. D., Tang, S., & Hong, H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.018 · Cited by 100

Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2

Loffredo, L., Ettorre, E., Zicari, A. M., Inghilleri, M., Nocella, C., Perri, L., Spalice, A., Fossati, C., De Lucia, M. C., Pigozzi, F., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8630275 · Cited by 100

The cholinergic anti-inflammatory pathway: An innovative treatment strategy for neurological diseases

Han, B., Li, X., & Hao, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.002 · Cited by 97

Our microbes not only produce antibiotics, they also overproduce amino acids

Sánchez, S., Rodrı́guez-Sanoja, R., Ramos, A., & Demain, A. L. (2017) · The Journal of Antibiotics · doi:10.1038/ja.2017.142 · Cited by 96

Is Alzheimer’s disease an inflammasomopathy?

Pereira, C., Santos, A. E., Moreira, P. I., Pereira, A. C., Sousa, F. J., Cardoso, S. M., & Cruz, M. T. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100966 · Cited by 95

Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in T H 1 and T H 17 Versions of Experimental Autoimmune Encephalomyelitis

Grant, J. L., Ghosn, E. E. B., Axtell, R. C., Herges, K., Kuipers, H. F., Woodling, N. S., Andreasson, K., Herzenberg, L. A., Herzenberg, L. A., & Steinman, L. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004145 · Cited by 92

Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

Li, H., Ye, D., Xie, W., Hua, F., Yang, Y., Wu, J. H., Gu, A., Ren, Y., & Mao, K. (2018) · Bioscience Reports · doi:10.1042/bsr20180127 · Cited by 92

Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation

Frick, L. R., Rapanelli, M., Abbasi, E., Ohtsu, H., & Pittenger, C. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.002 · Cited by 91

Immunomodulatory role of branched-chain amino acids

Bonvini, A., Coqueiro, A. Y., Tirapegui, J., Calder, P. C., & Rogero, M. M. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy037 · Cited by 86

Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation

Montoya, A., Elgueta, D., Campos, J., Chovar, O., Falcón, P., Matus, S., Alfaro, I. E., Bono, M. R., & Pacheco, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1652-8 · Cited by 84

Effects of Probiotic Supplementation on Short Chain Fatty Acids in the App NL - G - F Mouse Model of Alzheimer’s Disease

Kaur, H., Golovko, S. A., Golovko, M. Y., Singh, S., Darland, D. C., & Combs, C. K. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200436 · Cited by 78

Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats

Temiz-Resitoglu, M., Kucukkavruk, S. P., Guden, D. S., Cecen, P., Sari, A. N., Tunctan, B., Gorur, A., Tamer-Gumus, L., Buharalioglu, C. K., Malik, K. U., et al. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.02.034 · Cited by 77

Deficits in Spontaneous Cognition as an Early Marker of Alzheimer’s Disease

Kvavilashvili, L., Niedźwieńska, A., Gilbert, S. J., & Markostamou, I. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.01.005 · Cited by 74

Dual role of histamine on microglia-induced neurodegeneration

Barata‐Antunes, S., Cristóvão, A. C., Pires, J. P., Rocha, S. M., & Bernardino, L. I. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.12.016 · Cited by 73

Branched-chain amino acids and Alzheimer’s disease: a Mendelian randomization analysis

Larsson, S. C., & Markus, H. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-12931-1 · Cited by 71

Gastrointestinal (GI) Tract Microbiome-Derived Neurotoxins—Potent Neuro-Inflammatory Signals From the GI Tract via the Systemic Circulation Into the Brain

Lukiw, W. J. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00022 · Cited by 71

Gut Microbiota Influences Alzheimer’s Disease Pathogenesis by Regulating Acetate in Drosophila Model

Kong, Y., Jiang, B., & Luo, X. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0185 · Cited by 69

Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease

Takata, K., Amamiya, T., Mizoguchi, H., Kawanishi, S., Kuroda, E., Kitamura, R., Ito, A., Saito, Y., Tawa, M., Nagasawa, T., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.10.021 · Cited by 68

Infection-Induced Systemic Inflammation Is a Potential Driver of Alzheimer's Disease Progression

Giridharan, V. V., Masud, F. N., Petronilho, F. C., Dal‐Pizzol, F., & Barichello, T. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00122 · Cited by 68

Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism

Revathikumar, P., Bergqvist, F., Gopalakrishnan, S., Korotkova, M., Jakobsson, P., Lampa, J., & Maître, E. L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0725-1 · Cited by 67

Fold modulating function: bacterial toxins to functional amyloids

Syed, A. K., & Boles, B. R. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00401 · Cited by 65

Undigested Food and Gut Microbiota May Cooperate in the Pathogenesis of Neuroinflammatory Diseases: A Matter of Barriers and a Proposal on the Origin of Organ Specificity

Riccio, P., & Rossano, R. (2019) · Nutrients · doi:10.3390/nu11112714 · Cited by 60

The Immune System Drives Synapse Loss During Lipopolysaccharide-Induced Learning and Memory Impairment in Mice

Xin, Y., Jiang, J., Hu, Y., Pan, J., Mi, X.-N., Gao, Q. F., Xiao, F., Zhang, W., & Luo, H. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00279 · Cited by 59

Histamine Induces Microglia Activation and the Release of Proinflammatory Mediators in Rat Brain Via H1R or H4R

Zhang, W., Zhang, X., Zhang, Y., Qu, C., Zhou, X., & Zhang, S. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09887-6 · Cited by 57

What are the molecular mechanisms by which functional bacterial amyloids influence amyloid beta deposition and neuroinflammation in neurodegenerative disorders?

Friedland, R. P., McMillan, J. D., & Kurlawala, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051652 · Cited by 56

Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease

Haque, M. E., Kim, I., Jakaria, M., Akther, M., & Choi, D. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00258 · Cited by 55

Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids – A randomized, controlled trial

Lederer, A., Maul‐Pavicic, A., Hannibal, L., Hettich, M., Steinborn, C., Gründemann, C., Zimmermann-Klemd, A. M., Müller, A., Sehnert, B., Salzer, U., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.02.011 · Cited by 53

Systemic Inflammation and Multimodal Biomarkers in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

Magalhães, T. N. C., Weiler, M., Teixeira, C. V. L., Hayata, T., Moraes, A. S., Boldrini, V. D. O., dos Santos, L. M., de Campos, B. M., de Rezende, T. J. R., Joaquim, H. P. G., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0795-9 · Cited by 51

Histamine H3receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion

Iida, T., Yoshikawa, T., Matsuzawa, T., Naganuma, F., Nakamura, T., Miura, Y., Mohsen, A. S., Harada, R., Iwata, R., & Yanai, K. (2015) · Glia · doi:10.1002/glia.22812 · Cited by 50

Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways

Shi, S., Liang, D., Bao, M., Xie, Y., Xu, W., Wang, L., Wang, Z., & Qiao, Z. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150963 · Cited by 50

The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response

Pavlov, V. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107794 · Cited by 50

Temporal Changes of CD68 and α7 Nicotinic Acetylcholine Receptor Expression in Microglia in Alzheimer's Disease-Like Mouse Models

Matsumura, A., Suzuki, S., Iwahara, N., Hisahara, S., Kawamata, J., Suzuki, H., Yamauchi, A., Takata, K., Kitamura, Y., & Shimohama, S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141572 · Cited by 49

Corynebacterium glutamicum mechanosensitive channels: towards unpuzzling “glutamate efflux” for amino acid production

Nakayama, Y., Hashimoto, K.-I., Sawada, Y., Sokabe, M., Kawasaki, H., & Martinac, B. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0452-1 · Cited by 49

Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model

Barton, S. M., Janve, V. A., McClure, R., Anderson, A. W., Matsubara, J. A., Gore, J. C., & Pham, W. N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180755 · Cited by 49

Acetylcholine suppresses microglial inflammatory response via α7nAChR to protect hippocampal neurons

Lin, L., Liu, Z., Jiang, Y.-Y., Shen, W., Peng, Y.-P., & Qiu, Y. (2019) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2019.01.114 · Cited by 46

Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer’s disease

Agostini, A., Ding, Y., Bai, L., Kendall, D. A., & Pardon, M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.019 · Cited by 43

“Muscle-Gut-Brain Axis”: Can Physical Activity Help Patients with Alzheimer’s Disease Due to Microbiome Modulation?

Schlegel, P., Novotný, M., Klímová, B., & Vališ, M. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190460 · Cited by 39

TGFβ Contributes to the Anti-inflammatory Effects of Tauroursodeoxycholic Acid on an Animal Model of Acute Neuroinflammation

Yanguas‐Casás, N., Barreda-Manso, M. A., Pérez-Rial, S., Nieto‐Sampedro, M., & Romero‐Ramírez, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0142-6 · Cited by 36

Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343

Gut Microbiota Dysbiosis Induced by Decreasing Endogenous Melatonin Mediates the Pathogenesis of Alzheimer’s Disease and Obesity

Zhang, B., Chen, T., Cao, M., Yuan, C., Reiter, R. J., Zhao, Z., Zhao, Y., Chen, L., Fan, W., Wang, X., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.900132 · Cited by 80

Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer’s pathology: Insights and therapeutic approaches from periphery

Ullah, R., Park, T. J., Huang, X., & Kim, M. O. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101451 · Cited by 78

Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease

Qian, X.-H., Liu, X.-L., Chen, G., Chen, S.-D., & Tang, H.-D. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02599-4 · Cited by 56

Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease

Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56

Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system

He, Y., Wang, K., Su, N., Yuan, C., Zhang, N., Hu, X., Fu, Y., & Zhao, F. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70099 · Cited by 83

Gut hormones in microbiota-gut-brain cross-talk

Sun, L.-J., Li, J.-N., & Nie, Y.-Z. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000706 · Cited by 145

The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota

Al-Khafaji, A. H., Jepsen, S. D., Christensen, K. R., & Vigsnæs, L. K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104176 · Cited by 62

The role of gut microbiota in the gut-brain axis: current challenges and perspectives

Chen, X., D’Souza, R., & Hong, S. (2013) · Protein & Cell · doi:10.1007/s13238-013-3017-x · Cited by 160

Dietary flavonoids modulate the gut microbiota: A new perspective on improving autism spectrum disorder through the gut-brain axis

Dai, H., Jiang, Y., Liu, S., Li, D., & Zhang, X. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114404 · Cited by 19