Cited by 16Cannabis and Cannabinoid ResearchAlzheimer's disease research and treatmentsGut microbiota and health

The endocannabinoid system: a bridge between alzheimer’s disease and gut microbiota

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Bisogno, Tiziana, Lauritano, Anna, Piscitelli, Fabiana·2021·Life

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that progresses from mild cognitive impairment to severe dementia over time. The main clinical hallmarks of the disease (e.g., beta-amyloid plaques and neurofibrillary tangles) begin during preclinical AD when cognitive deficits are not yet apparent. Hence, a more profound understanding of AD pathogenesis is needed to develop new therapeutic strategies. In this context, the endocannabinoid (eCB) system and the gut microbiome are increasingly emerging as important players in maintaining the general homeostasis and the health status of the host. However, their interaction has come to light just recently with gut microbiota regulating the eCB tone at both receptor and enzyme levels in intestinal and adipose tissues. Importantly, eCB system and gut microbiome, have been suggested to play a role in AD in both animal and human studies. Therefore, the microbiome gut-brain axis and the eCB system are potential common denominators in the AD physiopathology. Hence, the aim of this review is to provide a general overview on the role of both the eCB system and the microbiome gut-brain axis in AD and to suggest possible mechanisms that underlie the potential interplay of these two systems.

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Authors
Bisogno, T., Lauritano, A., & Piscitelli, F.
Affiliations
  • Istituto di Farmacologia Traslazionale (IT)
  • Istituto di Chimica Biomolecolare (IT)
Corresponding author
  • Bisogno, Tiziana
  • Piscitelli, Fabiana
Venue
Life
Publisher
MDPI AG
Published
2021-09-08
Volume
11
Issue
9
Pages
934
ISSN
2075-1729 (ISSN-L)
OpenAlex
W3198513682
Cited by
16
References
191
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
  • Life (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Alzheimer's disease, endocannabinoid system, gut microbiota, gut-brain axis, neurodegeneration, amyloid plaques, neurofibrillary tangles, preclinical Alzheimer's disease, cannabinoid receptors, adipose tissue, intestinal tissue, host homeostasis

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