The endocannabinoid system: a bridge between alzheimer’s disease and gut microbiota
Open accessAbstract
Alzheimer's disease (AD) is a neurodegenerative disease that progresses from mild cognitive impairment to severe dementia over time. The main clinical hallmarks of the disease (e.g., beta-amyloid plaques and neurofibrillary tangles) begin during preclinical AD when cognitive deficits are not yet apparent. Hence, a more profound understanding of AD pathogenesis is needed to develop new therapeutic strategies. In this context, the endocannabinoid (eCB) system and the gut microbiome are increasingly emerging as important players in maintaining the general homeostasis and the health status of the host. However, their interaction has come to light just recently with gut microbiota regulating the eCB tone at both receptor and enzyme levels in intestinal and adipose tissues. Importantly, eCB system and gut microbiome, have been suggested to play a role in AD in both animal and human studies. Therefore, the microbiome gut-brain axis and the eCB system are potential common denominators in the AD physiopathology. Hence, the aim of this review is to provide a general overview on the role of both the eCB system and the microbiome gut-brain axis in AD and to suggest possible mechanisms that underlie the potential interplay of these two systems.
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The ECS and GM play a role in cognitive decline.
“Both animal and human studies have shown that the ECS and GM play a role in cognitive decline (254).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [254]
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A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · cited 6× · see citing works
“Although studies in GF mice have demonstrated that specific gut bacterial species increase colonic 5-HT levels, via tryptophan hydroxylase-1 (TPH1) overexpression [90,91], the impossibility of 5-HT to cross the BBB suggests that variation in intestinal 5-HT levels are unlikely to produce direct effect on the brain [89…”
BackgroundInfluentialMetagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877 · see citing works
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540 · see citing works
Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works
2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461 · see citing works
An integrated catalog of reference genes in the human gut microbiome
MetaHIT Consortium, Li, J., Jia, H., Cai, X., Zhong, H., Feng, Q., Sunagawa, S., Arumugam, M., Kultima, J. R., Prifti, E., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2942 · Cited by 2,164 · see citing works
Gut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Dominy, S. S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau3333 · Cited by 1,966 · see citing works
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · see citing works
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 1× · see citing works
“The CNS and the GI are in constant communication through a bidirectional pathway, the so-called “gut-brain axis” [78,79].”
BackgroundPasolli, E., Asnicar, F., Manara, S., Zolfo, M., Karcher, N., Armanini, F., Beghini, F., Manghi, P., Tett, A., Ghensi, P., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.001 · Cited by 1,591 · see citing works
Leptin-regulated endocannabinoids are involved in maintaining food intake
Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559 · see citing works
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,529 · see citing works
Neurotransmitter modulation by the gut microbiota
Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527 · see citing works
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503 · see citing works
Antibiotics, birth mode, and diet shape microbiome maturation during early life
Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., D. Lieber, A., Wu, F., Perez-Perez, G. I., Chen, Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7121 · Cited by 1,469 · see citing works
The vagus nerve at the interface of the microbiota-gut-brain axis
Bonaz, B., Bazin, T., & Pellissier, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00049 · Cited by 1,397 · see citing works
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
Cervenka, I., Agudelo, L. Z., & Ruas, J. L. (2017) · Science · doi:10.1126/science.aaf9794 · Cited by 1,382 · see citing works
Brain monoglyceride lipase participating in endocannabinoid inactivation
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373 · see citing works
The gut microbiome in neurological disorders
Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336 · see citing works
Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335 · see citing works
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291 · see citing works
Ursell, L. K., Metcalf, J. L., Parfrey, L. W., & Knight, R. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00493.x · Cited by 1,255 · see citing works
Endocannabinoid Signaling and Synaptic Function
Castillo, P. E., Younts, T. J., Chávez, A. E., & Hashimotodani, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.020 · Cited by 1,126 · see citing works
Chu, D. M., Ma, J., Prince, A. L., Antony, K. M., Seferovic, M. D., & Aagaard, K. M. (2017) · Nature Medicine · doi:10.1038/nm.4272 · Cited by 1,063 · see citing works
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
Cani, P. D., & de Vos, W. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01765 · Cited by 1,058 · see citing works
Yassour, M., Vatanen, T., Siljander, H., Hämäläinen, A.-M., Härkönen, T., Ryhänen, S. J., Franzosa, E. A., Vlamakis, H., Huttenhower, C., Gevers, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0917 · Cited by 1,043 · see citing works
Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M. G., Ligresti, A., Matias, I., Schiano-Moriello, A., Paul, P., Williams, E.-J., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305129 · Cited by 1,039 · see citing works
Gut Microbiota and Extreme Longevity
Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.016 · Cited by 1,025 · see citing works
Cannabinoids and the expanded endocannabinoid system in neurological disorders
Cristino, L., Bisogno, T., & Di Marzo, V. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0284-z · Cited by 970 · see citing works
Self-citationAkbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works
Gut microorganisms, mammalian metabolism and personalized health care
Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945 · see citing works
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901 · see citing works
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855 · see citing works
Mitochondria and Mitochondrial Cascades in Alzheimer’s disease
Swerdlow, R. H. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170585 · Cited by 850 · see citing works
Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners
Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T., & Ueda, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306642200 · Cited by 800 · see citing works
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793 · see citing works
MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., Louie, G., Kueider‐Paisley, A., Moseley, M. A., Thompson, J. W., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.217 · Cited by 706 · see citing works
Donia, M. S., Cimermancic, P., Schulze, C. J., Wieland Brown, L. C., Martin, J., Mitreva, M., Clardy, J., Linington, R. G., & Fischbach, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.08.032 · Cited by 705 · see citing works
Potential roles of gut microbiome and metabolites in modulating ALS in mice
Blacher, E., Bashiardes, S., Shapiro, H., Rothschild, D., Mor, U., Dori-Bachash, M., Kleimeyer, C., Moresi, C., Harnik, Y., Zur, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1443-5 · Cited by 700 · see citing works
The endocannabinoid system links gut microbiota to adipogenesis
Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691 · see citing works
D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675 · see citing works
Benito, C., Núñez, E., Tolón, R. M., Carrier, E. J., Rábano, A., Hillard, C. J., & Romero, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11136.2003 · Cited by 624 · see citing works
Kim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614 · see citing works
Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
Mosca, A., Leclerc, M., & Hugot, J. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00455 · Cited by 612 · see citing works
Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
Hoyles, L., Snelling, T., Umlai, U.-K., Nicholson, J. K., Carding, S. R., Glen, R. C., & McArthur, S. (2018) · Microbiome · doi:10.1186/s40168-018-0439-y · Cited by 591 · see citing works
Collective unconscious: How gut microbes shape human behavior
Dinan, T. G., Stilling, R. M., Stanton, C., & Cryan, J. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.021 · Cited by 571 · see citing works
Obesity-Induced Neuroinflammation: Beyond the Hypothalamus
Guillemot‐Legris, O., & Muccioli, G. G. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.02.005 · Cited by 565 · see citing works
Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works
Sun, J., Xu, J., Ling, Y., Wang, F., Gong, T., Yang, C., Ye, S., Ye, K., Wei, D., Song, Z., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0525-3 · Cited by 532 · see citing works
Gill, P. A., van Zelm, M. C., Muir, J. G., & Gibson, P. R. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14689 · Cited by 520 · see citing works
The endocannabinoid system in guarding against fear, anxiety and stress
Lutz, B., Marsicano, G., Maldonado, R., & Hillard, C. J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4036 · Cited by 506 · see citing works
Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works
New approaches and challenges to targeting the endocannabinoid system
Marzo, V. D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.115 · Cited by 480 · see citing works
Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder
Liu, S., Li, E., Sun, Z., Fu, D., Duan, G., Jiang, M., Yu, Y., Mei, L., Yang, P., Tang, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36430-z · Cited by 457 · see citing works
Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453 · see citing works
Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease
Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449 · see citing works
Signatures of early frailty in the gut microbiota
Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D., & Steves, C. J. (2016) · Genome Medicine · doi:10.1186/s13073-016-0262-7 · Cited by 436 · see citing works
Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging
Lieb, W. (2009) · JAMA · doi:10.1001/jama.2009.1836 · Cited by 428 · see citing works
Archaea and the Human Gut: New Beginning of an Old Story
Gaci, N., Borrel, G., Tottey, W., O’Toole, P. W., & Brugère, J.-F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i43.16062 · Cited by 422 · see citing works
Cannabinoids and the gut: New developments and emerging concepts
Izzo, A. A., & Sharkey, K. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.12.005 · Cited by 421 · see citing works
The progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Structure and function of the healthy pre-adolescent pediatric gut microbiome
Hollister, E. B., Riehle, K., Luna, R. A., Weidler, E. M., Rubio-Gonzales, M., Mistretta, T.-A., Raza, S., Doddapaneni, H. V., Metcalf, G. A., Muzny, D. M., et al. (2015) · Microbiome · doi:10.1186/s40168-015-0101-x · Cited by 406 · see citing works
A comprehensive repertoire of prokaryotic species identified in human beings
Hugon, P., Dufour, J.-C., Colson, P., Fournier, P., Sallah, K., & Raoult, D. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00293-5 · Cited by 406 · see citing works
The role of the gut microbiome in the healthy adult status
D’Argenio, V., & Salvatore, F. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.003 · Cited by 396 · see citing works
Ho, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., & Pasinetti, G. M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1400909 · Cited by 376 · see citing works
Endocannabinoids–at the crossroads between the gut microbiota and host metabolism
Cani, P. D., Plovier, H., Van Hul, M., Geurts, L., Delzenne, N. M., Druart, C., & Everard, A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.211 · Cited by 367 · cited 6× · see citing works
“In fact, AEA can induce gut permeability, causing a ‘leaky’ gut which in turn lead to the onset of metabolic endotoxemia releasing toxins, including LPS, to cross the epithelial barrier driving inflammatory signaling and affecting the CNS [20].”
BackgroundInfluentialGuida, F., Turco, F., Iannotta, M., De Gregorio, D., Palumbo, I., Sarnelli, G., Furiano, A., Napolitano, F., Boccella, S., Luongo, L., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.09.001 · Cited by 367 · see citing works
Bacterial Neuroactive Compounds Produced by Psychobiotics
Wall, R., Cryan, J. F., Ross, R. P., Fitzgerald, G. F., Dinan, T. G., & Stanton, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_10 · Cited by 362 · see citing works
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347 · see citing works
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338 · see citing works
Voices from within: gut microbes and the CNS
Forsythe, P., & Kunze, W. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1028-z · Cited by 336 · see citing works
Núñez, E., Benito, C., Pazos, M. R., Barbáchano, A., Fajardo, O., González, S. R., Tolón, R. M., & Romero, J. (2004) · Synapse · doi:10.1002/syn.20050 · Cited by 334 · see citing works
Fecal Microbiota Composition and Frailty
van Tongeren, S. P., Slaets, J. P. J., Harmsen, H. J. M., & Welling, G. W. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.10.6438-6442.2005 · Cited by 333 · see citing works
The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration
Ashton, J. C., & Glass, M. (2007) · Current Neuropharmacology · doi:10.2174/157015907780866884 · Cited by 332 · see citing works
Chevalier, G., Siopi, E., Guenin‐Macé, L., Pascal, M., Laval, T., Rifflet, A., Boneca, I. G., Demangel, C., Colsch, B., Pruvost, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19931-2 · Cited by 324 · see citing works
Biosynthesis of an Endogenous Cannabinoid Precursor in Neurons and its Control by Calcium and cAMP
Cadas, H., Gaillet, S., Beltramo, M., Venance, L., & Piomelli, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03934.1996 · Cited by 318 · see citing works
The human gut microbiota and virome: Potential therapeutic implications
Scarpellini, E., Ianiro, G., Attili, F., Bassanelli, C., Santis, A. D., & Gasbarrini, A. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.07.008 · Cited by 315 · see citing works
Microbiota-gut-brain axis and the central nervous system
Zhu, X., Han, Y., Du, J., Liu, R., Jin, K., & Yi, W. (2017) · Oncotarget · doi:10.18632/oncotarget.17754 · Cited by 308 · see citing works
Microbial Short-Chain Fatty Acids and Blood Pressure Regulation
Pluznick, J. L. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0722-5 · Cited by 301 · see citing works
The Microbiome and Risk for Obesity and Diabetes
Komaroff, A. L. (2016) · JAMA · doi:10.1001/jama.2016.20099 · Cited by 294 · see citing works
Effect of bile salts on the DNA and membrane integrity of enteric bacteria
Merritt, M. E., & Donaldson, J. R. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.014092-0 · Cited by 285 · see citing works
Adipokines: a link between obesity and dementia?
Kiliaan, A. J., Arnoldussen, I. A. C., & Gustafson, D. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70085-7 · Cited by 284 · see citing works
Human gut microbiota: the links with dementia development
Alkasir, R., Li, J., Li, X., Jin, M., & Zhu, B. (2016) · Protein & Cell · doi:10.1007/s13238-016-0338-6 · Cited by 283 · see citing works
Bonfili, L., Cecarini, V., Cuccioloni, M., Angeletti, M., Berardi, S., Scarpona, S., Rossi, G., & Eleuteri, A. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0973-4 · Cited by 277 · see citing works
Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
Chen, R., Zhang, J., Wu, Y., Wang, D., Feng, G., Tang, Y., Teng, Z., & Chen, C. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.030 · Cited by 272 · see citing works
Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study
Leblhuber, F., Steiner, K., Schuetz, B., Fuchs, D., & Gostner, J. M. (2018) · Current Alzheimer Research · doi:10.2174/1389200219666180813144834 · Cited by 269 · see citing works
Azm, S. A. N., Djazayeri, A., Safa, M., Azami, K., Ahmadvand, B., Sabbaghziarani, F., Sharifzadeh, M. S., & Vafa, M. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0648 · Cited by 262 · see citing works
Role of the Gut Microbiome in Obesity and Diabetes Mellitus
Barlow, G. M., Yu, A. T., & Mathur, R. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609896 · Cited by 261 · see citing works
Nutrition for the ageing brain: Towards evidence for an optimal diet
Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.010 · Cited by 241 · see citing works
Integration of Endocannabinoid and Leptin Signaling in an Appetite-Related Neural Circuit
Jo, Y., Chen, Y.-J. J., Chua, S. C., Talmage, D. A., & Role, L. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.021 · Cited by 233 · see citing works
Mancuso, C., & Santangelo, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.009 · Cited by 232 · see citing works
The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species
Bilen, M., Dufour, J.-C., Lagier, J.-C., Cadoret, F., Daoud, Z., Dubourg, G., & Raoult, D. (2018) · Microbiome · doi:10.1186/s40168-018-0485-5 · Cited by 231 · see citing works
Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., & Wu, Q. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00403 · Cited by 227 · see citing works
Lyte, M. (2014) · Gut Microbes · doi:10.4161/gmic.28682 · Cited by 225 · see citing works
Piro, J. R., Benjamin, D. I., Duerr, J. M., Pi, Y., Gonzales, C., Wood, K. M., Schwartz, J. W., Nomura, D. K., & Samad, T. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.05.001 · Cited by 223 · see citing works
Retrograde signaling by endocannabinoids
Kreitzer, A. C. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00328-8 · Cited by 220 · see citing works
Hosoi, T., Okuma, Y., & Nomura, Y. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r141 · Cited by 220 · see citing works
Obesity and dementia: Adipokines interact with the brain
Arnoldussen, I. A. C., Kiliaan, A. J., & Gustafson, D. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.002 · Cited by 219 · see citing works
Leptin Reduces Pathology and Improves Memory in a Transgenic Mouse Model of Alzheimer's Disease
Greco, S. J., Bryan, K. J., Sarkar, S., Zhu, X., Smith, M. A., Ashford, J. W., Johnston, J. M., Tezapsidis, N., & Casadesús, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1308 · Cited by 218 · see citing works
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
Marzo, V. D., PETROCELLIS, L. D., Sepe, N., & BUONO, A. (1996) · Biochemical Journal · doi:10.1042/bj3160977 · Cited by 195 · see citing works
Communicating systems in the body: how microbiota and microglia cooperate
Erny, D., de Angelis, A. L. H., & Prinz, M. (2016) · Immunology · doi:10.1111/imm.12645 · Cited by 190 · see citing works
Endocannabinoids, Related Compounds and Their Metabolic Routes
Fezza, F., Bari, M., Florio, R., Talamonti, E., Feole, M., & Maccarrone, M. (2014) · Molecules · doi:10.3390/molecules191117078 · Cited by 181 · see citing works
Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?
Asti, A., & Gioglio, L. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131394 · Cited by 180 · see citing works
Aldars‐García, L., Chaparro, M., & Gisbert, J. P. (2021) · Microorganisms · doi:10.3390/microorganisms9050977 · Cited by 177 · see citing works
Geurts, L., Everard, A., Hul, M. V., Essaghir, A., Duparc, T., Matamoros, S., Plovier, H., Castel, J., Denis, R., Bergiers, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7495 · Cited by 170 · see citing works
D'Mello, C., Ronaghan, N., Zaheer, R., Dicay, M., Le, T., MacNaughton, W. K., Surrette, M. G., & Swain, M. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0575-15.2015 · Cited by 169 · see citing works
Epigenetic Alterations in Alzheimer’s Disease
Sanchez-Mut, J. V., & Gräff, J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00347 · Cited by 168 · see citing works
Mehrpouya‐Bahrami, P., Chitrala, K. N., Ganewatta, M. S., Tang, C., Murphy, E. A., Enos, R. T., Velázquez, K. T., McCellan, J., Nagarkatti, M., & Nagarkatti, P. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-15154-6 · Cited by 163 · see citing works
Fasae, K. D., Abolaji, A. O., Faloye, T. R., Odunsi, A., Oyetayo, B. O., Enya, J. I., Rotimi, J. A., Akinyemi, R., Whitworth, A. J., & Aschner, M. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126779 · Cited by 160 · see citing works
Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019) · Aging Cell · doi:10.1111/acel.13037 · Cited by 156 · see citing works
Enteroendocrine cell signalling via the vagus nerve
Dockray, G. J. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.007 · Cited by 154 · see citing works
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota
Qian, X.-H., Song, X.-X., Liu, X.-L., Chen, S.-D., & Tang, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101317 · Cited by 153 · see citing works
Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G. G., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000424 · Cited by 152 · see citing works
Regional Ischemic Vulnerability of the Brain to Hypoperfusion
Payabvash, S., Souza, L. C. S., Wang, Y., Schaefer, P. W., Furie, K. L., Halpern, E. F., González, R., & Lev, M. H. (2011) · Stroke · doi:10.1161/strokeaha.110.600940 · Cited by 151 · see citing works
Serotonin and the regulation of mammalian energy balance
Donovan, M. H., & Tecott, L. H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00036 · Cited by 150 · see citing works
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids
Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_5 · Cited by 149 · see citing works
Rezaeiasl, Z., Sepehri, G., & Salami, M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112183 · Cited by 149 · see citing works
Fu, P., Gao, M., & Yung, K. K. L. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00607 · Cited by 145 · see citing works
Promiscuous Cross-seeding between Bacterial Amyloids Promotes Interspecies Biofilms
Zhou, Y., Smith, D. R., Leong, B. J., Brännström, K., Almqvist, F., & Chapman, M. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.383737 · Cited by 144 · see citing works
Yılmaz, A., Geddes, T., Han, B., Bahado-Singh, R. O., Wilson, G. D., Imam, K., Maddens, M. E., & Graham, S. F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161226 · Cited by 137 · see citing works
Cooray, R., Gupta, V. B., & Suphioglu, C. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02054-6 · Cited by 137 · see citing works
Cluny, N. L., Keenan, C. M., Reimer, R. A., Foll, B. L., & Sharkey, K. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144270 · Cited by 128 · see citing works
The Gut-Microglia Connection: Implications for Central Nervous System Diseases
Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 128 · see citing works
Cerovic, M., Forloni, G., & Balducci, C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00284 · Cited by 126 · see citing works
Leptin Dysfunction and Alzheimer’s Disease: Evidence from Cellular, Animal, and Human Studies
McGuire, M. J., & Ishii, M. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0282-7 · Cited by 125 · see citing works
Aguilera, M., Vergara, P., & Martínez, V. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12154 · Cited by 119 · see citing works
Gao, Q., Wang, Y., Wang, X., Fu, S., Zhang, X., Wang, R., & Zhang, X. (2019) · Aging · doi:10.18632/aging.102352 · Cited by 118 · see citing works
Chen, C., Lin, C., & Kao, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144589 · Cited by 113 · see citing works
Physical activity and the endocannabinoid system: an overview
Tantimonaco, M., Ceci, R., Sabatini, S., Catani, M. V., Rossi, A., Gasperi, V., & Maccarrone, M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1575-6 · Cited by 112 · see citing works
Probiotics for dementia: a systematic review and meta-analysis of randomized controlled trials
Krüger, J. F., Hillesheim, E., Pereira, A. C. D. S. N., Camargo, C. D. Q., & Rabito, E. I. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa037 · Cited by 109 · see citing works
Forte, N. R., Fernández-Rilo, A. C., Palomba, L., Marzo, V. D., & Cristino, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051554 · Cited by 104 · see citing works
Potential and Limits of Cannabinoids in Alzheimer’s Disease Therapy
Abate, G., Uberti, D. L., & Tambaro, S. (2021) · Biology · doi:10.3390/biology10060542 · Cited by 101 · see citing works
A review on gut microbiota: a central factor in the pathophysiology of obesity
Cunningham, A., Stephens, J. W., & Harris, D. A. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01491-z · Cited by 101 · see citing works
Porphyromonas gingivalis and Alzheimer disease: Recent findings and potential therapies
Ryder, M. I. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0104 · Cited by 97 · see citing works
Castonguay-Paradis, S., Lacroix, S., Rochefort, G., Parent, L., Perron, J., Martin, C., Lamarche, B., Raymond, F., Flamand, N., Marzo, V. D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72861-3 · Cited by 97 · see citing works
Esposito, G., Filippis, D. D., Steardo, L., Scuderi, C., Savani, C., Cuomo, V., & Iuvone, T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.012 · Cited by 95 · see citing works
NMR analysis of the human saliva metabolome distinguishes dementia patients from matched controls
Figueira, J., Jonsson, P., Adolfsson, A. N., Adolfsson, R., Nyberg, L. H., & Öhman, A. (2016) · Molecular BioSystems · doi:10.1039/c6mb00233a · Cited by 95 · see citing works
Kim, D. K., Park, J., Han, D., Yang, J., Kim, A., Woo, J., Kim, Y., & Mook-Jung, I. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0234-4 · Cited by 95 · see citing works
Marzo, V. D. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/vdimarzo · Cited by 91 · see citing works
Obesity as a Risk Factor for Alzheimer’s Disease: Implication of Leptin and Glutamate
Lloret, A., Monllor, P., Esteve, D., Cervera‐Ferri, A., & Lloret, M.-Á. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00508 · Cited by 90 · see citing works
The gut microbiome, endocannabinoids and metabolic disorders
Iannotti, F. A., & Marzo, V. D. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0444 · Cited by 89 · see citing works
(2015) · PubMed · Cited by 86 · see citing works
Williamson, L. L., McKenney, E. A., Holzknecht, Z. E., Belliveau, C., Rawls, J. F., Poulton, S., Parker, W., & Bilbo, S. D. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.006 · Cited by 84 · see citing works
Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice
Lacroix, S., Pechereau, F., Leblanc, N., Boubertakh, B., Houde, A., Martin, C., Flamand, N., Silvestri, C., Raymond, F., Marzo, V. D., et al. (2019) · mSystems · doi:10.1128/msystems.00407-19 · Cited by 84 · see citing works
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
Montoya, A., Elgueta, D., Campos, J., Chovar, O., Falcón, P., Matus, S., Alfaro, I. E., Bono, M. R., & Pacheco, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1652-8 · Cited by 83 · see citing works
Type-1 Cannabinoid Receptor Activity During Alzheimer's Disease Progression
Manuel, I., Román, E. G. D. S., Giralt, M. T., Ferrer, I., & Rodríguez‐Puertas, R. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140492 · Cited by 82 · see citing works
Pihlaja, R., Helin, J. S., Eskola, O., Vasara, J., Lopez‐Picon, F. R., Haaparanta‐Solin, M., & Rinne, J. O. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0305-9 · Cited by 79 · see citing works
The Microbiota–Gut–Brain Axis and Epilepsy
Yue, Q., Cai, M., Xiao, B., Zhan, Q., & Zeng, C. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01130-2 · Cited by 77 · see citing works
Grabner, G. F., Eichmann, T. O., Wagner, B., Gao, Y., Farzi, A., Taschler, U., Radner, F. P. W., Schweiger, M., Lass, A., Holzer, P. D., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.683615 · Cited by 73 · see citing works
Depommier, C., Vitale, R. M., Iannotti, F. A., Silvestri, C., Flamand, N., Druart, C., Everard, A., Pelicaen, R., Maiter, D. M., Thissen, J., et al. (2021) · Cells · doi:10.3390/cells10010185 · Cited by 73 · see citing works
van der Lugt, B., Rusli, F., Lute, C., Lamprakis, A., Salazar, E., Boekschoten, M. V., Hooiveld, G. J., Müller, M., Vervoort, J., Kersten, S., et al. (2018) · Aging · doi:10.18632/aging.101439 · Cited by 72 · see citing works
Parkinson’s Disease and the Gut: Symptoms, Nutrition, and Microbiota
Yemula, N., Dietrich, C. M., Dostal, V., & Hornberger, M. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212707 · Cited by 68 · see citing works
The microbiome and prostate cancer
Javier-DesLoges, J. F., McKay, R. R., Swafford, A. D.-E., Sepich‐Poore, G. D., Knight, R. D., & Parsons, J. K. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00413-5 · Cited by 64 · see citing works
Jones, É., & Vlachou, S. (2020) · Molecules · doi:10.3390/molecules25214930 · Cited by 61 · see citing works
Endocannabinoid system alterations in Alzheimer’s disease: A systematic review of human studies
Berry, A. J., Zubko, O., Reeves, S., & Howard, R. J. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147135 · Cited by 58 · see citing works
Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity
DiPatrizio, N. V. (2021) · Nutrients · doi:10.3390/nu13041214 · Cited by 56 · see citing works
Dione, N., Lacroix, S., Taschler, U., Deschênes, T., Abolghasemi, A., Leblanc, N., Marzo, V. D., & Silvestri, C. (2020) · Cells · doi:10.3390/cells9122705 · Cited by 55 · see citing works
Erratum: Strains, functions and dynamics in the expanded Human Microbiome Project
Lloyd‐Price, J., Mahurkar, A., Rahnavard, A., Crabtree, J., Orvis, J., Hall, A. B., Brady, A., Creasy, H. H., McCracken, C. L., Giglio, M. G., et al. (2017) · Nature · doi:10.1038/nature24485 · Cited by 53 · see citing works
Role of Intestinal Microbiota on Gut Homeostasis and Rheumatoid Arthritis
Li, M., & Wang, F. (2021) · Journal of Immunology Research · doi:10.1155/2021/8167283 · Cited by 52 · see citing works
Payahoo, L., Khajebishak, Y., Alivand, M. R., Soleimanzade, H., Alipour, S., Barzegari, A., & Ostadrahimi, A. (2019) · Appetite · doi:10.1016/j.appet.2019.05.032 · Cited by 51 · see citing works
Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism
Rakotoarivelo, V., Sihag, J., & Flamand, N. (2021) · Cells · doi:10.3390/cells10061279 · Cited by 51 · see citing works
Minichino, A., Jackson, M. A., Francesconi, M., Steves, C. J., Menni, C., Burnet, P. W. J., & Lennox, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01147-5 · Cited by 50 · see citing works
Tiwari, V., & Patel, A. B. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111502 · Cited by 49 · see citing works
Leweke, F. M., Mueller, J. K., Lange, B., Fritze, S., Topor, C. E., Koethe, D., & Rohleder, C. (2018) · CNS Drugs · doi:10.1007/s40263-018-0539-z · Cited by 47 · see citing works
Markey, L., Hooper, A., Melon, L. C., Baglot, S., Hill, M. N., Maguire, J., & Kumamoto, C. A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104808 · Cited by 45 · see citing works
Targeting the endocannabinoid system with microbial interventions to improve gut integrity
Jansma, J., Brinkman, F. N., van Hemert, S., & Aidy, S. E. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110169 · Cited by 45 · see citing works
Reddy, V. P., Grogan, D. P., Ahluwalia, M., Salles, É. L., Ahluwalia, P. K., Khodadadi, H., Alverson, K., Nguyen, A., Raju, S. P., Gaur, P., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00203-4 · Cited by 42 · see citing works
Yoshida, K., Kita, Y., Tokuoka, S. M., Hamano, F., Yamazaki, M., Sakimura, K., Kano, M., & Shimizu, T. (2018) · The FASEB Journal · doi:10.1096/fj.201801203r · Cited by 36 · see citing works
Endocannabinoids and the Digestive Tract and Bladder in Health and Disease
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Rao, J. S., Tangarife, M. A., Rodríguez‐Soacha, D. A., & Mukunda, R. (2026) · Academia Drug Development and Pharmacotherapy · doi:10.20935/acaddrug8564
- Authors
- Bisogno, T., Lauritano, A., & Piscitelli, F.
- Affiliations
- Istituto di Farmacologia Traslazionale (IT)
- Istituto di Chimica Biomolecolare (IT)
- Corresponding author
- Bisogno, Tiziana
- Piscitelli, Fabiana
- Venue
- Life
- Publisher
- MDPI AG
- Published
- 2021-09-08
- Volume
- 11
- Issue
- 9
- Pages
- 934
- ISSN
- 2075-1729 (ISSN-L)
- PMC
- PMC8470731
- OpenAlex
- W3198513682
- Cited by
- 16
- References
- 191
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Life (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Alzheimer's disease, endocannabinoid system, gut microbiota, gut-brain axis, neurodegeneration, amyloid plaques, neurofibrillary tangles, preclinical Alzheimer's disease, cannabinoid receptors, adipose tissue, intestinal tissue, host homeostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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