Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Dementia prevention, intervention, and care

Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072

Mechanisms of NAFLD development and therapeutic strategies

Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

2013 Alzheimer's disease facts and figures

Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,372

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

Breijyeh, Z., & Karaman, R. (2020) · Molecules · doi:10.3390/molecules25245789 · Cited by 2,789

Dynamics and functions of lipid droplets

Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia

Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433

Pathogenesis of Alzheimer’s Disease

Rostagno, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010107 · Cited by 391

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217

Role of Environmental Toxicants on Neurodegenerative Disorders

Nabi, M., & Tabassum, N. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.837579 · Cited by 217

Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease

Al-Ghraiybah, N. F., Wang, J., Alkhalifa, A. E., Roberts, A. B., Raj, R., Yang, E., & Kaddoumi, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810572 · Cited by 217

New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases

Chen, J., Xiao, Y., Li, D., Zhang, S., Wu, Y., Zhang, Q., & Bai, W. (2023) · iMeta · doi:10.1002/imt2.69 · Cited by 178

The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier

Rondinella, D., Raoul, P. C., Valeriani, E., Venturini, I., Cintoni, M., Severino, A., Galli, F. S., Mora, V., Mele, M. C., Cammarota, G., et al. (2025) · Nutrients · doi:10.3390/nu17050859 · Cited by 197

Gut microbiome-targeted therapies for Alzheimer’s disease

Zhang, T., Gao, G., Kwok, L., & Sun, Z. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2271613 · Cited by 162

Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment

Salim, S., Ahmad, F. A., Banu, A., & Mohammad, F. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.10.013 · Cited by 124

Diabetes and cognitive function: An evidence-based current perspective

Sebastian, M. J., Khan, S. K. A., Pappachan, J. M., & Jeeyavudeen, M. S. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i2.92 · Cited by 115

Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study

Fang, Z., Rossato, S. L., Hang, D., Khandpur, N., Wang, K., Lo, C.-H., Willett, W. C., Giovannucci, E. L., & Song, M. (2024) · BMJ · doi:10.1136/bmj-2023-078476 · Cited by 84

Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities

Wang, R., Gu, S., Kim, Y. H., Lee, A., Lin, H., & Jiang, D. (2025) · MedComm · doi:10.1002/mco2.70406 · Cited by 118

Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms

Feng, Z., Fang, C., Ma, Y., & Chang, J. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03104-9 · Cited by 109

Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis

Zheng, M., Ye, H., Yang, X., Shen, L., Dang, X., Liu, X., Gong, Y., Wu, Q., Wang, L., Ge, X., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.016 · Cited by 98

The microbiome-driven impact of western diet in the development of noncommunicable chronic disorders

Severino, A., Tohumcu, E., Tamai, L., D’Argenio, P., Porcari, S., Rondinella, D., Venturini, I., Maida, M. F., Gasbarrini, A., Cammarota, G., et al. (2024) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2024.101923 · Cited by 102

Effects of Intermittent Fasting on Brain Metabolism

Brocchi, A., Rebelos, E., Dardano, A., Mantuano, M., & Daniele, G. (2022) · Nutrients · doi:10.3390/nu14061275 · Cited by 99

Impact of high-fat diet on cognitive behavior and central and systemic inflammation with aging and sex differences in mice

Evans, A. K., Saw, N. L., Woods, C. E., Vidano, L. M., Blumenfeld, S. E., Lam, R. K., Chu, E. K., Reading, C., & Shamloo, M. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.025 · Cited by 86

A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms

Park, G., Kadyan, S., Hochuli, N., Pollak, J., Wang, B., Salazar, G., Chakrabarty, P., Efron, P. A., Sheffler, J., & Nagpal, R. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2323752 · Cited by 89

Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients

Zhang, Y., Shen, Y., Liufu, N., Liu, L., Li, W., Shi, Z., Zheng, H., Mei, X., Chen, C.-Y., Jiang, Z., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02216-7 · Cited by 83

Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease

Li, T., Chu, C., Yu, L., Zhai, Q., Wang, S., Zhao, J., Zhang, H., Chen, W., & Tian, F. (2022) · Nutrients · doi:10.3390/nu14214678 · Cited by 76

The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

Al‐kuraishy, H. M., Jabir, M. S., Albuhadily, A. K., Al-Gareeb, A. I., & Rafeeq, M. F. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102084 · Cited by 75

Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Grant, W. B., & Blake, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230418 · Cited by 82

Obesity-induced chronic low-grade inflammation in adipose tissue: A pathway to Alzheimer’s disease

Zhai, W., Meng, Z., Chunxiao, W., Lingjie, M., Anguo, Z., Zhang, Y., Xinran, C., Yanjiao, X., & Li, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102402 · Cited by 69

Peripheral Inflammation and Insulin Resistance: Their Impact on Blood–Brain Barrier Integrity and Glia Activation in Alzheimer’s Disease

Ponce-Lopez, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094209 · Cited by 75

Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation

Zhang, Q., Jin, K., Chen, B., Liu, R., Cheng, S., Zhang, Y., & Lü, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.884579 · Cited by 65

Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses

Zhang, R., Zhang, B., Shen, C., Sahakian, B. J., Li, Z., Zhang, W., Zhao, Y., Li, Y., Feng, J., & Cheng, W. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00226-0 · Cited by 64

Effect of nutrition in Alzheimer’s disease: A systematic review

Lou, I. X., Ali, K., & Chen, Q. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1147177 · Cited by 70

The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

Warren, A., Nyavor, Y., Zarabian, N., Mahoney, A., & Frame, L. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365673 · Cited by 64

Association between ultra-processed food consumption and cognitive performance in US older adults: a cross-sectional analysis of the NHANES 2011–2014

R Cardoso, B., Machado, P., & Steele, E. M. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02911-1 · Cited by 56

Melatonin: From Neurobiology to Treatment

Biggio, G., Biggio, F., Talani, G., Mostallino, M. C., Aguglia, A., Aguglia, E., & Palagini, L. (2021) · Brain Sciences · doi:10.3390/brainsci11091121 · Cited by 56

The gut microbiota is an emerging target for improving brain health during ageing

Boehme, M., Guzzetta, K. E., Wasén, C., & Cox, L. M. (2022) · Gut Microbiome · doi:10.1017/gmb.2022.11 · Cited by 57

Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice

Henn, R. E., Elzinga, S. E., Glass, E., Parent, R., Guo, K., Allouch, A. M., Mendelson, F. E., Hayes, J., Webber‐Davis, I. F., Murphy, G. G., et al. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00323-7 · Cited by 54

Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome

Wang, F., Zhu, N., Zhou, F., & Lin, D.-X. (2021) · Molecules · doi:10.3390/molecules26206117 · Cited by 52

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Вячеславовна, Г. А., Svirin, E. P., Pavlov, D., Cespuglio, R., Proshin, A. T., Schroeter, C. A., Lesch, K., & Strekalova, T. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020915 · Cited by 54

Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases

Mendoza-León, M. J., Mangalam, A. K., Regaldiz, A., González-Madrid, E., Rangel-Ramírez, M. A., Álvarez-Mardones, O., Vallejos, O. P., Méndez, C., Bueno, S. M., Melo-González, F., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1192216 · Cited by 56

Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response

Wang, Z., Zhang, L., & Qin, C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00857-6 · Cited by 60

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

Rinoldi, C., Ziai, Y., Zargarian, S. S., Nakielski, P., Zembrzycki, K., Bayan, M. A. H., Zakrzewska, A., Fiorelli, R., Lanzi, M., Kostrzewska-Księżyk, A., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c17025 · Cited by 47

Microglia and gut microbiota: A double-edged sword in Alzheimer's disease

Bano, N., Khan, S., Ahamad, S., Kanshana, J. S., Dar, N. J., Khan, S. J., Nazir, A., & Bhat, S. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102515 · Cited by 50

Bridging systemic metabolic dysfunction and Alzheimer’s disease: the liver interface

Song, D., Yang, L., Yang, L.-L., Luo, Y., & Yao, X. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00849-6 · Cited by 53

Effects of High-Fat and High-Fat High-Sugar Diets in the Anxiety, Learning and Memory, and in the Hippocampus Neurogenesis and Neuroinflammation of Aged Rats

Mota, B., Ramos, M., Marques, S. I., da Silva, A. B. G., Pereira, P. A., Madeira, M. D., Mateus, N. F. D. C. B., & Cardoso, A. (2023) · Nutrients · doi:10.3390/nu15061370 · Cited by 42

Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons

Neuffer, J., González-Domínguez, R., Lefèvre-Arbogast, S., Low, D. Y., Driollet, B., Helmer, C., Du Preez, A., de Lucia, C., Ruigrok, S. R., Altendorfer, B., et al. (2022) · Nutrients · doi:10.3390/nu14214688 · Cited by 40

Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s Disease

Afsar, A., Castro, M. D. C. C., Soladogun, A. S., & Li, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087258 · Cited by 45

The role of intestinal microbiota and metabolites in intestinal inflammation

Ma, W., Huang, Z., Liu, K., Li, D., Mo, T., & Liu, Q. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127838 · Cited by 45

Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling

Hayes, A., Lauer, L. T., Kao, A. E., Sun, S., Klug, M. E., Tsan, L., Rea, J. J., Subramanian, K. S., Gu, C., Tanios, N., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.015 · Cited by 42

Influence of human gut microbiome on the healthy and the neurodegenerative aging

Borrego-Ruiz, A., & Borrego, J. J. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112497 · Cited by 43

Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF‐кB pathway through microbiota‐gut‐brain axis

Zhang, Z., Deng, S., Chen, C., He, Q., Peng, X., Liang, Q., Zhuang, G., Wang, S., & Tang, D. (2023) · Phytotherapy Research · doi:10.1002/ptr.7827 · Cited by 40

Gut-brain axis: gut dysbiosis and psychiatric disorders in Alzheimer’s and Parkinson’s disease

Denman, C. R., Park, S. M., & Jo, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1268419 · Cited by 45

Mitophagy in Alzheimer's disease and other metabolic disorders: A focus on mitochondrial-targeted therapeutics

Skawratananond, S., Xiong, D. X., Zhang, C., Tonk, S. S., Pinili, A., Delacruz, B., Pham, P., Smith, S. C., Navab, R., & Reddy, P. H. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102732 · Cited by 41

Autophagy Balances Neuroinflammation in Alzheimer’s Disease

Cheng, X., Wei, Y. Q., Qian, Z., & Han, L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01269-6 · Cited by 40

A comprehensive review on the prevention and regulation of Alzheimer’s disease by tea and its active ingredients

Huang, Y., Wei, Y., Xu, J., & Wei, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2081128 · Cited by 38

Gut Microbiota and Immune System Dynamics in Parkinson’s and Alzheimer’s Diseases

Kuštrimović, N. Z., Balkhi, S., Bilato, G., & Mortara, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212164 · Cited by 39

Macrophages and the development and progression of non-alcoholic fatty liver disease

Alabdulaali, B., Al‐Rashed, F., Al‐Onaizi, M., Kandari, A., Razafiarison, J., Tonui, D., Williams, M. R., Blériot, C., Ahmad, R., & Alzaïd, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195699 · Cited by 38

How Modifiable Are Modifiable Dementia Risk Factors? A Framework for Considering the Modifiability of Dementia Risk Factors

Bransby, L., Rosenich, E., Maruff, P. T., & Lim, Y. Y. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.119 · Cited by 37

Nutrients and amyloid β status in the brain: A narrative review

Díaz, G., Lengelé, L., Sourdet, S., Soriano, G., & Barreto, P. D. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101728 · Cited by 33

Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis

Vegas‐Suárez, S., Simón, J., Martínez‐Chantar, M. L., & Moratalla, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.864263 · Cited by 35

Neuroimmune mechanisms underlying Alzheimer’s disease: Insights into central and peripheral immune cell crosstalk

Liu, Y., Tan, Y., Zhang, Z., Li, H., Yi, M., Zhang, Z., Hui, S., & Peng, W. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101831 · Cited by 34

Dietary pattern and hepatic lipid metabolism

Zou, P., & Wang, L. (2023) · Liver Research · doi:10.1016/j.livres.2023.11.006 · Cited by 37

Linking Nonalcoholic Fatty Liver Disease and Brain Disease: Focusing on Bile Acid Signaling

Ren, Z., Li, C.-X., Ma, C., Chen, D., Chen, J., Xu, W., Chen, C.-A., Cheng, F., & Wang, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113045 · Cited by 32

Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6 J mice

Demaria, T. M., Crepaldi, L. D., Costa-Bartuli, E., Branco, J. R., Zancan, P., & Sola‐Penna, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-30254-2 · Cited by 32

Trilobatin Alleviates Cognitive Deficits and Pathologies in an Alzheimer’s Disease Mouse Model

Ding, J., Huang, J. V., Yin, D., Liu, T., Ren, Z., Hu, S., Le, C., Le, C., Zhou, H., Zhu, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3298400 · Cited by 31

Appetitive interoception, the hippocampus and western-style diet

Davidson, T. L., & Stevenson, R. J. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09698-2 · Cited by 33

Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease

Li, N., Li, H., Liu, Z., Feng, G., Shi, C., & Wu, Y. (2023) · Foods · doi:10.3390/foods12152972 · Cited by 34

Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)

Negrey, J. D., Negrey, J. D., Johnson, C. S. C., Kim, J., Barcus, R. A., Lockhart, S. N., Whitlow, C. T., Sutphen, C. L., Snyder‐Mackler, N., Montine, T. J., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.016 · Cited by 29

The influence of genetic and acquired factors on the vulnerability to develop depression: a review

Zhang, X., Qiao, Y., Wang, M., Liang, X., Zhang, M., Li, C., Cairang, J., Wang, J., Bi, H., & Gao, T. (2023) · Bioscience Reports · doi:10.1042/bsr20222644 · Cited by 36

Intermittent fasting and neurodegenerative diseases: Molecular mechanisms and therapeutic potential

Lv, R., Liu, B., Jiang, Z., Zhou, R., Liu, X., Lu, T., Bao, Y., Huang, C., Zou, G., Zhang, Z., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156104 · Cited by 34

Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice

Mattar, J. M., Majchrzak, M., Iannucci, J., Bartman, S., Robinson, J. K., & Grammas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073921 · Cited by 28

Induction of Brain Insulin Resistance and Alzheimer’s Molecular Changes by Western Diet

Mietelska‐Porowska, A., Domańska, J. M., Want, A., Więckowska‐Gacek, A., Chutorański, D., Koperski, M., & Wojda, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094744 · Cited by 29

Assessing adipokines as potential biomarkers of dementia, Alzheimer's disease, and mild cognitive impairment: A systematic review and meta‐analysis

García‐García, I., Fernández‐Andújar, M., Narváez, M., & García‐Casares, N. (2023) · Obesity Reviews · doi:10.1111/obr.13573 · Cited by 30

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29

Alzheimer’s Disease Treatment: The Search for a Breakthrough

Reiss, A. B., Muhieddine, D., Jacob, B., Mesbah, M., Pinkhasov, A., Gomolin, I. H., Stecker, M. M., Wısnıewskı, T., & Leon, J. D. (2023) · Medicina · doi:10.3390/medicina59061084 · Cited by 31

Interplay between microglia and environmental risk factors in Alzheimer's disease

Zhang, M., Liang, C., Chen, X., Cai, Y., & Cui, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389745 · Cited by 30

Relationship between cognitive function and weight-adjusted waist index in people ≥ 60 years old in NHANES 2011–2014

Wang, X., Feng, H., Xu, X.-Z., Liu, J., & Han, X. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02649-8 · Cited by 28

Experimental modeling of Alzheimer's disease: Translational lessons from cross‐taxon analyses

Yenkoyan, K. B., Kotova, M. M., Apukhtin, K. V., Galstyan, D. S., Amstislavskaya, T. G., Strekalova, T. V., de Abreu, M. S., Chavushyan, V. A., Lim, L. W., Yang, L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70273 · Cited by 30

Environmental stimulation in Huntington disease patients and animal models

Novati, A., Nguyen, H. P., & Schulze-Hentrich, J. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105725 · Cited by 29

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Kueck, P. J., Morris, J. K., & Stanford, J. A. (2024) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s388579 · Cited by 30

Dietary Intake, Mediterranean and Nordic Diet Adherence in Alzheimer’s Disease and Dementia: A Systematic Review

Christodoulou, C. C., Pitsillides, M., Hadjisavvas, A., & Zamba‐Papanicolaou, E. (2025) · Nutrients · doi:10.3390/nu17020336 · Cited by 30

Chronic Probing of Deep Brain Neuronal Activity Using Nanofibrous Smart Conducting Hydrogel‐Based Brain–Machine Interface Probes

Zargarian, S. S., Rinoldi, C., Ziai, Y., Zakrzewska, A., Fiorelli, R., Gazińska, M. A., Marinelli, M., Majkowska, M., Hottowy, P., Mindur, B. A., et al. (2025) · Small Science · doi:10.1002/smsc.202400463 · Cited by 26

Interplay of Vitamin D and SIRT1 in Tissue-Specific Metabolism—Potential Roles in Prevention and Treatment of Non-Communicable Diseases Including Cancer

Németh, Z., Patonai, A., Simon-Szabó, L., & Takács, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076154 · Cited by 25

Maintaining brain health across the lifespan

García‐García, I., Donica, O., Cohen, A. A., Gonseth, S., Heini, A. F., Nusslé, S. C., Pichard, C., Rietschel, E., Tanačković, G., Folli, S., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105365 · Cited by 28

Ultraprocessed Foods and Neuropsychiatric Outcomes: Putative Mechanisms

Mariane Lutz, R., Marcelo Arancibia, M., Morán, J., & Manterola, M. (2025) · Nutrients · doi:10.3390/nu17071215 · Cited by 33

Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein

Fekete, M., Jarecsny, T., Lehoczki, A., Major, D., Fazekas‐Pongor, V., Csípő, T., Lipécz, Á., Szappanos, Á., Pázmándi, E. M., Varga, P., et al. (2025) · Nutrients · doi:10.3390/nu17243929 · Cited by 28

Promotion of neuroinflammation by the glymphatic system: a new insight into ethanol extracts from Alisma orientale in alleviating obesity-associated cognitive impairment

Zhan, M., Liu, X., Xia, X., Yang, Y., Xie, Y., Zhang, L., Lin, C., Zhu, J., Ding, W., & Xu, S. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155147 · Cited by 24

Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease

Ahanger, I. A., & Dar, T. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102538 · Cited by 26

Protective ApoE variants support neuronal function by effluxing oxidized phospholipids

Ralhan, I., Do, A. D., Bae, J.-Y., Feringa, F. M., Cai, W., Chang, J., Chik, K., Lee, N. Y. J., Gerry, C. J., van der Kant, R., et al. (2026) · Neuron · doi:10.1016/j.neuron.2025.10.040 · Cited by 23

Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta

Peng, W., Yuan, Y., Lei, J., Zhao, Y., Li, Y., Qu, Q., & Wang, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04320-3 · Cited by 24

Human hunger as a memory process.

Stevenson, R. J., Yeomans, M. R., & Francis, H. (2023) · Psychological Review · doi:10.1037/rev0000413 · Cited by 23

Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms

Navalon-Monllor, V., Soriano-Romaní, L., Silva, M., Hazas, M. L. D. L., Hernando-Quintana, N., Suárez-Diéguez, T., Morell, P., & Nieto, J. A. (2023) · Food & Function · doi:10.1039/d3fo01257c · Cited by 25

Research Progress of Microbiota-Gut-Brain Axis in Parkinson's Disease

Zhang, W., Ye, Y., Song, J., Sang, T., Xia, T., Xie, L., Qiu, X., Zeng, Q., & Luo, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2206157 · Cited by 30

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Czarnik, W., Fularski, P., Gajewska, A., Jakubowska, P., Uszok, Z., Młynarska, E., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16020308 · Cited by 24

Overview of the Gut–Brain Axis: From Gut to Brain and Back Again

Post, Z., Manfready, R. A., & Keshavarzian, A. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771464 · Cited by 25

The Importance of Gut Microbiota on Choline Metabolism in Neurodegenerative Diseases

Eslami, M., Alibabaei, F., Babaeizad, A., Banihashemian, S. Z., Mazandarani, M., Hoseini, A., Ramezankhah, M., Oksenych, V., & Yousefi, B. (2024) · Biomolecules · doi:10.3390/biom14111345 · Cited by 23

Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets

Chen, L., Wang, B., Liu, J., Wu, X., Xu, X., Cao, H., Ji, X., Zhang, P., Li, X., Hou, Z., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.974694 · Cited by 22

Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Liu, Q., Li, Z., Huang, L., Zhou, D., Fu, J., Duan, H., Wang, Z., Yang, T., Zhao, J., Li, W., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-022-00326-4 · Cited by 23

bsh 1 Gene of Lactobacillus plantarum AR113 Plays an Important Role in Ameliorating Western Diet-Aggravated Colitis

Shao, J., Mu, Z., Xia, Y., Xiong, Z., Song, X., Yang, Y., Zhang, H., Ai, L., & Wang, G. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08631 · Cited by 22

Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome

Wang, W., Li, J., Cui, S., Li, J., Ye, X., Wang, Z., Zhang, T., Jiang, X. J., Kong, Y., Chen, X., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj7813 · Cited by 22

RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation

Ye, D., Miyoshi, A., Ushitani, T., Kadoya, M., Igeta, M., Konishi, K., Shoji, T., Yasuda, K., Kitaoka, S., Yagi, H., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.12.022 · Cited by 21

Melatonin as Immune Potentiator for Enhancing Subunit Vaccine Efficacy against Bovine Viral Diarrhea Virus

Wang, Y., Yang, G., Zhang, L., Wang, J., & Wang, J. (2021) · Vaccines · doi:10.3390/vaccines9091039 · Cited by 21

Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer’s Disease

Momen, Y. S., Mishra, J., & Kumar, N. (2024) · Nutrients · doi:10.3390/nu16152558 · Cited by 26

Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease

Więckowska‐Gacek, A., Mietelska‐Porowska, A., Chutorański, D., Wydrych, M., Długosz, J., & Wojda, U. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654509 · Cited by 70

Greater sensitivity of the hippocampus than the entorhinal cortex in response to western diet, manifested by accelerated neuroinflammation and neurodegeneration in the progression of Alzheimer’s disease

Więckowska‐Gacek, A., Mietelska‐Porowska, A., Domańska, J. M., & Wojda, U. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.077040

Wpływ diety zachodniej na rozwój stanu zapalnego i patologicznych zmian w mózgu w mysim modelu choroby Alzheimera : praca doktorska

Więckowska-Gacek, A., & Więckowska-Gacek, A. (2023) · RCIN (Digital Repository of the Scientifics Institutes) (Institute of Archaeology and Ethnology of the Polish Academy of Sciences)

Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis

Poxleitner, M., Hoffmann, S. H. L., Berezhnoy, G., Ionescu, T. M., González-Menéndez, I., Maier, F. C., Seyfried, D., Ehrlichmann, W., Quintanilla‐Martínez, L., Schmid, A. M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03080-0 · Cited by 22

Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia

Hsu, T. M., & Kanoski, S. E. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00088 · Cited by 160