Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Dementia prevention, intervention, and care

Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072

Mechanisms of NAFLD development and therapeutic strategies

Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

2013 Alzheimer's disease facts and figures

Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,372

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

Breijyeh, Z., & Karaman, R. (2020) · Molecules · doi:10.3390/molecules25245789 · Cited by 2,789

Dynamics and functions of lipid droplets

Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740

Inflammation, metaflammation and immunometabolic disorders

Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570

2022 Alzheimer's disease facts and figures

Anonymous (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12638 · Cited by 2,469

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312 · cited 4×

Diet–microbiota interactions as moderators of human metabolism

Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257

Gut microbiome alterations in Alzheimer’s disease

Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137

The glymphatic system: a beginner's guide

Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075

Microglial M1/M2 polarization and metabolic states

Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070

Adipose tissue inflammation and metabolic dysfunction in obesity

Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947

Microglia emerge as central players in brain disease

Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767

Regulation of inflammation by short chain fatty acids

Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724

The glymphatic pathway in neurological disorders.

Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30318-1 · Cited by 1,560

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Marschallinger, J., Iram, T., Zardeneta, M., Lee, S. E., Lehallier, B., Haney, M. S., Pluvinage, J. V., Mathur, V., Hahn, O., Morgens, D. W., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0566-1 · Cited by 1,384

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., Witkowski, J. M., & Franceschi, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01960 · Cited by 1,364

Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease

Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291

Prevalence of the metabolic syndrome in the United States, 2003-2012

Aguilar, M., Bhuket, T., Torres, S., Liu, B., & Wong, R. J. (2015) · JAMA · doi:10.1001/jama.2015.4260 · Cited by 1,267

Synergy between amyloid-β and tau in Alzheimer’s disease

Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206

Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173

The blood-brain barrier in systemic inflammation

Varatharaj, A., & Galea, I. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.03.010 · Cited by 1,172

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

Iliff, J. J., Chen, M. J., Plog, B. A., Zeppenfeld, D. M., Soltero, M., Yang, L., Singh, I., Deane, R., & Nedergaard, M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3020-14.2014 · Cited by 1,159

Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines

Makki, K., Froguel, P., & Wolowczuk, I. (2013) · ISRN Inflammation · doi:10.1155/2013/139239 · Cited by 1,085

Microglial signatures and their role in health and disease

Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046 · cited 2×

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001

Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β

Dupont, N., Jiang, S., Pilli, M., Ornatowski, W., Bhattacharya, D., & Deretic, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.398 · Cited by 967

Western Diet and the Immune System: An Inflammatory Connection

Christ, A., Lauterbach, M., & Latz, E. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.020 · Cited by 907

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885

2018 Global Nutrition Report: Shining a light to spur action on nutrition

Fanzo, J., Hawkes, C., Udomkesmalee, E., Afshin, A., Allemandi, L., Assery, O. N., Baker, P., Battersby, J., Bhutta, Z. A., Chen, K. M., et al. (2018) · Middlesex University Research Repository (Middlesex University Of London) · Cited by 880

Functional morphology of the blood–brain barrier in health and disease

Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872

Differential roles of microglia and monocytes in the inflamed central nervous system

Yamasaki, R., Lu, H., Butovsky, O., Ohno, N., Rietsch, A. M., Cialic, R., Wu, P. M., Doykan, C. E., Lin, J., Cotleur, A. C., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132477 · Cited by 856

The Gut Microbiota and Alzheimer’s Disease

Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

Kellar, D., & Craft, S. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30231-3 · Cited by 832

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826

The blood–brain barrier in health and disease: Important unanswered questions

Profaci, C. P., Munji, R. N., Pulido, R. S., & Daneman, R. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190062 · Cited by 811

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723

Vascular dysfunction—The disregarded partner of Alzheimer's disease

Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.222 · Cited by 711

Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity

Kanoski, S. E., & Davidson, T. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 710

Cholesterol metabolism and homeostasis in the brain

Zhang, J., & Liu, Q. (2015) · Protein & Cell · doi:10.1007/s13238-014-0131-3 · Cited by 686

The gut microbiome and metabolic syndrome

Dabke, K., Hendrick, G., & Devkota, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129194 · Cited by 684

Risk factors for Alzheimer’s disease

Armstrong, R. A. (2019) · Folia Neuropathologica · doi:10.5114/fn.2019.85929 · Cited by 679

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

Zeppenfeld, D. M., Simon, M., Haswell, J. D., D’Abreo, D., Murchison, C., Quinn, J. F., Grafe, M. R., Woltjer, R. L., Kaye, J., & Iliff, J. J. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.4370 · Cited by 651

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

the Dominantly Inherited Alzheimer Network, Barthélemy, N. R., Li, Y., Joseph-Mathurin, N., Gordon, B. A., Hassenstab, J., Benzinger, T. L. S., Buckles, V., Fagan, A. M., Perrin, R. J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0781-z · Cited by 651

Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

Ho, L., Qin, W., Pompl, P. N., Xiang, Z., Wang, J., Zhao, Z., Peng, Y., Cambareri, G. M., Rocher, A. B., Mobbs, C. V., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0978fje · Cited by 640

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

Baker, L. D., Cross, D. J., Minoshima, S., Belongia, D., Watson, G. S., & Craft, S. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.225 · Cited by 639

Lipopolysaccharide-induced blood-brain barrier disruption: Roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

Banks, W. A., Gray, A. M., Erickson, M. A., Salameh, T. S., Damodarasamy, M., Sheibani, N., Meabon, J. S., Wing, E. E., Morofuji, Y., Cook, D. G., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0434-1 · Cited by 636

Cognitive impairment following high fat diet consumption is associated with brain inflammation

Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 623

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Lian, H., Litvinchuk, A., Chiang, A. C.-A., Aithmitti, N., Jankowsky, J. L., & Zheng, H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2117-15.2016 · Cited by 597

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

Peng, W., Achariyar, T. M., Li, B., Liao, Y., Mestre, H., Hitomi, E., Regan, S., Kasper, T., Peng, S., Ding, F., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.015 · Cited by 580

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance

Lee, Y. S., Li, P., Huh, J. Y., Hwang, I. J., Lu, M., Kim, J. I., Ham, M., Talukdar, S., Chen, A., Lu, W. J., et al. (2011) · Diabetes · doi:10.2337/db11-0194 · Cited by 566

Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity

Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.016 · Cited by 559

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

Korbecki, J., & Bajdak-Rusinek, K. (2019) · Inflammation Research · doi:10.1007/s00011-019-01273-5 · Cited by 558

On the path to 2025: understanding the Alzheimer’s disease continuum

Aisen, P. S., Cummings, J., Jack, C. R., Morris, J. C., Sperling, R., Frölich, L., Jones, R. W., Dowsett, S. A., Matthews, B. R., Raskin, J., et al. (2017) · Alzheimer's Research & Therapy · doi:10.1186/s13195-017-0283-5 · Cited by 556

Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies

McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 552

Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation

Martinez-Medina, M., Denizot, J., Dreux, N., Robin, F., Billard, E., Bonnet, R., Darfeuille-Michaud, A., & Barnich, N. (2014) · Gut · doi:10.1136/gutjnl-2012-304119 · Cited by 539

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

Zusso, M., Lunardi, V., Franceschini, D., Pagetta, A., Lo, R., Stifani, S., Frigo, A. C., Giusti, P., & Moro, S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1538-9 · Cited by 538

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

Schwartzentruber, J., Cooper, S., Liu, J. Z., Barrio-Hernandez, I., Bello, E., Kumasaka, N., Young, A. M. H., Franklin, R. J. M., Johnson, T., Estrada, K., et al. (2021) · Nature Genetics · doi:10.1038/s41588-020-00776-w · Cited by 532

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 530

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 524

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

Kaur, D., Sharma, V., & Deshmukh, R. R. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00580-x · Cited by 503

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Saint-Pol, J., Gosselet, F., Duban-Deweer, S., Pottiez, G., & Karamanos, Y. (2020) · Cells · doi:10.3390/cells9040851 · Cited by 503

Saturated fatty acids trigger TLR4-mediated inflammatory response

Rocha, D. M., Caldas, A. P., Oliveira, L. L., Bressan, J., & Hermsdorff, H. H. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.11.015 · Cited by 492

The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies

Pedditizi, E., Peters, R. K., & Beckett, N. S. (2016) · Age and Ageing · doi:10.1093/ageing/afv151 · Cited by 476

The relationship between obesity and cognitive health and decline

Dye, L., Boyle, N. B., Champ, C., & Lawton, C. (2017) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117002014 · Cited by 469

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461

The endotoxin hypothesis of neurodegeneration

Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

Yamazaki, Y., & Kanekiyo, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091965 · Cited by 451

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

Huh, J. Y., Park, Y. J., Ham, M., & Kim, J. B. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0074 · Cited by 440

Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders

MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 438

Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

Reeves, B. C., Karimy, J. K., Kundishora, A. J., Mestre, H., Cerci, H. M., Matouk, C., Alper, S. L., Lundgaard, I., Nedergaard, M., & Kahle, K. T. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.11.008 · Cited by 412

Role of cholesterol and sphingolipids in brain development and neurological diseases

Hussain, G., Wang, J., Rasul, A., Anwar, H., Imran, A., Qasim, M., Zafar, S., Kamran, S., Razzaq, A., Aziz, N., et al. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0965-z · Cited by 402

The role of microbial amyloid in neurodegeneration

Friedland, R. P., & Chapman, M. R. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006654 · Cited by 398

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

Sehgal, N., Gupta, A., Valli, R. K., Joshi, S. D., Mills, J. T., Hamel, E., Khanna, P., Jain, S. C., Thakur, S. S., & Ravindranath, V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112209109 · Cited by 390

Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier

Dyken, P. C. V., & Lacoste, B. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00930 · Cited by 377

Role of Blood-Brain Barrier in Alzheimer’s Disease

Cai, Z., Qiao, P.-F., Wan, C.-Q., Cai, M., Zhou, N.-K., & Li, Q. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180098 · Cited by 370

The longer-term impacts of Western diet on human cognition and the brain

Francis, H., & Stevenson, R. J. (2013) · Appetite · doi:10.1016/j.appet.2012.12.018 · Cited by 368

The integration of inflammaging in age-related diseases

Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 368

Saturated long‐chain fatty acids activate inflammatory signaling in astrocytes

Gupta, S., Knight, A. G., Gupta, S., Keller, J. N., & Bruce‐Keller, A. J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07660.x · Cited by 353

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347

High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

Thirumangalakudi, L., Prakasam, A., Zhang, R., Bimonte‐Nelson, H., Sambamurti, K., Kindy, M. S., & Bhat, N. R. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05415.x · Cited by 331

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Kim, D.-G., Krenz, A., Toussaint, L. E., Maurer, K. J., Robinson, S.-A., Yan, A., Torres, L., & Bynoe, M. S. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0467-5 · Cited by 330

Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A., & Johnson, R. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01832 · Cited by 330

The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential

Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_17 · Cited by 329

The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat

Kanoski, S. E., Zhang, Y., Zheng, W., & Davidson, T. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091414 · Cited by 324

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030598 · Cited by 323

Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells

Wenzel, T. J., Gates, E. J., Ranger, A. L., & Klegeris, A. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103493 · Cited by 320

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

Wu, X., Chen, P. S., Dallas, S., Wilson, B. C., Block, M. L., Wang, C.-C., Kinyamu, H. K., Lu, N. Z., Gao, X., Leng, Y., et al. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009024 · Cited by 318

Aging and Alzheimer's disease pathology

Sengoku, R. (2019) · Neuropathology · doi:10.1111/neup.12626 · Cited by 316

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

Lauro, C., & Limatola, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00493 · Cited by 315

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

Andrews, S. J., Fulton-Howard, B., & Goate, A. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30435-1 · Cited by 314

High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production

Miranda, P. M., Palma, G. D., Serkis, V., Lu, J., Louis-Auguste, M., McCarville, J. L., Verdu, E. F., Collins, S. M., & Berčík, P. (2018) · Microbiome · doi:10.1186/s40168-018-0433-4 · Cited by 302

Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease

Mader, S., & Brimberg, L. (2019) · Cells · doi:10.3390/cells8020090 · Cited by 302

Western diet is associated with a smaller hippocampus: a longitudinal investigation

Jacka, F. N., Cherbuin, N., Anstey, K. J., Sachdev, P. S., & Butterworth, P. (2015) · BMC Medicine · doi:10.1186/s12916-015-0461-x · Cited by 292

Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes

Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 292

A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans

Lê, K., Faeh, D., Stettler, R., Ith, M., Kreis, R., Vermathen, P., Boesch, C., Ravussin, É., & Tappy, L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1374 · Cited by 289

Human gut microbiota: the links with dementia development

Alkasir, R., Li, J., Li, X., Jin, M., & Zhu, B. (2016) · Protein & Cell · doi:10.1007/s13238-016-0338-6 · Cited by 289

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Émond, V., Julien, P., & Calon, F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.022 · Cited by 288

Lipopolysaccharide‐induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

Nair, S., Sobotka, K. S., Joshi, P., Gressèns, P., Fleiss, B., Thornton, C., Mallard, C. E., & Hagberg, H. (2019) · Glia · doi:10.1002/glia.23587 · Cited by 285

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

Kanekiyo, T., & Bu, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00093 · Cited by 281

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

Finucane, O. M., Lyons, C. L., Murphy, A. M., Reynolds, C. M., Klinger, R. W., Healy, N. P., Cooke, A. A., Coll, R. C., McAllan, L., Nilaweera, K. N., et al. (2015) · Diabetes · doi:10.2337/db14-1098 · Cited by 281

Gut microbiota and gastrointestinal health: current concepts and future directions

Aziz, Q., Doré, J., Emmanuel, A., Guarner, F., & Quigley, E. M. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12046 · Cited by 280

Corrigenda

Pedditzi, E., Peters, R. K., & Beckett, N. S. (2016) · Age and Ageing · doi:10.1093/ageing/afw095 · Cited by 279

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

Ward, R., Li, W., Abdul, Y., Jackson, L., Dong, G., Jamil, S., Filosa, J. A., Fagan, S. C., & Ergul, A. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.035 · Cited by 276

Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation

Testa, G., Staurenghi, E., Zerbinati, C., Gargiulo, S., Iuliano, L., Giaccone, G., Fantò, F., Poli, G., Leonarduzzi, G., & Gamba, P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.09.001 · Cited by 270

mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP

Hu, Y., Mai, W., Chen, L., Cao, K., Zhang, B., Zhang, Z., Liu, Y., Lou, H., Duan, S., & Gao, Z. (2019) · Glia · doi:10.1002/glia.23760 · Cited by 258

Early diagnosis of Alzheimer’s disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts

Rossini, P. M., Iorio, R. D., Vecchio, F., Anfossi, M., Babiloni, C., Bozzali, M., Bruni, A. C., Cappa, S. F., Escudero, J., Fraga, F. J., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.03.003 · Cited by 257

Alzheimer's disease and the microbiome

Bhattacharjee, S., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00153 · Cited by 253

Adipose tissue inflammation in obesity: A metabolic or immune response?

Stolarczyk, E. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.08.006 · Cited by 247

Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease

Vandal, M., White, P. J., Tremblay, C., St‐Amour, I., Chevrier, G., Émond, V., Lefrançois, D., Virgili, J., Planel, E., Giguère, Y., et al. (2014) · Diabetes · doi:10.2337/db14-0375 · Cited by 243

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

Wang, Z., Liu, D., Wang, F., Liu, S., Zhao, S., Ling, E.-A., & Hao, A. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511002868 · Cited by 239

Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease

Giau, V. V., Wu, S., Jamerlan, A., An, S. S. A., Kim, S., & Hulme, J. (2018) · Nutrients · doi:10.3390/nu10111765 · Cited by 239

Endothelial Cell Calcium Signaling during Barrier Function and Inflammation

Dalal, P., Müller, W. A., & Sullivan, D. P. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.11.004 · Cited by 239

Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease

Yang, J., Lunde, L. K., Nuntagij, P., Oguchi, T., Camassa, L. M. A., Nilsson, L. N. G., Lannfelt, L., Xu, Y., Amiry-Moghaddam, M. R., Ottersen, O. P., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110725 · Cited by 237

Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

Takeda, S., Sato, N., & Morishita, R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00171 · Cited by 236

Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats

Beilharz, J. E., Maniam, J., & Morris, M. J. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.11.016 · Cited by 234

High-fat diet-induced memory impairment in triple-transgenic Alzheimer’s disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.

Knight, E. M., Martins, I. V. A., Gümüsgöz, S., Allan, S. M., & Lawrence, C. B. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.010 · Cited by 232 · cited 3×

Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate

Liu, J., Sun, J., Wang, F., Yu, X., Ling, Z., Li, H., Zhang, H., Jin, J., Chen, W., Pang, M., et al. (2015) · BioMed Research International · doi:10.1155/2015/412946 · Cited by 225

Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

Zhao, N., Ren, Y., Yamazaki, Y., Qiao, W., Li, F., Felton, L. M., Mahmoudiandehkordi, S., Kueider-Paisley, A., Sonoustoun, B., Arnold, M., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.034 · Cited by 225

Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects

Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6435861 · Cited by 221

Diet, inflammation and the gut microbiome: mechanisms for obesity-associated cognitive impairment

Leigh, S.-J., & Morris, M. J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165767 · Cited by 221

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

Loera-Valencia, R., Goikolea, J., Parrado-Fernandez, C., Merino-Serrais, P., & Maioli, S. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.003 · Cited by 214

Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model

Jim, K. K., Engelen-Lee, J.-Y., van der Sar, A. M., Bitter, W., Brouwer, M. C., ENDE, A. V. D., Veening, J., van de Beek, D., & Vandenbroucke‐Grauls, C. M. J. E. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0655-y · Cited by 211

Saturated Fatty Acids in Obesity-Associated Inflammation

Zhou, H., Urso, C. J., & Jadeja, V. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s229691 · Cited by 211

The role of gut microbiota in pathogenesis of Alzheimer's disease

Bostancıklıoğlu, M. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14264 · Cited by 210

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

Rojas-Gutierrez, E., Muñoz‐Arenas, G., Treviño, S., Espinosa, B., Chávez, R., Rojas, K., Flores, G., Díaz, A., & Guevara, J. (2017) · Synapse · doi:10.1002/syn.21990 · Cited by 205

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

Shen, H., Guan, Q., Zhang, X., Yuan, C., Tan, Z., Zhai, L., Hao, Y., Gu, Y., & Han, C. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109884 · Cited by 204

Gut microbiome and metabolic syndrome

Mazidi, M., Rezaie, P., Kengne, A. P., Ghayour‐Mobarhan, M., & Ferns, G. A. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.024 · Cited by 199

Intersection of pathological tau and microglia at the synapse

Vogels, T., Murgoci, A.-N., & Hromádka, T. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0754-y · Cited by 197

Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives

Cheng, Y., Tian, D., & Wang, Y.-J. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00195-1 · Cited by 197

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

Chan, K. L., Pillon, N. J., Sivaloganathan, D. M., Costford, S. R., Liu, Z., Théret, M., Chazaud, B., & Klip, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646992 · Cited by 196

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

Wu, A., Zhou, X., Qiao, G., Yu, L., Tang, Y., Yan, L., Qiu, W., Pan, R., Yu, C., Law, B. Y. K., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101202 · Cited by 196

Communicating systems in the body: how microbiota and microglia cooperate

Erny, D., de Angelis, A. L. H., & Prinz, M. (2016) · Immunology · doi:10.1111/imm.12645 · Cited by 195

Luteolin Protects against High Fat Diet-Induced Cognitive Deficits in Obesity Mice

Liu, Y., Fu, X., Lan, N., Li, S., Zhang, J., Wang, S., Li, C., Shang, Y., Huang, T., & Zhang, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.040 · Cited by 194

The Role of Bifidobacteria in Gut Barrier Function After Thermal Injury in Rats

Wang, Z., Xiao, G., Yao, Y.-M., Guo, S., Lu, K., & Sheng, Z. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000196574.70614.27 · Cited by 193

Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

Francis, H., & Stevenson, R. J. (2011) · Behavioral Neuroscience · doi:10.1037/a0025998 · Cited by 190

Working memory and reward association learning impairments in obesity

Coppin, G., Nolan-Poupart, S., Jones‐Gotman, M., & Small, D. M. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.10.004 · Cited by 190

Arterial Stiffness and β-Amyloid Progression in Nondemented Elderly Adults

Hughes, T. M., Kuller, L. H., Barinas‐Mitchell, E., McDade, E., Klunk, W. E., Cohen, A. D., Mathis, C. A., DeKosky, S. T., Price, J. C., & López, O. L. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.186 · Cited by 189

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

Chornenkyy, Y., Wang, W., Wei, A. L., & Nelson, P. T. (2018) · Brain Pathology · doi:10.1111/bpa.12655 · Cited by 189

Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

Ye, X., Zhu, M., Che, X., Wang, H., Liang, X., Wu, C., Xue, X., & Yang, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1644-8 · Cited by 189

Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages

Schilling, J. D., Machkovech, H. M., Li, H., Sidhu, R., Fujiwara, H., Weber, K., Ory, D. S., & Schaffer, J. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.419978 · Cited by 186

High-fat diet feeding differentially affects the development of inflammation in the central nervous system

Guillemot‐Legris, O., Masquelier, J., Everard, A., Cani, P. D., Alhouayek, M., & Muccioli, G. G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0666-8 · Cited by 179

Differential Kv1.3, KCa3.1, and Kir2.1 expression in “classically” and “alternatively” activated microglia

Nguyen, H. M., Grössinger, E. M., Horiuchi, M., Davis, K. W., Jin, L., Maezawa, I., & Wulff, H. (2017) · Glia · doi:10.1002/glia.23078 · Cited by 178

Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits

Ullrich, C., Pirchl, M., & Humpel, C. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.001 · Cited by 175

Lipid rafts and neurodegeneration: structural and functional roles in physiologic aging and neurodegenerative diseases

Grassi, S., Giussani, P., Mauri, L., Prioni, S., Sonnino, S., & Prinetti, A. (2019) · Journal of Lipid Research · doi:10.1194/jlr.tr119000427 · Cited by 174

Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation

Beilharz, J. E., Maniam, J., & Morris, M. J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.018 · Cited by 169

Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

Kang, S. S., Kurti, A., Fair, D. A., & Fryer, J. D. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0156-9 · Cited by 167

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

Walsh, D. M., & Selkoe, D. J. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.02.003 · Cited by 164

Palmitate-Induced Apoptosis in Cultured Bovine Retinal Pericytes

Cacicedo, J. M., Benjachareowong, S., Chou, E. L., Ruderman, N. B., & Ido, Y. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1838 · Cited by 163

Imbalanced cholesterol metabolism in Alzheimer's disease

Xue-shan, Z., Peng, J., Wu, Q., Zhong, R., Li-hong, P., Tang, Z., Jiang, Z., Wang, G., & Liu, L. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.024 · Cited by 161

High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism

Sobesky, J. L., Barrientos, R. M., May, H. S. D., Thompson, B. M., Weber, M. D., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.017 · Cited by 160

Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia

Hsu, T. M., & Kanoski, S. E. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00088 · Cited by 160

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

Calvo‐Ochoa, E., Hernández‐Ortega, K., Ferrera, P., Morimoto, S., & Arias, C. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.48 · Cited by 158

Distinct inflammatory phenotypes of microglia and monocyte‐derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology

Martin, E., Boucher, C., Fontaine, B., & Delarasse, C. (2017) · Aging Cell · doi:10.1111/acel.12522 · Cited by 156

A four-day Western-style dietary intervention causes reductions in hippocampal-dependent learning and memory and interoceptive sensitivity

Attuquayefio, T., Stevenson, R. J., Oaten, M., & Francis, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172645 · Cited by 155

Ultraprocessed Food: Addictive, Toxic, and Ready for Regulation

Lustig, R. H. (2020) · Nutrients · doi:10.3390/nu12113401 · Cited by 154

Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota

Qian, X.-H., Song, X.-X., Liu, X.-L., Chen, S.-D., & Tang, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101317 · Cited by 153

Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity

Puig, K. L., Floden, A. M., Adhikari, R., Golovko, M. Y., & Combs, C. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030378 · Cited by 152

Dystrophic microglia in late‐onset Alzheimer's disease

Streit, W. J., Khoshbouei, H., & Bechmann, I. (2020) · Glia · doi:10.1002/glia.23782 · Cited by 152

Body Mass Index, Weight Change, and Clinical Progression in Mild Cognitive Impairment and Alzheimer Disease

Besser, L. M., Gill, D. P., Monsell, S. E., Brenowitz, W. D., Meranus, D. H., Kukull, W. A., & Gustafson, D. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000005 · Cited by 150

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance

Feng, W., Zhang, Y., Wang, Z., Xu, H., Wu, T., Marshall, C., Gao, J., & Xiao, M. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00688-1 · Cited by 150

Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease

Hoshi, A., Yamamoto, T., Shimizu, K., Ugawa, Y., Nishizawa, M., Takahashi, H., & Kakita, A. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182632566 · Cited by 146

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

de J.R. De-Paula, V., Forlenza, A. S., & Forlenza, O. V. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.07.007 · Cited by 145

APOE alleles and diet in brain aging and Alzheimer's disease

Yassine, H. N., & Finch, C. E. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00150 · Cited by 145

Liver Dysfunction as a Novel Player in Alzheimer’s Progression: Looking Outside the Brain

Estrada, L. D., Ahumada, P., Cabrera, D., & Arab, J. P. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00174 · Cited by 144

The role of aquaporin-4 in synaptic plasticity, memory and disease

Hubbard, J. A., Szu, J. I., & Binder, D. K. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.02.011 · Cited by 141

Age- and location-related changes in microglial function

Ritzel, R. M., Patel, A. R., Pan, S., Crapser, J., Hammond, M., Jellison, E., & McCullough, L. D. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.016 · Cited by 134

Aquaporin Expression in the Brains of Patients With or Without Cerebral Amyloid Angiopathy

Moftakhar, P., Lynch, M. D., Pomakian, J., & Vinters, H. V. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181fd252c · Cited by 134

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity

Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134

The effect of high fat, high sugar, and combined high fat-high sugar diets on spatial learning and memory in rodents: A meta-analysis

Abbott, K. N., Arnott, C. K., Westbrook, R. F., & Tran, D. M. D. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.010 · Cited by 132

Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease

Luo, Y., & Lin, H. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.391 · Cited by 132

Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes

Chen, X., & Devaraj, S. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1104-3 · Cited by 132

Dietary lipids are differentially associated with hippocampal-dependent relational memory in prepubescent children

Baym, C. L., Khan, N. A., Monti, J. M., Raine, L. B., Drollette, E. S., Moore, R. D., Scudder, M. R., Kramer, A. F., Hillman, C. H., & Cohen, N. J. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.079624 · Cited by 130

Is obesity a brain disease?

Shefer, G., Marcus, Y., & Stern, N. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.015 · Cited by 128

Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid

Yanguas‐Casás, N., Crespo‐Castrillo, A., CEBALLOS, M. L. D., Chowen, J. A., Azcoitia, Í., Arévalo, M., & García‐Segura, L. M. (2017) · Glia · doi:10.1002/glia.23263 · Cited by 126

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis

Abdul, Y., Li, W., Ward, R., Abdelsaid, M. A., Hafez, S. S., Dong, G., Jamil, S., Wolf, V., Johnson, M. H., Fagan, S. C., et al. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00844-7 · Cited by 126

Sodium Butyrate Prevents Memory Impairment by Re-Establishing BDNF and GDNF Expression in Experimental Pneumococcal Meningitis

Barichello, T., Generoso, J. S., Simões, L. R., Faller, C. J., Ceretta, R. A., Petronilho, F., Lopes-Borges, J., Valvassori, S. S., & Quevedo, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8914-3 · Cited by 125

Is Alzheimer’s Disease a Liver Disease of the Brain?

Bassendine, M. F., Taylor-Robinson, S. D., Fertleman, M., Khan, M., & Neely, D. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-190848 · Cited by 124

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

Lizarbe, B., Soares, A. F., Larsson, S., & Duarte, J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00985 · Cited by 123

Diabetes and Hypercholesterolemia Increase Blood-Brain Barrier Permeability and Brain Amyloid Deposition: Beneficial Effects of the LpPLA2 Inhibitor Darapladib

Acharya, N. K., Levin, E. C., Clifford, P. M., Han, M., Tourtellotte, R., Chamberlain, D., Pollaro, M., Coretti, N. J., Kosciuk, M. C., Nagele, E. P., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-122254 · Cited by 121

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01869-3 · Cited by 121

Greater Fructose Consumption Is Associated with Cardiometabolic Risk Markers and Visceral Adiposity in Adolescents3

Pollock, N. K., Bundy, V. L., Kanto, W. P., Davis, C. L., Bernard, P. J., Zhu, H., Gutin, B., & Dong, Y. (2011) · Journal of Nutrition · doi:10.3945/jn.111.150219 · Cited by 119

Associations Between Hepatic Functions and Plasma Amyloid-Beta Levels—Implications for the Capacity of Liver in Peripheral Amyloid-Beta Clearance

Wang, Y., Wang, Q., Zhang, T., Liu, Y.-H., Yao, X., Zeng, F., Li, J., Zhou, F.-Y., Wang, L., Yan, J.-C., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9826-1 · Cited by 119

The blood brain barrier in Alzheimer’s disease

Chakraborty, A., de Wit, N. M., van der Flier, W. M., & de Vries, H. E. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2016.11.008 · Cited by 118

Plaque-associated lipids in Alzheimer’s diseased brain tissue visualized by nonlinear microscopy

Kiškis, J., Fink, H., Nyberg, L. K., Thyr, J., Li, J., & Enejder, A. M. K. (2015) · Scientific Reports · doi:10.1038/srep13489 · Cited by 117

Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease

Barron, A. M., Rosario, E. R., Elteriefi, R., & Pike, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078554 · Cited by 117

Adverse Associations between Visceral Adiposity, Brain Structure, and Cognitive Performance in Healthy Elderly

Isaac, V., Sim, S. K. Y., Zheng, H., Zagorodnov, V., Tai, E. S., & Chee, M. W. L. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00012 · Cited by 115

The hippocampus and the regulation of human food intake.

Stevenson, R. J., & Francis, H. (2017) · Psychological Bulletin · doi:10.1037/bul0000109 · Cited by 114

Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer’s disease risk

Baranowski, B. J., Marko, D. M., Fenech, R. K., Yang, A. J. T., & MacPherson, R. E. K. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0910 · Cited by 114

Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

Graham, L. C., Harder, J. M., Soto, I., de Vries, W. N., John, S. W. M., & Howell, G. R. (2016) · Scientific Reports · doi:10.1038/srep21568 · Cited by 113

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia

Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433

Pathogenesis of Alzheimer’s Disease

Rostagno, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010107 · Cited by 391

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217

Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease

Więckowska‐Gacek, A., Mietelska‐Porowska, A., Chutorański, D., Wydrych, M., Długosz, J., & Wojda, U. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654509 · Cited by 70

Greater sensitivity of the hippocampus than the entorhinal cortex in response to western diet, manifested by accelerated neuroinflammation and neurodegeneration in the progression of Alzheimer’s disease

Więckowska‐Gacek, A., Mietelska‐Porowska, A., Domańska, J. M., & Wojda, U. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.077040

Wpływ diety zachodniej na rozwój stanu zapalnego i patologicznych zmian w mózgu w mysim modelu choroby Alzheimera : praca doktorska

Więckowska-Gacek, A., & Więckowska-Gacek, A. (2023) · RCIN (Digital Repository of the Scientifics Institutes) (Institute of Archaeology and Ethnology of the Polish Academy of Sciences)

Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis

Poxleitner, M., Hoffmann, S. H. L., Berezhnoy, G., Ionescu, T. M., González-Menéndez, I., Maier, F. C., Seyfried, D., Ehrlichmann, W., Quintanilla‐Martínez, L., Schmid, A. M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03080-0 · Cited by 22

Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia

Hsu, T. M., & Kanoski, S. E. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00088 · Cited by 160