Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

Španić, E., Horvat, L. L., Hof, P. R., & Šimić, G. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00271 · Cited by 112

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

Mietelska‐Porowska, A., & Wojda, U. (2017) · Journal of Immunology Research · doi:10.1155/2017/4626540 · Cited by 111

Intermittent Fasting Protects against Alzheimer’s Disease Possible through Restoring Aquaporin-4 Polarity

Zhang, J., Zhan, Z., Li, X., Xing, A., Jiang, C., Chen, Y., Shi, W., & An, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00395 · Cited by 111

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

Mast, N., Saadane, A., Valencia‐Olvera, A. C., Constans, J., Maxfield, E., Arakawa, H., Li, Y., Landreth, G. E., & Pikuleva, I. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.026 · Cited by 111

Toll-Like Receptor 4 Knockout Mice Are Protected against Endoplasmic Reticulum Stress Induced by a High-Fat Diet

Pierre, N., Deldicque, L., Barbé, C., Naslain, D., Cani, P. D., & Francaux, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065061 · Cited by 109

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling

Reichardt, F., Chassaing, B., Nezami, B. G., Li, G., Tabatabavakili, S., Mwangi, S. M., Uppal, K., Liang, B., Vijay–Kumar, M., Jones, D. P., et al. (2016) · The Journal of Physiology · doi:10.1113/jp273269 · Cited by 109

High Glucose Induces Mitochondrial Morphology and Metabolic Changes in Retinal Pericytes

Trudeau, K. M., Molina, A. J. A., & Roy, S. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7934 · Cited by 105

Western diets induce blood-brain barrier leakage and alter spatial strategies in rats.

Hargrave, S. L., Davidson, T. L., Zheng, W., & Kinzig, K. P. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000110 · Cited by 103

The Blood–Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders

Costea, L., Mészáros, Á., Bauer, H., Bauer, H., Traweger, A., Wilhelm, I., Farkas, A. E., & Krizbai, I. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215472 · Cited by 102

Impact of Dietary Lipids on Colonic Function and Microbiota: An Experimental Approach Involving Orlistat-Induced Fat Malabsorption in Human Volunteers

Morales, P., Fujio, S., Navarrete, P., Ugalde, J. A., Magne, F., Carrasco‐Pozo, C., Tralma, K., Quezada, M. P., Hurtado, C., Covarrubías, N., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.20 · Cited by 98

Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes

Liu, S., Liu, J., Weng, R., Gu, X., & Zhong, Z. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1194-0 · Cited by 98

Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption

Gianfrancesco, M. A., Dehairs, J., L’homme, L., Herinckx, G., Esser, N., Jansen, O., Habraken, Y., Lassence, C., Swinnen, J. V., Rider, M. H., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.04.001 · Cited by 97

Increased Food Intake Leads to Obesity and Insulin Resistance in the Tg2576 Alzheimer’s Disease Mouse Model

Kohjima, M., Sun, Y., & Chan, L. (2010) · Endocrinology · doi:10.1210/en.2009-1196 · Cited by 96

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

Nam, K. N., Mounier, A., Wolfe, C. M., Fitz, N. F., Carter, A. Y., Castranio, E. L., Kamboh, H., Reeves, V. L., Wang, J., Han, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04412-2 · Cited by 96

Human Gut Microbiota in Health and Alzheimer’s Disease

Szablewski, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170908 · Cited by 96

Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia–Ischemia: Potential Mechanism of Action

Jaworska, J., Zalewska, T., Sypecka, J., & Ziemka‐Nałęcz, M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1518-1 · Cited by 96

Habitual sugar intake and cognitive impairment among multi-ethnic Malaysian older adults

Chong, C. P., Shahar, S., Haron, H., & Din, N. C. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s211534 · Cited by 95

Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease

François, A., Terro, F., Janet, T., Bilan, A. R., Paccalin, M., & Page, G. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-151 · Cited by 92

Brain serotonin in high-fat diet-induced weight gain, anxiety and spatial memory in rats

Haleem, D. J., & Mahmood, K. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1619983 · Cited by 92

Midlife Modifiable Risk Factors for Dementia: A Systematic Review and Meta-analysis of 34 Prospective Cohort Studies

Li, X.-Y., Zhang, M., Xu, W., Li, J., Cao, X., Yu, J., & Tan, L. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200103111253 · Cited by 92

Increased oxidized low‐density lipoprotein causes blood‐brain barrier disruption in early‐onset preeclampsia through LOX‐1

Schreurs, M. P. H., Hubel, C. A., Bernstein, I. M., Jeyabalan, A., & Cipolla, M. J. (2012) · The FASEB Journal · doi:10.1096/fj.12-222216 · Cited by 90

Gut microbial taxa elevated by dietary sugar disrupt memory function

Noble, E. E., Olson, C. A., Davis, E. A., Tsan, L., Chen, Y.-W., Schade, R., Liu, C. M., Suarez, A. N., Jones, R. B., Serre, C. B. D. L., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01309-7 · Cited by 90

Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats

Xu, W., Liu, J., Ma, D., Yuan, G., Lü, Y., & Yang, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172477 · Cited by 89

Rapid and reversible impairment of episodic memory by a high-fat diet in mice

McLean, F. H., Grant, C., Morris, A. C., Horgan, G. W., Polanski, A. J., Allan, K., Campbell, F., Langston, R. F., & Williams, L. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-30265-4 · Cited by 88

Vascular Risk Factors and Alzheimer’s Disease: Blood-Brain Barrier Disruption, Metabolic Syndromes, and Molecular Links

He, J., Zhao, X., Xu, L., & Mao, C. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190764 · Cited by 88

Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice

Gali, C. C., Fanaee‐Danesh, E., Zandl‐Lang, M., Albrecher, N. M., Tam‐Amersdorfer, C., Stracke, A., Sachdev, V., Reichmann, F., Sun, Y., Avdili, A., et al. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103390 · Cited by 87

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

Cisternas, P., Salazar, P. L., Serrano, F. G., Montecinos-Oliva, C., Arredondo, S. B., Varela‐Nallar, L., Salesa Barja, Y., Vio, C. P., Gómez‐Pinilla, F., & Inestrosa, N. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.016 · Cited by 85

Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study

Sun, Z., Initiative, A. D. N., Wang, Z.-T., Sun, F.-R., Shen, X., Xu, W., Ma, Y., Dong, Q., Tan, L., & Yu, J. (2020) · Aging · doi:10.18632/aging.102738 · Cited by 85

Interaction of amyloid‐β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Brito-Moreira, J., Lourenco, M. V., Oliveira, M. M., Ribeiro, F. C., Ledo, J. H., Diniz, L. P., Vital, J. F. S., Magdesian, M. H., Melo, H. M., Barros-Aragão, F., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.761189 · Cited by 84

Shifting paradigms: The central role of microglia in Alzheimer’s disease

Schwabe, T., Srinivasan, K., & Rhinn, H. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104962 · Cited by 84

Sulfated polysaccharides from Undaria pinnatifida improved high fat diet-induced metabolic syndrome, gut microbiota dysbiosis and inflammation in BALB/c mice

Jiang, P., Zheng, W., Sun, X., Jiang, G., Wu, S. L., Xu, Y.-X., Song, S., & Ai, C. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.11.116 · Cited by 82

Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet

Stevenson, R. J., Francis, H. M., Attuquayefio, T., Gupta, D., Yeomans, M. R., Oaten, M. J., & Davidson, T. (2020) · Royal Society Open Science · doi:10.1098/rsos.191338 · Cited by 81

High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner

Spencer, S. J., Basri, B., Sominsky, L., Soch, A., Ayala, M. T., Reineck, P., Gibson, B. C., & Barrientos, R. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.018 · Cited by 80

Role of the blood–brain barrier in the evolution of feeding and cognition

Banks, W. A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06568.x · Cited by 79

Hypercholesterolemia accelerates amyloid β-induced cognitive deficits

Park, S. H., Kim, J. H., Choi, K. H., Jang, Y. J., Bae, S. S., Choi, B. T., & Shin, H. K. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1233 · Cited by 79

Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction

Qiu, W., Pan, R., Tang, Y., Zhou, X., Wu, J., Yu, L., Law, B. Y. K., Ai, W., Yu, C., Qin, D., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110575 · Cited by 78

Long-term Impact of Behavioral Weight Loss Intervention on Cognitive Function

Espeland, M. A., Rapp, S. R., Bray, G. A., Houston, D. K., Johnson, K., Kitabchi, A. E., Hergenroeder, A. L., Williamson, J. D., Jakicic, J. M., Dorsten, B. V., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu031 · Cited by 77

Obesity and Alzheimer’s disease: Molecular bases

Picone, P., Carlo, M. D., & Nuzzo, D. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14758 · Cited by 77

Dietary Fiber from Oat and Rye Brans Ameliorate Western Diet–Induced Body Weight Gain and Hepatic Inflammation by the Modulation of Short‐Chain Fatty Acids, Bile Acids, and Tryptophan Metabolism

Kundi, Z. M., Lee, J. C., Pihlajamäki, J., Chan, C. B., Leung, K. S., So, S. S. Y., Nordlund, E., Kolehmainen, M., & El-Nezami, H. S. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900580 · Cited by 77

Transport Across the Blood-Brain Barrier

Fu, B. M., & Akli, L. F. A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-22285-5_15 · Cited by 76

T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance

Zhong, J., Rao, X., Braunstein, Z., Taylor, A., Narula, V. K., Hazey, J. W., Mikami, D. J., NEEDLEMAN, B. J., Rutsky, J., Sun, Q., et al. (2013) · Diabetes · doi:10.2337/db13-1094 · Cited by 76

Shifting equilibriums in Alzheimer’s disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis

Gray, S. C., Kinghorn, K. J., & Woodling, N. S. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.272571 · Cited by 76

“Lipid raft aging” in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer's disease

Díaz, M. L., Fabelo, N., Ferrer, I., & Marín, R. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.02.022 · Cited by 75

Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N

Dalby, M. J., Aviello, G., Ross, A., Walker, A. W., Barrett, P., & Morgan, P. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-33928-4 · Cited by 75

Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress

de Aquino, C. C., Leitão, R. A., Alves, L. A. O., Coelho‐Santos, V., Guerrant, R. L., Ribeiro, C., Malva, J. O., Silva, A. P., & Oriá, R. B. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00131 · Cited by 75

Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation

Ji, Y., Han, J., Lee, N., Yoon, J.-H., Youn, K., Ha, H. J., Yoon, E., Kim, D. H., & Jun, M. (2020) · Molecules · doi:10.3390/molecules25215087 · Cited by 75

Interrelation of Diet, Gut Microbiome, and Autoantibody Production

Πέττα, Ι., Fraussen, J., Somers, V. A., & Kleinewietfeld, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00439 · Cited by 73

Microbiota modulation by eating patterns and diet composition: impact on food intake

Klingbeil, E. A., & Serre, C. B. D. L. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00037.2018 · Cited by 73

Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease

Więckowska‐Gacek, A., Mietelska‐Porowska, A., Chutorański, D., Wydrych, M., Długosz, J., & Wojda, U. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654509 · Cited by 70

Gut microbiota in dementia. Critical review of novel findings and their potential application

Łuc, M., Misiak, B., Pawłowski, M., Stańczykiewicz, B., Zabłocka, A., Szcześniak, D. M., Pałęga, A., & Rymaszewska, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110039 · Cited by 69

A Multilevel View of the Development of Alzheimer’s Disease

Ávila, J., & Perry, G. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.015 · Cited by 69

Non-Alcoholic Fatty Liver Disease in Overweight Children: Role of Fructose Intake and Dietary Pattern

Nier, A., Brandt, A., Conzelmann, I., Özel, Y., & Bergheim, I. (2018) · Nutrients · doi:10.3390/nu10091329 · Cited by 69

Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet

Nam, M., Choi, M., Jung, S., Jung, Y., Choi, J., Ryu, D. H., & Hwang, G. (2015) · Scientific Reports · doi:10.1038/srep16984 · Cited by 68

Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice

Rodríguez‐Navas, C., Morselli, E., & Clegg, D. J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.014 · Cited by 68

The effects of diet-induced obesity on B cell function

Shaikh, S. R., Haas, K. M., Beck, M. A., & Teague, H. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12444 · Cited by 67

Sustained high‐fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high‐fat model

Denver, P., Gault, V. A., & McClean, P. L. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13210 · Cited by 67

Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet

Ojo, B. A., El-Rassi, G. D., Payton, M. E., Perkins-Veazie, P. M., Clarke, S. L., Smith, B. J., & Lucas, E. A. (2016) · Journal of Nutrition · doi:10.3945/jn.115.226688 · Cited by 66

Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology

Riphagen, J. M., Ramakers, I. H. G. B., Freeze, W. M., Pagen, L. H. G., Hanseeuw, B. J., Verbeek, M. M., Verhey, F. R. J., & Jacobs, H. I. L. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.09.020 · Cited by 66

Sox11 Balances Dendritic Morphogenesis with Neuronal Migration in the Developing Cerebral Cortex

Hoshiba, Y., Toda, T., Ebisu, H., Wakimoto, M., Yanagi, S., & Kawasaki, H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3250-15.2016 · Cited by 65

Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease

Pugazhenthi, S. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.016 · Cited by 65

TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

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27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice

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Green Tea Polyphenol (−)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice

Mao, L., Hochstetter, D., Yao, L., Zhao, Y., Zhou, J., Wang, Y., & Xu, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205081 · Cited by 63

Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet

Rutkowsky, J. M., Lee, L. L., Puchowicz, M., Golub, M. S., Befroy, D. E., Wilson, D. W., Anderson, S., Cline, G. W., Bini, J., Borkowski, K., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191909 · Cited by 62

The Impact of Dietary Components on Regulatory T Cells and Disease

Hornero, R. A., Hamad, I., Côrte‐Real, B. F., & Kleinewietfeld, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00253 · Cited by 61

CD11a expression distinguishes infiltrating myeloid cells from plaque‐associated microglia in Alzheimer's disease

Shukla, A., McIntyre, L. L., Marsh, S. E., Schneider, C. A., Hoover, E. M., Walsh, C. M., Lodoen, M. B., Blurton-Jones, M. M., & Inlay, M. A. (2018) · Glia · doi:10.1002/glia.23575 · Cited by 59

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4

Allendorf, D. H., Franssen, E. H., & Brown, G. C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15024 · Cited by 57

What are the molecular mechanisms by which functional bacterial amyloids influence amyloid beta deposition and neuroinflammation in neurodegenerative disorders?

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High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

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Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation

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Membrane raft domains and remodeling in aging brain

Colin, J., Gregory-Pauron, L., Lanhers, M.-C., Claudepierre, T., Corbier, C., Yen, F. T., Malaplate-Armand, C., & Oster, T. (2016) · Biochimie · doi:10.1016/j.biochi.2016.08.014 · Cited by 55

Transport Across the Blood-Brain Barrier

Fu, B. M. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-96445-4_13 · Cited by 55

Habitual fat intake predicts memory function in younger women

Gibson, E. L., Barr, S., & Jeanes, Y. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00838 · Cited by 53

High-Fat Diet–Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice Are Reduced by Inhibiting Sialidases

Pilling, D., Karhadkar, T. R., & Gomer, R. H. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.09.011 · Cited by 52

Cereal Byproducts Have Prebiotic Potential in Mice Fed a High-Fat Diet

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Increased Levels of 27‐Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats

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Metabolic Inflammation in Obesity—At the Crossroads between Fatty Acid and Cholesterol Metabolism

Curley, S., Gall, J., Byrne, R., Yvan‐Charvet, L., & McGillicuddy, F. C. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900482 · Cited by 50

[Epidemiology of Alzheimer's disease: latest trends].

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A high-sugar high-fat diet induced metabolic syndrome shows some symptoms of Alzheimer's disease in rats

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Role of cholesterol metabolism in the pathogenesis of Alzheimerʼs disease

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On the fluxes of side-chain oxidized oxysterols across blood-brain and blood-CSF barriers and origin of these steroids in CSF (Review)

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Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

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A high-sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice

Yeh, S. H., Shie, F., Liu, H., Yao, H.-H., Kao, P.-C., Lee, Y.-H., Chen, L.-M., Hsu, S.-M., Chao, L.-J., Wu, K.-W., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.11.018 · Cited by 46

Apolipoprotein E4 association with metabolic syndrome depends on body fatness

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Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model

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