Membrane raft domains and remodeling in aging brain

Functional rafts in cell membranes

Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · see citing works

SNAREs — engines for membrane fusion

Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635 · see citing works

Alzheimer's disease

Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61349-9 · Cited by 2,336 · see citing works

Effect of Chain Length and Unsaturation on Elasticity of Lipid Bilayers

Rawicz, W., Olbrich, K. C., McIntosh, T. J., Needham, D., & Evans, E. A. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76295-3 · Cited by 1,938 · see citing works

Rafts defined: a report on the Keystone symposium on lipid rafts and cell function

PIKE, L. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.e600002-jlr200 · Cited by 1,500 · see citing works

Lipid Rafts Reconstituted in Model Membranes

Dietrich, C., Bagatolli, L. A., Volovyk, Z., Thompson, N. L., Levi, M., Jacobson, K., & Gratton, E. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76114-0 · Cited by 1,379 · see citing works

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J. J., Bryant‐Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., & Duff, K. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0304 · Cited by 1,003 · see citing works

Linking lipids to Alzheimer's disease: cholesterol and beyond

Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works

Docosahexaenoic acid: Membrane properties of a unique fatty acid

Stillwell, W., & Wassall, S. R. (2003) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(03)00101-4 · Cited by 872 · see citing works

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial

Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764 · see citing works

Lipid rafts: heterogeneity on the high seas

PIKE, L. J. (2004) · Biochemical Journal · doi:10.1042/bj20031672 · Cited by 705 · see citing works

Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study

Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W. F., & Wolf, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1545 · Cited by 686 · see citing works

Cholesterol metabolism and homeostasis in the brain

Zhang, J., & Liu, Q. (2015) · Protein & Cell · doi:10.1007/s13238-014-0131-3 · Cited by 686 · see citing works

Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements

Plourde, M., & Cunnane, S. C. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-034 · Cited by 586 · see citing works

GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease

Yanagisawa, K., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Nature Medicine · doi:10.1038/nm1095-1062 · Cited by 544 · see citing works

Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway

Lamaze, C., Dujeancourt-Henry, A., Baba, T., Lo, C. G., Benmerah, A., & Dautry‐Varsat, A. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00212-x · Cited by 525 · see citing works

Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment

Conquer, J. A., Tierney, M. C., Zecevic, J., Bettger, W. J., & Fisher, R. H. (2000) · Lipids · doi:10.1007/s11745-000-0646-3 · Cited by 523 · see citing works

Deregulation of sphingolipid metabolism in Alzheimer’s disease

He, X., Huang, Y., Li, B., Gong, C.-X., & Schuchman, E. H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.010 · Cited by 516 · see citing works

Omega-3 fatty acids and monoamine neurotransmission

Chalon, S. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.07.005 · Cited by 448 · see citing works

Docosahexaenoic acid promotes neurogenesis in vitro and in vivo

Kawakita, E., Hashimoto, M., & Shido, O. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.021 · Cited by 410 · see citing works

Cholesterol-dependent Formation of GM1 Ganglioside-bound Amyloid β-Protein, an Endogenous Seed for Alzheimer Amyloid

Kakio, A., Nishimoto, S., Yanagisawa, K., Kozutsumi, Y., & Matsuzaki, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100252200 · Cited by 406 · see citing works

The role of polyunsaturated fatty acids in restoring the aging neuronal membrane

Yehuda, S., Rabinovitz, S., LCARASSO, R., & Mostofsky, D. I. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00074-x · Cited by 404 · see citing works

Gangliosides as components of lipid membrane domains

Sonnino, S., Mauri, L., Chigorno, V., & Prinetti, A. (2006) · Glycobiology · doi:10.1093/glycob/cwl052 · Cited by 342 · see citing works

Regulated Migration of Epidermal Growth Factor Receptor from Caveolae

Mineo, C., Gill, G. N., & Anderson, R. G. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30636 · Cited by 320 · see citing works

Chronic Dietary α-Linolenic Acid Deficiency Alters Dopaminergic and Serotoninergic Neurotransmission in Rats ,

Delion, S., Chalon, S., Hérault, J., Guilloteau, D., Besnard, J., & Durand, G. (1994) · Journal of Nutrition · doi:10.1093/jn/124.12.2466 · Cited by 316 · see citing works

Lipid rafts in health and disease

Michel, V., & Bakovic, M. (2007) · Biology of the Cell · doi:10.1042/bc20060051 · Cited by 306 · see citing works

Lipid rafts and membrane traffic

Hanzal‐Bayer, M., & Hancock, J. F. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.019 · Cited by 306 · see citing works

Lipid Rafts have Different Sizes Depending on Membrane Composition: A Time-resolved Fluorescence Resonance Energy Transfer Study

de Almeida, R. F. M., Loura, L. M. S., Fedorov, A., & PRIETO, M. J. E. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.026 · Cited by 298 · see citing works

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Émond, V., Julien, P., & Calon, F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.022 · Cited by 288 · see citing works

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

Oksman, M., Iivonen, H., Hőgyes, E., Amtul, Z., Penke, B., Leenders, I., Broersen, L. M., Lütjohann, D., Hartmann, T., & Tanila, H. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.013 · Cited by 287 · see citing works

Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) – Implications for dietary recommendations

Guesnet, P., & Alessandri, J. (2010) · Biochimie · doi:10.1016/j.biochi.2010.05.005 · Cited by 287 · see citing works

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

Xiong, H., Callaghan, D., Jones, A., Walker, D. G., Lue, L., Beach, T. G., Sue, L. I., Woulfe, J., Xu, H., Stanimirovic, D. B., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.10.005 · Cited by 283 · see citing works

Membrane rafts in Alzheimer's disease beta-amyloid production

Vetrivel, K. S., & Thinakaran, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.03.007 · Cited by 283 · see citing works

Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

Chaves, E., & Sipione, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.010 · Cited by 273 · see citing works

Membrane lateral compressibility determined by NMR and x-ray diffraction: effect of acyl chain polyunsaturation

Koenig, B. W., Strey, H. H., & Gawrisch, K. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78226-2 · Cited by 272 · see citing works

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

Martín, M. V., Fabelo, N., Santpere, G., Puig, B., Marín, R., Ferrer, I., & Díaz, M. L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1242 · Cited by 269 · see citing works

Lipid Compositions of Different Regions of the Human Brain During Aging

Söderberg, M. P., Edlund, C., Kristensson, K., & Dallner, G. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01889.x · Cited by 269 · see citing works

Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases

Filippov, V., Song, M. A., Zhang, K., Vinters, H. V., Tung, S., Kirsch, W. M., Yang, J., & Duerksen-Hughes, P. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111202 · Cited by 264 · see citing works

Ceramide function in the brain: when a slight tilt is enough

Mencarelli, C., & Martínez‐Martínez, P. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1038-x · Cited by 261 · see citing works

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

Das, U., Scott, D. A., Ganguly, A., Koo, E. H., Tang, Y. P., & Roy, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.035 · Cited by 245 · see citing works

Serotoninergic neurotransmission is affected by n‐3 polyunsaturated fatty acids in the rat

Kodas, E., Galineau, L., Bodard, S., Vancassel, S., Guilloteau, D., Besnard, J., & Chalon, S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02401.x · Cited by 244 · see citing works

Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease

Li, G., Larson, E. B., Sonnen, J. A., Shofer, J. B., Petrie, E. C., Schantz, A. M., Peskind, E. R., Raskind, M. A., Breitner, J. C. S., & Montine, T. J. (2007) · Neurology · doi:10.1212/01.wnl.0000277657.95487.1c · Cited by 237 · see citing works

Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats

Beilharz, J. E., Maniam, J., & Morris, M. J. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.11.016 · Cited by 234 · see citing works

Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent‐resistant membrane domains

Molander‐Melin, M., Blennow, K., Bogdanović, N., Dellheden, B., Månsson, J., & Fredman, P. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02849.x · Cited by 224 · see citing works

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

Grimm, M. O. W., Kuchenbecker, J., Grösgen, S., Burg, V. K., Hundsdörfer, B., Rothhaar, T. L., Frieß, P., de Wilde, M. C., Broersen, L. M., Penke, B., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.182329 · Cited by 221 · see citing works

BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts

Suzuki, S., Numakawa, T., Shimazu, K., Koshimizu, H., Hara, T., Hatanaka, H., Mei, L., Lu, B., & Kojima, M. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404106 · Cited by 209 · see citing works

Influence of Lipid Composition on Physical Properties and PEG-Mediated Fusion of Curved and Uncurved Model Membrane Vesicles: “Nature's Own” Fusogenic Lipid Bilayer

Haque, M. E., McIntosh, T. J., & Lentz, B. R. (2001) · Biochemistry · doi:10.1021/bi002030k · Cited by 206 · see citing works

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

Arvanitakis, Z., Schneider, J. A., Wilson, R. S., Bienias, J. L., Kelly, J. F., Evans, D. A., & Bennett, D. A. (2008) · Neurology · doi:10.1212/01.wnl.0000288181.00826.63 · Cited by 199 · see citing works

Alzheimer’s disease: the lipid connection

Hartmann, T., Kuchenbecker, J., & Grimm, M. O. W. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04715.x · Cited by 199 · see citing works

The Role and Metabolism of Sulfatide in the Nervous System

Eckhardt, M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8022-3 · Cited by 193 · see citing works

Nutritional determinants of cognitive aging and dementia

Morris, M. C. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111003296 · Cited by 185 · see citing works

Cholesterol Level and Statin Use in Alzheimer Disease

Shepardson, N. E. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.242 · Cited by 181 · see citing works

Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion

Churchward, M. A., Rogasevskaia, T. P., Höfgen, J., Bau, J. T., & Coorssen, J. R. (2005) · Journal of Cell Science · doi:10.1242/jcs.02601 · Cited by 178 · see citing works

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

Bhattacharyya, R., Barren, C., & Kovacs, D. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4704-12.2013 · Cited by 176 · see citing works

Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease

Thomas, J., Thomas, C. J., Radcliffe, J., & Itsiopoulos, C. (2015) · BioMed Research International · doi:10.1155/2015/172801 · Cited by 173 · see citing works

Inter-relationships among diet, obesity and hippocampal-dependent cognitive function

Davidson, T. L., Hargrave, S. L., Swithers, S. E., Sample, C. H., Fu, X., Kinzig, K. P., & Zheng, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.044 · Cited by 171 · see citing works

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

Hooijmans, C. R., van der Zee, C. E. E. M., Dederen, P. J. W. C., Brouwer, K. M., Reijmer, Y. D., Groen, T. V., Broersen, L. M., Lütjohann, D., Heerschap, A., & Kiliaan, A. J. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.002 · Cited by 171 · see citing works

Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae

Vainio, S., Heino, S., Månsson, J., Fredman, P., Kuismanen, E., Vaarala, O., & Ikonen, E. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf010 · Cited by 170 · see citing works

Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study.

Angelié, E., Bonmartin, A., Boudraa, A., Gonnaud, P., Mallet, J.-J., & Sappey‐Marinier, D. (2001) · PubMed Central · Cited by 169 · see citing works

Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus

Aïd, S., Vancassel, S., Poumès‐Ballihaut, C., Chalon, S., Guesnet, P., & Lavialle, M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300079-jlr200 · Cited by 167 · see citing works

Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions

Fabelo, N., Martín, M. V., Marín, R., Moreno, D., Ferrer, I., & Díaz, M. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.005 · Cited by 164 · see citing works

Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease

Poirier, J. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00007-8 · Cited by 162 · see citing works

Loss of the neuroprotective factor sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

Couttas, T. A., Kain, N., Daniels, B., Lim, X. Y., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., & Don, A. S. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-9 · Cited by 161 · see citing works

Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation

Brzustowicz, M. R., Cherezov, V., Caffrey, M., Stillwell, W., & Wassall, S. R. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75394-0 · Cited by 161 · see citing works

Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures

Sonnino, S., & Chigorno, V. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0005-2736(00)00210-8 · Cited by 160 · see citing works

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis

Zhu, L., Zhong, M., Elder, G. A., Sano, M., Holtzman, D. M., Gandy, S., Cardozo, C., Haroutunian, V., Robakis, N. K., & Cai, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510011112 · Cited by 160 · see citing works

Structural determinants of protein partitioning into ordered membrane domains and lipid rafts

Lorent, J. H., & Levental, I. (2015) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2015.07.022 · Cited by 155 · see citing works

Partitioning of the Serotonin Transporter into Lipid Microdomains Modulates Transport of Serotonin

Magnani, F., Tate, C. G., Wynne, S. A., Williams, D. C., & Haase, J. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400831200 · Cited by 155 · see citing works

Imbalanced cholesterol metabolism in Alzheimer's disease

Xue-shan, Z., Peng, J., Wu, Q., Zhong, R., Li-hong, P., Tang, Z., Jiang, Z., Wang, G., & Liu, L. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.024 · Cited by 155 · see citing works

Sphingolipid-enriched Membrane Domains from Rat Cerebellar Granule Cells Differentiated in Culture

Prinetti, A., Chigorno, V., Tettamanti, G., & Sonnino, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11658 · Cited by 154 · see citing works

Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms

Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.007 · Cited by 150 · see citing works

Lipid changes in the aged brain: Effect on synaptic function and neuronal survival

Ledesma, M. D., Martín, M. G., & Dotti, C. G. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.004 · Cited by 148 · see citing works

Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500033-JLR200

Li, Q.-R., Wang, M., Tan, L., Wang, C., Ma, J., Li, N., Li, Y.-S., Xu, G.-W., & Li, J.-S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500033-jlr200 · Cited by 146 · see citing works

Lipid Raft Association of SNARE Proteins Regulates Exocytosis in PC12 Cells

Salaün, C., Gould, G. W., & Chamberlain, L. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501923200 · Cited by 143 · see citing works

Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells

Rajendran, L., Masilamani, M., Solomon, S., Tikkanen, R., Stuermer, C. A. O., Plattner, H., & Illges, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1331629100 · Cited by 142 · see citing works

Oxidized phosphatidylcholines in membrane‐level cellular signaling: from biophysics to physiology and molecular pathology

Volinsky, R., & Kinnunen, P. K. J. (2013) · FEBS Journal · doi:10.1111/febs.12247 · Cited by 141 · see citing works

Functional and Structural Benefits Induced by Omega-3 Polyunsaturated Fatty Acids During Aging

Cutuli, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160614091311 · Cited by 139 · see citing works

The aging human orbitofrontal cortex: Decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity

McNamara, R. K., Liu, Y., Jandacek, R. J., Rider, T., & Tso, P. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.04.001 · Cited by 135 · see citing works

Nerve Growth Factor Signaling in Caveolae-like Domains at the Plasma Membrane

Huang, C., Zhou, J. J., Feng, A. K., Lynch, C. C., Klumperman, J., DeArmond, S. J., & Mobley, W. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36707 · Cited by 134 · see citing works

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis

Yamamoto, N., Matsubara, T., Sato, T., & Yanagisawa, K. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.07.028 · Cited by 132 · see citing works

Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

Burg, V. K., Grimm, H. S., Rothhaar, T. L., Grösgen, S., Hundsdörfer, B., Haupenthal, V. J., Zimmer, V. C., Mett, J., Weingärtner, O., Laufs, U., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1506-13.2013 · Cited by 132 · see citing works

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

Sebastião, A. M., Colino-Oliveira, M., Assaife‐Lopes, N., Dias, R. B., & Ribeiro, J. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.053 · Cited by 128 · see citing works

The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease

Belkouch, M., Hachem, M., Elgot, A., Van, A. L., Picq, M., Guichardant, M., Lagarde, M., & Bernoud‐Hubac, N. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.03.002 · Cited by 128 · see citing works

Association of Aortic Atherosclerosis with Cerebral β-Amyloidosis and Learning Deficits in a Mouse Model of Alzheimer's Disease

Li, L., Cao, D., Garber, D. W., Kim, H., & Fukuchi, K.-I. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63572-9 · Cited by 127 · see citing works

Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments

Mazelova, J., Ransom, N. L., Astuto-Gribble, L. M., Wilson, M. C., & Deretic, D. (2009) · Journal of Cell Science · doi:10.1242/jcs.039982 · Cited by 126 · see citing works

Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain

Dyall, S. C., Michael, G. J., Whelpton, R., Scott, A. G., & Michael-Titus, A. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.01.002 · Cited by 126 · see citing works

Designation and Schematic Structure of Gangliosides and Allied Glycosphingolipids

Svennerholm, L. (1994) · Progress in brain research · doi:10.1016/s0079-6123(08)61935-4 · Cited by 124 · see citing works

GPI-anchored protein organization and dynamics at the cell surface

Saha, S., Anilkumar, A. A., & Mayor, S. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r062885 · Cited by 124 · see citing works

Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus

Favrelière, S. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00170-6 · Cited by 118 · see citing works

Human Cerebrospinal Fluid Fatty Acid Levels Differ between Supernatant Fluid and Brain-Derived Nanoparticle Fractions, and Are Altered in Alzheimer's Disease

Fonteh, A. N., Cipolla, M., Chiang, J., Arakaki, X., & Harrington, M. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100519 · Cited by 116 · see citing works

Plasmalogen synthesis is regulated via alkyl‐dihydroxyacetonephosphate‐synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

Grimm, M. O. W., Kuchenbecker, J., Rothhaar, T. L., Grösgen, S., Hundsdörfer, B., Burg, V. K., Frieß, P., Müller, U., Grimm, H. S., Riemenschneider, M. J., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07070.x · Cited by 115 · see citing works

Enrichment of cholesterol in microdissected Alzheimer’s disease senile plaques as assessed by mass spectrometry

Panchal, M., Loeper, J., Cossec, J., Perruchini, C., Lazar, A. N., Pompon, D., & Duyckaerts, C. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001859 · Cited by 115 · see citing works

Lipids in Regulated Exocytosis: What are They Doing?

Ammar, M. R., Kassas, N., Chasserot‐Golaz, S., Bader, M. F., & Vitale, N. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00125 · Cited by 115 · see citing works

The Tyrosine Kinase Fyn Determines the Localization of TrkB Receptors in Lipid Rafts

Pereira, D. B., & Chao, M. V. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4587-06.2007 · Cited by 110 · see citing works

Specific changes of sulfatide levels in individuals with pre‐clinical Alzheimer's disease: an early event in disease pathogenesis

Cheng, H., Wang, M., Li, J., Cairns, N. J., & Han, X. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12368 · Cited by 103 · see citing works

With or without rafts? Alternative views on cell membranes

Sevcsik, E., & Schütz, G. J. (2015) · BioEssays · doi:10.1002/bies.201500150 · Cited by 101 · see citing works

Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer’s Disease: A Meta-Analysis

Wang, H.-L., Wang, Y.-Y., Liu, X., Kuo, S., Liu, N., Song, Q.-Y., & Wang, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150734 · Cited by 99 · see citing works

The lipid compositions of different regions of rat brain during development and aging

Zhang, Y., Appelkvist, E., Kristensson, K., & Dallner, G. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00076-0 · Cited by 98 · see citing works

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

Couttas, T. A., Kain, N., Suchowerska, A. K., Quek, L., Turner, N. A., Fath, T., Garner, B., & Don, A. S. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.03.027 · Cited by 96 · see citing works

Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro

Martín, M. G., Perga, S., Trovò, L., Rasola, A., Holm, P. C., Rantamäki, T., Harkany, T., Ċastrén, E., Chiara, F., & Dotti, C. G. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0897 · Cited by 94 · see citing works

Changes in the fatty acid and sphingosine composition of the major gangliosides of human brain with age

Månsson, J., Vanier, M. T., & Svennerholm, L. T. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb07064.x · Cited by 93 · see citing works

Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?

Cunnane, S. C., Chouinard‐Watkins, R., Castellano, C., & Barberger‐Gateau, P. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.04.006 · Cited by 92 · see citing works

Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats

Ulmann, L., Mimouni, V., Roux, S., Porsolt, R. D., & Poisson, J. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0260 · Cited by 91 · see citing works

Mediterranean Diet in Predementia and Dementia Syndromes

Solfrizzi, V., Frisardi, V., Seripa, D., Logroscino, G., Imbimbo, B. P., D’Onofrio, G., Addante, F., Sancarlo, D., Cascavilla, L., Pilotto, A., et al. (2011) · Current Alzheimer Research · doi:10.2174/156720511796391809 · Cited by 91 · see citing works

Localization and signaling of GPCRs in lipid rafts

Villar, V. A. M., Cuevas, S., Zheng, X., & José, P. A. (2016) · Methods in cell biology · doi:10.1016/bs.mcb.2015.11.008 · Cited by 91 · see citing works

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging

Uranga, R. M., Bruce‐Keller, A. J., Morrison, C. D., Fernandez‐Kim, S. O., Ebenezer, P. J., Zhang, L., Dasuri, K., & Keller, J. N. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06803.x · Cited by 87 · see citing works

The Mechanism of Docosahexaenoic Acid-induced Phospholipase D Activation in Human Lymphocytes Involves Exclusion of the Enzyme from Lipid Rafts

Diaz, O., Berquand, A., Dubois, M., Agostino, S. D., Sette, C., Bourgoin, S. G., Lagarde, M., Némoz, G., & Prigent, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202376200 · Cited by 86 · see citing works

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86 · see citing works

Lipid Rafts in Neurodegeneration and Neuroprotection

Sonnino, S., Aureli, M., Grassi, S., Mauri, L., Prioni, S., & Prinetti, A. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8614-4 · Cited by 85 · see citing works

Age-associated changes in the content and fatty acid composition of brain glycerophospholipids

López, G. H., de Boschero, M. G. I., Castagnet, P. I., & Giusto, N. M. (1995) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)00079-8 · Cited by 83 · see citing works

Omega‐3 fatty acids deficiency aggravates glutamatergic synapse and astroglial aging in the rat hippocampal CA 1

Latour, A., Grintal, B., Champeil‐Potokar, G., Hennebelle, M., Lavialle, M., Dutar, P., Potier, B., Billard, J., Vancassel, S., & Denis, I. (2012) · Aging Cell · doi:10.1111/acel.12026 · Cited by 82 · see citing works

Domain Formation in Models of the Renal Brush Border Membrane Outer Leaflet

Milhiet, P., Domec, C., Giocondi, M., Mau, N. D. V., Heitz, F., & Grimellec, C. L. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75721-9 · Cited by 81 · see citing works

Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice

Lee, P., Kim, J., Williams, R., Sandhir, R., Gregory, E., Brooks, W. M., & Berman, N. E. J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.016 · Cited by 78 · see citing works

Hypercholesterolemia accelerates amyloid β-induced cognitive deficits

Park, S. H., Kim, J. H., Choi, K. H., Jang, Y. J., Bae, S. S., Choi, B. T., & Shin, H. K. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1233 · Cited by 78 · see citing works

Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro

Sodero, A. O., Weissmann, C., Ledesma, M. D., & Dotti, C. G. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.001 · Cited by 78 · see citing works

The Effect of Membrane Lipid Composition on the Formation of Lipid Ultrananodomains

Pathak, P., & London, E. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.08.029 · Cited by 77 · see citing works

Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice

Oster, T., & Pillot, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.011 · Cited by 74 · see citing works

Brain Gangliosides in Dementia of the Alzheimer Type

Crino, P. B., Ullman, M. D., Vogt, B. A., Bird, E. D., & Volicer, L. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520400054019 · Cited by 71 · see citing works

Changes in the Ceramide Composition of Rat Forebrain Gangliosides with Age

Palestini, P., Masserini, M., Sonnino, S., Giuliani, A., & Tettamanti, G. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb13305.x · Cited by 71 · see citing works

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

Cheng, H., Vetrivel, K. S., Drisdel, R. C., Meckler, X., Gong, P., Leem, J. Y., Li, T., Carter, M., Chen, Y., Nguyen, P. A. H., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806380200 · Cited by 70 · see citing works

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

Torres, M., Price, S. L., Fiol-deRoque, M. A., Marcilla-Etxenike, A., Ahyayauch, H., Barceló‐Coblijn, G., Terés, S., Katsouri, L., Ordinas, M., López, D. J., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.12.016 · Cited by 69 · see citing works

Sphingomyelin-enriched microdomains define the efficiency of native Ca2+-triggered membrane fusion

Rogasevskaia, T. P., & Coorssen, J. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.03007 · Cited by 69 · see citing works

Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses

Suzuki, T., Zhang, J., Miyazawa, S., Liu, Q., Farzan, M., & Yao, W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07404.x · Cited by 68 · see citing works

Ceramides and sphingomyelinases in senile plaques

Panchal, M., Gaudin, M., Lazar, A. N., Salvati, E., Rivals, I., Ayciriex, S., Dauphinot, L., Dargère, D., Auzeil, N., Masserini, M., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.010 · Cited by 68 · see citing works

Increase in sphingolipid catabolic enzyme activity during aging

Sacket, S. J., Chung, H., Okajima, F., & Im, D. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.136 · Cited by 68 · see citing works

Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice

Eckert, G. P., Kirsch, C., & Mueller, W. E. (2001) · Neuroreport · doi:10.1097/00001756-200104170-00003 · Cited by 67 · see citing works

Altered Ion Channel Formation by the Parkinson's-Disease-Linked E46K Mutant of α-Synuclein Is Corrected by GM3 but Not by GM1 Gangliosides

Pasquale, E. D., Fantini, J., Chahinian, H., Maresca, M., Taïeb, N., & Yahi, N. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.01.046 · Cited by 67 · see citing works

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing

Sakurai, T., Kaneko, K., Okuno, M., Wada, K., Kashiyama, T., Shimizu, H., Akagi, T., Hashikawa, T., & Nukina, N. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804075 · Cited by 62 · see citing works

Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging

Sodero, A. O., Trovò, L., Iannilli, F., Veldhoven, P. P. V., Dotti, C. G., & Martín, M. G. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07079.x · Cited by 58 · see citing works

Altered Distribution of the Gangliosides GM1 and GM2 in Alzheimer’s Disease

Pernber, Z., Blennow, K., Bogdanović, N., Månsson, J., & Blomqvist, M. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000338181 · Cited by 58 · see citing works

Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia?

Cederholm, T., & Palmblad, J. E. W. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328335c40b · Cited by 56 · see citing works

Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing

Grimm, M. O. W., Haupenthal, V. J., Mett, J., Stahlmann, C. P., Blümel, T., Mylonas, N. T., Endres, K., Grimm, H. S., & Hartmann, T. (2015) · Neurodegenerative Diseases · doi:10.1159/000440839 · Cited by 56 · see citing works

Intracellular APP Domain Regulates Serine‐Palmitoyl‐CoA Transferase Expression and Is Affected in Alzheimer′s Disease

Grimm, M. O. W., Grösgen, S., Rothhaar, T. L., Burg, V. K., Hundsdörfer, B., Haupenthal, V. J., Frieß, P., Müller, U., Fassbender, K. C., Riemenschneider, M. J., et al. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/695413 · Cited by 55 · see citing works

Fatty Acid and Peptide Profiles in Plasma Membrane and Membrane Rafts of PUFA Supplemented RAW264.7 Macrophages

Schumann, J. E., Leichtle, A. B., Thiery, J., & Fuhrmann, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024066 · Cited by 53 · see citing works

Analysis of the protein network of cholesterol homeostasis in different brain regions: An age and sex dependent perspective

Segatto, M., Di Giovanni, A., Marino, M., & Pallottini, V. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24315 · Cited by 52 · see citing works

Lipid raft disarrangement as a result of neuropathological progresses: A novel strategy for early diagnosis?

Marín, R., Rojo, J. A. P., Fabelo, N., Fernandez, C. E., & Díaz, M. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.025 · Cited by 49 · see citing works

Membrane fatty acid composition shows δ-6-desaturase abnormalities in Alzheimerʼs disease

Nakada, T., Kwee, I. L., & Ellis, W. G. (1990) · Neuroreport · doi:10.1097/00001756-199010000-00018 · Cited by 49 · see citing works

Alterations of the synaptosomal membrane ‘microviscosity’ in the brain cortex of rats during aging and centrophenoxine treatment

Nagy, K., Zs.-Nagy, V., Bertoni–Freddari, C., & Zs.-Nagy, I. (1983) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(83)90014-6 · Cited by 47 · see citing works

Resveratrol induces ordered domains formation in biomembranes: Implication for its pleiotropic action

Neves, A. R., Nunes, C., & Reis, S. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.10.005 · Cited by 45 · see citing works

Towards a nutritional approach for prevention of Alzheimer's disease: Biochemical and cellular aspects

Florent‐Béchard, S., Malaplate, C., Koziel, V., Kriem, B., Olivier, J. L., Pillot, T., & Oster, T. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.046 · Cited by 44 · see citing works

Low dietary fish-oil threshold for myocardial membrane n-3 PUFA enrichment independent of n-6 PUFA intake in rats

Slee, E. L., McLennan, P. L., Owen, A. J., & Theiss, M. L. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m004069 · Cited by 43 · see citing works

The Pathogenic Role of Ganglioside Metabolism in Alzheimer’s Disease-Cholinergic Neuron-Specific Gangliosides and Neurogenesis

Ariga, T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9641-0 · Cited by 43 · see citing works

Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains

Nicastro, M. C., Spigolon, D., Librizzi, F., Morán, Ó., Ortore, M. G., Bulone, D., Biagio, P. L. S., & Carrotta, R. (2015) · Biophysical Chemistry · doi:10.1016/j.bpc.2015.07.010 · Cited by 43 · see citing works

Substitution of membrane cholesterol with β-sitosterol promotes nonamyloidogenic cleavage of endogenous amyloid precursor protein

Wang, J., Wu, F., & Shi, C. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.022 · Cited by 40 · see citing works

Alzheimer's disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus

Hirano, W., Sugiyama, E., Hayasaka, T., Ravid, R., Setou, M., & Taki, T. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.09.033 · Cited by 40 · see citing works

Cholesterol: A Two-Edged Sword in Brain Aging

Joseph, J. A., Villalobos-Molinas, R., Denisova, N. A., Erat, S., & Strain, J. G. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00376-0 · Cited by 38 · see citing works

Lipid Raft Alterations in Aged-Associated Neuropathologies.

Marín, R., Fabelo, N., Fernández-Echevarría, C., Canerina-Amaro, A., Rodriguez-Barreto, D., Quinto-Alemany, D., Mesa-Herrera, F., & Díaz, M. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160314150017 · Cited by 38 · see citing works

Up‐regulation of hepatic lipolysis stimulated lipoprotein receptor by leptin: a potential lever for controlling lipid clearance during the postprandial phase

Stenger, C., Hanse, M., Pratte, D., Mbala, M., Akbar, S., Koziel, V., Escanyé, M., Kriem, B., Malaplate, C., Olivier, J. L., et al. (2010) · The FASEB Journal · doi:10.1096/fj.10-160440 · Cited by 35 · see citing works

NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts

PRYOR, S. C., McCaffrey, G., Young, L. R., & Grimes, M. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035163 · Cited by 33 · see citing works

Citrulline diet supplementation improves specific age-related raft changes in wild-type rodent hippocampus

Marquet, P., Clamagirand, C., Facchinetti, P., Rose, C., Sargueil, F., Guihenneuc‐Jouyaux, C., Cynober, L., Moinard, C., & Allinquant, B. (2012) · AGE · doi:10.1007/s11357-012-9462-2 · Cited by 32 · see citing works

Flotillins bind to the dileucine sorting motif of β‐site amyloid precursor protein‐cleaving enzyme 1 and influence its endosomal sorting

John, B. A., Meister, M., Banning, A., & Tikkanen, R. (2014) · FEBS Journal · doi:10.1111/febs.12763 · Cited by 31 · see citing works

Regulation of the high‐affinity choline transporter activity and trafficking by its association with cholesterol‐rich lipid rafts

Cuddy, L. K., Winick‐Ng, W., & Rylett, R. J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12490 · Cited by 31 · see citing works

Erythrocyte DHA level as a biomarker of DHA status in specific brain regions ofn-3 long-chain PUFA-supplemented aged rats

Létondor, A., Buaud, B., Vaysse, C., Fonseca, L., Herrouin, C., Servat, B., Layé, S., Pallet, V., & Alfos, S. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002529 · Cited by 28 · see citing works

Lipid Raft Size and Lipid Mobility in Non-raft Domains Increase during Aging and Are Exacerbated in APP/PS1 Mice Model of Alzheimer's Disease. Predictions from an Agent-Based Mathematical Model

Santos, G., Díaz, M. L., & Torres, N. V. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00090 · Cited by 26 · see citing works

Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis

Trovò, L., Veldhoven, P. P. V., Martín, M. G., & Dotti, C. G. (2011) · Journal of Cell Science · doi:10.1242/jcs.078766 · Cited by 21 · see citing works

Increased Susceptibility of Dyslipidemic LSR+/− Mice to Amyloid Stress is Associated with Changes in Cortical Cholesterol Levels

Pinçon, A., Thomas, M. H., Huguet, M., Allouche, A., Colin, J., Georges, A., Derien, A., Lanhers, M., Malaplate, C., Oster, T., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142127 · Cited by 19 · see citing works

NCAM-140 Translocation into Lipid Rafts Mediates the Neuroprotective Effects of GDNF

Li, L., Chen, H., Wang, M., Chen, F., Gao, J., Sun, S., Li, Y.-Q., & Gao, D. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9749-x · Cited by 19 · see citing works

Age-associated changes in synaptic lipid raft proteins revealed by two-dimensional fluorescence difference gel electrophoresis

Jiang, L., Fang, J., Moore, D. S., Gogichaeva, N. V., Galeva, N. A., Michaelis, M. L., & Zaidi, A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.11.005 · Cited by 18 · see citing works

Age-related changes of the ganglioside long-chain base composition in rat cerebellum

Valsecchi, M., Palestini, P., Chigorno, V., & Sonnino, S. (1996) · Neurochemistry International · doi:10.1016/0197-0186(95)00069-0 · Cited by 18 · see citing works

Cellular traffic cops: the interplay between lipids and proteins regulates vesicular formation, trafficking, and signaling in mammalian cells

Kumar, A., Baycin‐Hizal, D., Zhang, Y., Bowen, M. A., & Betenbaugh, M. J. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.09.006 · Cited by 13 · see citing works

Alzheimer's Disease: Treatment Strategies and Their Limitations.

Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works

Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343 · see citing works

Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers

Mesa-Herrera, F., Taoro‐González, L., Valdés‐Baizabal, C., Díaz, M. L., & Marín, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153810 · Cited by 182 · see citing works

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

Arenas, F., García‐Ruiz, C., & Fernández-Checa, J. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00382 · Cited by 161 · see citing works

Amyloid plaques beyond Aβ: a survey of the diverse modulators of amyloid aggregation

Stewart, K. L., & Radford, S. E. (2017) · Biophysical Reviews · doi:10.1007/s12551-017-0271-9 · Cited by 93 · see citing works

DHA and Its Elaborated Modulation of Antioxidant Defenses of the Brain: Implications in Aging and AD Neurodegeneration

Díaz, M., Mesa-Herrera, F., & Marín, R. (2021) · Antioxidants · doi:10.3390/antiox10060907 · Cited by 84 · see citing works

Perspective: The Potential Role of Circulating Lysophosphatidylcholine in Neuroprotection against Alzheimer Disease

Semba, R. D. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa024 · Cited by 79 · see citing works

“Lipid raft aging” in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer's disease

Díaz, M. L., Fabelo, N., Ferrer, I., & Marín, R. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.02.022 · Cited by 75 · see citing works

On the role of sphingolipids in cell survival and death

Iessi, E., Marconi, M., Manganelli, V., Sorice, M., Malorni, W., Garofalo, T., & Matarrese, P. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.02.004 · Cited by 74 · see citing works

Estrogen Interactions With Lipid Rafts Related to Neuroprotection. Impact of Brain Ageing and Menopause

Marín, R., & Díaz, M. L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00128 · Cited by 58 · see citing works

The translational potential of cholesterol-based therapies for neurological disease

Valenza, M., Birolini, G., & Cattaneo, E. F. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00864-5 · Cited by 48 · see citing works

Exploring the Dynamic Changes of Brain Lipids, Lipid Rafts, and Lipid Droplets in Aging and Alzheimer’s Disease

Cerasuolo, M., Di Meo, I., Auriemma, M. C., Paolisso, G., Papa, M., & Rizzo, M. R. (2024) · Biomolecules · doi:10.3390/biom14111362 · Cited by 47 · see citing works

Caveolin-1, a novel player in cognitive decline

Tang, W., Li, Y., Li, Y., & Wang, Q. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.044 · Cited by 43 · see citing works

Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization

Martín‐Segura, A., Ahmed, T., Casadomé‐Perales, Á., Palomares-Pérez, I., Palomer, E., Kerstens, A., Munck, S., Balschun, D., & Dotti, C. G. (2019) · Aging Cell · doi:10.1111/acel.12932 · Cited by 40 · see citing works

Molecular and biophysical features of hippocampal “lipid rafts aging” are modified by dietary n‐3 long‐chain polyunsaturated fatty acids

Díaz, M. L., Pereda, D., Valdés‐Baizabal, C., Santos, G., & Marín, R. (2023) · Aging Cell · doi:10.1111/acel.13867 · Cited by 33 · see citing works

Mechanisms Mediating the Actions of Fatty Acids in the Hypothalamus

Dragano, N. R. V., Monfort‐Pires, M., & Velloso, L. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.012 · Cited by 30 · see citing works

STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome

Arenas, F., Castro, F., Núñez, S., Gay, G., García‐Ruiz, C., & Fernández-Checa, J. C. (2020) · Aging · doi:10.18632/aging.102641 · Cited by 28 · see citing works

Preferential Protein Partitioning in Biological Membrane with Coexisting Liquid Ordered and Liquid Disordered Phase Behavior: Underlying Design Principles

Bodosa, J., Iyer, S. S., & Srivastava, A. K. (2020) · The Journal of Membrane Biology · doi:10.1007/s00232-020-00150-1 · Cited by 25 · see citing works

Changes in metabolomics and lipidomics in brain tissue and their correlations with the gut microbiome after chronic food-derived arsenic exposure in mice

Wang, C., Deng, H., Wang, D., Wang, J., Huang, H., Qiu, J., Li, Y., Zou, T., & Guo, L. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112935 · Cited by 22 · see citing works

Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis

Antonini, A., Caioli, S., Saba, L., Vindigni, G., Biocca, S., Canu, N., & Zona, C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.008 · Cited by 22 · see citing works

Plasma membrane and brain dysfunction of the old: Do we age from our membranes?

Martín, M. G., & Dotti, C. G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1031007 · Cited by 22 · see citing works

AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer’s Disease Therapy

Azzaz, F., Chahinian, H., Yahi, N., Fantini, J., & Scala, C. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021760 · Cited by 21 · see citing works

Alzheimer’s disease: an axonal injury disease?

Liang, D., & Zhang, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1264448 · Cited by 18 · see citing works

Caveolin-1–Mediated Blood-Brain Barrier Disruption via MMP2/9 Contributes to Postoperative Cognitive Dysfunction

Li, X., Ding, W., Zhang, X., Tang, X., Zheng, Y., Ma, Y., Bao, X., Kang, X., & Zhu, S. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04458-z · Cited by 16 · see citing works

Maintenance of membrane organization in the aging mouse brain as the determining factor for preventing receptor dysfunction and for improving response to anti-Alzheimer treatments

Colin, J., Thomas, M. H., Gregory-Pauron, L., Pinçon, A., Lanhers, M.-C., Corbier, C., Claudepierre, T., Yen, F. T., Oster, T., & Malaplate-Armand, C. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.02.015 · Cited by 14 · see citing works

Biophysical characteristics of lipid‐induced Aβ oligomers correlate to distinctive phenotypes in transgenic mice

Saha, J., Dean, D. N., Dhakal, S., Stockmal, K. A., Morgan, S. E., Dillon, K. D., Adamo, M. F., Levites, Y., & Rangachari, V. (2021) · The FASEB Journal · doi:10.1096/fj.202002025rr · Cited by 12 · see citing works

Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPARγ/ABCA1-dependent Cholesterol Efflux Mechanisms

Xu, G., Yang, L., Guan, P.-P., Wang, Z., & Wang, P. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00704-1 · Cited by 12 · see citing works

Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds

Tonini, C., Segatto, M., & Pallottini, V. (2020) · Metabolites · doi:10.3390/metabo10080304 · Cited by 9 · see citing works

Cholesterol‐24‐hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes

Cataldi, G. G., Elorza, S. D., Toledano‐Zaragoza, A., de Olmos, S., Cragnolini, A. B., & Martín, M. G. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25436 · Cited by 6 · see citing works

Increasing the Survival of a Neuronal Model of Alzheimer’s Disease Using Docosahexaenoic Acid, Restoring Endolysosomal Functioning by Modifying the Interactions between the Membrane Proteins C99 and Rab5

Vigier, M., Uriot, M., Djelti, F., Claudepierre, T., Hajj, A. E., Yen, F. T., Oster, T., & Malaplate, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136816 · Cited by 6 · see citing works

Interfacial and intrinsic molecular effects on the phase separation/transition of heteroprotein condensates

Nobeyama, T., Yoshida, T., & Shiraki, K. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128095 · Cited by 6 · see citing works

Lipostatic Mechanisms Preserving Cerebellar Lipids in MPTP-Treated Mice: Focus on Membrane Microdomains and Lipid-Related Gene Expression

Díaz, M. L., Canerina‐Amaro, A., Rodríguez‐Barreto, D., Casañas‐Sánchez, V., Pérez, J. A. P., & Marín, R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00093 · Cited by 4 · see citing works

Mixing small proteins with lipids and cholesterol

Basu, S., & Farago, O. (2024) · The Journal of Chemical Physics · doi:10.1063/5.0239257 · Cited by 3 · see citing works

Lipids, brain ageing, dementia, and lipidomics

Poljak, A., Braidy, N., Wong, M. W. K., Liu, Y., Housseini, M., & Sachdev, P. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815854-8.00012-4 · Cited by 3 · see citing works

The Role of Lipid Domains and Physical Properties of Membranes in the Development of Age-Related Neurodegenerative Diseases

Krasnobaev, V. D., & Batishchev, O. V. (2022) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s199074782209001x · Cited by 3 · see citing works

Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human

Godoy-Lugo, J. A., Thorwald, M. A., Head, E., Gomm, A., Zhang, C., Tanzi, R. E., & Finch, C. E. (2025) · GeroScience · doi:10.1007/s11357-025-01926-w · Cited by 2 · see citing works

Glucose-regulated protein 78 in lipid rafts elevates vascular smooth muscle cell proliferation of spontaneously hypertensive rats by controlling platelet-derived growth factor receptor signaling

Kim, D. Y., Hwang, D. I., Park, S. M., Jung, S. H., Kim, B., Won, K., & Lee, H. M. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2199-8 · Cited by 2 · see citing works

Intralipid treatment for Alzheimer Disease

Eldor, J. (2017) · Clinical and Medical Investigations · doi:10.15761/cmi.1000139 · Cited by 1 · see citing works

The Role of Lipid Domains and Physical Properties of Membranes in the Development of Age-Related Neurodegenerative Diseases

Krasnobaev, V. D., & Batishchev, O. V. (2023) · Биологические мембраны Журнал мембранной и клеточной биологии · doi:10.31857/s023347552301005x · Cited by 1 · see citing works

Alzheimer's disease neurotoxic peptides : towards a comprehension of their modes of action on model membranes.

Azouz, M. (2019) · theses.fr (ABES) · doi:10.70675/4c3b6c12z1da5z497cz9e34zea6e6bf189d9 · Cited by 1 · see citing works

Cellular Repair Processes

de Grey, A. D. N. J., & Rae, M. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_436-1

The signalosome malfunctions in age-associated neuropathologies

Puertas‐Avendaño, R., Quinto‐Alemany, D., González‐Gómez, M., & Marín, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00018-9

Znaczenie kwasu dokozaheksaenowego (DHA) w prewencji zaburzeń funkcji poznawczych u osób starszych

Białecka-Dębek, A., Granda, D., & Pietruszka, B. (2021) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0014.8986

Cellular Repair Processes

de Grey, A. D. N. J., & Rae, M. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_436

Cellular Repair Processes

de Grey, A. D. N. J., & Rae, M. J. (2021) · Springer eBooks · doi:10.1007/978-3-319-69892-2_436-2

ProRafts: A machine-learning predictor for raftophilicity , the protein affinity for biomembrane raftsPreprint

Yurtsever, D., Keşmir, C., & Sperotto, M. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.20.533471

An Observation of the Deformation Dynamics of Model Lipid Rafts Induced by NanobiodevicePreprint

Nobeyama, T. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4765187

Impact of aging on the GABAB receptor-mediated connectomePreprint

Vásquez, E., López, A. L., Oresti, G. M., Paez, M. D., Callegari, E. A., Masone, D., & Muñoz, E. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.31.606013

Caractérisation du site de liaison du cholestérol sur l'APP : un modulateur de la sécrétion de peptides amyloïdes

Hanbouch, L. (2017) · theses.fr (ABES) · doi:10.70675/c4d2c894zf69dz4ae4z9ab1zf4135d0efa12

Altérations lipidiques et homéostatiques dans les tissus nerveux associées au vieillissement et à des dérégulations métaboliques : implication du microbiote intestinal et de l’autophagie

Albouery, M. (2020) · theses.fr (ABES) · doi:10.70675/3e190ceczf22dz44b0z936cz6c92f9f5309f

Use of nanoliposomes rich in omega-3 for the prevention of neurodegenerative diseases : bioavailability in vivo and in cortical neurons

Passeri, E. (2021) · theses.fr (ABES) · doi:10.70675/166b0026zefe8z41f8z88e1zc5f79765fd6a

Influence des lipides membranaires sur les interactions protéiques liées aux anomalies endolysosomales dans un modèle neuronal de la maladie d'Alzheimer

Vigier, M. (2022) · theses.fr (ABES) · doi:10.70675/45a1855bz1cb2z4326zb34az61e2ad59f5c2

Impact of chronic SSRI administration on memory parameters, lipid components and membrane properties in C57Bl/6J mice

Szuwarzyński, M., Kostecka, A., Domin, H., Depciuch, J., Karska, A., Sowa-Kućma, M., Pańczyszyn-Trzewik, P., & Stachowicz, K. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1769754

New Aspects of N-stearoylethanolamine's Neuroprotective Actions in Ageing Rats

Kosiakova, H. V., Tm, H., Ah, B., Meged’, O. F., KLIMASHEVSKII, V., Mykhalskiy, S., Kvitnitskaya-Ryzhova, T., Hula, N. M., Tkachenko, O. S., & ЖУКОВ, О. (2026) · The Open Biochemistry Journal · doi:10.2174/011874091x497944261007030541

Lipids and Membranes in Brain Aging ☆

Wood, W. G., & Sun, G. Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02593-1

Aging Brain and Lipids

Susumu, A. N. D. O. (1992) · Journal of Japan Oil Chemists Society · doi:10.5650/jos1956.41.757

The Role of Lipid Domains and Physical Properties of Membranes in the Development of Age-Related Neurodegenerative Diseases

Krasnobaev, V. D., & Batishchev, O. V. (2023) · Биологические мембраны Журнал мембранной и клеточной биологии · doi:10.31857/s023347552301005x · Cited by 1 · see citing works

Mechanisms underlying the sprint-endurance trade-off in rat lateral gastrocnemius muscle mechanics

James, R. S., Walter, I. J., & Seebacher, F. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.04.206

Brain cholesterol in normal and pathological aging

Martin, M., Dotti, C. G., & Ledesma, M. D. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.03.011 · Cited by 162 · see citing works