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Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis
Abstract
PURPOSE: The aim of our study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA). METHODS: The study involved 150 patients affected by cartilage degenerative lesions and early and severe OA. Fifty symptomatic patients were treated with 3 autologous PRP intra-articular injections and were evaluated prospectively at enrollment and at 2- and 6-month follow-up. The results obtained were compared with 2 homogeneous groups of patients treated with HA injections. One group was treated with injections of high-molecular weight HA; the other group was treated with low-molecular weight (LW) HA. International Knee Documentation Committee and EQ VAS scores were used for clinical evaluation; adverse events and patient satisfaction were also recorded. RESULTS: At 2 months' follow-up, the PRP and LW HA groups showed a similar improvement, with higher results compared with the high-molecular weight HA group (P < .005). At 6 months' follow-up, better results were observed in the PRP group (P < .005). PRP and LW HA treatments offered similar results in patients aged over 50 years and in the treatment of advanced OA. PRP showed a better performance compared with HA in younger patients affected by cartilage lesions or early OA. CONCLUSIONS: Autologous PRP injections showed more and longer efficacy than HA injections in reducing pain and symptoms and recovering articular function. Better results were achieved in younger and more active patients with a low degree of cartilage degeneration, whereas a worse outcome was obtained in more degenerated joints and in older patients, in whom results similar to those of viscosupplementation have been observed. LEVEL OF EVIDENCE: Level II, prospective comparative study.
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The Abuse of Power: The Pervasive Fallacy of Power Calculations for Data Analysis
Hoenig, J. M., & Heisey, D. M. (2001) · The American Statistician · doi:10.1198/000313001300339897 · Cited by 2,046
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Clegg, D. O., Reda, D. J., Harris, C. L., Klein, M. A., O'Dell, J. R., Hooper, M. M., Bradley, J. D., Bingham, C. O., Weisman, M. H., Jackson, C. G., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052771 · Cited by 1,329
Cited by
Chahla, J., Cinque, M. E., Piuzzi, N. S., Mannava, S., Geeslin, A. G., Murray, I. R., Dornan, G. J., Muschler, G. F., & LaPrade, R. F. (2017) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.16.01374 · Cited by 504
Raeissadat, S. A., Rayegani, S. M., Hassanabadi, H., Fathi, M., Ghorbani, E., Babaee, M., & Azma, K. (2015) · Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders · doi:10.4137/cmamd.s17894 · Cited by 331
Nguyen, P. D., Tran, T. D.-X., Nguyen, H. T.-N., Vu, H. T., Le, P. T.-B., Phan, N. L.-C., Vu, N. B., Phan, N. K., & Van Pham, P. (2017) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0023 · Cited by 112
Zhao, J., Liang, G., Han, Y., Yang, W., Xu, N., Luo, M., Pan, J., Liu, J., & Zeng, L.-F. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-061008 · Cited by 32
Metadata
- Authors
- Kon, E., Mandelbaum, B., Buda, R., Filardo, G., Delcogliano, M., Timoncini, A., Fornasari, P. M., Giannini, S., & Marcacci, M.
- Venue
- Arthroscopy: The Journal of Arthroscopic & Related Surgery
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 27
- Issue
- 11
- Pages
- 1490-1501
- ISSN
- 0749-8063 (ISSN-L)
- OpenAlex
- W2141157018
- Cited by
- 582
- References
- 2
- FWCI
- 30.81
- Type
- journal article
- Language
- en
- Open access
- closed
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