The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Platelet-Rich Plasma: A Milieu of Bioactive Factors
Abstract
Platelet concentrates such as platelet-rich plasma (PRP) have gained popularity in sports medicine and orthopaedics to promote accelerated physiologic healing and return to function. Each PRP product varies depending on patient factors and the system used to generate it. Blood from some patients may fail to make PRP, and most clinicians use PRP without performing cell counts on either the blood or the preparation to confirm that the solution is truly PRP. Components in this milieu have bioactive functions that affect musculoskeletal tissue regeneration and healing. Platelets are activated by collagen or other molecules and release growth factors from alpha granules. Additional substances are released from dense bodies and lysosomes. Soluble proteins also present in PRP function in hemostasis, whereas others serve as biomarkers of musculoskeletal injury. Electrolytes and soluble plasma hormones are required for cellular signaling and regulation. Leukocytes and erythrocytes are present in PRP and function in inflammation, immunity, and additional cellular signaling pathways. This article supports the emerging paradigm that more than just platelets are playing a role in clinical responses to PRP. Depending on the specific constituents of a PRP preparation, the clinical use can theoretically be matched to the pathology being treated in an effort to improve clinical efficacy.
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Cites
Neutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Platelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
McCarrel, T., & Fortier, L. (2009) · Journal of Orthopaedic Research · doi:10.1002/jor.20853 · Cited by 389
Self-citation
Cited by
The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in Osteoarthritis
Sundman, E. A., Cole, B. J., Karas, V., Della Valle, C., Tetreault, M. W., Mohammed, H. O., & Fortier, L. A. (2014) · The American Journal of Sports Medicine · doi:10.1177/0363546513507766 · Cited by 396
Self-citationPlatelet-rich Concentrates Differentially Release Growth Factors and Induce Cell Migration In Vitro
Schär, M. O., Diaz-Romero, J., Kohl, S., Zumstein, M. A., & Nesic, D. (2015) · Clinical Orthopaedics & Related Research · doi:10.1007/s11999-015-4192-2 · Cited by 273
Usuelli, F. G., Grassi, M., Maccario, C., Vigano’, M., Lanfranchi, L., Alfieri Montrasio, U., & de Girolamo, L. (2018) · Knee Surgery, Sports Traumatology, Arthroscopy · doi:10.1007/s00167-017-4479-9 · Cited by 156
Platelet-Rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology
Kia, C., Baldino, J., Bell, R., Ramji, A., Uyeki, C., & Mazzocca, A. (2018) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-018-9515-y · Cited by 94
Cook, J. L., Smith, P. A., Bozynski, C. C., Kuroki, K., Cook, C. R., Stoker, A. M., & Pfeiffer, F. M. (2016) · Journal of Orthopaedic Research · doi:10.1002/jor.23054 · Cited by 91
Metadata
- Authors
- Boswell, S. G., Cole, B. J., Sundman, E. A., Karas, V., & Fortier, L. A.
- Venue
- Arthroscopy: The Journal of Arthroscopic & Related Surgery
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 28
- Issue
- 3
- Pages
- 429-439
- ISSN
- 0749-8063 (ISSN-L)
- OpenAlex
- W1983106010
- Cited by
- 613
- References
- 3
- FWCI
- 39.98
- Type
- journal article
- Language
- en
- Open access
- closed
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