Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction
Abstract
Objective Several studies show that the inflammatory component in atherosclerosis may contribute to increased risk for cardiovascular disease (CVD). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-stimulatory cytokine of presumed importance for CVD and the metabolic syndrome.Methods and results In this case-control study, 1179 surviving myocardial infarction (MI) cases and 1528 healthy controls were genotyped for three IL-6 promoter SNPs, and serum concentrations of IL-6 and C-reactive protein (CRP) were measured. In men, MI risk assessed as odds ratios (OR) was higher with increasing IL-6 levels, with the highest compared to the lowest IL-6 quartiles giving an OR of 2.7 [95% CI 1.7-4.4]. The ORs were independent from the effects of elevated CRP which were associated with modest MI risks (OR = 1.6 [95% CI 1.0-2.5]). Also, synergistic interactions between high IL-6 levels and hypercholesterolaemia further increased MI risk estimates. The -174C allele was associated with lower serum-insulin levels among male controls but did not significantly influence MI risk or IL-6 levels.Conclusions Elevated IL-6 levels are important risk markers for MI in men, the risk being further enhanced through synergistic interaction with hypercholesterolaemia. The data provide no clear evidence that polymorphisms in the IL-6 promotor region play a significant role in the pathogenesis of MI, and it remains to be further evaluated whether or not the -174C allele is of relevance for insulin resistance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Plasma concentrations of IL-6 and TNF-α predict the risk of myocardial infarction.
“Plasma concentrations of IL-6 [31] and TNF-α have been shown to predict the risk of myocardial infarction in several studies [32]”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [31]
Cites
OLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467 · see citing works
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V, Yudkin, J. S., Humphries, S., & Woo, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2629 · Cited by 2,243 · see citing works
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775 · see citing works
Immune mechanisms in atherosclerosis.
Hansson, G. K., Jonasson, L., Seifert, P. S., & Stemme, S. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.5.567 · Cited by 1,169 · see citing works
Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
Kuller, L. H., Tracy, R. P., Shaten, J., & Meilahn, E. N. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008963 · Cited by 1,098 · see citing works
Cytokines and Cytokine Receptors in Advanced Heart Failure
Deswal, A. M., Petersen, N. J., Feldman, A. M., Young, J. B., White, B. G., & Mann, D. L. (2001) · Circulation · doi:10.1161/01.cir.103.16.2055 · Cited by 1,007 · see citing works
Frostegård, J., Ulfgren, A., Nyberg, P., Hedin, U., Swedenborg, J., Andersson, U., & Hansson, G. K. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00011-8 · Cited by 1,002 · see citing works
Interleukin-6 induces cellular insulin resistance in hepatocytes.
Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883 · see citing works
C-Reactive Protein as a Cardiovascular Risk Factor
Lagrand, W. K., Visser, C. A., Hermens, W. T., Niessen, H. W. M., Verheugt, F. W. A., Wolbink, G., & Hack, C. E. (1999) · Circulation · doi:10.1161/01.cir.100.1.96 · Cited by 833 · see citing works
Inflammatory bio‐markers and cardiovascular risk prediction
Blake, G., & Ridker, P. M. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01019.x · Cited by 702 · see citing works
Girasole, G., Jilka, R. L., Passeri, G., Boswell, S. H., Boder, G. B., Williams, D. C., & Manolagas, S. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115668 · Cited by 677 · see citing works
Changes in job strain in relation to changes in physiological state. A longitudinal study.
Theorell, T., Perski, A., Åkerstedt, T., Sigala, F., Ahlberg-Hultén, G., Svensson, J., & Eneroth, P. H. E. (1988) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1932 · Cited by 468 · see citing works
Linkage disequilibrium and the mapping of complex human traits.
Weiss, K., & Clark, A. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(01)02550-1 · Cited by 423 · see citing works
Brull, D. J., Montgomery, H., Sanders, J., Dhamrait, S. S., Luong, L. A., Rumley, A., Lowe, G. D. O., & Humphries, S. E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0901.094280 · Cited by 408 · see citing works
Humphries, S. E. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2678 · Cited by 388 · see citing works
Interleukin-6 ( IL-6 ) and the Prognosis of Abdominal Aortic Aneurysms
Jones, K. G., Brull, D. J., Brown, L. C., Sian, M., Greenhalgh, R. M., Humphries, S. E., & Powell, J. T. (2001) · Circulation · doi:10.1161/01.cir.103.18.2260 · Cited by 369 · see citing works
Interleukin-6 gene polymorphism and insulin sensitivity.
Fernández‐Real, J. M., Broch, M., Vendrell, J. J., Gutiérrez, C., Casamitjana, R., Pugeat, M., Richart, C., & Ricart, W. (2000) · Diabetes · doi:10.2337/diabetes.49.3.517 · Cited by 244 · see citing works
Hamsten, A., Walldius, G., Szamosi, A., Dahlén, G., & Fairé, U. D. (1986) · Circulation · doi:10.1161/01.cir.73.6.1097 · Cited by 192 · see citing works
Prince, J. A., Feuk, L., Howell, W. M., Jobs, M., Emahazion, T., Blennow, K., & Brookes, A. J. (2001) · Genome Research · doi:10.1101/gr.150201 · Cited by 188 · see citing works
Basso, F., Lowe, G. D. O., Rumley, A., McMahon, A. D., & Humphries, S. E. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013283.84306.1a · Cited by 172 · see citing works
Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study
Georges, J., Loukaci, V., Poirier, O., Evans, A., Luc, G., Arveiler, D., Ruidavets, J., Cambien, F., & Tiret, L. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100209 · Cited by 170 · see citing works
Interleukin-6: The Endocrine Cytokine
Papanicolaou, D. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6582 · Cited by 159 · see citing works
Leander, K., Hallqvist, J., Reuterwall, C., Ahlbom, A., & Faire, A. (2001) · Epidemiology · doi:10.1097/00001648-200103000-00014 · Cited by 152 · see citing works
Reuterwall, C., Hallqvist, J., Ahlbom, A., Fairé, U. D., Diderichsen, F., Hogstedt, C., Pershagen, G., Theorell, T., Wiman, B., Wolk, A., et al. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00554.x · Cited by 148 · see citing works
Serum lipoproteins and apolipoproteins in young male survivors of myocardial infarction
Hamsten, A., Walldius, G., Dahlén, G., JOHANSSON, B., & DEFAIRE, U. (1986) · Atherosclerosis · doi:10.1016/0021-9150(86)90051-1 · Cited by 138 · see citing works
Kilpinen, S. K., Hulkkonen, J., Wang, X. Y., & Hurme, M. (2001) · PubMed · Cited by 128 · see citing works
Retterstøl, L., Eikvar, L., Bohn, M., Bakken, A., Erikssen, J., & Berg, K. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00595-0 · Cited by 92 · see citing works
Bennet, A. M., Brismar, K., Hallqvist, J., Reuterwall, C., & Fairé, U. D. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470641 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Exercise as a Mean to Control Low‐Grade Systemic Inflammation
Mathur, N., & Pedersen, B. K. (2008) · Mediators of Inflammation · doi:10.1155/2008/109502 · Cited by 514 · see citing works
Panasevich, S., Leander, K., Rosenlund, M., Ljungman, P. L. S., Bellander, T., Fairé, U. D., Pershagen, G., & Nyberg, F. (2009) · Occupational and Environmental Medicine · doi:10.1136/oem.2008.043471 · Cited by 145 · see citing works
Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mouse hearts
Lee, J., Lee, S., Zhang, H., Hill, M. A., Zhang, C., & Park, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187189 · Cited by 133 · see citing works
Janszky, I., Mukamal, K. J., Ljung, R., Ahnve, S., Ahlbom, A., & Hallqvist, J. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02088.x · Cited by 113 · see citing works
Interleukin 6 −174 G/C Promoter Polymorphism and Risk of Coronary Heart Disease
Sie, M. P. S., Sayed‐Tabatabaei, F. A., Oei, H.-H. S., Uitterlinden, A. G., Pols, H. A. P., Albert Hofman, D., van Duijn, C. M., & Witteman, J. C. M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000194099.65024.17 · Cited by 101 · see citing works
Janszky, I., Hallqvist, J., Tomson, T., Ahlbom, A., Mukamal, K. J., & Ahnve, S. (2009) · Brain · doi:10.1093/brain/awp216 · Cited by 92 · see citing works
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection
Labò, N., Ohnuki, H., & Tosato, G. (2020) · Cells · doi:10.3390/cells9071583 · Cited by 89 · see citing works
Mukamal, K. J., Hallqvist, J., Hammar, N., Ljung, R., Gémes, K., Ahlbom, A., Ahnve, S., & Janszky, I. (2009) · American Heart Journal · doi:10.1016/j.ahj.2008.11.009 · Cited by 69 · see citing works
Antunes, T. T., Gagnon, A., Chen, B., Pacini, F., Smith, T. J., & Sorisky, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2005 · Cited by 68 · see citing works
Molecular genetics of atherosclerosis
Roy, H., Bhardwaj, S., & Ylä‐Herttuala, S. (2009) · Human Genetics · doi:10.1007/s00439-009-0654-5 · Cited by 64 · see citing works
Harmon, M. E., Lewis, J. L., Miller, C. P., Hoover, J. H., Ali, A.-M. S., Shuey, C., Cajero, M., Lucas, S., Zychowski, K. E., Pacheco, B., et al. (2017) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2016.79 · Cited by 63 · see citing works
Gene variants for osteoporosis and their pleiotropic effects in aging
Ferrari, S., & Rizzoli, R. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.01.002 · Cited by 61 · see citing works
Alcohol and long-term prognosis after a first acute myocardial infarction: the SHEEP study
Janszky, I., Ljung, R., Ahnve, S., Hallqvist, J., Bennet, A. M., & Mukamal, K. J. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm509 · Cited by 60 · see citing works
Self-citationInterleukin‐6 gene polymorphism is an age‐dependent risk factor for myocardial infarction in men
Chiappelli, M., Tampieri, C., Tumini, E., Porcellini, E., Caldarera, C. M., Nanni, S., Branzi, A., Lio, D., Caruso, M., Hoffmann, E., et al. (2005) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2005.00537.x · Cited by 59 · see citing works
Inflammatory cytokine gene variants in coronary artery disease patients in Greece
Manginas, A., Tsiavou, A., Chaidaroglou, A. S., Giamouzis, G., Degiannis, D., Panagiotakos, D. B., & Cokkinos, D. V. (2008) · Coronary Artery Disease · doi:10.1097/mca.0b013e32831286e8 · Cited by 57 · see citing works
Huth, C., Illig, T., Herder, C., Gieger, C., Grallert, H., Vollmert, C., Rathmann, W., Hamid, Y. H., Pedersen, O. B., Hansen, T. F., et al. (2008) · Annals of Medicine · doi:10.1080/07853890802337037 · Cited by 57 · see citing works
Hou, H., Wang, C., Sun, F., Zhao, L., Dun, A., & Sun, Z. (2015) · Inflammation Research · doi:10.1007/s00011-015-0850-9 · Cited by 55 · see citing works
Niu, W., Liu, Y., Qi, Y., Wu, Z., Zhu, D., & Jin, W. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.12.098 · Cited by 53 · see citing works
László, K. D., Ahnve, S., Hallqvist, J., Ahlbom, A., & Janszky, I. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02196.x · Cited by 51 · see citing works
Katzov, H., Bennet, A. M., Kehoe, P. G., Wiman, B., Gatz, M., Blennow, K., Lenhard, B., Pedersen, N. L., Fairé, U. D., & Prince, J. A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh286 · Cited by 48 · see citing works
Self-citationVelásquez, I. M., Frumento, P., Johansson, K., Berglund, A., Fairé, U. D., Leander, K., & Gigante, B. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.12.170 · Cited by 48 · see citing works
The inflammation and coagulation cross-talk in patients with systemic lupus erythematosus
Meesters, E. W., Hansen, H., Spronk, H. M. H., Hamulyák, K., Rosing, J., Rowshani, A. T., ten Berge, I. J. M., & Cate, H. T. (2006) · Blood Coagulation & Fibrinolysis · doi:10.1097/01.mbc.0000256022.01900.c2 · Cited by 45 · see citing works
Leander, K., Wiman, B., Hallqvist, J., Andersson, T., Ahlbom, A., & Fairé, U. D. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e328012e3cc · Cited by 45 · see citing works
Interleukin-6 promoter polymorphism and cardiovascular risk factors: The Health 2000 Survey
Riikola, A., Sipilä, K., Kähönen, M. A. P., Jula, A., Nieminen, M. S., Moilanen, L., Kesäniemi, Y. A., Lehtimäki, T. J., & Hulkkonen, J. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.06.004 · Cited by 45 · see citing works
Adiloğlu, A. K., Can, R., Nazlı, C., Öcal, A., Ergene, O., Tinaz, G. B., & Kişioğlu, N. (2005) · Europe PMC (PubMed Central) · Cited by 43 · see citing works
González‐Castro, T. B., Hernández‐Díaz, Y., Pérez‐Hernández, N., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., López‐Narváez, M. L., Blachman-Braun, R., Posadas‐Sánchez, R., Vargas‐Alarcón, G., García-Flores, E., et al. (2019) · EXCLI journal · doi:10.17179/excli2019-1248 · Cited by 42 · see citing works
Velásquez, I. M., Golabkesh, Z., Källberg, H., Leander, K., Fairé, U. D., & Gigante, B. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.04.014 · Cited by 39 · see citing works
End‐stage renal disease – not an equal opportunity disease: the role of genetic polymorphisms
Nordfors, L., Lindholm, B., & Stenvinkel, P. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01516.x · Cited by 39 · see citing works
Mullen, A., Moloney, F., Nugent, A. P., Doyle, L., Cashman, K. D., & Roche, H. M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.12.008 · Cited by 37 · see citing works
Serum Interleukin-15 Concentration in Patients With Essential Hypertension
Kaibe, M., Ohishi, M., Ito, N., Ma, Y., TAKAGI, T., TERAI, M., Tatara, Y., Komai, N., Rakugi, H., & Ogihara, T. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.02.014 · Cited by 36 · see citing works
Araki, A., Hosoi, T., Orimo, H., & Ito, H. (2005) · Metabolism · doi:10.1016/j.metabol.2005.02.001 · Cited by 35 · see citing works
Rai, H., Colleran, R., Cassese, S., Joner, M., Kastrati, A., & Byrne, R. A. (2021) · Inflammation Research · doi:10.1007/s00011-021-01505-7 · Cited by 34 · see citing works
Şekuri, C., Çam, F. S., Sağcan, A., Ercan, E., Tengiz, İ., Alioğlu, E., & Berdelı, A. (2007) · Coronary Artery Disease · doi:10.1097/mca.0b013e32820588ae · Cited by 34 · see citing works
Gene Polymorphism Association Studies in Dialysis: The Nutrition‐Inflammation Axis
Jaber, B. L., Balakrishnan, V. S., Stenvinkel, P., Pecoits‐Filho, R., & Lindholm, B. (2005) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2005.18317.x · Cited by 35 · see citing works
Yin, Y.-W., Li, J.-C., Zhang, M., Wang, J., Li, B., Liu, Y., Liao, S.-Q., Zhang, M.-J., Gao, C., & Zhang, L. (2013) · Gene · doi:10.1016/j.gene.2013.07.074 · Cited by 32 · see citing works
Zheng, G., Chen, H., & Xiong, S.-Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034839 · Cited by 31 · see citing works
Panasevich, S., Leander, K., Ljungman, P. L. S., Bellander, T., Fairé, U. D., Pershagen, G., & Nyberg, F. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003058 · Cited by 29 · see citing works
Barati, E., Ghazizadeh, H., Sadabadi, F., Kazemi, E., Ferns, G. A., Avan, A., & Ghayour‐Mobarhan, M. (2019) · Biochemical Genetics · doi:10.1007/s10528-019-09913-5 · Cited by 29 · see citing works
Malaponte, G., Polesel, J., Candido, S., Sambataro, D., Bevelacqua, V., Anzaldi, M., Vella, N., Fiore, V., Militello, L., Mazzarino, M. C., et al. (2013) · Cytokine · doi:10.1016/j.cyto.2013.02.017 · Cited by 28 · see citing works
Yin, Y.-W., Hu, A., Sun, Q., Liu, H.-L., Wang, Q., Zeng, Y., Xu, R., Hou, Z., Zhang, Z.-D., Zhang, S.-J., et al. (2012) · Gene · doi:10.1016/j.gene.2012.04.075 · Cited by 27 · see citing works
The interleukin-6 –174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study
Witteman, J. C. M. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s1693 · Cited by 25 · see citing works
Russo, G. T., Giandalia, A., Romeo, E. L., Alibrandi, A., Horvath, K. V., Asztalos, B. F., & Cucinotta, D. (2014) · International Journal of Endocrinology · doi:10.1155/2014/607924 · Cited by 25 · see citing works
Role of non‐HLA genetic variants in end‐stage renal disease
Ranganath, P., Tripathi, G., Sharma, R. K., Sankhwar, S., & Agrawal, S. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01276.x · Cited by 25 · see citing works
Giurgea, A., Margeta, C., Maca, T., Rezaie-Majd, A., Bucek, R. A., Manavi, M., Afarideh, R., Minar, E., & Baghestanian, M. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000191970.65998.7a · Cited by 25 · see citing works
Ma, Y., Tang, R., Xu, Y., Peng, G., Liu, Y., Wang, X.-M., Wu, B., & Yu, J. (2011) · Human Immunology · doi:10.1016/j.humimm.2011.03.019 · Cited by 24 · see citing works
Interleukin 6 polymorphism corresponds to the number of severely stenosed coronary arteries.
Myśliwska, J. M., Więckiewicz, J., Hak, Ł., Siebert, J., Rogowski, J. A., Szyndler, K., & Myśliwski, A. (2006) · PubMed · Cited by 23 · see citing works
Gigante, B., Bennet, A. M., Leander, K., Vikström, M., & Fairé, U. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011300 · Cited by 22 · see citing works
Self-citationChiu, Y.-H. M., Garshick, E., Hart, J. E., Spiegelman, D. L., Dockery, D. W., Smith, T. J., & Laden, F. (2016) · Environmental Research · doi:10.1016/j.envres.2016.04.008 · Cited by 20 · see citing works
Sanderson, S. C., Meena Kumari, B., Brunner, E. J., Miller, M. A., Rumley, A., Lowe, G. D. O., Marmot, M. G., & Humphries, S. E. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.09.019 · Cited by 20 · see citing works
Sanders, J., Hawe, E., Brull, D. J., Hubbart, C., Lowe, G. D. O., Rumley, A., Humphries, S. E., & Montgomery, H. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.08.032 · Cited by 19 · see citing works
Present and Future Biochemical Markers for Detection of Acute Coronary Syndrome
Eriksson, S., Wittfooth, S., & Pettersson, K. S. I. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360600793082 · Cited by 19 · see citing works
Interleukin-6 -634 C/G and -174 G/C Polymorphisms in Korean Patients Undergoing Hemodialysis
Ryu, J.-H., & Kim, S.-J. (2012) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2012.27.3.327 · Cited by 19 · see citing works
Toutouzas, K. P., Klettas, D., Anousakis‐Vlachochristou, N., Melidis, K., Azilazian, Z., Asimomiti, M., Καρανάσος, Α., Spanos, A., Tsiamis, E. G., Nihoyannopoulos, P., et al. (2017) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2017.02.002 · Cited by 18 · see citing works
Johnson, D. R., O’Connor, J. C., Satpathy, A. T., & Freund, G. G. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74017-1 · Cited by 19 · see citing works
Ezaki, S., Itoh, K., Kunikata, T., Suzuki, K., Sobajima, H., & Tamura, M. (2012) · Allergology International · doi:10.2332/allergolint.11-oa-0305 · Cited by 18 · see citing works
Mannila, M. N., Eriksson, P. O., Leander, K., Wiman, B., Fairé, U. D., Hamsten, A., & Silveira, A. M. V. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01749.x · Cited by 18 · see citing works
Job insecurity and prognosis after myocardial infarction: The SHEEP Study
László, K. D., Engström, K., Hallqvist, J., Ahlbom, A., & Janszky, I. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.07.005 · Cited by 17 · see citing works
Bennet, A. M., Alarcón-Riquelme, M. E., Wiman, B., Fairé, U. D., & Prokunina‐Olsson, L. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.05.005 · Cited by 17 · see citing works
Self-citationThe role of dietary polyunsaturated fatty acids in inflammation
Vučić, V. (2013) · Serbian Journal of Experimental and Clinical Research · doi:10.5937/sjecr14-4774 · Cited by 14 · see citing works
Tabaei, S., Motallebnezhad, M., & Tabaee, S. S. (2020) · Inflammation Research · doi:10.1007/s00011-020-01385-3 · Cited by 14 · see citing works
Wang, Y., Yin, B., Liu, S., & Xue, S. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.07.006 · Cited by 14 · see citing works
The IL-6 −174G/C polymorphism and renal scarring in children with first acute pyelonephritis
Spasojević, B., Živković, M., Stanković, A., Stojković, L., & Kostić, M. (2010) · Pediatric Nephrology · doi:10.1007/s00467-010-1587-x · Cited by 13 · see citing works
YE, W., CHEN, S., JIN, S., & LU, J. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1616 · Cited by 12 · see citing works
Zotova, E., Lyrenäs, L., Fairé, U. D., Morgenstern, R., Gigante, B., & Bennet, A. M. (2009) · Coronary Artery Disease · doi:10.1097/mca.0b013e32832da06d · Cited by 12 · see citing works
Self-citationAssociation between the interleukin-6 genetic polymorphism 174 G/C and thrombosis disorder risk
Ren, H., Zhang, Y., Yao, Y., Guo, T., Wang, H., Mei, H., & Hu, Y. (2016) · Medicine · doi:10.1097/md.0000000000004030 · Cited by 12 · see citing works
Petrovay, F., Heltai, K., Kis, Z., Tresó, B., Gönczöl, É., Burián, K., Endrész, V., & Valyi-Nagy, I. T. (2007) · Inflammation Research · doi:10.1007/s00011-007-7045-y · Cited by 12 · see citing works
Velásquez, I. M., Ärnlöv, J., Leander, K., Lind, L., Gigante, B., & Carlsson, A. C. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.962596 · Cited by 12 · see citing works
Huang, M.-Y., Wang, L., Ma, H., Wang, J., & Xiang, M. (2013) · DNA and Cell Biology · doi:10.1089/dna.2013.2148 · Cited by 11 · see citing works
Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients
Shinohara, T., Takahashi, N., Yufu, K., Anan, F., Kakuma, T., Hara, M., Nakagawa, M., Saikawa, T., & Yoshimatsu, H. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0809-y · Cited by 11 · see citing works
Katzov, H., Bennet, A. M., Höglund, K., Wiman, B., Lütjohann, D., Brookes, A. J., Andreasen, N., Blennow, K., Fairé, U. D., & Prince, J. A. (2005) · Journal of Human Genetics · doi:10.1007/s10038-005-0341-x · Cited by 10 · see citing works
Self-citationShinohara, T. (2012) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.1000209 · Cited by 10 · see citing works
Gonzales, T. K., Yonker, J. A., Chang, V., Roan, C., Herd, P., & Atwood, C. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-011529 · Cited by 11 · see citing works
Meng, Q., Sun, Z., Gu, H., Luo, J., Wang, J., Wang, C., & Su, H. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0185-6 · Cited by 9 · see citing works
Apolipoprotein E is associated with blood lipids and inflammation in Taiwanese older adults
Vasunilashorn, S. M., Glei, D. A., Lan, C.-Y., Brookmeyer, R., Weinstein, M., & Goldman, N. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.07.100 · Cited by 9 · see citing works
Bayoumy, N. M. K., Al-Sharaidh, A. S., Babay, Z. A., & Abdulgader, A. (2013) · Saudi Medical Journal · doi:10.15537/1658-3175.5784 · Cited by 8 · see citing works
Bulut, E. C., Kutucu, D. E., Üstünova, S., Ağırbaşlı, M. A., Dedeakayoğulları, H., Tarhan, Ç., Kapucu, A., Yeğen, B. Ç., Tansel, C. D., & Gürel-Gürevin, E. (2024) · Experimental Physiology · doi:10.1113/ep092052 · Cited by 7 · see citing works
El-Mashad, N., Elemshaty, W., Arfat, M. S., Koura, B. A., & Metwally, S. S. (2009) · PubMed · Cited by 7 · see citing works
Rantala, A. K., Lajunen, T. K., Juvonen, R., Paldanius, M., Silvennoinen‐Kassinen, S., Peitso, A., Vainio, O., Leinonen, M., & Saikku, P. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02542.x · Cited by 6 · see citing works
Fonseca, D. M., Bonato, V. L. D., Silva, C. L., & Sartori, A. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006005000175 · Cited by 6 · see citing works
Plasma fluorescent oxidation products and short‐term occupational particulate exposures
Hart, J. E., Wu, T., Laden, F., & Garshick, E. (2012) · American Journal of Industrial Medicine · doi:10.1002/ajim.22073 · Cited by 5 · see citing works
Zhou, J., Feng, J., & Li, X. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15038358 · Cited by 5 · see citing works
Hong, M., Bennet, A. M., Fairé, U. D., & Prince, J. A. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201803 · Cited by 5 · see citing works
Self-citationAtherogenese: Wechselspiel zwischen Cholesterin, Inflammation und Koagulation
Fraunberger, P., Wang, Y., Blessing, F., Seidel, D., & Walli, A. K. (2005) · Herz · doi:10.1007/s00059-005-2658-9 · Cited by 5 · see citing works
Use of Single-Nucleotide Polymorphisms in the Search for Genetic Modifiers of the Uremic Phenotype
Witasp, A., Nordfors, L., Lindholm, B., & Stenvinkel, P. (2007) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2006.10.005 · Cited by 5 · see citing works
Environmental factors in cardiovascular disease
Rosenlund, M. (2005) · Figshare · Cited by 5 · see citing works
Luo, Y., Li, S., Ding, Y., & Shi, S. (2025) · BMC Medical Genomics · doi:10.1186/s12920-025-02167-8 · Cited by 4 · see citing works
VictoriaHernndez, M., Vidal, S., & Sanmartí, R. (2013) · Advances in Pharmacoepidemiology & Drug Safety · doi:10.4172/2167-1052.1000141 · Cited by 5 · see citing works
Zhang, H., Liu, C., Zhao, B., & Zhou, X. (2018) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0075 · Cited by 3 · see citing works
Bezuch, N. E., Bradburn, S., Sipilä, S., Pääsuke, M., Gapeyeva, H., Maier, A. B., Hogrel, J., Barnouin, Y., Butler-Browne, G. S., Narici, M. V., et al. (2018) · Meta Gene · doi:10.1016/j.mgene.2018.10.007 · Cited by 3 · see citing works
Gonçalves, B. P., Flauzino, T., Inoue, C. J., de Paula, J. C. C., Galvão, T. C., de Alcantara, C. C., Miyazaki, P. K., Rosa, L., Westmore, S., Lozovoy, M. A. B., et al. (2020) · International Journal of Colorectal Disease · doi:10.1007/s00384-020-03743-3 · Cited by 3 · see citing works
Serum and genetic markers related to rapid clinical progression of coronary artery disease
Camarero, T. G., Remuzgo‐Martínez, S., Genre, F., López‐Mejías, R., Pulito‐Cueto, V., Fernández, G. V., Hwang, D.-H. L., Laso, F. S., Ongay, A. G., González-Gay, M. Á., et al. (2023) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2023.04.005 · Cited by 3 · see citing works
Camarero, T. G., Remuzgo‐Martínez, S., Genre, F., López‐Mejías, R., Pulito‐Cueto, V., Veiga, G., Hwang, D.-H. L., Laso, F. S., Ongay, A. G., González-Gay, M. Á., et al. (2023) · Revista Española de Cardiología · doi:10.1016/j.recesp.2023.04.009 · Cited by 3 · see citing works
Cytokines and Late Preconditioning
Buxton, D. B. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.07.019 · Cited by 3 · see citing works
Gene polymorphism among hypertensive patients with coronary artery disease
Selvakumar, D. (2022) · Bioinformation · doi:10.6026/97320630018239 · Cited by 2 · see citing works
Genetic Factors Underlying Susceptibility to Acute Pyelonephritis and Post-infectious Renal Damage
Živković, M., Stojković, L., Spasojević, B., Kostic, M., & Stanković, A. (2013) · InTech eBooks · doi:10.5772/52852 · Cited by 2 · see citing works
Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
Tretjakovs, P., Latkovskis, G., Licis, N., Juhnēviča, D., Jurka, A., Bormane, I., Aivars, J. I., Stifts, A., & Pīrāgs, V. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.260 · Cited by 2 · see citing works
Interleukin-6 gene −572 G > C polymorphism and myocardial infarction risk
Ding, H.-G., Yin, Y.-W., & Liu, S.-L. (2020) · Open Medicine · doi:10.1515/med-2020-0407 · Cited by 1 · see citing works
Keshmiri, A., Derakhshan, A. R., Fazlinejad, A., & Faridhosseini, R. (2019) · Nepalese Heart Journal · doi:10.3126/njh.v16i1.23896 · Cited by 1 · see citing works
The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress
Kaplan, M., Yavuz, F., Davutoğlu, V., Yüce, M., Dönmez, Y., & Abacıoğlu, Ö. Ö. (2019) · European Journal of Therapeutics · doi:10.5152/eurjther.2019.19063 · Cited by 1 · see citing works
Is interleukin-6 circulating levels associated with coronary artery disease?
Liu, C. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.015 · Cited by 1 · see citing works
- Authors
- Bennet, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Bennet, A
- ORCID
- Bennet, A
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 171
- Issue
- 2
- Pages
- 359-367
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1983297804
- Cited by
- 113
- References
- 30
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 10
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjärt-Lungfonden
- Vetenskapsrådet
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- interleukin-6, myocardial infarction, IL-6 promoter polymorphism, serum IL-6, C-reactive protein, hypercholesterolemia, genetic susceptibility, inflammation, insulin resistance, insulin, metabolic syndrome, cardiovascular risk
- MeSH terms
- C-Reactive Protein, Female, Genetic Markers, Genotype, Humans, Male, Myocardial Infarction, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Cohort Studies, Interleukin-6, Incidence, Survival Rate, Case-Control Studies, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
