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Cited by 59

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

IL-6 and the acute phase response in murine atherosclerosis

Song, Li, Schindler, Christian·2004·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2004.06.018
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Abstract

Numerous studies have implicated C-reactive protein (CRP) and the acute phase response (APR) in the development of atherosclerotic heart disease. Interleukin (IL)-6, which regulates both CRP expression and the APR, has also been identified as a risk factor for heart disease. To more directly evaluate the role of IL-6 in the development of atherosclerosis, IL-6 knockout mice were crossed with atherosclerosis prone LDL receptor (LDL-R) knockout mice. Lesion development was evaluated on Chow, Western type and Paigen diets. As anticipated, the Paigen diet stimulated the expression of APR genes in LDL-R[-/-] mice, but not IL-6[-/-]/LDL-R[-/-] mice. Despite this difference in acute phase response, only modest and statistically not significant differences were noted in the development of atherosclerotic lesions in LDL-R[-/-] and IL-6[-/-]/LDL-R[-/-] mice. These observations suggest that IL-6 and the acute phase response may not play as significant role in atherogenesis as other studies have indicated.

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Crossref · 10.1016/j.atherosclerosis.2004.06.018

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Research works printed but not linked: 28

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Cited by

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Metadata

Authors
Song, L., & Schindler, C.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2004-11
Volume
177
Issue
1
Pages
43-51
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2004.06.018
Cited by
59
References
2
Language
en
Licence

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CoChat. (2026). Citation check: IL-6 and the acute phase response in murine atherosclerosis. https://app.cochat.ai/papers/10.1016/j.atherosclerosis.2004.06.018
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Song, L., & Schindler, C. (2004). IL-6 and the acute phase response in murine atherosclerosis. Atherosclerosis. https://doi.org/10.1016/j.atherosclerosis.2004.06.018