Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: A randomized, crossover, controlled, clinical trial
Abstract
The Mediterranean diet, in which olive oil is the main source of fat, has been associated with a reduced incidence of coronary heart disease (CHD) and low blood pressure levels. Virgin olive oil (VOO), besides containing monounsaturated fat, is rich in phenolic compounds (PC) with antioxidant properties. The aim of this study was to examine the antioxidant and anti-hypertensive effect of two similar olive oils, but with differences in their PC (refined: 14.7 mg/kg versus virgin: 161.0 mg/kg), in 40 males with stable CHD. The study was a placebo controlled, crossover, randomized trial. A raw daily dose of 50 mL of VOO and refined olive oil (ROO) were sequentially administered over two periods of 3 weeks, preceded by 2-week washout periods in which ROO was used. Lower plasma oxidized LDL (p < 0.001) and lipid peroxide levels (p = 0.003), together with higher activities of glutathione peroxidase (p = 0.033), were observed after VOO intervention. Systolic blood pressure decreased after intake of VOO (p = 0.001) in hypertensive patients. No changes were observed in diastolic blood pressure, glucose, lipids, and antibodies against oxidized LDL. Consumption of VOO, rich in PC, could provide beneficial effects in CHD patients as an additional and complementary intervention to the pharmacological treatment.
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Several studies have shown a decrease in the ability of LDL to be oxidized after consumption of polyphenol-rich EVOO.
“Beside PREDIMED, several studies have shown a decrease in the ability of LDL to be oxidized after consumption of polyphenol-rich EVOO [209,210]”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [210]
Cites
Adherence to a Mediterranean diet and survival in a Greek population
Trichopoulou, A., Costacou, T., Bamia, C., & Trichopoulos, D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025039 · Cited by 4,397 · see citing works
The oxidation hypothesis of atherosclerosis
Witztum, J. L. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92346-9 · Cited by 1,394 · see citing works
The role of oxidized lipoproteins in atherogenesis
Berliner, J. A., & Heinecke, J. W. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02173-6 · Cited by 1,365 · see citing works
Ehara, S., Ueda, M., Naruko, T., Haze, K., Itoh, A., Otsuka, M., Komatsu, R., Matsuo, T., Itabe, H., Takano, T., et al. (2001) · Circulation · doi:10.1161/01.cir.103.15.1955 · Cited by 780 · see citing works
The antioxidant/anticancer potential of phenolic compounds isolated from olive oil
Owen, R. W., Giacosa, A., Hull, W. E., Haubner, R., Spiegelhalder, B., & Bartsch, H. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00103-9 · Cited by 723 · see citing works
Holvoet, P., Vanhaecke, J., Janssens, S., de Werf, F. V., & Collen, D. (1998) · Circulation · doi:10.1161/01.cir.98.15.1487 · Cited by 673 · see citing works
Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease
Blankenberg, S., Rupprecht, H. J., Bickel, C., Torzewski, M., Hafner, G., Tiret, L., Smieja, M., Cambien, F., Meyer, J., & Lackner, K. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030535 · Cited by 596 · see citing works
Owen, R. W., Mier, W., Giacosa, A., Hull, W. E., Spiegelhalder, B., & Bartsch, H. (2000) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00061-2 · Cited by 577 · see citing works
Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish Men
Elosua, R., Marrugat, J., Molina, L., Pons, S., & Pujol, E. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116966 · Cited by 499 · see citing works
Parthasarathy, S., Khoo, J., Miller, E., Barnett, J., Witztum, J. L., & Steinberg, D. (1990) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.87.10.3894 · Cited by 474 · see citing works
Leikert, J. F., Räthel, T. R., Wohlfart, P., Cheynier, V., Vollmar, A. M., & Dirsch, V. M. (2002) · Circulation · doi:10.1161/01.cir.0000034445.31543.43 · Cited by 424 · see citing works
Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents
Visioli, F., Bellomo, G., Montedoro, G. F., & Galli, C. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05546-9 · Cited by 422 · see citing works
Monounsaturated Fatty Acids and Risk of Cardiovascular Disease
Kris‐Etherton, P. M. (1999) · Circulation · doi:10.1161/01.cir.100.11.1253 · Cited by 397 · see citing works
Olive Oil and Reduced Need for Antihypertensive Medications
Ferrara, L. A., Raimondi, A. S., d'Episcopo, L., Guida, L., Russo, A. D., & Marotta, T. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.6.837 · Cited by 288 · see citing works
Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels
Guzik, T. J., West, N. E. J., Pillai, R. G., Taggart, D. P., & Channon, K. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000018041.48432.b5 · Cited by 264 · see citing works
and the members of the SOLOS Investigators*, Marrugat, J., Covas, M.-I., Fitó, M., Schröder, H., Miró-Casas, E., Gimeno, E., López-Sabater, M. C., de la Torre, R., & Farré, M. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0452-8 · Cited by 259 · see citing works
Self-citationSchröder, H., Covas, M.-I., Marrugat, J., Vila, J., PENA, A., Alcantara, M., & Masià, R. (2001) · Clinical Nutrition · doi:10.1054/clnu.2001.0460 · Cited by 232 · see citing works
Gimeno, E., Castellote, A. I., Lamuela-Raventós, R. M., de la Torre-Boronat, M. C., & López‐Sabater, M. C. (2002) · Food Chemistry · doi:10.1016/s0308-8146(01)00399-5 · Cited by 202 · see citing works
Olive Phenol Hydroxytyrosol Prevents Passive Smoking–Induced Oxidative Stress
Visioli, F., Galli, C., Plasmati, E., Viappiani, S., Hernandez, A., Colombo, C., & Sala, A. (2000) · Circulation · doi:10.1161/01.cir.102.18.2169 · Cited by 192 · see citing works
Protective effect of olive oil and its phenolic compounds against low density lipoprotein oxidation
Fitó, M., Covas, M. I., Lamuela-Raventós, R. M., Vila, J., Torrents, J., de la Torre, C., & Marrugat, J. (2000) · Lipids · doi:10.1007/s11745-000-0567-1 · Cited by 189 · see citing works
Masella, R., Varı́, R., D’Archivio, M., Benedetto, R. D., Scazzocchio, B., Giovannini, C., Matarrese, P., & Malorni, W. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.785 · Cited by 185 · see citing works
Reaven, P. D., Grasse, B. J., & Tribble, D. L. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.4.557 · Cited by 181 · see citing works
Hypertension and coronary heart disease
Escobar, E. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001345 · Cited by 179 · see citing works
Wiseman, S. A., Mathot, J. N. J. J., de Fouw, N. J., & Tijburg, L. B. M. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05656-4 · Cited by 172 · see citing works
rrez, V. R.-G., Muriana, F. J. G., Guerrero, A., Cert, A. M., & Villar, J. (1996) · Journal of Hypertension · doi:10.1097/00004872-199612000-00016 · Cited by 168 · see citing works
High oxidative stress in patients with stable coronary heart disease
Weinbrenner, T., Cladellas, M., Covas, M. I., Fitó, M., Tomás, M., Sentı́, M., Bruguera, J., & Marrugat, J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00053-4 · Cited by 154 · see citing works
Ramírez-Tortosa, M. C., Urbano, G., López-Jurado, M., Nestares, T., Gómez, M. C., MIR, A., Ros, E., Mataix, J., & Gil, Á. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2177 · Cited by 151 · see citing works
Miró‐Casas, E., Farré, M., Covas, M., Rodriguez, J. O., Colomer, E. M., Lamuela-Raventós, R. M., & de la Torre, R. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5160 · Cited by 150 · see citing works
Mata, P., Varela, O., Rodrigo Alonso, K., Lahoz, C., de Oya, M., & Badimón, L. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2088 · Cited by 116 · see citing works
Comparison of conventional and fast gas chromatography in human plasma fatty acid determination
Bondia‐Pons, I., Castellote, A. I., & López‐Sabater, M. C. (2004) · Journal of Chromatography B · doi:10.1016/j.jchromb.2004.07.002 · Cited by 88 · see citing works
Gimeno, E., Calero, E., Castellote, A. I., Lamuela-Raventós, R. M., de la Torre-Boronat, M. C., & López‐Sabater, M. C. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)00272-7 · Cited by 85 · see citing works
Waddington, E. I., Croft, K. D., Sienuarine, K., Latham, B. I., & Puddey, I. B. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00391-x · Cited by 76 · see citing works
Nicolaı̈ew, N., Lemort, N., Adorni, L., Berra, B., Montorfano, G., Rapelli, S., Cortesi, N., & JACOTOT, B. (1998) · Annals of Nutrition and Metabolism · doi:10.1159/000012741 · Cited by 75 · see citing works
Changing the Mediterranean Diet: Effects on Blood Pressure
Strazzullo, P., Ferro-Luzzi, A., Siani, A., Scaccini, C., Sette, S., Catasta, G., & Mancini, M. (1986) · Journal of Hypertension · doi:10.1097/00004872-198608000-00003 · Cited by 75 · see citing works
Effect of phenol-rich extra virgin olive oil on markers of oxidation in healthy volunteers
Vissers, M. N., Zock, P. L., Wiseman, S. A., Meyboom, S., & Katan, M. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601161 · Cited by 68 · see citing works
Herrera, M. D., Pérez‐Guerrero, C., Marhuenda, E., & Ruiz-Gutiéerrez, V. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001397 · Cited by 58 · see citing works
Postprandial and short‐term effects of dietary virgin olive oil on oxidant/antioxidant status
Fitó, M., Gimeno, E., Covas, M., Miró‐Casas, E., López‐Sabater, M. C., Farré, M., de la Torre, R., & Marrugat, J. (2002) · Lipids · doi:10.1007/s11745-002-0887-1 · Cited by 50 · see citing works
Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients With Coronary Artery Disease
Blankenberg, S., Rupprecht, H. J., Bickel, C., Torzewski, M., Hafner, G., Tiret, L., Smieja, M., Cambien, F., Meyer, J., & Lackner, K. J. (2004) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000119183.22237.1b · Cited by 49 · see citing works
Covas, M.-I., Fitó, M., Lamuela-Raventós, R. M., Sebastià, N., de la Torre-Boronat, C., & Marrugat, J. (2000) · PubMed · Cited by 47 · see citing works
Moschandreas, J. A., Vissers, M. N., Wiseman, S. A., van Putte, K. P. A. M., & Kafatos, A. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601444 · Cited by 43 · see citing works
Virgin olive and fish oils enhance the hepatic antioxidant defence system in atherosclerotic rabbits
Aguilera, C. M., Mesa, M. D., Ramírez-Tortosa, M. C., Quiles, J. L., & Gil, Á. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(03)00038-4 · Cited by 36 · see citing works
Dulak, J., Polus, M., Guevara, I., Hartwich, J., Wybrańska, I., Krzesz, R., & Dembinska-Kiec, A. (1999) · PubMed · Cited by 22 · see citing works
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Cited by
Sorted by citations
Mediterranean Diet and Mild Cognitive Impairment
Scarmeas, N., Stern, Y., Mayeux, R., Manly, J. J., Schupf, N., & Luchsinger, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.536 · Cited by 757 · see citing works
Valuable Nutrients and Functional Bioactives in Different Parts of Olive (Olea europaea L.)—A Review
Ghanbari, R., Anwar, F., Alkharfy, K. M., Gilani, A. H., & Saari, N. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13033291 · Cited by 611 · see citing works
Bioactive Compounds and Quality of Extra Virgin Olive Oil
Jiménez-López, C., Carpena, M., Lourenço‐Lopes, C., Gallardo‐Gómez, M., Lorenzo, J. M., Barba, F. J., Prieto, M. A., & Simal‐Gándara, J. (2020) · Foods · doi:10.3390/foods9081014 · Cited by 527 · see citing works
López-Miranda, J., Pérez-Jiménez, F., Ros, E., De Caterina, R., Badimón, L., Covas, M. I., Escrich, E., Ordovás, J. M., Soriguer, F., Abiá, R., et al. (2010) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.12.007 · Cited by 520 · see citing works
Self-citationBiological Activities of Phenolic Compounds Present in Virgin Olive Oil
Cicerale, S., Lucas, L., & Keast, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11020458 · Cited by 449 · see citing works
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Khurana, S., Venkataraman, K., Hollingsworth, A., Piché, M., & Tai, T. C. (2013) · Nutrients · doi:10.3390/nu5103779 · Cited by 438 · see citing works
Mediterranean Diet, Alzheimer Disease, and Vascular Mediation
Scarmeas, N., Stern, Y., Mayeux, R. P., & Luchsinger, J. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.12.noc60109 · Cited by 434 · see citing works
Olive oil and the cardiovascular system
Covas, M. I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.010 · Cited by 401 · see citing works
Mediterranean diet and health status: Active ingredients and pharmacological mechanisms
Schwingshackl, L., Morze, J., & HOFFMANN, G. E. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14778 · Cited by 393 · see citing works
The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor
D’Oria, R., Schipani, R., Leonardini, A., Natalicchio, A., Perrini, S., Cignarelli, A., Laviola, L., & Giorgino, F. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5732956 · Cited by 387 · see citing works
Chemistry and Health of Olive Oil Phenolics
Cicerale, S., Conlan, X. A., Sinclair, A. J., & Keast, R. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701856223 · Cited by 335 · see citing works
Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis
Grattagliano, I., Palmieri, V. O., Portincasa, P., Moschetta, A., & Palasciano, G. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.011 · Cited by 296 · see citing works
Diet and Alzheimer’s disease risk factors or prevention: the current evidence
Solfrizzi, V., Panza, F., Frisardi, V., Seripa, D., Logroscino, G., Imbimbo, B. P., & Pilotto, A. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.56 · Cited by 298 · see citing works
Salas-Salvadó, J., Garcia-Arellano, A., Estruch, R., Marquez-Sandoval, F., Corella, D., Fiol, M., Gómez-Gracia, E., Viñoles, E., Arós, F., Herrera, C., et al. (2008) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602762 · Cited by 295 · see citing works
Chatzi, L., Apostolaki, G., Bibakis, I., Skypala, I. J., Bibaki‐Liakou, V., Tzanakis, Ν., Kogevinas, M., & Cullinan, P. (2007) · Thorax · doi:10.1136/thx.2006.069419 · Cited by 287 · see citing works
Sharifi‐Rad, J., Rodrigues, C. F., Sharopov, F. S., Docea, A. O., Karaça, A. C., Sharifi‐Rad, M., Kahveci, D., Gülseren, G., Şenol, E., Demircan, E., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072326 · Cited by 295 · see citing works
Covas, M., de la Torre‐Carbot, K., Farré, M., Kaikkonen, J., Fitó, M., López‐Sabater, M. C., Pujadas, M., Joglar, J., Weinbrenner, T., Lamuela-Raventós, R. M., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.09.027 · Cited by 284 · see citing works
Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood
Chatzi, L., Torrent, M., Romieu, I., García‐Esteban, R., Ferrer, C., Vioqué, J., Kogevinas, M., & Sunyer, J. (2008) · Thorax · doi:10.1136/thx.2007.081745 · Cited by 280 · see citing works
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
“Beside PREDIMED, several studies have shown a decrease in the ability of LDL to be oxidized after consumption of polyphenol-rich EVOO [209,210], although the true contribution of such modifications to CVD risk reduction remains elusive [208].”
BackgroundHydroxytyrosol: A natural compound with promising pharmacological activities
Bertelli, M., Kiani, A. K., Paolacci, S., Manara, E., Kurti, D., Dhuli, K., Bushati, V., Miertuš, J., Pangallo, D., Baglivo, M., et al. (2019) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2019.12.016 · Cited by 272 · see citing works
Martín‐Peláez, S., Covas, M. I., Fitó, M., Kušar, A., & Pravst, I. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200421 · Cited by 260 · see citing works
The influence of olive oil on human health: not a question of fat alone
Pérez‐Jiménez, F., Ruano, J., Pérez‐Martínez, P., Lopez‐Segura, F., & López‐Miranda, J. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600273 · Cited by 257 · see citing works
Ditano-Vázquez, P., Torres-Peña, J. D., Valle, F. G., Pérez-Caballero, A. I., Rodríguez, P. D., López‐Miranda, J., Katsiki, N., Delgado‐Lista, J., & Alvarez-Sala-Walther, L. A. (2019) · Nutrients · doi:10.3390/nu11112833 · Cited by 242 · see citing works
Inflammation, obesity and comorbidities: the role of diet
Bulló, M., Casas‐Agustench, P., Amigó‐Correig, P., Bartrina, J. A., & Salas‐Salvadó, J. (2007) · Public Health Nutrition · doi:10.1017/s1368980007000663 · Cited by 233 · see citing works
Extra virgin olive oil: More than a healthy fat
Yubero‐Serrano, E. M., López-Moreno, J., Gómez-Delgado, F., & López‐Miranda, J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0304-x · Cited by 226 · see citing works
Minor Components of Olive Oil: Evidence to Date of Health Benefits in Humans
Covas, M.-I., Ruíz-Gutiérrez, V., de la Torre, R., Kafatos, A., Lamuela-Raventós, R. M., Osada, J., Owen, R. W., & Visioli, F. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00260.x · Cited by 209 · see citing works
Sánchez, C. S., Troncoso, A. M., García-Parrilla, M. C., Granados, J. J. Q., de la Serrana, H. L. G., & Martínez, M. C. L. (2007) · Analytica Chimica Acta · doi:10.1016/j.aca.2007.04.037 · Cited by 202 · see citing works
Hutcheson, R., & Ročić, P. (2012) · Experimental Diabetes Research · doi:10.1155/2012/271028 · Cited by 200 · see citing works
Nutrigenomics of extra‐virgin olive oil: A review
Piroddi, M., Albini, A., Fabiani, R., Giovannelli, L., Luceri, C., Natella, F., Rosignoli, P., Rossi, T., Taticchi, A., Servili, M., et al. (2016) · BioFactors · doi:10.1002/biof.1318 · Cited by 200 · see citing works
Gaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187 · see citing works
Nutraceutical therapies for atherosclerosis
Moss, J. W. E., & Ramji, D. P. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.103 · Cited by 186 · see citing works
Fitó, M., Cladellas, M., de la Torre, R., Martí‐Almor, J., Muñoz, D., Schröder, H., Alcantara, M., Pujadas, M., Marrugat, J., López‐Sabater, M. C., et al. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602724 · Cited by 185 · see citing works
Adherence to a Mediterranean diet and Alzheimer’s disease risk in an Australian population
Gardener, S. L., Gu, Y., Rainey‐Smith, S. R., Keogh, J. B., Clifton, P. M., Mathieson, S., Taddei, K., Mondal, A., Ward, V., Scarmeas, N., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.91 · Cited by 183 · see citing works
Rietjens, S. J., Bast, A., & Haenen, G. R. M. M. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0706934 · Cited by 180 · see citing works
Mozaffarian, D., Marfisi, R., Levantesi, G., Silletta, M. G., Tavazzi, L., Tognoni, G., Valagussa, F., & Marchioli, R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61343-9 · Cited by 179 · see citing works
Virgin olive oil: a key food for cardiovascular risk protection
Covas, M., de la Torre, R., & Fitó, M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000136 · Cited by 174 · see citing works
George, E. S., Marshall, S., Mayr, H. L., Trakman, G., Tatucu-Babet, O. A., Lassemillante, A. M., Bramley, A. L., Reddy, A. J., Forsyth, A. K., Tierney, A. C., et al. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1470491 · Cited by 171 · see citing works
Varı́, R., D’Archivio, M., Filesi, C., Carotenuto, S., Scazzocchio, B., Santangelo, C., Giovannini, C., & Masella, R. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.03.008 · Cited by 171 · see citing works
Effects of dietary factors on oxidation of low-density lipoprotein particles
Lapointe, A., Couillard, C., & Lemieux, S. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.01.001 · Cited by 169 · see citing works
Olive oil and cardiovascular health
Covas, M.-I., Konstantinidou, V., & Fitó, M. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181c5e7fd · Cited by 158 · see citing works
Rodríguez-Morató, J., Boronat, A., Kotronoulas, A., Pujadas, M., Pastor, A., Olesti, E., Pérez‐Mañá, C., Khymenets, O., Fitó, M., Farré, M., et al. (2016) · Drug Metabolism Reviews · doi:10.1080/03602532.2016.1179754 · Cited by 157 · see citing works
Nutrition and human health from a sex–gender perspective
Marino, M., Masella, R., Bulzomi, P., Campesi, I., Malorni, W., & Franconi, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.02.001 · Cited by 152 · see citing works
Olive oil and oxidative stress
Fitó, M., de la Torre, R., & Covas, M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600308 · Cited by 143 · see citing works
Nutritional and biological properties of extra virgin olive oil
Frankel, E. N. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103813t · Cited by 143 · see citing works
de la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Nurmi, T., Poulsen, H. E., Gaddi, A. V., Kaikkonen, J., Zunft, H.-F., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.112912 · Cited by 132 · see citing works
Antioxidants in Sport Nutrition
Lamprecht, M. (2014) · CRC Press eBooks · doi:10.1201/b17442 · Cited by 133 · see citing works
Tomé‐Carneiro, J., & Visioli, F. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.10.018 · Cited by 132 · see citing works
Bayram, B., Özçelik, B., Grimm, S., Roeder, T., Schrader, C., Ernst, I. M. A., Wagner, A. E., Grune, T., Frank, J., & Rimbach, G. H. (2012) · Rejuvenation Research · doi:10.1089/rej.2011.1245 · Cited by 129 · see citing works
Martín‐Peláez, S., Mosele, J. I., Pizarro, N., Farràs, M., de la Torre, R., Subirana, I., Pérez-Cano, F. J., Castañer, O., Solà, R., Fernández‐Castillejo, S., et al. (2015) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s00394-015-1063-2 · Cited by 124 · see citing works
Antioxidant Activity of Olive Polyphenols in Humans: a Review
Raederstorff, D. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.3.152 · Cited by 122 · see citing works
Hohmann, C. D., Cramer, H., Michalsen, A., Keßler, C. S., Steckhan, N., Choi, K., & Dobos, G. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.03.019 · Cited by 114 · see citing works
Effects of olive oil polyphenols on erythrocyte oxidative damage
Paiva‐Martins, F., Fernandes, J. C., Rocha, S., Nascimento, H., Vitorino, R. M. P., Amado, F. M. L., Borges, F., Belo, L., & Santos‐Silva, A. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800276 · Cited by 114 · see citing works
Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review.
Fitó, M., de la Torre, R., Farré, M., Khymenetz, O., Marrugat, J., & Covas, M. (2007) · PubMed · Cited by 112 · see citing works
Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation
Ahmadi, A., Jamialahmadi, T., & Sahebkar, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106414 · Cited by 111 · see citing works
Valls, R. M., Farràs, M., Suárez, M., Fernández‐Castillejo, S., Fitó, M., Konstantinidou, V., Fuentes, F. J., López‐Miranda, J., Giralt, M., Covas, M., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.06.107 · Cited by 106 · see citing works
Cardiovascular friendly natural products: a promising approach in the management of CVD
Shukla, S. K., Gupta, S., Ojha, S. K., & Sharma, S. B. (2010) · Natural Product Research · doi:10.1080/14786410903417378 · Cited by 102 · see citing works
Research in Olive Oil: Challenges for the Near Future
García‐González, D. L., & Aparicio, R. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102735n · Cited by 99 · see citing works
Olive Polyphenols and the Metabolic Syndrome
Saibandith, B., Spencer, J. P. E., Rowland, I. R., & Commane, D. M. (2017) · Molecules · doi:10.3390/molecules22071082 · Cited by 93 · see citing works
Mediterranean Diet in Predementia and Dementia Syndromes
Solfrizzi, V., Frisardi, V., Seripa, D., Logroscino, G., Imbimbo, B. P., D’Onofrio, G., Addante, F., Sancarlo, D., Cascavilla, L., Pilotto, A., et al. (2011) · Current Alzheimer Research · doi:10.2174/156720511796391809 · Cited by 91 · see citing works
Effects of Enrichment of Refined Olive Oil with Phenolic Compounds from Olive Leaves
Paiva‐Martins, F., Correia, R., Félix, S., Ferreira, P., & Gordon, M. H. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf063093y · Cited by 91 · see citing works
Oliveras‐López, M., Muros, J. J., Mir, M. V., Rey, E. F., Martín, F., & de la Serrana, H. L.-G. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.04.002 · Cited by 91 · see citing works
Harper, C. R., Edwards, M. C., & Jacobson, T. A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.11.2844 · Cited by 89 · see citing works
Bagetta, D., Maruca, A., Lupia, A., Mesiti, F., Catalano, R., Romeo, I., Moraca, F., Ambrosio, F. A., Costa, G., Artese, A., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111903 · Cited by 100 · see citing works
Scoditti, E., Capurso, C. A., Capurso, A., & Massaro, M. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.07.001 · Cited by 87 · see citing works
Schwingshackl, L., Krause, M., Schmucker, C. M., HOFFMANN, G. E., Rücker, G., & Meerpohl, J. J. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.07.001 · Cited by 87 · see citing works
Suárez, M., Romero, M., Macià, A., Valls, R. M., Fernández‐Castillejo, S., Solà, R., & Motilva, M. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.10.025 · Cited by 85 · see citing works
Farràs, M., Martínez-Gili, L., Portune, K. J., Arranz, S., Frost, G. S., Tondo, M., & Blanco‐Vaca, F. (2020) · Nutrients · doi:10.3390/nu12082200 · Cited by 84 · see citing works
Phenolic Profile and Antioxidant Activity of Italian Monovarietal Extra Virgin Olive Oils
Negro, C., Aprile, A., Luvisi, A., Nicolì, F., Nutricati, E., Vergine, M., Miceli, A., Blando, F., Sabella, E., & Bellis, L. D. (2019) · Antioxidants · doi:10.3390/antiox8060161 · Cited by 82 · see citing works
Toda, N., & Okamura, T. (2016) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.07.001 · Cited by 80 · see citing works
Virgin olive oil in preventive medicine: From legend to epigenetics
Caramia, G., Gori, A., Valli, E., & Cerretani, L. (2012) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201100164 · Cited by 79 · see citing works
The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial
Castañer, O., Fitó, M., López‐Sabater, M. C., Poulsen, H. E., Nyyssönen, K., Schröder, H., Salonen, J. T., de la Torre‐Carbot, K., Zunft, H.-F., de la Torre, R., et al. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.01.013 · Cited by 78 · see citing works
Faveri, D. D., Aliakbarian, B., Avogadro, M., Perego, P., & Converti, A. (2008) · Biochemical Engineering Journal · doi:10.1016/j.bej.2008.04.007 · Cited by 77 · see citing works
Jiménez‐Sánchez, A., Martínez-Ortega, A. J., Remón-Ruiz, P., Piñar-Gutiérrez, A., Cunill, J. L. P., & García‐Luna, P. P. (2022) · Nutrients · doi:10.3390/nu14071440 · Cited by 76 · see citing works
Sousa, A., Casal, S. I. P., Malheiro, R., Lamas, H., Bento, A. A., & Pereira, J. A. (2014) · LWT · doi:10.1016/j.lwt.2014.08.026 · Cited by 76 · see citing works
de la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Fitó, M., Covas, M., Muñoz‐Aguayo, D., & López‐Sabater, M. C. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.10.029 · Cited by 76 · see citing works
Gimeno, E., de la Torre‐Carbot, K., Lamuela-Raventós, R. M., Castellote, A. I., Fitó, M., de la Torre, R., Covas, M., & López‐Sabater, M. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507778698 · Cited by 76 · see citing works
Cândido, F. G., Valente, F. X., da Silva, L. E., Coelho, O. G. L., Pelúzio, M. D. C. G., & Alfenas, R. D. C. G. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1517-9 · Cited by 76 · see citing works
Omar, S. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112797 · Cited by 76 · see citing works
Acetylation of hydroxytyrosol enhances its transport across differentiated Caco-2 cell monolayers
Mateos, R., Pereira‐Caro, G., Saha, S., Cert, R., Redondo‐Horcajo, M., Bravo, L., & Kroon, P. A. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.09.054 · Cited by 70 · see citing works
Wang, X., Li, H., Zheng, A., Yang, L., Liu, J., Chen, C., Tang, Y., Zou, X., Li, Y., Long, J., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.473 · Cited by 69 · see citing works
Khymenets, O., Fitó, M., Covas, M.-I., Farré, M., Pujadas, M.-A., Muñoz, D., Konstantinidou, V., & Torre, R. D. L. (2009) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2008.0079 · Cited by 68 · see citing works
Rosenblat, M., Volkova, N., Coleman, R., Almagor, Y., & Aviram, M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.007 · Cited by 68 · see citing works
Effects of Olive Oil on Blood Pressure: Epidemiological, Clinical, and Mechanistic Evidence
Massaro, M., Scoditti, E., Carluccio, M. A., Calabriso, N., Santarpino, G., Verri, T., & Caterina, R. D. (2020) · Nutrients · doi:10.3390/nu12061548 · Cited by 71 · see citing works
Martín‐Peláez, S., Castañer, O., Konstantinidou, V., Subirana, I., Muñoz‐Aguayo, D., Blanchart, G., Gaixas, S., de la Torre, R., Farré, M., Sáez, G. T., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1110-z · Cited by 67 · see citing works
Squalene: a multi-task link in the crossroads of cancer and aging
Ronco, Á. L., & Stéfani, E. D. (2013) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v3i12.30 · Cited by 65 · see citing works
Castro-Rodríguez, J. A., García‐Marcos, L., Sánchez‐Solís, M., Pérez‐Fernández, V., Martínez-Torres, A., & Mallol, J., V (2010) · Pediatric Pulmonology · doi:10.1002/ppul.21205 · Cited by 63 · see citing works
D’Angelo, C., Franceschelli, S., Quiles, J. L., & Speranza, L. (2020) · Cells · doi:10.3390/cells9091932 · Cited by 63 · see citing works
Paiva‐Martins, F., Fernandes, J. C., Santos, V. P., Silva, L. M., Borges, F., Rocha, S., Belo, L., & Santos‐Silva, A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9031052 · Cited by 61 · see citing works
What's in Placebos: Who Knows? Analysis of Randomized, Controlled Trials
Golomb, B. A., Erickson, L. C., Koperski, S., Sack, D., Enkin, M. W., & Howick, J. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-8-201010190-00010 · Cited by 61 · see citing works
Hydroxytyrosol in Foods: Analysis, Food Sources, EU Dietary Intake, and Potential Uses
Gallardo-Fernández, M., Gonzalez‐Ramirez, M., Cerezo, A. B., Troncoso, A. M., & García-Parrilla, M. C. (2022) · Foods · doi:10.3390/foods11152355 · Cited by 55 · see citing works
Schmidt, L., Prestes, O. D., Augusti, P. R., & Moreira, J. C. F. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102626 · Cited by 55 · see citing works
A quantum chemical study on the free radical scavenging activity of tyrosol and hydroxytyrosol
Galano, A., Alvarez-Idaboy, J. R., Francisco‐Márquez, M., & Medina, M. E. (2012) · Theoretical Chemistry Accounts · doi:10.1007/s00214-012-1173-3 · Cited by 52 · see citing works
Alcaide‐Hidalgo, J. M., Romero, M., Duarte, J., & López‐Huertas, E. (2020) · Nutrients · doi:10.3390/nu12010271 · Cited by 50 · see citing works
Nadifiyine, S., Haddam, M., Mandli, J., Chadel, S., Calas‐Blanchard, C., Marty, J., & Amine, A. (2013) · Analytical Letters · doi:10.1080/00032719.2013.811679 · Cited by 47 · see citing works
Rozati, M., Barnett, J. B., Wu, D., Handelman, G. J., Saltzman, E. J., Wilson, T. A., Li, L., Wang, J., Marcos, A., Ordovás, J. M., et al. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0022-5 · Cited by 46 · see citing works
Giacco, R., Costabile, G., Fatati, G., Frittitta, L., Maiorino, M. I., Marelli, G., Parillo, M., Pistis, D., Tubili, C., Vetrani, C., et al. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.11.015 · Cited by 45 · see citing works
Olive oil consumption and its repercussions on lipid metabolism
Tomé‐Carneiro, J., Crespo, M. C., Hazas, M. L. D. L., Visioli, F., & Dávalos, A. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa014 · Cited by 45 · see citing works
Sarapis, K., Thomas, C. J., Hoskin, J., George, E. S., Marx, W., Mayr, H. L., Kennedy, G., Pipingas, A., Willcox, J. C., Prendergast, L. A., et al. (2020) · Nutrients · doi:10.3390/nu12082272 · Cited by 45 · see citing works
Effects of antioxidant-rich foods on vascular reactivity: Review of the clinical evidence
Kay, C. D., Kris‐Etherton, P. M., & West, S. G. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0027-7 · Cited by 45 · see citing works
Diamantakos, P., Ioannidis, K., Papanikolaοu, C., Tsolakou, A., Rigakou, A., Melliou, E., & Magiatis, P. (2021) · Molecules · doi:10.3390/molecules26041115 · Cited by 44 · see citing works
- Authors
- Fitó, M., Cladellas, M., de la Torre, R., Martí, J., Alcántara, M., Pujadas-Bastardes, M., Marrugat, J., Bruguera, J., López-Sabater, M. C., Vila, J., & Covas, M. I.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Hospital Del Mar (ES)
- Corresponding author
- Covas, M.I.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 181
- Issue
- 1
- Pages
- 149-158
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2149294300
- Cited by
- 258
- References
- 42
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 8 · 2020: 19 · 2019: 21 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 15 · 2014: 14 · 2013: 12 · 2012: 12
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- virgin olive oil, coronary artery disease, antioxidant activity, phenolic compounds, oxidized LDL, lipid peroxidation, glutathione peroxidase, blood pressure, hypertension, refined olive oil, Mediterranean diet, dietary intervention
- MeSH terms
- Olive Oil, Aged, Antioxidants, Blood Pressure, Coronary Disease, Dietary Fats, Unsaturated, Glutathione Peroxidase, Humans, Lipoproteins, LDL, Male, Plant Oils, Lipid Peroxidation, Cross-Over Studies
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