Cited by 90Diabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular HealthLipid metabolism and disorders

Remnant lipoproteinemia is a risk factor for endothelial vasomotor dysfunction and coronary artery disease in metabolic syndrome.

Nakamura, Takamitsu, Takano, Hajime, Umetani, Ken, Kawabata, Ken-ichi, Obata, Jyun-ei, Kitta, Yoshinobu, Kodama, Yasushi, Mende, Akira +4 more·2005·Atherosclerosis

Abstract

This study aimed to determine whether elevated levels of remnant lipoprotein, an atherogenic triglyceride-rich lipoprotein, might be associated with coronary artery disease (CAD) and endothelial vasomotor dysfunction in metabolic syndrome. The fasting serum levels of remnant lipoproteins (remnant-like lipoprotein particles cholesterol; RLP-C) were measured by an immunoseparation method in 210 patients with metabolic syndrome meeting ATP III criteria. Flow-mediated endothelium-dependent dilatation (FMD) in the brachial artery during reactive hyperemia was examined by high-resolution ultrasound technique. This study found that elevated RLP-C levels were a significant and independent risk factor for impaired FMD and angiographically proven coronary artery disease (CAD). Treatment with bezafibrate (n = 20) or atorvastatin (n = 20) for 4 weeks significantly reduced RLP-C levels, with a concomitant improvement in FMD. The % reduction in RLP-C levels from baseline after the treatment was independently correlated with the magnitude of improvement in FMD after adjustment for the % changes in levels of triglyceride, hsCRP, and IL-6, and HOMA index. Thus, elevated levels of RLP-C are a risk factor for CAD and endothelial vasomotor dysfunction, a predictor of coronary events, in metabolic syndrome. Measurement of RLP-C is useful for assessment of CAD risk and therapeutic effects in metabolic syndrome.

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Crossref · 10.1016/j.atherosclerosis.2005.01.012

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Authors
Nakamura, T., Takano, H., Umetani, K., Kawabata, K.-I., Obata, J.-E., Kitta, Y., Kodama, Y., Mende, A., Ichigi, Y., Fujioka, D., Saito, Y., & Kugiyama, K.
Affiliations
University of Yamanashi (JP)
Corresponding author
Kugiyama, Kiyotaka
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2005-08
Volume
181
Issue
2
Pages
321-327
ISSN
0021-9150 (ISSN-L)
OpenAlex
W1992204797
Cited by
90
References
31
Citations by year
2026: 2 · 2025: 7 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 6 · 2013: 4 · 2012: 7
FWCI
3.28
Type
journal article
Language
en
Open access
closed
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
Smoking Research Foundation
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
metabolic syndrome, coronary artery disease, endothelial dysfunction, flow-mediated dilation, triglyceride-rich lipoproteins, bezafibrate, atorvastatin, cardiovascular risk factors, atherogenic lipoproteins
MeSH terms
Atorvastatin, Aged, Anticholesteremic Agents, Hypolipidemic Agents, Bezafibrate, Cholesterol, Coronary Artery Disease, Endothelium, Vascular, Female, Heptanoic Acids, Humans, Hyperlipoproteinemias, Lipoproteins, Male, Middle Aged, Pyrroles, Risk Factors, Triglycerides, Vasodilation, Biomarkers, Metabolic Syndrome

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