Remnant lipoproteinemia is a risk factor for endothelial vasomotor dysfunction and coronary artery disease in metabolic syndrome.
Abstract
This study aimed to determine whether elevated levels of remnant lipoprotein, an atherogenic triglyceride-rich lipoprotein, might be associated with coronary artery disease (CAD) and endothelial vasomotor dysfunction in metabolic syndrome. The fasting serum levels of remnant lipoproteins (remnant-like lipoprotein particles cholesterol; RLP-C) were measured by an immunoseparation method in 210 patients with metabolic syndrome meeting ATP III criteria. Flow-mediated endothelium-dependent dilatation (FMD) in the brachial artery during reactive hyperemia was examined by high-resolution ultrasound technique. This study found that elevated RLP-C levels were a significant and independent risk factor for impaired FMD and angiographically proven coronary artery disease (CAD). Treatment with bezafibrate (n = 20) or atorvastatin (n = 20) for 4 weeks significantly reduced RLP-C levels, with a concomitant improvement in FMD. The % reduction in RLP-C levels from baseline after the treatment was independently correlated with the magnitude of improvement in FMD after adjustment for the % changes in levels of triglyceride, hsCRP, and IL-6, and HOMA index. Thus, elevated levels of RLP-C are a risk factor for CAD and endothelial vasomotor dysfunction, a predictor of coronary events, in metabolic syndrome. Measurement of RLP-C is useful for assessment of CAD risk and therapeutic effects in metabolic syndrome.
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Metabolic products of triglyceride-rich lipoproteins are atherogenic.
“In contrast, there is no doubt that metabolic products of triglyceride-rich lipoproteins are atherogenic (140 -142).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [141]
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Self-citation
- Authors
- Nakamura, T., Takano, H., Umetani, K., Kawabata, K.-I., Obata, J.-E., Kitta, Y., Kodama, Y., Mende, A., Ichigi, Y., Fujioka, D., Saito, Y., & Kugiyama, K.
- Affiliations
- University of Yamanashi (JP)
- Corresponding author
- Kugiyama, Kiyotaka
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 181
- Issue
- 2
- Pages
- 321-327
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1992204797
- Cited by
- 90
- References
- 31
- Citations by year
- 2026: 2 · 2025: 7 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 6 · 2013: 4 · 2012: 7
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Smoking Research Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- metabolic syndrome, coronary artery disease, endothelial dysfunction, flow-mediated dilation, triglyceride-rich lipoproteins, bezafibrate, atorvastatin, cardiovascular risk factors, atherogenic lipoproteins
- MeSH terms
- Atorvastatin, Aged, Anticholesteremic Agents, Hypolipidemic Agents, Bezafibrate, Cholesterol, Coronary Artery Disease, Endothelium, Vascular, Female, Heptanoic Acids, Humans, Hyperlipoproteinemias, Lipoproteins, Male, Middle Aged, Pyrroles, Risk Factors, Triglycerides, Vasodilation, Biomarkers, Metabolic Syndrome
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