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Cited by 67Lipoproteins and Cardiovascular HealthInflammatory Biomarkers in Disease PrognosisAdipokines, Inflammation, and Metabolic Diseases

Inflammatory markers and long-term risk of ischemic heart disease in men

St-Pierre, Annie C., Cantin, Bernard, Bergeron, Jean, Pirro, Matteo, Dagenais, Gilles R., Després, Jean-Pierre, Lamarche, Benoît·2005·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2005.02.009
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Abstract

We tested the hypothesis that elevated plasma interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen concentrations are independent risk factors and interact in increasing the long-term risk of ischemic heart disease (IHD) in men. A total of 1982 IHD-free men from the Quebec Cardiovascular Study were followed over a period of 13 years during which 210 first fatal IHD events and non-fatal myocardial infarctions were recorded. Increased CRP levels (4th versus 1st quartile) were not associated with an increased risk of IHD after adjustment for non-lipid risk factors (age, body mass index, systolic blood pressure, diabetes, smoking and medication use at baseline), lipid risk factors (LDL and HDL cholesterol and triglyceride levels) and for IL-6 and fibrinogen (RR=0.70, 95% CI=0.43-1.13). High plasma IL-6 levels (4th versus 1st quartile) were associated with a 70% greater risk of IHD independent of confounding risk factors and of the other 2 inflammatory markers (RR=1.71, 95% CI=1.07-2.75). The relationship between high fibrinogen levels (4th versus 1st quartile) and IHD risk was borderline significant in multivariate analyses (RR=1.53, 95% CI=0.97-2.43). An inflammation score based on plasma IL-6 and fibrinogen levels improved the IHD risk predictive value of a multivariate model of traditional risk factors (p=0.03). Including plasma CRP levels into the inflammatory score provided no additional predictive value. In conclusion, elevated plasma IL-6 concentrations are more strongly related to IHD risk than CRP and fibrinogen. An inflammation score based on high plasma IL-6 and fibrinogen levels used in combination with traditional risk factors may improve our ability to adequately identify high risk individuals.

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  • C-reactive protein may serve as a useful prognostic tool and as a marker of long-term mortality in patients with acute MI.

    “C-reactive protein, a heavily studied serum marker of inflammation, may serve as a useful prognostic tool and as a marker of long-term mortality in patients with acute MI (329, 332).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [329]

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Authors
St-Pierre, A. C., Cantin, B., Bergeron, J., Pirro, M., Dagenais, G. R., Després, J.-P., & Lamarche, B.
Affiliations
  • Université Laval (CA)
  • Centre hospitalier de l'Université Laval (CA)
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2005-10
Volume
182
Issue
2
Pages
315-321
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2005.02.009
OpenAlex
W69281787
Cited by
67
References
30
Citations by year
2026: 1 · 2021: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
9.83
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Heart and Stroke Foundation of Canada
  • Canada Research Chairs
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
ischemic heart disease, interleukin-6, C-reactive protein, fibrinogen, inflammatory markers, inflammation score, myocardial infarction, cardiovascular risk prediction, men
MeSH terms
Adult, C-Reactive Protein, Cholesterol, Fibrinogen, Follow-Up Studies, Humans, Male, Middle Aged, Quebec, Risk Factors, Biomarkers, Interleukin-6, Myocardial Ischemia

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