Cited by 144Sleep and Work-Related FatigueWorkplace Health and Well-beingHealthcare Systems and Public Health

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The relation of exposure to shift work with atherosclerosis and myocardial infarction in a general population

Haupt, Christiane M., Alte, Dietrich, Dörr, Marcus, Robinson, Daniel M., Felix, Stephan B., John, Ulrich, Völzke, Henry·2008·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2007.12.059

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Abstract

Objectives We tested the hypothesis that working shifts is related to atherosclerosis and myocardial infarction.Background The number of shift workers is continuously increasing. Shift work is discussed to be related with cardiovascular heart disease.Methods A total of 2510 subjects recruited for the population-based Study of Health in Pomerania were tested, 698 of whom were former shift workers. A general population sample was examined to reach generalizibility and to produce results independent from the effects of the personal shift schedule and from the specific working conditions. Carotid ultrasound was performed to evaluate carotid intima-media thickness. We used multivariable analyses to estimate the coronary heart disease risk, adjusted for age, sex and atherosclerotic risk factors, stratified by exposure to shift work and its duration.Results Atherosclerotic risk factors differed in part between shift workers and non-shift workers. Shift work was associated with atherosclerosis and myocardial infarction, depending on the duration of the exposure and the age of the participants. Multivariable Cox regression analysis identified shift work as a risk factor for myocardial infarction to be manifest at younger ages (adjusted hazard ratio 1.53, 95% CI 1.06-2.22).Conclusions Exposure to shift work is a risk factor for atherosclerosis and myocardial infarction. Special prevention programs for shift workers should be provided.

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Authors: Haupt, C. M., Alte, D., Dörr, M., Robinson, D. M., Felix, S. B., John, U., & Völzke, H.
Affiliations: Universität Greifswald (DE)
Corresponding author: Haupt, Christiane M.
ORCID: Dörr, Marcus
Felix, Stephan B.
John, Ulrich
Völzke, Henry
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2008-11
Volume: 201
Issue: 1
Pages: 205-211
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2007.12.059
OpenAlex: W2061102470
Cited by: 144
References: 28
Citations by year: 2026: 4 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 11
FWCI: 12.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung (01ZZ96030)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Workplace Health and Well-being
Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Keywords: shift work, myocardial infarction, carotid intima-media thickness, coronary heart disease risk, cardiovascular risk factors, exposure duration, young age at onset, Study of Health in Pomerania
MeSH terms: Age Factors, Aged, Circadian Rhythm, Cross-Sectional Studies, Employment, Female, Germany, Humans, Life Style, Male, Middle Aged, Myocardial Infarction, Occupational Diseases, Risk Factors, Stress, Physiological, Time Factors, Case-Control Studies, Photoperiod, Atherosclerosis

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The relation of exposure to shift work with atherosclerosis and myocardial infarction in a general population

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