Cited by 192Circadian rhythm and melatoninSleep and Work-Related FatigueDietary Effects on Health

Circadian disruption and metabolic disease: Findings from animal models

Open access
Arble, Deanna Marie, Ramsey, Kathryn Moynihan, Bass, Joseph, Turek, Fred W.·2010·Best Practice & Research Clinical Endocrinology & Metabolism

Abstract

Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one. This voluntarily decision to stay awake long into the evening hours leads to circadian disruption at the system, tissue, and cellular levels. These derangements are in turn associated with clinical impairments in metabolic processes and physiology. The use of animal models for circadian disruption provides an important opportunity to determine mechanisms by which disorganization in the circadian system can lead to metabolic dysfunction in response to genetic, environmental, and behavioral perturbations. Here we review recent key animal studies involving circadian disruption and discuss the possible translational implications of these studies for human health and particularly for the development of metabolic disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.beem.2010.08.003

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Arble, D. M., Ramsey, K. M., Bass, J., & Turek, F. W.
Affiliations
Northwestern University (US)
Corresponding author
Turek, Fred W.
Venue
Best Practice & Research Clinical Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2010-10
Volume
24
Issue
5
Pages
785-800
ISSN
1521-690X (ISSN-L)
OpenAlex
W2043741320
Cited by
192
References
94
Citations by year
2026: 5 · 2025: 17 · 2024: 12 · 2023: 11 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 16 · 2016: 12 · 2015: 14 · 2014: 8 · 2013: 14 · 2012: 18
FWCI
1.26
Type
journal article
Language
en
Open access
Locations
  • Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • e-Publications@Marquette (Marquette University) (submittedVersion)
Funders
  • National Institute on Aging (P01AG011412)
  • National Heart, Lung, and Blood Institute (T32HL007909)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
circadian rhythm disruption, metabolic disorders, animal models, nocturnal activity, circadian system, metabolic dysfunction, translational research
MeSH terms
Animals, Biological Clocks, Brain, Circadian Rhythm, Disease Models, Animal, Humans, Metabolic Diseases, Models, Biological, Photoperiod, Sleep Disorders, Circadian Rhythm

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review