Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial
Abstract
Aims Coronary artery disease (CAD) is associated with endothelial dysfunction and mitochondrial dysfunction (MD). The aim of this study was to investigate whether co-enzyme Q10 (CoQ) supplementation, which is an obligatory coenzyme in the mitochondrial respiratory transport chain, can reverse MD and improve endothelial function in patients with ischaemic left ventricular systolic dysfunction (LVSD).Methods and results We performed a randomized, double-blind, placebo-controlled trial to determine the effects of CoQ supplement (300 mg/day, n=28) vs. placebo (controls, n=28) for 8 weeks on brachial flow-mediated dilation (FMD) in patients with ischaemic LVSD(left ventricular ejection fraction <45%). Mitochondrial function was determined by plasma lactate/pyruvate ratio (LP ratio). After 8 weeks, CoQ-treated patients had significant increases in plasma CoQ concentration (treatment effect 2.20 μg/mL, P<0.001) and FMD (treatment effect 1.51%, P=0.03); and decrease in LP ratio (treatment effect -2.46, P=0.03) compared with controls. However, CoQ treatment did not alter nitroglycerin-mediated dilation, blood pressure, blood levels of fasting glucose, haemoglobin A1c, lipid profile, high-sensitivity C-reactive protein and oxidative stress as determined by serum superoxide dismutase and 8-isoprostane (all P>0.05). Furthermore, the reduction in LP ratio significantly correlated with improvement in FMD (r=-0.29, P=0.047).Conclusion In patients with ischaemic LVSD, 8 weeks supplement of CoQ improved mitochondrial function and FMD; and the improvement of FMD correlated with the change in mitochondrial function, suggesting that CoQ improved endothelial function via reversal of mitochondrial dysfunction in patients with ischaemic LVSD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Mitochondrial Dysfunction in Atherosclerosis
Madamanchi, N. R., & Runge, M. S. (2007) · Circulation Research · doi:10.1161/01.res.0000258450.44413.96 · Cited by 794 · see citing works
Endothelial Function in Obstructive Sleep Apnea and Response to Treatment
Ip, M. S. M., Tse, H.-F., Lam, B., Tsang, K. W. T., & Lam, W.-K. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200306-767oc · Cited by 615 · see citing works
Self-citationLate prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain
Neunteufl, T., Heher, S., Katzenschlager, R., Wölfl, G., Kostner, K., Maurer, G., & Weidinger, F. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00857-2 · Cited by 553 · see citing works
Ballinger, S. W., Patterson, C., Yan, C.-N., Doan, R., Burow, D. L., Young, C. G., Yakes, F. M., Houten, B. V., Ballinger, C. A., Freeman, B. Α., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.9.960 · Cited by 442 · see citing works
Chan, S., Mancini, G. B. J., Kuramoto, L., Schulzer, M., Frohlich, J. J., & Ignaszewski, A. P. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00927-6 · Cited by 326 · see citing works
Yeşilova, Z., Yaman, H., Öktenli, Ç., Özcan, A., Uygun, A., Çakır, E., Sanisoğlu, S. Y., Erdil, A., Ateş, Y., Aslan, M., et al. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41500.x · Cited by 290 · see citing works
DE PINIEUX, G., CHARIOT, P., AMMI‐SAÏD, M., LOUARN, F., LEJONC, J. L., ASTIER, A., JACOTOT, B., & GHERARDI, R. (1996) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1996.04178.x · Cited by 262 · see citing works
Hodgson, J., Watts, G. F., Playford, D. A., Burke, V., & Croft, K. D. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601464 · Cited by 253 · see citing works
Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials
Rosenfeldt, F., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J.-Y., & Watts, G. F. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002138 · Cited by 246 · see citing works
Shimbo, D., Grahame-Clarke, C., Miyake, Y., Rodriguez, C., Sciacca, R., Di Tullio, M., Boden-Albala, B., Sacco, R., & Homma, S. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.005 · Cited by 219 · see citing works
Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z., Uyeminami, D. L., Pinkerton, K. E., Ischiropoulos, H., & Ballinger, S. W. (2002) · Circulation · doi:10.1161/hc0702.103977 · Cited by 217 · see citing works
Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus
Watts, G. F., Playford, D. A., Croft, K. D., Ward, N. C., Mori, T. A., & Burke, V. (2002) · Diabetologia · doi:10.1007/s00125-001-0760-y · Cited by 193 · see citing works
Coenzyme Q10 and exercise training in chronic heart failure
Belardinelli, R., Muçaj, A., Lacalaprice, F., Solenghi, M., Seddaiu, G., Principi, F., Tiano, L., & Littarru, G. P. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl158 · Cited by 167 · see citing works
Coenzyme Q10 in cardiovascular disease
Pepe, S., Marasco, S., Haas, S. J., Sheeran, F. L., Krum, H., & Rosenfeldt, F. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.005 · Cited by 165 · see citing works
The Impact of Coenzyme Q10 on Systolic Function in Patients With Chronic Heart Failure
Sander, S. D., Coleman, C. I., Patel, A., Kluger, J., & White, C. M. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.03.007 · Cited by 159 · see citing works
Tiano, L., Belardinelli, R., Carnevali, P., Principi, F., Seddaiu, G., & Littarru, G. P. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm267 · Cited by 153 · see citing works
Clinical presentations and laboratory investigations in respiratory chain deficiency
Münnich, A., Rötig, A., Chrétien, D., Saudubray, J., Cormier‐Daire, V., & Rustin, P. (1996) · European Journal of Pediatrics · doi:10.1007/bf02002711 · Cited by 147 · see citing works
Rosenfeldt, F., Marasco, S., Lyon, W. J., Wowk, M., Sheeran, F. L., Bailey, M., Esmore, D. S., Davis, B. B., Pick, A., Rabinov, M., et al. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.03.034 · Cited by 131 · see citing works
Coenzyme Q10 Improves Endothelial Dysfunction in Statin-Treated Type 2 Diabetic Patients
Hamilton, S. J., Chew, G. T., & Watts, G. F. (2009) · Diabetes Care · doi:10.2337/dc08-1736 · Cited by 120 · see citing works
Alleva, R., Tomasetti, M., Battino, M. A., CURATOLA, G., Littarru, G. P., & Folkers, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9388 · Cited by 118 · see citing works
Mortensen, S. A. (2003) · BioFactors · doi:10.1002/biof.5520180210 · Cited by 109 · see citing works
Coenzyme Q10 Concentrations in Normal and Pathological Human Seminal Fluid
MANCINI, A., Marinis, L. D., ORADEI, A., et al. (1994) · Journal of Andrology · doi:10.1002/j.1939-4640.1994.tb00504.x · Cited by 77 · see citing works
Chan, Y., Lau, K. K., Yiu, K., Li, S.-W., Chan, H.-T., Fong, D., Tam, S., LAU, C., & Tse, H. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn409 · Cited by 75 · see citing works
Self-citationChariot, P., Monnet, I., Mouchet, M., Rohr, M., Lefaucheur, J., Dubreuil‐Lemaire, M., Chousterman, M., & Gherardi, R. K. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370421 · Cited by 55 · see citing works
Luk, T.-H., Dai, Y.-L., Siu, C., Yiu, K., Chan, H.-T., Fong, D., Lee, S. W. L., Li, S.-W., Tam, S., Lau, C., et al. (2009) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32832b38be · Cited by 53 · see citing works
Self-citationKaikkonen, J., Nyyssönen, K., Tomasi, A., Iannone, A., Tuomainen, T., Porkkala-Sarataho, E., & Salonen, J. T. (2000) · Free Radical Research · doi:10.1080/10715760000301501 · Cited by 51 · see citing works
Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure
Belardinelli, R., Muçaj, A., Lacalaprice, F., Solenghi, M., Principi, F., Tiano, L., & Littarru, G. P. (2005) · BioFactors · doi:10.1002/biof.5520250115 · Cited by 46 · see citing works
Lim, S. C., Lekshminarayanan, R., Goh, S. K., Ong, Y. Y., Subramaniam, T., Sum, C. F., Ong, C. N., & Lee, B. L. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.012 · Cited by 42 · see citing works
Dai, Y.-L., Luk, T.-H., Siu, C., Yiu, K., Chan, H.-T., Lee, S. W. L., Li, S.-W., Tam, S., Fong, B. M.-W., Lau, C., et al. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9071-1 · Cited by 28 · see citing works
Self-citationKuettner, A., Pieper, A. G., Koch, J., et al. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.01.004 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)
Cirilli, I., Damiani, E., Dludla, P. V., Hargreaves, I., Marcheggiani, F., Millichap, L. E., Orlando, P., Silvestri, S., & Tiano, L. (2021) · Antioxidants · doi:10.3390/antiox10081325 · Cited by 115 · see citing works
Huo, J., Xu, Z., Hosoe, K., Kubo, H., Miyahara, H., Dai, J., Mori, M., Sawashita, J., & Higuchi, K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3181759 · Cited by 87 · see citing works
Olivieri, F., Lazzarini, R., Babini, L., Prattichizzo, F., Rippo, M. R., Tiano, L., Di Nuzzo, S., Graciotti, L., Festa, R., Brugè, F., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.033 · Cited by 84 · see citing works
Cicero, A. F. G., Grassi, D., Tocci, G., Galletti, F., Borghi, C., & Ferri, C. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-018-0296-6 · Cited by 79 · see citing works
Pek, S. L., Tavintharan, S., Woon, K., Lin, L., Ong, C. N., Lim, S. C., & Sum, C. F. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370215605588 · Cited by 26 · see citing works
Kovacic, S., Habicht, S. D., & Eckert, G. P. (2025) · Journal of Nutritional Science · doi:10.1017/jns.2025.10043 · Cited by 4 · see citing works
- Authors
- Dai, Y.-L., Luk, T.-H., Yiu, K.-H., Wang, M., Yip, P. M. C., Lee, S. W. L., Li, S.-W., Tam, S., Fong, B., Lau, C.-P., Siu, C.-W., & Tse, H.-F.
- Affiliations
- University of Hong Kong (HK)
- Tung Wah Hospital (CN)
- Queen Mary Hospital (CN)
- Corresponding author
- Tse, Hung-Fat
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 216
- Issue
- 2
- Pages
- 395-401
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2042702713
- Cited by
- 104
- References
- 31
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 11 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 6
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- CRCG Small Project Funding of University of Hong Kong (200907176063)
- Sun Chieh Yeh Heart Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- coenzyme Q10 supplementation, mitochondrial dysfunction, endothelial dysfunction, coronary artery disease, flow-mediated dilation, lactate/pyruvate ratio, mitochondrial function, nitric oxide bioavailability
- MeSH terms
- Aged, Blood Pressure, Brachial Artery, Cross-Sectional Studies, Double-Blind Method, Endothelium, Vascular, Female, Nitroglycerin, Humans, Male, Middle Aged, Placebos, Risk Factors, Superoxide Dismutase, Ubiquinone, Dinoprost, Ventricular Dysfunction, Left, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
