Lipid‐lowering drugs and mitochondrial function: effects of HMG‐CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge

Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works

The Metabolic Basis of Inherited Disease.

(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-503_7 · Cited by 7,807 · see citing works

HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia

Oates, J. A., Wood, A. J. J., & Grundy, S. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807073190105 · Cited by 760 · see citing works

Myopathy and Rhabdomyolysis Associated With Lovastatin-Gemfibrozil Combination Therapy

Pierce, L. R. (1990) · JAMA · doi:10.1001/jama.1990.03450010075034 · Cited by 425 · see citing works

Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy.

Ogasahara, S., Engel, A. G., Frens, D. B., & Mack, D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2379 · Cited by 365 · see citing works

Evidence of Plasma CoQ10‐Lowering Effect by HMG‐CoA Reductase Inhibitors: A Double‐Blind, Placebo‐Controlled Study

Ghirlanda, G., Oradei, A., Manto, A., Lippa, S., Uccioli, L., Caputo, S., Greco, A. V., & Littarru, G. P. (1993) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1993.tb03948.x · Cited by 324 · see citing works

Comparison of current methods for high-density lipoprotein cholesterol quantitation.

Warnick, G. R., Cheung, M. C., & Albers, J. J. (1979) · Clinical Chemistry · doi:10.1093/clinchem/25.4.596 · Cited by 224 · see citing works

HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies.

Smith, P. F., Eydelloth, R. S., Grossman, S. J., Stubbs, R. J., Schwartz, M. S., Germershausen, J. I., Vyas, K. P., Kari, P. H., & MacDonald, J. S. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24759-0 · Cited by 146 · see citing works

In Vitro Myotoxicity of the 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors, Pravastatin, Lovastatin, and Simvastatin, Using Neonatal Rat Skeletal Myocytes

Masters, B. A., Palmoski, M. J., Flint, O. P., Gregg, R. E., Wang‐Iverson, D. B., & Durham, S. K. (1995) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1995.1058 · Cited by 132 · see citing works

Coenzyme Q 10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease

Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A. L., Karpati, G., Andermann, F., & Arnold, D. L. (1993) · Neurology · doi:10.1212/wnl.43.5.884 · Cited by 125 · see citing works

Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin.

Watts, G. F., Castelluccio, C., Rice-Evans, C. A., Taub, N. A., Baum, H., & Quinn, P. J. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.11.1055 · Cited by 109 · see citing works

Pravastatin-Associated Inflammatory Myopathy

Schalke, B. C. G., Schmidt, B. L., Toyka, K. V., & Hartung, H. ‐. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208273270919 · Cited by 104 · see citing works

Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors

Laaksonen, R., Ojala, J.-P., Tikkanen, M. J., & Himberg, J. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00194398 · Cited by 94 · see citing works

Determination of reduced and total ubiquinones in biological materials by liquid chromatography with electrochemical detection

Okamoto, T., Fukunaga, Y., Ida, Y., & Kishi, T. (1988) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)83129-1 · Cited by 82 · see citing works

Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.

Elmberger, P. G., Kalén, A., Lund, E. G., Reihnér, E., Eriksson, M., Berglund, L., Angelin, B., & Dallner, G. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41990-x · Cited by 72 · see citing works

Experimental Lovastatin Myopathy

Waclawik, A. J., Lindal, S., & Engel, A. G. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199309000-00012 · Cited by 67 · see citing works

LOVASTATIN, ISOPRENES, AND MYOPATHY

Walravens, P., Greene, C. L., & Frerman, F. E. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91108-2 · Cited by 66 · see citing works

Rhabdomyolysis and Simvastatin

Deslypère, J. P., & Vermeulen, A. T. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-4-342_1 · Cited by 57 · see citing works

Determination of the blood lactate:pyruvate ratio as a noninvasive test for the diagnosis of zidovudine myopathy

Chariot, P., Monnet, I., Mouchet, M., Rohr, M., Lefaucheur, J., Dubreuil‐Lemaire, M., Chousterman, M., & Gherardi, R. K. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370421 · Cited by 55 · see citing works

Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells.

Maltese, W. A., & Aprille, J. R. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39062-2 · Cited by 53 · see citing works

Experimental simvastatin-induced myopathy in rabbits

Nakahara, K., Kuriyama, M., Yoshidome, H., Nagata, K., Nagado, T., Nakagawa, M., Arimura, K., Higuchi, I., & Osame, M. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90273-n · Cited by 44 · see citing works

Effects of mevinolin treatment on tissue dolichol and ubiquinone levels in the rat

Lőw, P., Andersson, M., Edlund, C., & Dallner, G. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90081-6 · Cited by 42 · see citing works

Mitochondrial myopathy ?A result of clofibrate/etofibrate treatment?

Bardosi, A., Scheidt, P., & Goebel, H. (1985) · Acta Neuropathologica · doi:10.1007/bf00688640 · Cited by 16 · see citing works

A comparison of the effects of simvastatin and pravastatin monotherapy on muscle histology and permeability in hypercholesterolaemic patients.

Contermans, J., Smit, J. W. A., Bär, P. R., & Erkelens, D. W. (1995) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1995.tb04420.x · Cited by 11 · see citing works

Cholesterol lowering agent myopathy

Karasoy, H., Yüceyar, N., ŞİRİN, H., & Ara̧c, N. (2001) · Cited by 6 · see citing works

The epidemiology of Parkinson's disease: risk factors and prevention

Ascherio, A., & Schwarzschild, M. A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30230-7 · Cited by 1,843 · see citing works

Statin-associated myopathy

Thompson, P. D., Clarkson, P., & Karas, R. H. (2003) · JAMA · doi:10.1001/jama.289.13.1681 · Cited by 1,463 · see citing works

Statin Toxicity

Ward, N. C., Watts, G. F., & Eckel, R. H. (2019) · Circulation Research · doi:10.1161/circresaha.118.312782 · Cited by 772 · see citing works

The toxicology of perfluorooctanoate

Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742 · see citing works

Statin Adverse Effects: A Review of the Literature and Evidence for a Mitochondrial Mechanism

Golomb, B. A., & Evans, M. A. (2008) · American Journal of Cardiovascular Drugs · doi:10.2165/0129784-200808060-00004 · Cited by 677 · see citing works

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions

Shitara, Y., & Sugiyama, Y. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.03.003 · Cited by 574 · see citing works

Subchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys

Seacat, A. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.249 · Cited by 564 · see citing works

The Role of Coenzyme Q10 in Statin-Associated Myopathy

Marcoff, L., & Thompson, P. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.049 · Cited by 537 · see citing works

Rhabdomyolysis: A review

Warren, J. D., Blumbergs, P. C., & Thompson, P. D. (2002) · Muscle & Nerve · doi:10.1002/mus.10053 · Cited by 428 · see citing works

Resistance Exercise Reverses Aging in Human Skeletal Muscle

Melov, S., Tarnopolsky, M. A., Beckman, K. B., Felkey, K., & Hubbard, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000465 · Cited by 344 · see citing works

Effect of Coenzyme Q10 on myopathic symptoms in patients treated with statins

Caso, G., Kelly, P., McNurlan, M. A., & Lawson, W. E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.063 · Cited by 286 · see citing works

Toxicity of Ammonium Perfluorooctanoate in Male Cynomolgus Monkeys after Oral Dosing for 6 Months

Butenhoff, J. L. (2002) · Toxicological Sciences · doi:10.1093/toxsci/69.1.244 · Cited by 259 · see citing works

Effects of statins on mitochondrial pathways

Mollazadeh, H., Tavana, E., Fanni, G., Bo, S., Banach, M., Pirro, M., von Haehling, S., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12654 · Cited by 259 · see citing works

Low-density lipoprotein-independent effects of statins

Davignon, J., & Laaksonen, R. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199912000-00010 · Cited by 244 · see citing works

Chronic heart failure and micronutrients

Witte, K. K., Clark, A. L., & Cleland, J. G. F. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01227-x · Cited by 237 · see citing works

Human skeletal muscle drug transporters determine local exposure and toxicity of statins

Knauer, M. J., Urquhart, B. L., Meyer zu Schwabedissen, H. E., Schwarz, U. I., Lemke, C. J., Leake, B. F., Kim, R. B., & Tirona, R. G. (2010) · Circulation Research · doi:10.1161/circresaha.109.203596 · Cited by 222 · see citing works

New insights into mechanisms of statin-associated myotoxicity

Sirvent, P., Mercier, J. G., & Lacampagne, A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.010 · Cited by 190 · see citing works

Coenzyme Q10 and statins: Biochemical and clinical implications

Littarru, G. P., & Langsjoen, P. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.002 · Cited by 188 · see citing works

Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.

Fosslien, E. (2001) · PubMed · Cited by 186 · see citing works

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Proceedings of a Canadian Working Group Consensus Conference

Mancini, G. B. J., Baker, S. K., Bergeron, J., FITCHETT, D. H., Frohlich, J. J., Genest, J. J., Gupta, M., Hegele, R. A., Ng, D. S., & Pope, J. E. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.05.007 · Cited by 184 · see citing works

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis

Fotino, A. D., Thompson‐Paul, A. M., & Bazzano, L. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.040741 · Cited by 185 · see citing works

Comparative Tolerability of the HMG-CoA Reductase Inhibitors

Farmer, J. A., & Torre‐Amione, G. (2000) · Drug Safety · doi:10.2165/00002018-200023030-00003 · Cited by 181 · see citing works

Statin therapy is associated with lower mortality among patients with severe heart failure

Mozaffarian, D., Nye, R., & Levy, W. C. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.01.039 · Cited by 178 · see citing works

Coenzyme Q10 in cardiovascular disease

Pepe, S., Marasco, S., Haas, S. J., Sheeran, F. L., Krum, H., & Rosenfeldt, F. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.005 · Cited by 165 · see citing works

Rhabdomyolysis with HMG‐CoA reductase inhibitors and gemfibrozil combination therapy

Chang, J. T., Staffa, J. A., Parks, M. A., & Green, L. (2004) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.977 · Cited by 152 · see citing works

The role of mitochondria in statin‐induced myopathy

Apostolopoulou, M., Corsini, A., & Roden, M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12461 · Cited by 142 · see citing works

Molecular clues into the pathogenesis of statin‐mediated muscle toxicity

Baker, S. K. (2005) · Muscle & Nerve · doi:10.1002/mus.20291 · Cited by 139 · see citing works

Prospective Study of Statin Use and Risk of Parkinson Disease

Gao, X. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.1060 · Cited by 123 · see citing works

Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway

Do, R., Kiss, R., Gaudet, D., & Engert, J. C. (2008) · Clinical Genetics · doi:10.1111/j.1399-0004.2008.01099.x · Cited by 118 · see citing works

Reduction of Serum Ubiquinol-10 and Ubiquinone-10 Levels by Atorvastatin in Hypercholesterolemic Patients

Mabuchi, H., Higashikata, T., Kawashiri, M., Katsuda, S., Mizuno, M., Nohara, A., Inazu, A., Koizumi, J., & Kobayashi, J. (2005) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12.111 · Cited by 119 · see citing works

Ubiquinone: cholesterol's reclusive cousin

Hargreaves, I. P. (2003) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456303321610493 · Cited by 117 · see citing works

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

Kwak, H.-B., Thalacker-Mercer, A., Anderson, E. J., Lin, C.-T., Kane, D. A., Lee, N.-S., Cortright, R. N., Bamman, M. M., & Neufer, P. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.449 · Cited by 114 · see citing works

The clinical use of HMG CoA‐reductase inhibitors and the associated depletion of coenzyme Q ₁₀ . A review of animal and human publications

Langsjoen, P. H., & Langsjoen, A. M. (2003) · BioFactors · doi:10.1002/biof.5520180212 · Cited by 112 · see citing works

Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

Mohn, E. S., Kern, H., Saltzman, E. J., Mitmesser, S. H., & McKay, D. L. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10010036 · Cited by 116 · see citing works

Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors

Jamal, S. M., Eisenberg, M. J., & Christopoulos, S. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.12.037 · Cited by 111 · see citing works

Statin myotoxicity: a review of genetic susceptibility factors

Needham, M., & Mastaglia, F. L. (2014) · Neuromuscular Disorders · doi:10.1016/j.nmd.2013.09.011 · Cited by 108 · see citing works

Effects of Troglitazone on HepG2 Viability and Mitochondrial Function

Tirmenstein, M. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/69.1.131 · Cited by 110 · see citing works

The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions

Pallotti, F., Bergamini, C., Lamperti, C., & Fato, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010128 · Cited by 109 · see citing works

Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial

Dai, Y.-L., Luk, T.-H., Yiu, K.-H., Wang, M., Yip, P. M. C., Lee, S. W. L., Li, S.-W., Tam, S., Fong, B., Lau, C.-P., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.013 · Cited by 104 · see citing works

Coenzyme Q10 Supplementation and Heart Failure

Singh, U. S., Devaraj, S., & Jialal, I. (2007) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00306.x · Cited by 104 · see citing works

Statin‐associated myopathy and its exacerbation with exercise

Meador, B. M., & Huey, K. A. (2010) · Muscle & Nerve · doi:10.1002/mus.21817 · Cited by 98 · see citing works

Endothelium-ameliorating effects of statin therapy and coenzyme Q10 reductions in chronic heart failure

Strey, C. H., Young, J. M., Molyneux, S. L., George, P. M., Florkowski, C. M., Scott, R. S., & FRAMPTON, C. M. A. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.10.009 · Cited by 93 · see citing works

The Effect of HMG-CoA Reductase Inhibitors on Coenzyme Q10: Possible Biochemical/Clinical Implications

Hargreaves, I. P., Duncan, A. J., Heales, S. J. R., & Land, J. M. (2005) · Drug Safety · doi:10.2165/00002018-200528080-00002 · Cited by 91 · see citing works

Statin myopathies: pathophysiologic and clinical perspectives.

Baker, S. K., & Tarnopolsky, M. A. (2001) · PubMed · Cited by 90 · see citing works

Effect of Coenzyme Q10 supplementation on statin-induced myalgias

Bookstaver, D. A., Burkhalter, N. A., & Hatzigeorgiou, C. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.026 · Cited by 89 · see citing works

Mitochondrial Dysfunction as an Initiating Event in Atherogenesis: A Plausible Hypothesis

Puddu, P., Puddu, G. M., Galletti, L., Cravero, E., & Muscari, A. (2005) · Cardiology · doi:10.1159/000083440 · Cited by 87 · see citing works

Coenzyme Q10: is there a clinical role and a case for measurement?

Molyneux, S. L., Young, J. M., Florkowski, C. M., Lever, M., & George, P. M. (2008) · PubMed Central · Cited by 87 · see citing works

Effect of Ezetimibe and/or Simvastatin on Coenzyme Q10 Levels in Plasma

Berthold, H. K., Naini, A., Mauro, S. D., Hallikainen, M., Gylling, H. K., Krone, W., & Gouni‐Berthold, I. (2006) · Drug Safety · doi:10.2165/00002018-200629080-00007 · Cited by 86 · see citing works

Coronary heart disease in HIV-infected patients in the highly active antiretroviral treatment era

Vittecoq, D., Escaut, L., Chironi, G. N., Teicher, E., Monsuez, J. J., Andréjak, M., & Simon, A. C. (2003) · AIDS · doi:10.1097/00002030-200304001-00010 · Cited by 84 · see citing works

Statin-associated myopathy and the quest for biomarkers: can we effectively predict statin-associated muscle symptoms?

Muntean, D. M., Thompson, P. D., Catapano, A. L., Stasiolek, M., Fabis, J., Muntner, P., Serban, M.-C., & Banach, M. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.09.001 · Cited by 82 · see citing works

Clinical Implications of Pharmacogenetic Variation on the Effects of Statins

Maggo, S. D. S., Kennedy, M. A., & Clark, D. W. J. (2010) · Drug Safety · doi:10.2165/11584380-000000000-00000 · Cited by 82 · see citing works

HMG-CoA reductase inhibitors and coenzyme Q10

Nawarskas, J. J. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000154790.42283.a1 · Cited by 80 · see citing works

Understanding coenzyme Q

Wang, Y., Lilienfeldt, N., & Hekimi, S. (2024) · Physiological Reviews · doi:10.1152/physrev.00040.2023 · Cited by 83 · see citing works

From Mitochondria to Atherosclerosis: The Inflammation Path

Suarez-Rivero, J. M., Pastor‐Maldonado, C. J., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Talaverón-Rey, M., Suárez-Carrillo, A., Munuera-Cabeza, M., & Sánchez-Alcázar, J. A. (2021) · Biomedicines · doi:10.3390/biomedicines9030258 · Cited by 77 · see citing works

Statins induce calcium-dependent mitochondrial permeability transition

Velho, J. A., Okanobo, H., Degasperi, G. R., Matsumoto, M. Y., Alberici, L. C., Cosso, R. G., Oliveira, H. C. F., & Vercesi, A. E. (2005) · Toxicology · doi:10.1016/j.tox.2005.11.007 · Cited by 77 · see citing works

Presymptomatic Neuromuscular Disorders Disclosed Following Statin Treatment

Tsivgoulis, G. K., Spengos, K. M., Karandreas, N., Πάνας, Μ., Kladi, A., & Manta, P. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.14.1519 · Cited by 77 · see citing works

Roles of Exercise and Pharmacokinetics in Cerivastatin-Induced Skeletal Muscle Toxicity

Seachrist, J. L., Loi, C., Evans, M. G., Criswell, K. A., & Rothwell, C. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi305 · Cited by 77 · see citing works

The effect of pravastatin and atorvastatin on coenzyme Q10

Bleske, B. E., Willis, R. A., Anthony, M. J., Casselberry, N., Datwani, M., Uhley, V. E., Secontine, S. G., & Shea, M. J. (2001) · American Heart Journal · doi:10.1067/mhj.2001.116762 · Cited by 77 · see citing works

Squalene Synthase Induces Tumor Necrosis Factor Receptor 1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis

Yang, Y., Jan, Y., Liu, Y., Yang, C., Su, C., Chang, Y., Lai, T., Chiou, J., Tsai, H., Lu, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201404-0714oc · Cited by 75 · see citing works

Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes

Paniagua, J. A., López‐Miranda, J., Escribano, A., Berral, F. J., Marı́n, C., Bravo, D., Paz-Rojas, E., Gomez, P. J., Barcos, M., Moreno, J. A., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2596 · Cited by 74 · see citing works

Effects of ubiquinone (coenzyme Q10) on myopathy in statin users

Schaars, C. F., & Stalenhoef, A. F. H. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283168ecd · Cited by 74 · see citing works

Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury

Fu, Q., Huang, X., Shu, B., Xue, M., Zhang, P., Wang, T., Liu, L., Jiang, Z., & Zhang, L. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.08.019 · Cited by 71 · see citing works

Analysis of the Global RNA Expression Profiles of Skeletal Muscle Cells Treated with Statins

Morikawa, S., Murakami, T., Yamazaki, H., Izumi, A., Saitō, Y., Hamakubo, T., & Kodama, T. (2005) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12.121 · Cited by 70 · see citing works

Association between risk of myopathy and cholesterol-lowering effect: A comparison of all statins

Kobayashi, M., Chisaki, I., Narumi, K., Hidaka, K., Kagawa, T., Itagaki, S., Hirano, T., & Iseki, K. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.02.019 · Cited by 66 · see citing works

Treatment of hyperlipidemia in cardiac transplant recipients

Bilchick, K. C., Henrikson, C. A., Skojec, D. V., Kasper, E. K., & Blumenthal, R. S. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.03.050 · Cited by 66 · see citing works

Drug-Induced Mitochondrial Toxicity

Hargreaves, I. P., Shahrani, M. M. A., Wainwright, L., & Heales, S. (2016) · Drug Safety · doi:10.1007/s40264-016-0417-x · Cited by 63 · see citing works

Pharmacogenomics and Pharmacogenetics of Cholesterol-Lowering Therapy

Schmitz, G., & Drobnik, W. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.088 · Cited by 64 · see citing works

Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library

Tiziani, S., Kang, Y., Choi, J. S., Roberts, W., & Paternostro, G. (2011) · Nature Communications · doi:10.1038/ncomms1562 · Cited by 60 · see citing works

Lipid-Lowering Drugs: Are Adverse Effects Predictable and Reversible?

Muscari, A., Puddu, G. M., & Puddu, P. (2002) · Cardiology · doi:10.1159/000063326 · Cited by 59 · see citing works

Potential role of coenzyme Q10 in health and disease conditions

Rodick, T. C., Seibels, D. R., Babu, J. R., Huggins, K. W., Ren, G., & Mathews, S. T. (2018) · Nutrition and Dietary Supplements · doi:10.2147/nds.s112119 · Cited by 58 · see citing works

Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA

Passi, S., Stancato, A., Aleo, E., Dmitrieva, A., & Littarru, G. P. (2003) · BioFactors · doi:10.1002/biof.5520180213 · Cited by 57 · see citing works

Conceptual foundations of the UCSD Statin Study: a randomized controlled trial assessing the impact of statins on cognition, behavior, and biochemistry.

Golomb, B. A., Criqui, M. H., White, H., & Dimsdale, J. E. (2004) · PubMed · doi:10.1001/archinte.164.2.153 · Cited by 57 · see citing works

Polymyosites induites ou associées aux traitements hypolipémiants ?

Fauchais, A. L., Ba, J. I., Maurage, P., Kyndt, X., Bataille, D., HACHULLA, E., Parent, D., Queyrel, V., Lambert, M., Pasturel, U. M., et al. (2003) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2003.10.013 · Cited by 57 · see citing works

Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat

Garjani, A., Andalib, S., Biabani, S., Soraya, H., Doustar, Y., Garjani, A., & Maleki‐Dizaji, N. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.061 · Cited by 56 · see citing works

Statins in the treatment of chronic heart failure: Biological and clinical considerations

van der Harst, P., Voors, A. A., van Gilst, W. H., Böhm, M., & VANVELDHUISEN, D. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.04.011 · Cited by 55 · see citing works

Biochemistry of Statins

Egom, E. E. A., & Hafeez, H. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.10.005 · Cited by 54 · see citing works

Coenzyme Q10: A therapy for hypertension and statin-induced myalgia?

Wyman, M. J., Leonard, M. C., & Morledge, T. J. (2010) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.77a.09078 · Cited by 52 · see citing works

Rosuvastatin: Characterization of Induced Myopathy in the Rat

Westwood, F. R., Scott, R. C., Marsden, A. M., Bigley, A. L., & Randall, K. (2008) · Toxicologic Pathology · doi:10.1177/0192623307311412 · Cited by 51 · see citing works

Effects of Lipid-Lowering Drugs on Left Ventricular Function and Exercise Tolerance in Dyslipidemic Coronary Patients

de Lorgeril, M., Salen, P., Bontemps, L., Bélichard, P., GEYSSANT, A., & Itti, R. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199903000-00018 · Cited by 51 · see citing works

Implications of statin adverse effects in the elderly

Golomb, B. A. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.3.389 · Cited by 49 · see citing works

Statins and Modulation of Oxidative Stress

Bełtowski, J. (2005) · Toxicology Mechanisms and Methods · doi:10.1080/15376520590918766 · Cited by 49 · see citing works

Amyotrophic Lateral Sclerosis-Like Conditions in Possible Association with Cholesterol-Lowering Drugs

Golomb, B. A., Kwon, E. K., Koperski, S., & Evans, M. A. (2009) · Drug Safety · doi:10.2165/00002018-200932080-00004 · Cited by 48 · see citing works

Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation

Guardia, P. G. L., Alberici, L. C., Ravagnani, F. G., Catharino, R. R., & Vercesi, A. E. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00103 · Cited by 46 · see citing works

A Neuromuscular Approach to Statin-Related Myotoxicity

Baker, S. K., & Samjoo, I. A. (2008) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100007514 · Cited by 45 · see citing works

Coenzyme Q10 and Statin Myalgia: What is the Evidence?

Mas, E., & Mori, T. A. (2010) · Current Atherosclerosis Reports · doi:10.1007/s11883-010-0134-3 · Cited by 43 · see citing works

The effects of statins on exercise and physical activity

Noyes, A. M., & Thompson, P. D. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.07.003 · Cited by 44 · see citing works

Targeting cellular energy production in neurological disorders

Baker, S. K., & Tarnopolsky, M. A. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.10.1655 · Cited by 43 · see citing works

Coenzyme Q10 Alleviated Behavioral Dysfunction and Bioenergetic Function in an Animal Model of Depression

Andalib, S., Mashhadi-Mousapour, M., Bijani, S., & Hosseini, M.-J. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02761-0 · Cited by 43 · see citing works

Coronary Heart Disease in HIV-Infected Individuals

Vittecoq, D., Escaut, L., Merad, M., Teicher, E., Monsuez, J.-J., & Chironi, G. N. (2003) · KARGER eBooks · doi:10.1159/000073181 · Cited by 42 · see citing works

Protective Effects of Coenzyme Q10 on Decreased Oxidative Stress Resistance Induced by Simvastatin

Kettawan, A., Takahashi, T., Kongkachuichai, R., Charoenkiatkul, S., Kishi, T., & Okamoto, T. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.40.194 · Cited by 41 · see citing works

Considerations for Supplementing with Coenzyme Q 10 During Statin Therapy

Levy, H. B., & Kohlhaas, H. K. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1g409 · Cited by 37 · see citing works

Potential metabolic consequences of statins in sepsis*

Brealey, D. A., Singer, M., & Terblanche, M. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31820eb74f · Cited by 36 · see citing works

The controversy of a wider statin utilization: why?

Mansi, I. A., & Mortensen, E. M. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.779667 · Cited by 36 · see citing works

Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content

Goodman, C. A., Derk, P., Zacharewicz, E., Lee, R. S., Snow, R. J., Russell, A. P., & McConell, G. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128398 · Cited by 35 · see citing works

Reversible Atorvastatin-Associated External Ophthalmoplegia, Anti-acetylcholine Receptor Antibodies, and Ataxia

Negvesky, G. J., Kolsky, M. P., Laureno, R., & Yau, T. H. (2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.3.427 · Cited by 35 · see citing works

Efficacy and safety of Monascus purpureus Went rice in subjects with secondary hyperlipidemia

Gheith, O. A. A., Sheashaa, H., Abdelsalam, M. A. M., Shoeir, Z., & Sobh, M. A. K. (2008) · Clinical and Experimental Nephrology · doi:10.1007/s10157-008-0033-x · Cited by 35 · see citing works

Effects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo-controlled trial

Cai, Y., Xing, G., Tian, S., Zhang, S., Rao, J., & Shi, R. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0640-1 · Cited by 33 · see citing works

Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury

Sardão, V. A., Pereira, S. L., & Oliveira, P. J. (2008) · Expert Opinion on Drug Safety · doi:10.1517/14740338.7.2.129 · Cited by 33 · see citing works

Prosarcopenic Effects of Statins May Limit Their Effectiveness in Patients with Heart Failure

Bielecka-Dabrowa, A. M., Fabiś, J., Mikhailidis, D. P., von Haehling, S., Sahebkar, A., Rysz, J., & Banach, M. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.02.003 · Cited by 30 · see citing works

Biomarkers of Metabolism in Amyotrophic Lateral Sclerosis

Kirk, S. E., Tracey, T. J., Steyn, F. J., & Ngo, S. T. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00191 · Cited by 32 · see citing works

Decreased Ubiquinone Availability and Impaired Mitochondrial Cytochrome Oxidase Activity Associated With Statin Treatment

Duncan, A. J., Hargreaves, I. P., Damian, M. S., Land, J. M., & Heales, S. (2008) · Toxicology Mechanisms and Methods · doi:10.1080/15376510802305047 · Cited by 41 · see citing works

High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

PAIVA, H., THELEN, K., COSTER, R., SMET, J., PAEPE, B., MATTILA, K., LAAKSO, J., LEHTIMAKI, T., VONBERGMANN, K., & LUTJOHANN, D. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.03.006 · Cited by 308 · see citing works

Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans

Laaksonen, R., Jokelainen, K., Sahi, T., Tikkanen, M. J., & Himberg, J.-J. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90266-x · Cited by 177 · see citing works

Influence of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors on Ubiquinone Levels in Rat Skeletal Muscle and Heart: Relationship to Cytotoxicity and Inhibitory Activity for Cholesterol Synthesis in Human Skeletal Muscle Cells

Yamazaki, H., Suzuki, M., Aoki, T., Morikawa, S., Maejima, T., Sato, F., Sawanobori, K., Kitahara, M., Kodama, T., & Saitō, Y. (2006) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.13.295 · Cited by 25 · see citing works

A comparison of the effects of lovastatin and pravastatin on ubiquinone tissue levels in rats

Rousseau, G., Rosiers, C. D., & Varin, F. (1998) · Current Therapeutic Research · doi:10.1016/s0011-393x(98)85064-9 · Cited by 7 · see citing works