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Cited by 104Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

The DOI matches its Crossref record; 37 of the 39 references it cites were found in a registry or an index.

Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)

Iso, Hiroyasu, Imano, Hironori, Yamagishi, Kazumasa, Ohira, Tetsuya, Cui, Renzhe, Noda, Hiroyuki, Sato, Shinichi, Kiyama, Masahiko, Okada, Takeo, Hitsumoto, Shinichi, Tanigawa, Takeshi, Kitamura, Akihiko·2014·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2014.08.028
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Abstract

Background Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited.Methods We used 1975-1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40-69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (<8 h after meal) participants.Results During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14-2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25-2.05), P for trend <0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant.Conclusion Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.

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Crossref · 10.1016/j.atherosclerosis.2014.08.028

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Metadata

Authors
Iso, H., Imano, H., Yamagishi, K., Ohira, T., Cui, R., Noda, H., Sato, S., Kiyama, M., Okada, T., Hitsumoto, S., Tanigawa, T., & Kitamura, A.
Affiliations
  • The University of Osaka (JP)
  • Osaka Center for Cancer and Cardiovascular Disease Prevention (JP)
  • University of Tsukuba (JP)
  • Chiba Prefectural Institute of Public Health (JP)
  • Ehime University Hospital (JP)
  • Ehime University (JP)
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2014-11
Volume
237
Issue
1
Pages
361-368
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2014.08.028
OpenAlex
W1977704640
Cited by
104
References
39
Citations by year
2026: 3 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 2 · 2015: 4
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (04304036, 02454209, 50223053, 06454234, 08457125, 10470103, 12470092, 19590629, 19590663, 15659146)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
fasting triglycerides, ischemic cardiovascular disease, ischemic heart disease, ischemic stroke, dyslipidemia, sex differences, HDL cholesterol, Japanese adults, Circulatory Risk in Communities Study
MeSH terms
Adult, Aged, Fasting, Female, Follow-Up Studies, Humans, Japan, Cholesterol, HDL, Male, Middle Aged, Risk Factors, Triglycerides, Multivariate Analysis, Proportional Hazards Models, Treatment Outcome, Myocardial Ischemia, Stroke

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