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Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels
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Treatment with ezetimibe protects mice from diet-induced hypercholesterolemia and atherosclerosis.
“Treatment with EZ protects mice from diet-induced hypercholesterolemia and atherosclerosis (1, 3, 12, 13).”
From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [1]
The intestine regulates systemic lipid homeostasis by gating dietary cholesterol intake.
“The intestine regulates systemic lipid homeostasis by gating dietary cholesterol intake (1).”
From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [1]
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Research works printed but not linked: 49
- Wilson, 1980, Prevalence of coronary heart disease in the Framingham Offspring Study: role of lipoprotein cholesterols, Am. J. Cardiol., 46, 649, 10.1016/0002-9149(80)90516-0 · DOI
- Dietschy, 1993, Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans, J. Lipid Res., 34, 1637, 10.1016/S0022-2275(20)35728-X · DOI · Paper page
- Van Heek, 1997, In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461, J. Pharmacol. Exp. Ther., 283, 157, 10.1016/S0022-3565(24)36992-7 · DOI
- Brown, 1978, Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase, J. Biol. Chem., 253, 1121, 10.1016/S0021-9258(17)38120-6 · DOI
- Bays, 2001, Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: pooled analysis of two phase II studies, Clin. Ther., 23, 1209, 10.1016/S0149-2918(01)80102-8 · DOI
- Davies, 2000, Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1, Genomics, 65, 137, 10.1006/geno.2000.6151 · DOI
- Altmann, 2004, Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption, Science, 303, 1201, 10.1126/science.1093131 · DOI
- Garcia-Calvo, 2005, The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1), Proc. Natl. Acad. Sci. U. S. A., 102, 8132, 10.1073/pnas.0500269102 · DOI · Paper page
- Weinglass, 2008, Extracellular loop C of NPC1L1 is important for binding to ezetimibe, Proc. Natl. Acad. Sci. U. S. A., 105, 11140, 10.1073/pnas.0800936105 · DOI
- Yu, 2006, Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake, J. Biol. Chem., 281, 6616, 10.1074/jbc.M511123200 · DOI
- Temel, 2007, Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe, J. Clin. Invest., 117, 1968, 10.1172/JCI30060 · DOI
- Tang, 2006, Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice, Hepatology, 44, 1259, 10.1002/hep.21380 · DOI
- Davies, 2005, Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia, J. Biol. Chem., 280, 12710, 10.1074/jbc.M409110200 · DOI
- Davis, 2004, Niemann-Pick C1 like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis, J. Biol. Chem., 279, 33586, 10.1074/jbc.M405817200 · DOI · Paper page
- Jia, 2010, Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis, J. Lipid Res., 51, 3135, 10.1194/jlr.M006353 · DOI
- Jia, 2010, Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1, J. Lipid Res., 51, 3024, 10.1194/jlr.M008599 · DOI
- Labonte, 2008, Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1−/− mice, Am. J. Physiol. Gastrointest. Liver Physiol., 295, G776, 10.1152/ajpgi.90275.2008 · DOI
- Davis, 2007, Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE−/− mice, Arterioscler. Thromb. Vasc. Biol., 27, 841, 10.1161/01.ATV.0000257627.40486.46 · DOI
- Kesaniemi, 1987, Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population, Eur. J. Clin. Invest., 17, 391, 10.1111/j.1365-2362.1987.tb01132.x · DOI
- Cohen, 2006, Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels, Proc. Natl. Acad. Sci. U. S. A., 103, 1810, 10.1073/pnas.0508483103 · DOI
- Bosner, 1999, Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry, J. Lipid Res., 40, 302, 10.1016/S0022-2275(20)33370-8 · DOI
- Sehayek, 1998, U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans, J. Lipid Res., 39, 2415, 10.1016/S0022-2275(20)33320-4 · DOI
- Madison, 2002, Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine, J. Biol. Chem., 277, 33275, 10.1074/jbc.M204935200 · DOI
- Garber, 2000, A sensitive and convenient method for lipoprotein profile analysis of individual mouse plasma samples, J. Lipid Res., 41, 1020, 10.1016/S0022-2275(20)32045-9 · DOI
- Siri, 2001, Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistance, J. Biol. Chem., 276, 46064, 10.1074/jbc.M108909200 · DOI
- Li, 2011, Effects of antisense-mediated inhibition of 11beta-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism, J. Lipid Res., 52, 971, 10.1194/jlr.M013748 · DOI
- Valasek, 2005, Caveolin-1 is not required for murine intestinal cholesterol transport, J. Biol. Chem., 280, 28103, 10.1074/jbc.M504609200 · DOI
- Roth, 2009, Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology, Genesis, 47, 7, 10.1002/dvg.20446 · DOI
- Repa, 2000, Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers, Science, 289, 1524, 10.1126/science.289.5484.1524 · DOI
- Rashid, 2005, Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9, Proc. Natl. Acad. Sci. U. S. A., 102, 5374, 10.1073/pnas.0501652102 · DOI · Paper page
- Grundy, 1983, Absorption and metabolism of dietary cholesterol, Annu. Rev. Nutr., 3, 71, 10.1146/annurev.nu.03.070183.000443 · DOI
- Yu, 2002, Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion, Proc. Natl. Acad. Sci. U. S. A., 99, 16237, 10.1073/pnas.252582399 · DOI
- Yu, 2002, Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol, J. Clin. Invest., 110, 671, 10.1172/JCI0216001 · DOI
- Graf, 2002, Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface, J. Clin. Invest., 110, 659, 10.1172/JCI0216000 · DOI
- Davis, 2001, Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice, Arterioscler. Thromb. Vasc. Biol., 21, 2032, 10.1161/hq1201.100260 · DOI · Paper page
- Davis, 2011, Effects of ezetimibe on atherosclerosis in preclinical models, Atherosclerosis, 215, 266, 10.1016/j.atherosclerosis.2011.02.010 · DOI
- Repa, 2005, Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption, J. Lipid Res., 46, 779, 10.1194/jlr.M400475-JLR200 · DOI
- Gagne, 2002, Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia, Circulation, 105, 2469, 10.1161/01.CIR.0000018744.58460.62 · DOI
- Wang, 2007, Regulation of intestinal cholesterol absorption, Annu. Rev. Physiol., 69, 221, 10.1146/annurev.physiol.69.031905.160725 · DOI
- Xie, 2012, Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine, J. Lipid Res., 53, 2092, 10.1194/jlr.M027359 · DOI · Paper page
- Rudel, 2001, Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis, Curr. Opin. Lipidol., 12, 121, 10.1097/00041433-200104000-00005 · DOI
- Xie, 2002, Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse, J. Lipid Res., 43, 1508, 10.1194/jlr.M200146-JLR200 · DOI
- Telford, 2007, The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin, J. Lipid Res., 48, 699, 10.1194/jlr.M600439-JLR200 · DOI
- Greeve, 1993, Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins, J. Lipid Res., 34, 1367, 10.1016/S0022-2275(20)36966-2 · DOI
- Warnakula, 2011, New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: frontiers for new pharmaceutical therapies to lower cardiovascular disease risk, Can. J. Cardiol., 27, 183, 10.1016/j.cjca.2010.12.020 · DOI
- Phillips, 2000, Improved metabolic control reduces the number of postprandial apolipoprotein B-48-containing particles in type 2 diabetes, Atherosclerosis, 148, 283, 10.1016/S0021-9150(99)00275-0 · DOI
- Mamo, 2001, Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression?, Am. J. Physiol. Endocrinol. Metabol., 281, E626, 10.1152/ajpendo.2001.281.3.E626 · DOI
- Adeli, 2008, Intestinal lipoprotein overproduction in insulin-resistant states, Curr. Opin. Lipidol., 19, 221, 10.1097/MOL.0b013e3282ffaf82 · DOI
- Su, 2009, Impaired postprandial metabolism of apolipoprotein B48-containing remnant particles in normolipidemic subjects with brittle type 1 diabetes, Diabetes Care, 32, e21, 10.2337/dc08-1573 · DOI
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Mechanisms and regulation of cholesterol homeostasis
Luo, J., Yang, H., & Song, B.-L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0190-7 · Cited by 1,980
Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake
Ferrari, A., Whang, E., Xiao, X., Kennelly, J. P., Romartinez-Alonso, B., Mack, J. J., Weston, T., Chen, K., Kim, Y., Tol, M. J., et al. (2023) · Science · doi:10.1126/science.adf0966 · Cited by 61
Niemann-Pick C1-Like 1 (NPC1L1) inhibition and cardiovascular diseases
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Metadata
- Authors
- Xie, P., Zhu, H., Jia, L., Ma, Y., Tang, W., Wang, Y., Xue, B., Shi, H., & Yu, L.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 237
- Issue
- 2
- Pages
- 609-617
- ISSN
- 0021-9150
- PMC
- PMC4262594
- Cited by
- 24
- References
- 0
- Language
- en
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