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Niemann-Pick C1 Like 1 (NPC1L1) Is the Intestinal Phytosterol and Cholesterol Transporter and a Key Modulator of Whole-body Cholesterol Homeostasis
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NPC1L1 is an important mediator of intestinal cholesterol uptake.
“Niemann-Pick C1-Like 1 (NPC1L1) is an important mediator of intestinal cholesterol uptake (6, 7), but how cholesterol is delivered to the enterocyte ER for esterification remains to be defined.”
From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [7]
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Cites
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
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Mechanisms and regulation of cholesterol homeostasis
Luo, J., Yang, H., & Song, B.-L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0190-7 · Cited by 1,980
Lipids and Lipid-Based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs
Porter, C. J. H., Trevaskis, N. L., & Charman, W. N. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2197 · Cited by 1,824
Dyslipidemia in obesity: Mechanisms and potential targets
Klop, B., Elte, J., & Cabezas, M. (2013) · Nutrients · doi:10.3390/nu5041218 · Cited by 1,665
“Cholesterol is taken up by the enterocytes via the specific cholesterol transporter Niemann-Pick C1 Like 1 protein (NPC1L1) [9,10].”
Lipid-Based Delivery Systems and Intestinal Lymphatic Drug Transport: A Mechanistic Update
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Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
The Myocardial Infarction Genetics Consortium Investigators (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1405386 · Cited by 419
Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids
Harrison, E. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.002 · Cited by 365
Mechanisms of digestion and absorption of dietary vitamin A
Harrison, E. H. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092614 · Cited by 262
Smagris, E., Gilyard, S., BasuRay, S., Cohen, J. C., & Hobbs, H. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719955 · Cited by 226
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Hypercholesterolemia Induces Angiogenesis and Accelerates Growth of Breast Tumors In Vivo
Pelton, K., Coticchia, C. M., Curatolo, A. S., Schaffner, C. P., Zurakowski, D., Solomon, K. R., & Moses, M. A. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2014.03.006 · Cited by 109
Glucagon receptor antagonism induces increased cholesterol absorption
Guan, H.-P., Yang, X., Lu, K., Wang, S.-P., Castro-Perez, J. M., Previs, S., Wright, M., Shah, V., Herath, K., Xie, D., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m060897 · Cited by 76
Self-citationAster-dependent nonvesicular transport facilitates dietary cholesterol uptake
Ferrari, A., Whang, E., Xiao, X., Kennelly, J. P., Romartinez-Alonso, B., Mack, J. J., Weston, T., Chen, K., Kim, Y., Tol, M. J., et al. (2023) · Science · doi:10.1126/science.adf0966 · Cited by 61
Niemann-Pick C1-Like 1 (NPC1L1) inhibition and cardiovascular diseases
Pirillo, A., L. Catapano, A., & D. Norata, G. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160229114111 · Cited by 45
Takei, K., Nakagawa, Y., Wang, Y., Han, S.-I., Satoh, A., Sekiya, M., Matsuzaka, T., & Shimano, H. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.02.003 · Cited by 43
Ip, C.-K., Jin, D.-M., Gao, J.-J., Meng, Z., Meng, J., Tan, Z., Wang, J.-F., & Geng, D.-F. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.228 · Cited by 43
Naghipour, A., Amini-Salehi, E., Orang Gorabzarmakhi, M., Shahdkar, M., Fouladi, B., Alipourfard, I., & Sanat, Z. M. (2023) · Systematic Reviews · doi:10.1186/s13643-023-02299-x · Cited by 37
“Cholesterol particles of the medium are absorbed via Niemann–Pick C1 like 1 (NPC1L1) that are transporters located on intestinal cells membrane [80, 81].”
BackgroundThe Administration of Probiotics against Hypercholesterolemia: A Systematic Review
Sivamaruthi, B. S., Bharathi, M., Kesika, P., Suganthy, N., & Chaiyasut, C. (2021) · Applied Sciences · doi:10.3390/app11156913 · Cited by 20
Mohammadi, A., Vafaei, S. A., Nabi Moradi, M., Ahmadi, M., Pourjafar, M., & Abbasi Oshaghi, E. (2015) · Avicenna Journal of Medical Biochemistry · doi:10.17795/ajmb-23205 · Cited by 7
Metadata
- Authors
- Davis, H. R., Zhu, L.-J., Hoos, L. M., Tetzloff, G., Maguire, M., Liu, J., Yao, X., Iyer, S. P. N., Lam, M.-H., Lund, E. G., Detmers, P. A., Graziano, M. P., & Altmann, S. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 279
- Issue
- 32
- Pages
- 33586-33592
- ISSN
- 0021-9258
- Cited by
- 615
- References
- 1
- Language
- en
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