CoChat
Sign Up
Cited by 64

The DOI matches its Crossref record.

Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine

Xie 谢畅, Chang, Zhou 周章森, Zhang-Sen, Li 李钠, Na, Bian 卞艳, Yan, Wang 王永建, Yong-Jian, Wang 王丽娟, Li-Juan, Li 李伯良, Bo-Liang, Song 宋保亮, Bao-Liang·2012·Journal of Lipid Research
DOI 10.1194/jlr.m027359
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1194/jlr.m027359

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 56

  1. Wang, 2007, Regulation of intestinal cholesterol absorption, Annu. Rev. Physiol., 69, 221, 10.1146/annurev.physiol.69.031905.160725 · DOI
  2. Nguyen, 2012, Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation, J. Lipid Res., 53, 95, 10.1194/jlr.M018820 · DOI · Paper page
  3. Burrier, 1995, The effect of acyl CoA: cholesterol acyltransferase inhibition on the uptake, esterification and secretion of cholesterol by the hamster small intestine, J. Pharmacol. Exp. Ther., 272, 156
  4. Buhman, 2000, Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice, Nat. Med., 6, 1341, 10.1038/82153 · DOI · Paper page
  5. Repa, 2004, ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis, Hepatology, 40, 1088, 10.1002/hep.20439 · DOI
  6. Altmann, 2004, Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption, Science, 303, 1201, 10.1126/science.1093131 · DOI
  7. Davies, 2005, Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia, J. Biol. Chem., 280, 12710, 10.1074/jbc.M409110200 · DOI
  8. Davis, 2004, Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis, J. Biol. Chem., 279, 33586, 10.1074/jbc.M405817200 · DOI · Paper page
  9. Ge, 2008, The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1, Cell Metab., 7, 508, 10.1016/j.cmet.2008.04.001 · DOI
  10. Wang, 2012, Niemann–Pick C1-Like 1 and cholesterol uptake., Biochim. Biophys. Acta., 1821, 964, 10.1016/j.bbalip.2012.03.004 · DOI
  11. Ge, 2011, Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake, Proc. Natl. Acad. Sci. USA, 108, 551, 10.1073/pnas.1014434108 · DOI
  12. Ullrich, 1996, Rab11 regulates recycling through the pericentriolar recycling endosome, J. Cell Biol., 135, 913, 10.1083/jcb.135.4.913 · DOI · Paper page
  13. Chu, 2009, Requirement of myosin Vb.Rab11a.Rab11–FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface, J. Biol. Chem., 284, 22481, 10.1074/jbc.M109.034355 · DOI
  14. Hao, 2002, Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle, J. Biol. Chem., 277, 609, 10.1074/jbc.M108861200 · DOI · Paper page
  15. Xie, 2011, The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner, J. Biol. Chem., 286, 35933, 10.1074/jbc.M111.270199 · DOI
  16. Yu, 2006, Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake, J. Biol. Chem., 281, 6616, 10.1074/jbc.M511123200 · DOI
  17. Zhang, 2011, The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake, J. Biol. Chem., 286, 25088, 10.1074/jbc.M111.244475 · DOI
  18. Wang, 2009, Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption, J. Lipid Res., 50, 1653, 10.1194/jlr.M800669-JLR200 · DOI
  19. Uelmen, 1995, Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro, J. Biol. Chem., 270, 26192, 10.1074/jbc.270.44.26192 · DOI
  20. Lee, 1998, Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines, J. Lipid Res., 39, 1722, 10.1016/S0022-2275(20)32203-3 · DOI
  21. Lee, 2000, Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates, J. Lipid Res., 41, 1991, 10.1016/S0022-2275(20)32360-9 · DOI
  22. Chang, 2000, Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine, J. Biol. Chem., 275, 28083, 10.1074/jbc.M003927200 · DOI
  23. Song, 2006, Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma, Biochem. J., 394, 617, 10.1042/BJ20051417 · DOI
  24. Kushwaha, 2005, Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipids, J. Nutr. Biochem., 16, 714, 10.1016/j.jnutbio.2005.03.010 · DOI
  25. Zhang, 2012, Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood, J. Lipid Res., 53, 1144, 10.1194/jlr.M024356 · DOI · Paper page
  26. Meiner, 1996, Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals, Proc. Natl. Acad. Sci. USA, 93, 14041, 10.1073/pnas.93.24.14041 · DOI
  27. Mutch, 2004, Regional variations in ABC transporter expression along the mouse intestinal tract, Physiol. Genomics, 17, 11, 10.1152/physiolgenomics.00150.2003 · DOI
  28. Coons, 1950, Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody, J. Exp. Med, 91, 1, 10.1084/jem.91.1.1 · DOI
  29. Sugii, 2003, Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and Niemann-Pick type C1 cells, J. Lipid Res., 44, 1033, 10.1194/jlr.D200036-JLR200 · DOI
  30. Borgstrom, 1968, Quantitative aspects of the intestinal absorption and metabolism of cholesterol and beta-sitosterol in the rat, J. Lipid Res., 9, 473, 10.1016/S0022-2275(20)42726-9 · DOI
  31. Wang, 2003, Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies, J. Lipid Res., 44, 1042, 10.1194/jlr.D200041-JLR200 · DOI
  32. Cao, 2007, Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase, Cell Metab., 6, 115, 10.1016/j.cmet.2007.07.002 · DOI
  33. Wang, 2011, Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers, J. Biol. Chem., 286, 7397, 10.1074/jbc.M110.178368 · DOI
  34. Tang, 2011, Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques, Cell Metab., 13, 44, 10.1016/j.cmet.2010.12.004 · DOI · Paper page
  35. Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues., J. Biol. Chem., 226, 497, 10.1016/S0021-9258(18)64849-5 · DOI · Paper page
  36. Barker, 2007, Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, 449, 1003, 10.1038/nature06196 · DOI · Paper page
  37. Anderson, 1998, Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates, J. Biol. Chem., 273, 26747, 10.1074/jbc.273.41.26747 · DOI
  38. Rudel, 2001, Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis, Curr. Opin. Lipidol., 12, 121, 10.1097/00041433-200104000-00005 · DOI
  39. Chang, 2001, Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2, Curr. Opin. Lipidol., 12, 289, 10.1097/00041433-200106000-00008 · DOI
  40. Chang, 2009, Acyl-coenzyme A:cholesterol acyltransferases, Am. J. Physiol. Endocrinol. Metab., 297, E1, 10.1152/ajpendo.90926.2008 · DOI · Paper page
  41. Temel, 2007, Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe, J. Clin. Invest., 117, 1968, 10.1172/JCI30060 · DOI
  42. Sane, 2006, Localization and role of NPC1L1 in cholesterol absorption in human intestine, J. Lipid Res., 47, 2112, 10.1194/jlr.M600174-JLR200 · DOI
  43. Skov, 2011, Dietary cholesterol induces trafficking of intestinal Niemann-Pick Type C1 Like 1 from the brush border to endosomes, Am. J. Physiol. Gastrointest. Liver Physiol., 300, G33, 10.1152/ajpgi.00344.2010 · DOI
  44. Telford, 2007, The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin, J. Lipid Res., 48, 699, 10.1194/jlr.M600439-JLR200 · DOI
  45. Goldenring, 1996, Rab11 is an apically located small GTP-binding protein in epithelial tissues, Am. J. Physiol., 270, G515
  46. Lapierre, 2012, Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells, Exp. Cell Res., 318, 103, 10.1016/j.yexcr.2011.10.010 · DOI
  47. Temel, 2005, Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2, J. Lipid Res., 46, 2423, 10.1194/jlr.M500232-JLR200 · DOI
  48. Matsuda, 1998, Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase, Biochim. Biophys. Acta, 1391, 193, 10.1016/S0005-2760(98)00007-1 · DOI
  49. Hori, 2004, Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats, Arterioscler. Thromb. Vasc. Biol., 24, 1689, 10.1161/01.ATV.0000137976.88533.13 · DOI
  50. Wang, 1996, J. Lipid Res., 37, 606, 10.1016/S0022-2275(20)37603-3 · DOI
  51. Hussain, 2012, Multiple functions of microsomal triglyceride transfer protein, Nutr. Metab. (Lond), 9, 14, 10.1186/1743-7075-9-14 · DOI
  52. Swift, 2005, Microsomal triglyceride transfer protein expression in mouse intestine, Histochem. Cell Biol., 123, 475, 10.1007/s00418-005-0772-7 · DOI
  53. Ros, 2000, Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk, Atherosclerosis, 151, 357, 10.1016/S0021-9150(00)00456-1 · DOI
  54. Duan, 2004, Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice, J. Lipid Res., 45, 1312, 10.1194/jlr.M400030-JLR200 · DOI
  55. Hawes, 2007, In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: comparison of multiple species NPC1L1 orthologs, Mol. Pharmacol., 71, 19, 10.1124/mol.106.027896 · DOI
  56. Weinglass, 2008, Extracellular loop C of NPC1L1 is important for binding to ezetimibe, Proc. Natl. Acad. Sci. USA, 105, 11140, 10.1073/pnas.0800936105 · DOI

Cited by

Sorted by citations

Metadata

Authors
Xie 谢畅, C., Zhou 周章森, Z.-S., Li 李钠, N., Bian 卞艳, Y., Wang 王永建, Y.-J., Wang 王丽娟, L.-J., Li 李伯良, B.-L., & Song 宋保亮, B.-L.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2012-10
Volume
53
Issue
10
Pages
2092-2101
ISSN
0022-2275
DOI
10.1194/jlr.m027359
Cited by
64
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review