The DOI matches its Crossref record; 241 of the 241 references it cites were found in a registry or an index.
Vascular endothelium – Gatekeeper of vessel health
Open accessAbstract
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the artery wall are believed of primary importance in the pathogenesis of vascular disease/atherosclerosis. The endothelium responds to humoral, neural and especially hemodynamic stimuli and regulates platelet function, inflammatory responses, vascular smooth muscle cell growth and migration, in addition to modulating vascular tone by synthesizing and releasing vasoactive substances. Compromised endothelial function contributes to the pathogenesis of cardiovascular disease; endothelial 'dysfunction' is associated with risk factors, correlates with disease progression, and predicts cardiovascular events. Therapies for atherosclerosis have been developed, therefore, that are directed towards improving endothelial function.
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“Endothelial cells can reconstruct the intima structure of vessels and regulate vascular regeneration by secreting growth factors (VEGF) and active factor (NO) [159].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [159]
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Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Intravenous Fluids and Acute Kidney Injury
Ding, X., Cheng, Z., & Qian, Q. (2017) · Blood Purification · doi:10.1159/000452702 · Cited by 6,869
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,796
Moncada, S., Gryglewski, R. J., Bunting, S., & Vane, J. R. (1976) · Nature · doi:10.1038/263663a0 · Cited by 3,593
Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
Owens, G. K., Kumar, M. S., & Wamhoff, B. R. (2004) · Physiological Reviews · doi:10.1152/physrev.00041.2003 · Cited by 3,472
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
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Markers and Biomarkers of Endothelium: When Something Is Rotten in the State
Goncharov, N. V., Nadeev, A. D., Jenkins, R. O., & Avdonin, P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9759735 · Cited by 190
Holder, S. M., Bruno, R. M., Shkredova, D. A., Dawson, E. A., Jones, H., Hopkins, N. D., Hopman, M. T. E., Bailey, T. G., Coombes, J. S., Askew, C. D., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.15754 · Cited by 118
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction
Yu, H., Liao, K., Hu, Y., Lv, D., Luo, M., Liu, Q., Huang, L., & Luo, S. (2022) · Aging and disease · doi:10.14336/ad.2022.0316 · Cited by 84
Wang, W.-L., Shih, Y.-T., Wei, S.-Y., & Chiu, J.-J. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01177-z · Cited by 50
Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7
“Endothelial cells can reconstruct the intima structure of vessels and regulate vascular regeneration by secreting growth factors (VEGF) and active factor (NO) [159].”
Alsaedi, A. Q., Nader, M. A., El-Kashef, D. H., & Abdelmageed, M. E. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1572758 · Cited by 5
Metadata
- Authors
- Cahill, P. A., & Redmond, E. M.
- Affiliations
- Dublin City University (IE)
- University of Rochester Medicine (US)
- Corresponding author
- Redmond, Eileen M.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 248
- Pages
- 97-109
- ISSN
- 0021-9150 (ISSN-L)
- PMC
- PMC6478391
- OpenAlex
- W2300272821
- Cited by
- 518
- References
- 241
- Citations by year
- 2026: 23 · 2025: 59 · 2024: 41 · 2023: 50 · 2022: 77 · 2021: 82 · 2020: 62 · 2019: 51 · 2018: 31 · 2017: 31 · 2016: 8
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA023213)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- vascular endothelium, endothelial dysfunction, cardiovascular disease, platelet function, vascular smooth muscle cell migration, vasoactive substances, vascular tone, inflammation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cardiovascular Diseases, Coronary Artery Disease, Endothelium, Vascular, Fibrinolytic Agents, Hemodynamics, Humans, Inflammation, Muscle, Smooth, Vascular, Permeability, Risk Factors, Stem Cells, Stress, Mechanical, Vasoconstrictor Agents, Vasodilator Agents, Exercise, Glycocalyx, Atherosclerosis, Mice
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