Vascular endothelium – Gatekeeper of vessel health

Ischemic preconditioning and superoxide dismutase protect against endothelial dysfunction and endothelium glycocalyx disruption in the postischemic guinea-pig hearts

Berȩsewicz, A., Czarnowska, E., & Ma̧czewski, M. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006867214448 · Cited by 54

Physiological cyclic strain promotes endothelial cell survival via the induction of heme oxygenase-1

Liu, X., Peyton, K. J., & Durante, W. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00872.2012 · Cited by 52

Wall shear stress on LDL accumulation in human RCAs

Soulis, J. V., Fytanidis, D. K., Papaioannou, V. C., & Giannoglou, G. D. (2010) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2010.05.011 · Cited by 51

12/15-Lipoxygenase Mediates High-fat Diet-induced Endothelial Tight Junction Disruption and Monocyte Transmigration

Kundumani‐Sridharan, V., Dyukova, E., Hansen, D. E., & Rao, G. N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.453290 · Cited by 51

Atheroprotective mechanisms activated by fluid shear stress in endothelial cells

Berk, B. C., Min, W., Yan, C., et al. (2002) · Drug News & Perspectives · doi:10.1358/dnp.2002.15.3.704684 · Cited by 47

A Flow System for the Study of Shear Forces Upon Cultured Endothelial Cells

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Reactive carbonyls from tobacco smoke increase arterial endothelial layer injury

Mullick, A. E., McDonald, J. M., Melkonian, G., Talbot, P., Pinkerton, K. E., & Rutledge, J. C. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01046.2001 · Cited by 46

Vasoactive peptides in cardiovascular (patho)physiology

Callera, G. E., Tostes, R. C., Savoia, C., Muscará, M. N., & Touyz, R. M. (2007) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.5.3.531 · Cited by 46

Small but smart: MicroRNAs orchestrate atherosclerosis development and progression

Santovito, D., Egea, V., & Weber, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.12.013 · Cited by 45

VEGF-induced blood flow increase causes vascular hyper-permeability in vivo

Ashina, K., Tsubosaka, Y., Kobayashi, K., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.014 · Cited by 44

Interaction of Wall Shear Stress Magnitude and Gradient in the Prediction of Arterial Macromolecular Permeability

LaMack, J. A., Himburg, H. A., Li, X.-M., et al. (2005) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-2500-9 · Cited by 44

Mechanosensitive Properties in the Endothelium and Their Roles in the Regulation of Endothelial Function

Liu, H., Zhang, J., Xin, S.-Y., Liu, C., Wang, C.-Y., Zhao, D., & Zhang, Z.-R. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31828c0933 · Cited by 42

Differential inhibition by hyperglycaemia of shear stress‐ but not acetylcholine‐mediated dilatation in the iliac artery of the anaesthetized pig

Kelly-Laubscher, R. F., Ruane-O’Hora, T., Noble, M. I. M., Drake‐Holland, A. J., & Snow, H. M. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.106500 · Cited by 40

Flow-Mediated Regulation of G-Protein Expression in Cocultured Vascular Smooth Muscle and Endothelial Cells

Redmond, E. M., Cahill, P. A., & Sitzmann, J. V. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.75 · Cited by 39

Dysfunctional Endothelial Progenitor Cells in Metabolic Syndrome

Devaraj, S., & Jialal, I. (2011) · Experimental Diabetes Research · doi:10.1155/2012/585018 · Cited by 39

Role of bone marrow renin–angiotensin system in the pathogenesis of atherosclerosis

Fukuda, D., & Sata, M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.02.007 · Cited by 39

Effect of the Endothelin Family of Peptides on Human Coronary Artery Smooth-Muscle Cell Migration

Kohno, M., Yokokawa, K., Yasunari, K., Kano, H., Minami, M., & Yoshikawa, J. (1998) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199800001-00027 · Cited by 36

Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells.

Jantzen, F., Könemann, S., Wolff, B., Barth, S., Staudt, A., Kroemer, H.-K., Dahm, J. B., Felix, S. B., & Landsberger, M. (2007) · PubMed · Cited by 35

Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases

Surapisitchat, J., & Beavo, J. A. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17969-3_8 · Cited by 33

Acute activation of eNOS by statins involves scavenger receptor‐B1, G protein subunit Gi, phospholipase C and calcium influx

Datar, R. A., Kaesemeyer, W., Chandra, S., Fulton, D. J., & Caldwell, R. B. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00817.x · Cited by 33

Intimal Tissue Factor Activity Is Released from the Arterial Wall after Injury

Giesen, P., Fyfe, B. S., Fallon, J. T., et al. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613874 · Cited by 31

Low density lipoprotein transport across a microvascular endothelial barrier after permeability is increased.

Rutledge, J., CURRY, F. E., Lenz, J. F., & Davis, P. A. (1990) · Circulation Research · doi:10.1161/01.res.66.2.486 · Cited by 31

Chronic Ethanol Ingestion Increases Aortic Endothelial Nitric Oxide Synthase Expression and Nitric Oxide Production in the Rat

Kleinhenz, D. J., Sutliff, R. L., Polikandriotis, J. A., Walp, E. R., Dikalov, S., Guidot, D. M., & Hart, C. M. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00550.x · Cited by 29

Endothelial progenitor cell therapy in atherosclerosis: A double-edged sword?

Liu, P., Zhou, B., Gu, D., Zhang, L., & Han, Z. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.11.002 · Cited by 29

Physical activity throughout life reduces the atherosclerotic wall process in the carotid artery

Sandrock, M., Schulze, C., Schmitz, D., Hh, D., & Schmidt‐Trucksäss, A. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.040014 · Cited by 29

Update on the Important New Drug Target in Cardiovascular Medicine – the Vascular Glycocalyx

Drake‐Holland, A. J., & Noble, M. I. M. (2012) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/187152912801823183 · Cited by 28

The effect of prolonged dietary nitrate supplementation on atherosclerosis development

Marsch, E., Theelen, T. L., Janssen, B. J., Briedé, J. J., Haenen, G. R. M. M., Senden, J. M., van Loon, L. J. C., Poeze, M., Bierau, J., Gijbels, M. J., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.11.031 · Cited by 27

Regulation of Thrombomodulin Expression and Release in Human Aortic Endothelial Cells by Cyclic Strain

Martin, F. A., McLoughlin, A., Rochfort, K. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108254 · Cited by 26

Mechanisms Underlying the Vascular Actions of Endothelin 1, Angiotensin II and Bradykinin in the Rat Carotid

Tirapelli, C. R., Bonaventura, D., Tirapelli, L. F., et al. (2009) · Pharmacology · doi:10.1159/000231974 · Cited by 25

Inhibition of Restenosis by Beraprost Sodium (a Prostaglandin I2 Analogue) in the Atherosclerotic Rabbit Artery After Angioplasty

Isogaya, M., Yamada, N., Koike, H., et al. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199506000-00013 · Cited by 24

Endothelial Piezo1: Life depends on it

Li, J., Hou, B., & Beech, D. J. (2015) · Channels · doi:10.4161/19336950.2014.986623 · Cited by 23

The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease

Williams, P. A., & Silva, E. A. (2015) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1400-x · Cited by 22

In Vivo Cardioprotection by Pitavastatin From Ischemic-reperfusion Injury Through Suppression of IKK/NF-κB and Upregulation of pAkt–e-NOS

Malik, S., Sharma, A. K., Bharti, S., Nepal, S., Bhatia, J., Nag, T. C., Narang, R., & Arya, D. S. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31822002a6 · Cited by 22

Molecular and biological effects of hemodynamics on vascular cells

Pradhan, S. (2004) · Frontiers in bioscience · doi:10.2741/1480 · Cited by 21

Endothelium-Derived Endothelin-1 Reduces Cerebral Artery Sensitivity to Nitric Oxide by a Protein Kinase C–Independent Pathway

Gilbert, P., Tremblay, J., & Thorin, É. (2001) · Stroke · doi:10.1161/hs1001.096007 · Cited by 20

The Important New Drug Target in Cardiovascular Medicine – the Vascular Glycocalyx

Drake‐Holland, A. J., & Noble, M. I. M. (2009) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/187152909788488708 · Cited by 16

Extracellular and cell-associated localizations of plasminogen activators and plasminogen activator inhibitor-1 in cultured endothelium

Murata, T., Nakashima, Y., Yasunaga, C., et al. (1991) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(91)90046-z · Cited by 13

Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration

Cullen, J. P., Nicholl, S. M., Sayeed, S., et al. (2004) · Thrombosis Research · doi:10.1016/j.thromres.2004.05.003 · Cited by 13

Vascular Endothelial Growth Factor Increases Human Cardiac Microvascular Endothelial Cell Permeability to Low-Density Lipoproteins

Wong, B. W., Rahmani, M., Luo, Z., et al. (2009) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2009.05.005 · Cited by 13

Diazoxide may protect endothelial glycocalyx integrity during coronary artery bypass grafting

Mennander, A., Shalaby, A., Oksala, N., et al. (2012) · Scandinavian Cardiovascular Journal · doi:10.3109/14017431.2012.717303 · Cited by 13

Novel effects of beraprost sodium on vasculatures.

Sugawara, A., Kudo, M., Saito, A., et al. (2010) · PubMed · Cited by 7

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Goncharov, N. V., Nadeev, A. D., Jenkins, R. O., & Avdonin, P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9759735 · Cited by 190

Reference intervals for brachial artery flow-mediated dilation and the relation with cardiovascular risk factors

Holder, S. M., Bruno, R. M., Shkredova, D. A., Dawson, E. A., Jones, H., Hopkins, N. D., Hopman, M. T. E., Bailey, T. G., Coombes, J. S., Askew, C. D., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.15754 · Cited by 118

Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction

Yu, H., Liao, K., Hu, Y., Lv, D., Luo, M., Liu, Q., Huang, L., & Luo, S. (2022) · Aging and disease · doi:10.14336/ad.2022.0316 · Cited by 84

Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development

Wang, W.-L., Shih, Y.-T., Wei, S.-Y., & Chiu, J.-J. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01177-z · Cited by 50

Application of PLCL as a biodegradable polymer in biomedical engineering

Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7

Endothelial Dysfunction and Hypertension

Lu, X.-Z. (2009) · Advances in Cardiovascular Diseases

Myocardial bridging and endothelial dysfunction – Computational fluid dynamics study

Javadzadegan, A., Moshfegh, A., Qian, Y., et al. (2019) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2019.01.021 · Cited by 15

Clinical Aspects of Endothelial Dysfunction Associated With Human Immunodeficiency Virus Infection and Antiretroviral Agents

Shankar, S. S., & Dubé, M. P. (2004) · Cardiovascular Toxicology · doi:10.1385/ct:4:3:261 · Cited by 38

Review: Hypercholesterolemia-associated endothelial progenitor cell dysfunction

Pirro, M., Bagaglia, F., Paoletti, L., Razzi, R., & Mannarino, M. R. (2008) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944708094769 · Cited by 43

Abstract P615: Hypertension-Dependent Reprogramming of the Endothelial Transcriptome

Nelson, J. W., Barnes, A. P., Kaul, S., et al. (2015) · Hypertension · doi:10.1161/hyp.66.suppl_1.p615