Exercise in the postural orthostatic tachycardia syndrome
Open accessAbstract
Patients with the Postural Orthostatic Tachycardia Syndrome (POTS) have orthostatic intolerance, as well as exercise intolerance. Peak oxygen uptake (VO2peak) is generally lower in these patients compared with healthy sedentary individuals, suggesting a lower physical fitness level. During acute exercise, POTS patients have an excessive increase in heart rate and reduced stroke volume for each level of absolute workload; however, when expressed at relative workload (%VO2peak), there is no difference in the heart rate response between patients and healthy individuals. The relationship between cardiac output and VO2 is similar between POTS patients and healthy individuals. Short-term (i.e., 3 months) exercise training increases cardiac size and mass, blood volume, and VO2peak in POTS patients. Exercise performance is improved after training. Specifically, stroke volume is greater and heart rate is lower at any given VO2 during exercise after training versus before training. Peak heart rate is the same but peak stroke volume and cardiac output are greater after training. Heart rate recovery from peak exercise is significantly faster after training, indicating an improvement in autonomic circulatory control. These results suggest that patients with POTS have no intrinsic abnormality of heart rate regulation during exercise. The tachycardia in POTS is due to a reduced stroke volume. Cardiac remodeling and blood volume expansion associated with exercise training increase physical f…
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Cardiac remodeling and blood volume expansion associated with exercise training increase physical fitness and improve performance in POTS patients.
“cardiac remodeling and blood volume expansion associated with exercise training increase physical fitness and improve performance in these patients [31]”
During acute exercise, POTS patients have excessive increases in BP and reduced stroke volume at absolute workload compared to sedentary controls without intrinsic abnormality of HR regulation.
“it has been demonstrated that, during acute exercise, POTS patients have excessive increases in BP and reduced stroke volume at absolute workload compared to sedentary controls without intrinsic abnormality of HR regulation.”
Cites
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Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management
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“In addition, cardiac remodeling and blood volume expansion associated with exercise training increase physical fitness and improve performance in these patients [31]”
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- Authors
- Fu, Q., & Levine, B. D.
- Affiliations
- Texas Health Dallas (US)
- Corresponding author
- Fu, Qi
- Venue
- Autonomic Neuroscience
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 188
- Pages
- 86-89
- ISSN
- 1566-0702 (ISSN-L)
- PMC
- PMC4336603
- OpenAlex
- W2090154799
- Cited by
- 71
- References
- 11
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autonomic Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HL075238 grant)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- postural orthostatic tachycardia syndrome, exercise training, peak oxygen uptake, stroke volume, heart rate response, cardiac output, cardiac remodeling, blood volume expansion, heart rate recovery, exercise intolerance, orthostatic intolerance
- MeSH terms
- Blood Pressure, Exercise Therapy, Humans, Exercise, Postural Orthostatic Tachycardia Syndrome
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