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Cited by 55Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiology

Effects of exercise training on arterial-cardiac baroreflex function in POTS

Galbreath, M. Melyn, Shibata, Shigeki, VanGundy, Tiffany B., Okazaki, Kazunobu, Fu, Qi, Levine, Benjamin D.·2011·Clinical Autonomic Research
DOI 10.1007/s10286-010-0091-5
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Abstract

Purpose Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia in the upright position. To test the hypothesis that patients with POTS have impaired arterial-cardiac baroreflex function, while exercise training normalizes the baroreflex function in these patients.Methods Seventeen POTS patients aged 27 ± 9 (mean ± SD) years underwent an exercise training program for 3 months. Arterial-cardiac baroreflex function was assessed by spectral and transfer function analysis of beat-to-beat R-R interval (RRI) and systolic blood pressure (SBP) variability in the supine position and at 60° upright tilt during spontaneous breathing before and after training. Data were compared with 17 healthy sedentary controls.Results Even though upright heart rate (HR) was greater in patients than controls, indexes of RRI variability did not differ between groups. Transfer function gain (SBP to RRI), used as an index of arterial-cardiac baroreflex sensitivity was similar between patients and controls in both low- (LF, P = 0.470) and high-frequency (HF, P = 0.663) ranges. Short-term exercise training decreased upright HR and increased RRI variability in POTS patients. LF baroreflex gain increased significantly in the supine position and during upright tilt [analysis of variance (ANOVA), P = 0.04 for training], while HF gain increased modestly after training (ANOVA, P = 0.105 for training) in these patients; however, the baroreflex gains remained within the normal ranges when compared with healthy controls.Conclusions These data suggest that patients with POTS have normal arterial-cardiac baroreflex function in both supine and upright postures. Short-term exercise training increases the baroreflex sensitivity in these patients, associated with a decrease in upright heart rate.

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  • Reconditioning via exercise may not improve all symptoms.

    “Reconditioning via exercise may not improve all symptoms (101).”

    From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [101]

  • The majority of patients who complete the exercise training program no longer meet criteria for POTS, and the vast majority, if not all, report improved quality of life using a reliable and valid questionnaire.

    “The majority of patients who complete the exercise training program no longer meet criteria for POTS, and the vast majority, if not all patients, report improved quality of life using a reliable and valid questionnaire (4,101).”

    From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [101]

  • 50-70% of POTS patients who complete 3 months of endurance training exhibit hemodynamic changes that no longer meet criteria for POTS.

    “In fact, 50-70% of POTS patients who complete 3 months of endurance training exhibit hemodynamic changes that no longer meet criteria for POTS (42, 62, 63).”

    From Postural orthostatic tachycardia syndrome: mechanisms and new therapies (2020) · cites this paper as [62]

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Authors
Galbreath, M. M., Shibata, S., VanGundy, T. B., Okazaki, K., Fu, Q., & Levine, B. D.
Affiliations
Texas Health Dallas (US)
Corresponding author
Fu, Qi
ORCID
Venue
Clinical Autonomic Research
Publisher
Springer Science and Business Media LLC
Published
2010-11-20
Volume
21
Issue
2
Pages
73-80
ISSN
  • 0959-9851 (ISSN-L)
  • 1619-1560
DOI
10.1007/s10286-010-0091-5
OpenAlex
W2076051291
Cited by
54
References
36
Citations by year
2025: 7 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 1 · 2012: 1
FWCI
1.69
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Clinical Autonomic Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Space Biomedical Research Institute
  • National Institutes of Health
  • Japan Society for the Promotion of Science (23689014)
  • National Heart, Lung, and Blood Institute (K23 HL0752)
  • National Cancer Institute (CA00701)
  • National Center for Research Resources (RR 00633, M01RR000633)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
postural orthostatic tachycardia syndrome, exercise training, baroreflex sensitivity, heart rate variability, systolic blood pressure variability, autonomic dysfunction
MeSH terms
Adult, Blood Pressure, Exercise Therapy, Female, Heart Rate, Humans, Male, Exercise, Baroreflex, Postural Orthostatic Tachycardia Syndrome

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