Cited by 179Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVenous Thromboembolism Diagnosis and Management

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Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: A systematic review and meta-analysis

Reynaud, Quitterie, Lega, Jean-Christophe, Mismetti, Patrick, Chapelle, Céline, Wahl, Denis, Cathébras, Pascal, Laporte, Silvy·2014·Autoimmunity Reviews

DOI 10.1016/j.autrev.2013.11.004

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Abstract

Aim To evaluate the magnitude of venous and arterial thrombosis risk associated with antiphospholipid antibodies (APLs) in adults without systemic lupus erythematosus (SLE).Methods Case-control and cohort studies were selected from the MEDLINE and Cochrane Library databases. Two investigators independently extracted data on study design, patient characteristics, venous and arterial events and exposure to APLs, including lupus anticoagulant (LA), anticardiolipin (aCL), anti-β2 Glycoprotein I (β2GpI), anti-prothrombin (aPT), anti-phosphatidyl serine (aPS), and anti-phosphatidyl ethanolamine (aPE).Results 30 studies were included (16,441 patients). The odds ratio (OR) for venous thrombosis was 6.14 (95% confidence interval [CI] 2.74-13.8) in LA-positive patients (5 studies, 1650 patients) and 1.46 (CI 1.06-2.03) in aCL-positive patients (12 studies, 5375 patients). None of the associations with more recently identified APLs was significant, but fewer studies were available. For arterial thrombosis, the OR for LA and aCL was 3.58 (CI 1.29-9.92) and 2.65 (CI 1.75-4.00) respectively. The associations between β2GpI, aPT and aPS and the risk of arterial thrombosis were also significant, the OR being 3.12 (CI 1.51-6.44), 2.95 (CI 1.31-6.66) and 6.00 (CI 3.07-11.7), respectively. Owing to the heterogeneity of cut-off values for each APL assay, we were unable to perform any sensitivity analysis to determine the optimal value. The presence of low-quality studies may have led to overestimation of the magnitude of the associations.Conclusions LA and aCL were significantly associated with an increased risk of thrombosis, especially arterial, in patients without SLE. Systematic thromboprophylaxis in high-risk patients with APL should be evaluated.

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Authors: Reynaud, Q., Lega, J.-C., Mismetti, P., Chapelle, C., Wahl, D., Cathébras, P., & Laporte, S.
Affiliations: Centre Hospitalier Universitaire de Saint-Étienne (FR)
Lyon 1 Université (FR)
Inserm (FR)
Corresponding author: Lega, Jean-Christophe
ORCID: Reynaud, Quitterie
Lega, Jean-Christophe
Mismetti, Patrick
Chapelle, Céline
Wahl, Denis
Cathébras, Pascal
Laporte, Silvy
Venue: Autoimmunity Reviews
Publisher: Elsevier BV
Published: 2014-06
Volume: 13
Issue: 6
Pages: 595-608
ISSN: 1568-9972 (ISSN-L)
DOI: 10.1016/j.autrev.2013.11.004
OpenAlex: W2020778344
Cited by: 179
References: 68
Citations by year: 2026: 5 · 2025: 10 · 2024: 16 · 2023: 1 · 2022: 12 · 2021: 13 · 2020: 19 · 2019: 15 · 2018: 21 · 2017: 19 · 2016: 18 · 2015: 22 · 2014: 8
FWCI: 3.68
Type: journal article
Language: en
Open access: closed
Locations: Autoimmunity Reviews (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Keywords: antiphospholipid antibodies, venous thrombosis, arterial thrombosis, lupus anticoagulant, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, anti-prothrombin antibodies, antiphosphatidylserine antibodies, thrombosis risk, thromboprophylaxis
MeSH terms: Adult, Humans, Lupus Erythematosus, Systemic, Risk Factors, Thrombosis, Cohort Studies, Case-Control Studies, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, beta 2-Glycoprotein I

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Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: A systematic review and meta-analysis

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