The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Ca2+ transfer from the ER to mitochondria: When, how and why
Open accessAbstract
The heterogenous subcellular distribution of a wide array of channels, pumps and exchangers allows extracellular stimuli to induce increases in cytoplasmic Ca2+ concentration ([Ca2+]c) with highly defined spatial and temporal patterns, that in turn induce specific cellular responses (e.g. contraction, secretion, proliferation or cell death). In this extreme complexity, the role of mitochondria was considered marginal, till the direct measurement with targeted indicators allowed to appreciate that rapid and large increases of the [Ca2+] in the mitochondrial matrix ([Ca2+]m) invariably follow the cytosolic rises. Given the low affinity of the mitochondrial Ca2+ transporters, the close proximity to the endoplasmic reticulum (ER) Ca2+-releasing channels was shown to be responsible for the prompt responsiveness of mitochondria. In this review, we will summarize the current knowledge of: i) the mitochondrial and ER Ca2+ channels mediating the ion transfer, ii) the structural and molecular foundations of the signaling contacts between the two organelles, iii) the functional consequences of the [Ca2+]m increases, and iv) the effects of oncogene-mediated signals on mitochondrial Ca2+ homeostasis. Despite the rapid progress carried out in the latest years, a deeper molecular understanding is still needed to unlock the secrets of Ca2+ signaling machinery.
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Citations
Cites
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“[43–46].”
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“localized in the matrix, the pyruvate-, α-ketoglutarate- and isocitrate-dehydrogenases (collectively called the Ca2+-sensitive mitochondrial dehydrogenases, CSMDHs) are activated by Ca2+, with different mechanisms: the first through a Ca2+-dependent dephosphorylation step, the others via direct binding to a regulatory…”
BackgroundThe ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
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Cited by
Mitochondria as sensors and regulators of calcium signalling
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Mitochondrial calcium exchange in physiology and disease
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Metadata
- Authors
- Rizzuto, R., Marchi, S., Bonora, M., Aguiari, P., Bononi, A., De Stefani, D., Giorgi, C., Leo, S., Rimessi, A., Siviero, R., Zecchini, E., & Pinton, P.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 1787
- Issue
- 11
- Pages
- 1342-1351
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W2101300328
- Cited by
- 476
- References
- 10
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rizzuto, R., Marchi, S., Bonora, M., Aguiari, P., Bononi, A., De Stefani, D., Giorgi, C., Leo, S., Rimessi, A., Siviero, R., Zecchini, E., & Pinton, P. (2009). Ca2+ transfer from the ER to mitochondria: When, how and why. Biochimica et Biophysica Acta (BBA) - Bioenergetics. https://doi.org/10.1016/j.bbabio.2009.03.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
