Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function
Abstract
In skeletal muscle, two major types of muscle fibers exist: slow-twitch oxidative (type I) fibers designed for low-intensity long-lasting contractions, and fast-twitch glycolytic (type II) fibers designed for high-intensity short-duration contractions. Such a wide range of capabilities has emerged through the selection across fiber types of a narrow set of molecular characteristics suitable to achieve a specific contractile phenotype. In this article we review evidence supporting the existence of distinct functional phenotypes in mitochondria from slow and fast fibers that may be required to ensure optimal muscle function. This includes differences with respect to energy substrate preferences, regulation of oxidative phosphorylation, dynamics of reactive oxygen species, handling of Ca2+, and regulation of cell death. The potential physiological implications on muscle function and the putative mechanisms responsible for establishing and maintaining distinct mitochondrial phenotype across fiber types are also discussed.
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Mitochondrial function is well known to differ between oxidative and glycolytic muscles.
“The latter point is particularly important since mitochondrial function is well known to differ between oxidative and glycolytic muscles (Picard et al., 2012).”
From Effects of Aging and Caloric Restriction on Fiber Type Composition, Mitochondrial Morphology and Dynamics in Rat Oxidative and Glycolytic Muscles (2019) · cites this paper as Picard et al., 2012
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“surface)): a measure sensitive to the complexity and the branched appearance of the mitochondria, Feret's diameter (the longest distance (μm) between two points of the mitochondria studied) and minimum Feret diameter (corresponds to the smallest diameter of the mitochondria) (Picard et al., 2012).”
BackgroundOsório Alves, J., Matta Pereira, L., Cabral Coutinho do Rêgo Monteiro, I., Pontes dos Santos, L. H., Soares Marreiros Ferraz, A., Carneiro Loureiro, A. C., Calado Lima, C., Leal-Cardoso, J. H., Pires Carvalho, D., Soares Fortunato, R., et al. (2020) · Antioxidants · doi:10.3390/antiox9010057 · Cited by 53 · see citing works
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- Authors
- Picard, M., Hepple, R. T., & Burelle, Y.
- Affiliations
- McGill University (CA)
- Royal Victoria Hospital (CA)
- Université de Montréal (CA)
- Corresponding author
- Burelle, Yan
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2012-02-15
- Volume
- 302
- Issue
- 4
- Pages
- C629-C641
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2017311214
- Cited by
- 214
- References
- 128
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 14 · 2023: 27 · 2022: 22 · 2021: 19 · 2020: 18 · 2019: 11 · 2018: 13 · 2017: 6 · 2016: 11 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 4
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (84673_1, MOP57808)
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- skeletal muscle fiber types, reactive oxygen species, mitochondrial dynamics, calcium handling, cell death regulation, mitochondrial phenotype
- MeSH terms
- Animals, Calcium, Glycolysis, Humans, Mitochondria, Muscle, Muscle Contraction, Oxidation-Reduction, Oxidative Phosphorylation, Cell Death, Reactive Oxygen Species, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Mice, Rats
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