Cited by 214Mitochondrial Function and PathologyMuscle Physiology and DisordersAdipose Tissue and Metabolism

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function

Picard, Martin, Hepple, Russell T., Burelle, Yan·2012·American Journal of Physiology-Cell Physiology

Abstract

In skeletal muscle, two major types of muscle fibers exist: slow-twitch oxidative (type I) fibers designed for low-intensity long-lasting contractions, and fast-twitch glycolytic (type II) fibers designed for high-intensity short-duration contractions. Such a wide range of capabilities has emerged through the selection across fiber types of a narrow set of molecular characteristics suitable to achieve a specific contractile phenotype. In this article we review evidence supporting the existence of distinct functional phenotypes in mitochondria from slow and fast fibers that may be required to ensure optimal muscle function. This includes differences with respect to energy substrate preferences, regulation of oxidative phosphorylation, dynamics of reactive oxygen species, handling of Ca2+, and regulation of cell death. The potential physiological implications on muscle function and the putative mechanisms responsible for establishing and maintaining distinct mitochondrial phenotype across fiber types are also discussed.

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Crossref · 10.1152/ajpcell.00368.2011

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Authors
Picard, M., Hepple, R. T., & Burelle, Y.
Affiliations
  • McGill University (CA)
  • Royal Victoria Hospital (CA)
  • Université de Montréal (CA)
Corresponding author
Burelle, Yan
Venue
American Journal of Physiology-Cell Physiology
Published
2012-02-15
Volume
302
Issue
4
Pages
C629-C641
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
OpenAlex
W2017311214
Cited by
214
References
128
Citations by year
2026: 11 · 2025: 20 · 2024: 14 · 2023: 27 · 2022: 22 · 2021: 19 · 2020: 18 · 2019: 11 · 2018: 13 · 2017: 6 · 2016: 11 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 4
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Cell Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research (84673_1, MOP57808)
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
skeletal muscle fiber types, reactive oxygen species, mitochondrial dynamics, calcium handling, cell death regulation, mitochondrial phenotype
MeSH terms
Animals, Calcium, Glycolysis, Humans, Mitochondria, Muscle, Muscle Contraction, Oxidation-Reduction, Oxidative Phosphorylation, Cell Death, Reactive Oxygen Species, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Mice, Rats

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