Cited by 311Alzheimer's disease research and treatmentsRNA Research and SplicingAmyotrophic Lateral Sclerosis Research

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Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases

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Andreadis, Athena·2005·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2004.08.010

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Abstract

Organization of cytoskeletal elements is critical for cellular migration and maintenance of morphology. Tau protein, which binds to and organizes microtubules, is instrumental in forming and maintaining the neuronal axon. Disturbances in tau expression result in disruption of the neuronal cytoskeleton and formation of pathological tau structures (neurofibrillary tangles, NFTs) found in brains of dementia sufferers. Null tau mice, although viable, exhibit developmental and cognitive defects and transgenic mice which overexpress tau develop severe neuropathies. The neuron-specific tau transcript produces multiple isoforms by intricately regulated alternative splicing. These isoforms modulate tau function in normal brain. Moreover, aberrations in tau splicing regulation directly cause several neurodegenerative diseases. Thus, tau splicing regulation is vital to neuronal health and correct brain function. This review briefly presents our cumulative knowledge of tau splicing-cis elements and trans factors which influence it at the RNA level, its effect on the structure and roles of the tau protein and its repercussions on neuronal morphology and neurodegeneration.

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Authors: Andreadis, A.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Andreadis, Athena
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2005-01
Volume: 1739
Issue: 2-3
Pages: 91-103
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2004.08.010
OpenAlex: W2013013393
Cited by: 311
References: 111
Citations by year: 2026: 12 · 2025: 19 · 2024: 17 · 2023: 13 · 2022: 24 · 2021: 22 · 2020: 25 · 2019: 15 · 2018: 13 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 15 · 2013: 6 · 2012: 15
FWCI: 1.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3120 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institute on Aging
National Institute of Neurological Disorders and Stroke
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: tau protein, alternative splicing, tau isoforms, splicing regulation, cis-regulatory elements, trans-acting factors, neurofibrillary tangles, neurodegenerative diseases, neuronal cytoskeleton, microtubule binding, neuronal morphology, tau overexpression, dementia
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Brain, Gene Expression Regulation, Humans, Molecular Sequence Data, tau Proteins, Alternative Splicing, Neurodegenerative Diseases, Protein Isoforms, Mice

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Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases

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