Role of transforming growth factor-β superfamily signaling pathways in human disease

TGF-β Signaling in Tumor Suppression and Cancer Progression

Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275

Soluble endoglin contributes to the pathogenesis of preeclampsia

Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855

Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child

Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1777 · Cited by 1,026

Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

Brunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011

Functional improvement of dystrophic muscle by myostatin blockade

Bogdanovich, S., Krag, T. O. B., Barton, E. R., Morris, L. D., Whittemore, L.-A., Ahima, R. S., & Khurana, T. S. (2002) · Nature · doi:10.1038/nature01154 · Cited by 831

Transforming Growth Factor-β1 to the Bone

Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710

The transforming growth factor-β superfamily of receptors

de Caestecker, M. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.004 · Cited by 464

Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology

Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J. V., Lin, A. H., Crews, L., Tremblay, P., Mathews, P., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27341 · Cited by 355

Protection from obesity and diabetes by blockade of TGF-β/smad3 signaling

Yadav, H., Quijano, C., Kamaraju, A. K., Gavrilova, O., Malek, R., Chen, W., Zerfas, P., Zhigang, D., Wright, E. C., Stuelten, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.013 · Cited by 709

Transforming growth factor‐β in stem cells and tissue homeostasis

Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

Anderton, M. J., Mellor, H. R., Bell, A., Sadler, C., Pass, M., Powell, S., Steele, S. J., Roberts, R. R. A., & Heier, A. (2011) · Toxicologic Pathology · doi:10.1177/0192623311416259 · Cited by 284

Inflammation induced loss of skeletal muscle

Londhe, P., & Guttridge, D. C. (2015) · Bone · doi:10.1016/j.bone.2015.03.015 · Cited by 276

Transforming growth factor β as regulator of cancer stemness and metastasis

Bellomo, C., Caja, L., & Moustakas, A. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.255 · Cited by 235

TGF-β family co-receptor function and signaling

Nickel, J., Ten Dijke, P., & Mueller, T. D. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx126 · Cited by 198

The Function of Myostatin in the Regulation of Fat Mass in Mammals

Deng, B., Zhang, F., Wen, J., Ye, S., Wang, L., Yang, Y., Gong, P., & Jiang, S. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0179-1 · Cited by 98

The Anti-proliferative Function of the TGF-β1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3

Li, J., Ballim, D., Rodriguez, M., Cui, R., Goding, C. R., Teng, H., & Prince, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.596411 · Cited by 44

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Pervin, S., Reddy, S. T., & Singh, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.653179 · Cited by 42

BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion

Hill, C. R., Sanchez, N. S., Love, J. D., Arrieta, J. A., Hong, C. C., Brown, C. B., Austin, A. F., & Barnett, J. V. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.022 · Cited by 40

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium

Flanders, K. C., Yang, Y.-A., Herrmann, M., Chen, J., Mendoza, N., Mirza, A. M., & Wakefield, L. M. (2016) · Oncotarget · doi:10.18632/oncotarget.9416 · Cited by 39

Regulation of Transforming Growth Factor-β-dependent Cyclooxygenase-2 Expression in Fibroblasts

Matsumura, T., Suzuki, T., Aizawa, K., Sawaki, D., Munemasa, Y., Ishida, J., & Nagai, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014639 · Cited by 28

Expression of TGFβ-1 and EHD1 correlated with survival of non-small cell Lung cancer

Gao, Y., Wang, Y., Sun, L., Meng, Q., Cai, L., & Dong, X. (2014) · Tumor Biology · doi:10.1007/s13277-014-2164-x · Cited by 15

Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-β Signaling

Noh, S., Ahn, K.-S., Oh, S.-R., Kim, K. H., & Joo, M. (2015) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2015/897272 · Cited by 10