Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,299 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Double muscling in cattle due to mutations in the myostatin gene

McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039 · see citing works

Controlling TGF-beta signaling.

Massagué, J., & Chen, Y. (2000) · PubMed · Cited by 1,780 · see citing works

Regulation of myostatin activity and muscle growth

Lee, S.-J., & McPherron, A. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151270098 · Cited by 1,616 · see citing works

Controlling TGF-β signalingPreprint

Massagué, J., & Chen, Y. (2000) · Genes & Development · doi:10.1101/gad.14.6.627 · Cited by 1,571 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Branched-chain amino acids in metabolic signalling and insulin resistance

Lynch, C. J., & Adams, S. H. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.171 · Cited by 1,461 · see citing works

Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child

Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399 · see citing works

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263 · see citing works

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics · doi:10.1038/ng1810 · Cited by 1,260 · see citing works

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

Mutations in <i>myostatin</i> ( <i>GDF8</i> ) in Double-Muscled Belgian Blue and Piedmontese Cattle

Kambadur, R., Sharma, M., Smith, T. P. L., & Bass, J. J. (1997) · Genome Research · doi:10.1101/gr.7.9.910 · Cited by 1,204 · see citing works

Adipose tissue browning and metabolic health

Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177 · see citing works

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174 · see citing works

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works

Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation

Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., & Kambadur, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004356200 · Cited by 1,014 · see citing works

Induction of Cachexia in Mice by Systemically Administered Myostatin

Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P. A., Esquela‐Kerscher, A., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., & Lee, S. (2002) · Science · doi:10.1126/science.1069525 · Cited by 908 · see citing works

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D., Svensson, K. J., Lo, J. C., Zeng, X., Ye, L., Khandekar, M. J., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.021 · Cited by 878 · see citing works

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Bi-directional interconversion of brite and white adipocytes

Rosenwald, M., Perdikari, A., Rülicke, T., & Wolfrum, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2740 · Cited by 792 · see citing works

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · cited 3× · see citing works

Protection from obesity and diabetes by blockade of TGF-β/smad3 signaling

Yadav, H., Quijano, C., Kamaraju, A. K., Gavrilova, O., Malek, R., Chen, W., Zerfas, P., Zhigang, D., Wright, E. C., Stuelten, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.013 · Cited by 709 · see citing works

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

Sidossis, L. S., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 689 · see citing works

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

Lee, Y., Petkova, A. P., Mottillo, E. P., & Granneman, J. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.009 · Cited by 676 · see citing works

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

Verdin, E., Hirschey, M. D., Finley, L. W. S., & Haigis, M. C. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.003 · Cited by 661 · see citing works

Evidence for two types of brown adipose tissue in humans

Lidell, M. E., Betz, M. J., Leinhard, O. D., Heglind, M., Elander, L., Slawik, M., Mussack, T., Nilsson, D., Romu, T., Nuutila, P., et al. (2013) · Nature Medicine · doi:10.1038/nm.3017 · Cited by 658 · see citing works

Role of transforming growth factor-β superfamily signaling pathways in human disease

Gordon, K. J., & Blobe, G. C. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.01.006 · Cited by 644 · see citing works

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

Sharp, L. Z., Shinoda, K., Ohno, H., Scheel, D. W., Tomoda, E., Ruiz, L., Hu, H., Wang, L. L., Pavlova, Z., Gilsanz, V., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049452 · Cited by 635 · see citing works

FNDC5/irisin is not only a myokine but also an adipokine

Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · see citing works

Multiple defects and perinatal death in mice deficient in follistatin

Matzuk, M. M., Lu, N., Vogel, H. S., Sellheyer, K., Roop, D. R., & Bradley, A. (1995) · Nature · doi:10.1038/374360a0 · Cited by 584 · see citing works

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vázquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.066 · Cited by 573 · see citing works

A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity

Combs, T. P., Pajvani, U. B., Berg, A. H., Lin, Y., Jelicks, L. A., Laplante, M., Nawrocki, A. R., Rajala, M. W., Parlow, A. F., Cheeseboro, L., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1068 · Cited by 545 · see citing works

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

Jespersen, N. Z., Larsen, T. J., Peijs, L., Daugaard, S., Homøe, P., Loft, A., de Jong, J. M. A., Mathur, N., Cannon, B., Nedergaard, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.011 · Cited by 539 · see citing works

Circulating irisin in relation to insulin resistance and the metabolic syndrome.

Park, K., Zaichenko, L., Brinkoetter, M. T., Thakkar, B., Sahin-Efe, A., Joung, K., Tsoukas, M. A., Geladari, E., Huh, J., Dinçer, F., et al. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-2373 · Cited by 527 · see citing works

A Smooth Muscle-Like Origin for Beige Adipocytes

Long, J. Z., Svensson, K. J., Tsai, L. T.-Y., Zeng, X., Roh, H. C., Kong, X., Rao, R. R., Lou, J., Lokurkar, I. A., Baur, W. E., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.025 · Cited by 462 · see citing works

Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ

Frontini, A., & Cinti, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.004 · Cited by 458 · see citing works

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

Iemura, S.-I., Yamamoto, T. S., Takagi, C., Uchiyama, H., Natsume, T., Shimasaki, S., Sugino, H., & Ueno, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9337 · Cited by 450 · see citing works

Circulating branched‐chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents

McCormack, S. E., Shaham, O., McCarthy, M. A., Deik, A., Wang, T. J., Gerszten, R. E., Clish, C. B., Mootha, V. K., Grinspoon, S. K., & Fleischman, A. (2012) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00087.x · Cited by 439 · see citing works

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7356 · Cited by 428 · see citing works

Transcriptional Control of Brown Fat Development

Kajimura, S., Seale, P., & Spiegelman, B. M. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.005 · Cited by 417 · see citing works

The different shades of fat

Peirce, V. J., Carobbio, S., & Vidal‐Puig, A. (2014) · Nature · doi:10.1038/nature13477 · Cited by 414 · see citing works

Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis

Amthor, H., Nicholas, G., McKinnell, I., Kemp, C. F., Sharma, M., Kambadur, R., & Patel, K. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.01.046 · Cited by 401 · see citing works

β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse

Atit, R., Sgaier, S. K., Mohamed, O. A., Taketo, M. M., Dufort, D., Joyner, A. L., Niswander, L., & Conlon, R. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.449 · Cited by 400 · see citing works

Is irisin a human exercise gene?

Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 389 · see citing works

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

Harms, M. J., Ishibashi, J., Wang, W., Lim, H., Goyama, S., Sato, T., Kurokawa, M., Won, K., & Seale, P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.007 · Cited by 385 · see citing works

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 380 · see citing works

Inducible lineage tracing of Pax7‐descendant cells reveals embryonic origin of adult satellite cells

Lepper, C., & Fan, C. (2010) · genesis · doi:10.1002/dvg.20630 · Cited by 377 · see citing works

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

Barber, M., Risis, S., Yang, C., Meikle, P. J., Staples, M., Febbraio, M. A., & Bruce, C. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041456 · Cited by 370 · see citing works

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

Xia, J. Y., Holland, W. L., Kusminski, C. M., Sun, K., Sharma, A. X., Pearson, M. J., Sifuentes, A. J., McDonald, J. G., Gordillo, R., & Scherer, P. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.007 · Cited by 348 · see citing works

Irisin – a myth rather than an exercise-inducible myokine

Albrecht, E., Norheim, F., Thiede, B., Holen, T., Ohashi, T., Schering, L., Lee-Ødegård, S., Brenmoehl, J., Thomas, S., Drevon, C. A., et al. (2015) · Scientific Reports · doi:10.1038/srep08889 · Cited by 346 · see citing works

Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.

Alessi, M. C., Bastelica, D., Morange, P., Berthet, B., Leduc, I., Verdier, M., Geel, O., & Juhan-Vague, I. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1374 · Cited by 344 · see citing works

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

Sánchez-Gurmaches, J., Hung, C., Sparks, C. A., Tang, Y., Li, H., & Guertin, D. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.003 · Cited by 342 · see citing works

β-Adrenergic Activation of p38 MAP Kinase in Adipocytes

Cao, W., Medvedev, A. V., Daniel, K. W., & Collins, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101049200 · Cited by 327 · see citing works

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

Vishvanath, L., MacPherson, K. A., Hepler, C., Wang, Q. A., Shao, M., Spurgin, S. B., Wang, M. Y., Kusminski, C. M., Morley, T. S., & Gupta, R. K. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.018 · Cited by 326 · see citing works

Activins, Inhibins, and Follistatins: From Endocrinology to Signaling. A Paradigm for the New Millennium

Welt, C. K., Sidis, Y., Keutmann, H. T., & Schneyer, A. L. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700905 · Cited by 324 · see citing works

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

Zhang, L., Rajan, V. R., Lin, E., Hu, Z., Han, H. Q., Zhou, X., Song, Y., Min, H., Wang, X., Du, J., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-176917 · Cited by 317 · see citing works

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

Kong, X., Banks, A. S., Liu, T., Kazak, L., Rao, R. R., Cohen, P., Wang, X., Yu, S., Lo, J. C., Tseng, Y., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.049 · Cited by 315 · see citing works

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

Palmer, A. K., & Kirkland, J. L. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.013 · Cited by 313 · see citing works

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

Qian, S., Tang, Y., Li, X., Liu, Y., Zhang, Y.-Y., Huang, H.-Y., Xue, R.-D., Yu, H.-Y., Guo, L., Gao, H.-D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215236110 · Cited by 311 · see citing works

Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome

Arhire, L. I., Mihalache, L., & Covașă, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00524 · Cited by 306 · see citing works

Myostatin Knockout Drives Browning of White Adipose Tissue through Activating the AMPK-PGC1α-Fndc5 Pathway in Muscle

Shan, T., Liang, X., Bi, P., & Kuang, S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225755 · Cited by 301 · see citing works

Adipo-myokines: two sides of the same coin–mediators of inflammation and mediators of exercise

Raschke, S., & Eckel, J. (2013) · Mediators of Inflammation · doi:10.1155/2013/320724 · Cited by 296 · see citing works

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

Fabbiano, S., Suárez-Zamorano, N., Rigo, D., Veyrat‐Durebex, C., Đokić, A., Colin, D., & Trajkovski, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.023 · Cited by 291 · see citing works

Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility

Budi, E. H., Duan, D., & Derynck, R. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.04.005 · Cited by 287 · see citing works

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

Haidet, A. M., Rizo, L., Handy, C. R., Umapathi, P., Eagle, A., Shilling, C., Boué, D. R., Martin, P. T., Sahenk, Z., Mendell, J. R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709144105 · Cited by 267 · see citing works

CD81 controls beige fat progenitor cell growth and energy balance via FAK signaling

Oguri, Y., Shinoda, K., Kim, H., Alba, D. L., Bolus, W. R., Wang, Q., Brown, Z., Pradhan, R., Tajima, K., Yoneshiro, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.021 · Cited by 250 · see citing works

The -Adrenergic Receptors and the Control of Adipose Tissue Metabolism and Thermogenesis

Collins, S. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.309 · Cited by 249 · see citing works

Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

Gilson, H., Schakman, O., Kalista, S., Lause, P., Tsuchida, K., & Thissen, J.-P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00193.2009 · Cited by 248 · see citing works

A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

Mendell, J. R., Sahenk, Z., Malik, V., Gomez, A. M., Flanigan, K. M., Lowes, L. P., Alfano, L. N., Berry, K., Meadows, E., Lewis, S., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.200 · Cited by 246 · see citing works

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

Mori, M., Nakagami, H., Rodriguez-Araujo, G., Nimura, K., & Kaneda, Y. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001314 · Cited by 243 · see citing works

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

Xiong, X.-Q., Chen, D., Sun, H.-J., Ding, L., Wang, J.-J., Chen, Q., Li, Y.-H., Zhou, Y.-B., Han, Y., Zhang, F., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.017 · Cited by 242 · see citing works

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.030 · Cited by 234 · see citing works

Primary structure of the human follistatin precursor and its genomic organization

Shimasaki, S., Koga, M., Esch, F., Cooksey, K., Mercado, M., Koba, A., Ueno, N., Ying, S. Y., Ling, N., & Guillemin, R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4218 · Cited by 232 · see citing works

Thermal stress induces glycolytic beige fat formation via a myogenic state

Chen, Y., Ikeda, K., Yoneshiro, T., Scaramozza, A., Tajima, K., Wang, Q., Kim, K., Shinoda, K., Sponton, C. H., Brown, Z. D., et al. (2018) · Nature · doi:10.1038/s41586-018-0801-z · Cited by 228 · see citing works

Ebf2 is a selective marker of brown and beige adipogenic precursor cells

Wang, W., Kissig, M., Rajakumari, S., Huang, L., Lim, H., Won, K., & Seale, P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412685111 · Cited by 222 · see citing works

Global metabolomic profiling targeting childhood obesity in the Hispanic population

Butte, N. F., Liu, Y., Zakeri, I., Mohney, R. P., Mehta, N. R., Voruganti, V. S., Göring, H. H. H., Cole, S. A., & Comuzzie, A. G. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.111872 · Cited by 220 · see citing works

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

Douris, N., Stevanovic, D. M., Fisher, F. M., Cisu, T. I., Chee, M. J., Nguyen, N. L., Zarebidaki, E., Adams, A. C., Kharitonenkov, A., Flier, J. S., et al. (2015) · Endocrinology · doi:10.1210/en.2014-2001 · Cited by 215 · see citing works

Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues

Dong, J., Dong, Y., Dong, Y., Chen, F., Mitch, W. E., & Zhang, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.200 · Cited by 212 · see citing works

Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins

Sidis, Y., Mukherjee, A., Keutmann, H., Delbaere, A., Sadatsuki, M., & Schneyer, A. (2006) · Endocrinology · doi:10.1210/en.2006-0089 · Cited by 211 · see citing works

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Gustafson, B., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Svensson, P., Grimsby, J. S., Rondinone, C. M., & Smith, U. (2015) · Diabetes · doi:10.2337/db14-1127 · Cited by 211 · see citing works

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211 · see citing works

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

Martínez‐Fernández, L., Laiglesia, L. M., Huerta, A. E., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.07.003 · Cited by 208 · see citing works

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes

Ussar, S., Lee, K. Y., Dankel, S. N., Boucher, J., Haering, M.-F., Kleinridders, A., Thomou, T., Xue, R., Macotela, Y., Cypess, A. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008490 · Cited by 208 · see citing works

Exercise induces a marked increase in plasma follistatin: Evidence that follistatin is a contraction-induced hepatokine

Hansen, J., Brandt, C., Nielsen, A. R., Hojman, P., Whitham, M., Febbraio, M. A., Pedersen, B. K., & Plomgaard, P. (2011) · Endocrinology · doi:10.1210/en.2010-0868 · Cited by 200 · see citing works

Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

Zheng, Q., Lin, J., Huang, J., Zhang, H., Zhang, R., Zhang, X., Cao, C., Hambly, C., Qin, G., Yao, J. T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707853114 · Cited by 193 · see citing works

Identification and Characterization of a Novel Follistatin-like Protein as a Binding Protein for the TGF-β Family

Tsuchida, K., Arai, K. Y., Kuramoto, Y., Yamakawa, N., Hasegawa, Y., & Sugino, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006114200 · Cited by 192 · see citing works

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

Zhang, C., McFarlane, C., Lokireddy, S., Masuda, S., Ge, X., Gluckman, P. D., Sharma, M., & Kambadur, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2304-4 · Cited by 192 · see citing works

Crosstalk between adipokines and myokines in fat browning

Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works

MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

Fu, T., Seok, S., Choi, S.-E., Huang, Z., Suino-Powell, K., Xu, H., Kemper, B., & Kemper, J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00596-14 · Cited by 187 · see citing works

Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice

Nakatani, M., Takehara, Y., Sugino, H., Matsumoto, M., Hashimoto, O., Hasegawa, Y., Murakami, T., Uezumi, A., Takeda, S., Noji, S., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8673com · Cited by 187 · see citing works

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

Berry, D. C., Jiang, Y., & Graff, J. M. (2016) · Nature Communications · doi:10.1038/ncomms10184 · Cited by 185 · see citing works

The Regulation and Functions of Activin and Follistatin in Inflammation and Immunity

Hedger, M. P., Winnall, W. R., Phillips, D. J., & de Kretser, D. M. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-385961-7.00013-5 · Cited by 177 · see citing works

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

Elsen, M., Raschke, S., Tennagels, N., Schwahn, U., Jeleník, T., Roden, M., Romacho, T., & Eckel, J. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00290.2013 · Cited by 168 · see citing works

Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates

Kota, J., Handy, C. R., Haidet, A. M., Montgomery, C. L., Eagle, A., Rodino‐Klapac, L. R., Tucker, D., Shilling, C. J., Therlfall, W. R., Walker, C. M., et al. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000112 · Cited by 166 · see citing works

Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review

Chen, N., Li, Q., Liu, J., & Jia, S. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2660 · Cited by 164 · see citing works

Recombinant Expression of Human Follistatin with 315 and 288 Amino Acids: Chemical and Biological Comparison with Native Porcine Follistatin*

Inouye, S., Guo, Y.-L., DePaolo, L. V., Shimonaka, M., LING, N. C., & Shimasaki, S. (1991) · Endocrinology · doi:10.1210/endo-129-2-815 · Cited by 161 · see citing works

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

Hoeke, G., Kooijman, S., Boon, M. R., Rensen, P. C. N., & Berbée, J. F. P. (2016) · Circulation Research · doi:10.1161/circresaha.115.306647 · Cited by 159 · see citing works

Enhanced metabolic flexibility associated with elevated adiponectin levels

Asterholm, I. W., & Scherer, P. E. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090647 · Cited by 157 · see citing works

MiR-27 orchestrates the transcriptional regulation of brown adipogenesis

Sun, L., & Trajkovski, M. (2013) · Metabolism · doi:10.1016/j.metabol.2013.10.004 · Cited by 155 · see citing works

Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice

Zhou, Y., Jiang, L., & Rui, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900754200 · Cited by 154 · see citing works

Transforming Growth Factor β1 release by human adipose tissue is enhanced in obesity

Fain, J. N., Tichansky, D. S., & Madan, A. K. (2005) · Metabolism · doi:10.1016/j.metabol.2005.05.024 · Cited by 154 · see citing works

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

Martins, L., Seoane-Collazo, P., Contreras, C., González-García, I., Martínez-Sánchez, N., González, F., Zalvide, J., Gallego, R., Diéguez, C., Nogueiras, R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.045 · Cited by 154 · see citing works

Human Follistatin-Related Protein: A Structural Homologue of Follistatin with Nuclear Localization

Tortoriello, D. V., Sidis, Y., Holtzman, D. A., Holmes, W. E., & Schneyer, A. L. (2001) · Endocrinology · doi:10.1210/endo.142.8.8319 · Cited by 152 · see citing works

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling

Tang, H. W., Yu, R., Liu, S., Huwatibieke, B., Li, Z., & Zhang, W. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.041 · Cited by 151 · see citing works

Characterization of the metabolic effects of irisin on skeletal muscle <i>in vitro</i>

Vaughan, R. A., Gannon, N. P., Barberena, M. A., Garcia‐Smith, R., Bisoffi, M., Mermier, C. M., Conn, C. A., & Trujillo, K. A. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12268 · Cited by 150 · see citing works

miR-133a Regulates Adipocyte Browning In Vivo

Liu, W., Bi, P., Shan, T., Yang, X., Yin, H., Wang, Y.-X., Liu, N., Rudnicki, M. A., & Kuang, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003626 · Cited by 144 · see citing works

Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients.

Crujeiras, A., Zulet, M. D. L. Á., Lopez-Legarrea, P., de la Iglesia, R., Pardo, M., Carreira, M., Martinez, J., & Casanueva, F. (2014) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2013.12.007 · Cited by 143 · see citing works

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

Bartelt, A., John, C., Schaltenberg, N., Berbée, J. F. P., Worthmann, A., Cherradi, M. L., Schlein, C., Piepenburg, J., Boon, M. R., Rinninger, F., et al. (2017) · Nature Communications · doi:10.1038/ncomms15010 · Cited by 138 · see citing works

miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140

Hu, F., Wang, M., Xiao, T., Yin, B., He, L., Meng, W., Dong, M., & Liu, F. (2015) · Diabetes · doi:10.2337/db14-1117 · Cited by 132 · see citing works

Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ β-Catenin and Follistatin/Transforming Growth Factor-β Signaling Pathways

Singh, R., Bhasin, S., Braga, M., Artaza, J. N., Pervin, S., Taylor, W. E., Krishnan, V., Sinha, S. K., Rajavashisth, T. B., & Jasuja, R. (2008) · Endocrinology · doi:10.1210/en.2008-0858 · Cited by 131 · see citing works

Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice

Hui, X., Zhu, W., Wang, Y., Lam, K. S. L., Zhang, J., Wu, D., Kraegen, E. W., Li, Y., & Xu, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001107 · Cited by 130 · see citing works

AMP-activated Protein Kinase Inhibits Transforming Growth Factor-β-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation

Mishra, R., Cool, B. L., Laderoute, K. R., Foretz, M., Viollet, B., & Simonson, M. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800902200 · Cited by 128 · see citing works

Selective Activation of Mitogen-Activated Protein (MAP) Kinase Kinase 3 and p38α MAP Kinase Is Essential for Cyclic AMP-Dependent UCP1 Expression in Adipocytes

Robidoux, J., Cao, W., Quan, H. Y., Daniel, K. W., Moukdar, F., Bai, X., Floering, L. M., & Collins, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5466-5479.2005 · Cited by 122 · see citing works

White Adipose Tissue Browning: A Double-edged Sword

Abdullahi, A., & Jeschke, M. G. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.006 · Cited by 119 · see citing works

Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378

Kim, J., Okla, M., Erickson, A., Carr, T. P., Natarajan, S. K., & Chung, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.721480 · Cited by 119 · see citing works

Brown Adipose Tissue: Mechanisms and Potential Therapeutic Targets

Tam, C. S., Lecoultre, V., & Ravussin, E. (2012) · Circulation · doi:10.1161/circulationaha.111.042929 · Cited by 116 · see citing works

Follistatin Promotes Adipocyte Differentiation, Browning, and Energy Metabolism

Braga, M., Reddy, S. T., Vergnes, L., Pervin, S., Grijalva, V., Stout, D., David, J., Li, X., Tomasian, V., Reid, C. B., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m039719 · Cited by 111 · cited 7× · see citing works

A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling

Koncarevic, A., Kajimura, S., Cornwall-Brady, M. R., Andreucci, A., Pullen, A. E., Sako, D., Kumar, R., Grinberg, A. V., Liharska, K., Ucran, J. A., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1016 · Cited by 109 · see citing works

An update on the role of irisin in the regulation of endocrine and metabolic functions

Mahgoub, M., D’Souza, C. M., Darmaki, R. S. A., Baniyas, M. M. Y. H., & Adeghate, E. A. (2018) · Peptides · doi:10.1016/j.peptides.2018.03.018 · Cited by 109 · see citing works

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

Fournier, B., Murray, B., Gutzwiller, S., Marcaletti, S., Marcellin, D., Bergling, S., Brachat, S., Persohn, E., Pierrel, E., Bombard, F., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06575-11 · Cited by 108 · see citing works

MicroRNAs Are Required for the Feature Maintenance and Differentiation of Brown Adipocytes

Kim, H.-J., Cho, H., Alexander, R., Patterson, H. C., Gu, M., Lo, K. A., Xu, D., Goh, V. J., Nguyen, L. N., Chai, X., et al. (2014) · Diabetes · doi:10.2337/db14-0466 · Cited by 105 · see citing works

Irisin: ‘fat’ or artefact

Crujeiras, A. B., Pardo, M., & Casanueva, F. F. (2014) · Clinical Endocrinology · doi:10.1111/cen.12627 · Cited by 103 · see citing works

Transforming Growth Factor-β, Bioenergetics, and Mitochondria in Renal Disease

Casalena, G., Daehn, I. S., & Böttinger, E. P. (2012) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.04.009 · Cited by 101 · see citing works

Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

Perry, J. R. B., McCarthy, M. I., Hattersley, A. T., Zeggini, E., Weedon, M. N., & Frayling, T. M. (2009) · Diabetes · doi:10.2337/db08-1378 · Cited by 101 · see citing works

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2

Lee, Y., & Lee, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309907110 · Cited by 99 · see citing works

Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: Potential role of follistatin in mediating testosterone action

Braga, M., Bhasin, S., Jasuja, R., Pervin, S., & Singh, R. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.11.019 · Cited by 96 · see citing works

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts

Xie, C., Zhang, Y., Tran, T. D. N., Wang, H., Li, S., George, E. V., Zhuang, H., Zhang, P., Kandel, A., Lai, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136816 · Cited by 95 · see citing works

Relevance of brown adipose tissue in infancy and adolescence

Gilsanz, V., Hu, P., & Kajimura, S. (2012) · Pediatric Research · doi:10.1038/pr.2012.141 · Cited by 95 · see citing works

Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass

Lee, S. (2010) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152210793663748 · Cited by 87 · see citing works

Transforming Growth Factor-β1 and Incident Type 2 Diabetes

Herder, C., Zierer, A., Köenig, W., Roden, M., Meisinger, C., & Thorand, B. (2009) · Diabetes Care · doi:10.2337/dc09-0476 · Cited by 81 · see citing works

Differential Binding and Neutralization of Activins A and B by Follistatin and Follistatin Like-3 (FSTL-3/FSRP/FLRG)

Schneyer, A. L., Schoen, A., Quigg, A., & Sidis, Y. (2003) · Endocrinology · doi:10.1210/en.2002-0203 · Cited by 71 · see citing works

Irisin in obesity and type 2 diabetes

Højlund, K., & Boström, P. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.04.002 · Cited by 71 · see citing works

Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects

Lopez‐Legarrea, P., de la Iglesia, R., Crujeiras, A. B., Pardo, M., Casanueva, F. F., Zulet, M. Á., & Martínez, J. A. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.7 · Cited by 70 · see citing works

Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity

Tang, R., Harasymowicz, N. S., Wu, C., Collins, K. H., Choi, Y., Oswald, S. J., & Guilak, F. (2020) · Science Advances · doi:10.1126/sciadv.aaz7492 · Cited by 70 · see citing works

Postnatal PPARδ Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice

Bernardo, B. L., Wachtmann, T. S., Cosgrove, P. G., Kühn, M., Opsahl, A., Judkins, K. M., Freeman, T. B., Hadcock, J. R., & LeBrasseur, N. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011307 · Cited by 69 · see citing works

Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions

Abdullahi, A., & Jeschke, M. G. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00163 · Cited by 67 · see citing works

Differential actions of follistatin and follistatin-like 3

Schneyer, A. L., Sidis, Y., Xia, Y. Y., Saito, S., del Re, E. C., Lin, H. Y.-F., & Keutmann, H. T. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.02.009 · Cited by 65 · see citing works

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin

Braga, M., Pervin, S., Norris, K. C., Bhasin, S., & Singh, R. (2013) · Obesity · doi:10.1002/oby.20117 · Cited by 64 · see citing works

Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients

de la Iglesia, R., Lopez‐Legarrea, P., Crujeiras, A. B., Pardo, M., Casanueva, F. F., Zulet, M. Á., & Martínez, J. A. (2013) · Clinical Endocrinology · doi:10.1111/cen.12383 · Cited by 64 · see citing works

Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes

Gao, S., Li, F., Li, H., Yi, H., Liu, Y., & Chen, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147480 · Cited by 63 · see citing works

Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

Duan, H., Ma, B., Ma, X., Wang, H., Ni, Z., Wang, B., Li, X., Jiang, P., Umar, M., & Li, M. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.12.049 · Cited by 62 · see citing works

Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization

Kim, W. K., Choi, H.-R., Park, S. G., Ko, Y., Bae, K., & Lee, S. C. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.11.004 · Cited by 59 · see citing works

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis

Pérez-Sotelo, D., Roca-Rivada, A., de la Torre, I. B., Baltar, J., Castro, A. I., Domínguez, E., Collado, M., Casanueva, F. F., & Pardo, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16602-z · Cited by 59 · see citing works

Follistatin and follistatin like-3 differentially regulate adiposity and glucose homeostasis

Brown, M. L., Bonomi, L., Ungerleider, N., Zina, J., Kimura, F., Mukherjee, A., Sidis, Y., & Schneyer, A. (2011) · Obesity · doi:10.1038/oby.2011.97 · Cited by 55 · see citing works

Follistatin targets distinct pathways to promote Brown adipocyte characteristics in Brown and white adipose tissues

Singh, R., Braga, M., Reddy, S. T., Lee, S.-J., Parveen, M., Grijalva, V., Vergnes, L., & Pervin, S. (2017) · Endocrinology · doi:10.1210/en.2016-1607 · Cited by 54 · see citing works

The Therapeutic Potential of Brown Adipocytes in Humans

Porter, C. C., Chondronikola, M., & Sidossis, L. S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00156 · Cited by 50 · see citing works

Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs

Cai, C., Qian, L., Jiang, S., Sun, Y., Wang, Q., Ma, D., Xiao, G., Li, B., Xie, S., Gao, T., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16822 · Cited by 49 · see citing works

Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice

Choi, S. J., Yablonka‐Reuveni, Z., Kaiyala, K. J., Ogimoto, K., Schwartz, M. W., & Wisse, B. E. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00656.2010 · Cited by 48 · see citing works

Building muscle, browning fat and preventing obesity by inhibiting myostatin

LeBrasseur, N. K. (2012) · Diabetologia · doi:10.1007/s00125-011-2361-8 · Cited by 46 · see citing works

Overcoming Insulin Insufficiency by Forced Follistatin Expression in β -cells of db/db Mice

Zhao, C., Qiao, C., Tang, R., Jiang, J., Li, J., Martin, C. B., Bulaklak, K., Li, J., Wang, D. W., & Xiao, X. (2015) · Molecular Therapy · doi:10.1038/mt.2015.29 · Cited by 37 · see citing works

Regulation of UCP1 in the Browning of Epididymal Adipose Tissue byβ3-Adrenergic Agonist: A Role for MicroRNAs

Zheng, Z., Liu, X., Zhao, Q., Zhang, L., Li, C., & Xue, Y. (2014) · International Journal of Endocrinology · doi:10.1155/2014/530636 · Cited by 34 · see citing works

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue

Tang, Y., Qian, S., Wu, M., Wang, J., Lü, P., Li, X., Huang, H., Guo, L., Sun, X., Xu, C., et al. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw019 · Cited by 33 · see citing works

Codon optimization and expression of irisin in Pichia pastoris GS115

Duan, H., Wang, H., Ma, B., Jiang, P., Tu, P., Ni, Z., Li, X., Li, M., 麻晓峰, Wang, B., et al. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.04.030 · Cited by 31 · see citing works

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

Singh, R., Pervin, S., Lee, S., Kuo, A., Grijalva, V. R., David, J., Vergnes, L., & Reddy, S. T. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s159315 · Cited by 29 · see citing works

Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice

Li, H., Zhang, C., Liu, J., Xie, W., Xu, W., Liang, F., Huang, K., & He, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220310 · Cited by 26 · see citing works

Site-specific mutagenesis of human follistatin

Inouye, S., Guo, Y.-L., LING, N. C., & Shimasaki, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91377-o · Cited by 25 · see citing works

AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis

Guo, W., Wong, S., & Bhasin, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071017 · Cited by 24 · see citing works

Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons

Pydi, S. P., Cui, Z., He, Z., Barella, L. F., Pham, J., Cui, Y., Oberlin, D. J., EĞRİTAĞ, H. E., Urs, N. M., Gavrilova, O., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz1341 · Cited by 19 · see citing works

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Davey, J. R., Estévez, E., Thomson, R. E., Whitham, M., Watt, K. I., Hagg, A., Qian, H., Henstridge, D. C., Ludlow, H., Hedger, M. P., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201802059rrr · Cited by 15 · see citing works

Insights into an adipocyte whitening program

Hill, B. G. (2014) · Adipocyte · doi:10.4161/21623945.2014.960351 · Cited by 12 · see citing works

Correction: Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice

Li, H., Zhang, C., Liu, J., Xie, W., Xu, W., Liang, F., Huang, K., & He, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226344 · Cited by 9 · see citing works

Getting the Skinny on Follistatin and Fat

Li, J.-X., & Cummins, C. L. (2017) · Endocrinology · doi:10.1210/en.2017-00223 · Cited by 5 · see citing works

Diet, exercise, and pharmacotherapy for sarcopenia in people with diabetes

Hashimoto, Y., Takahashi, F., Okamura, T., Hamaguchi, M., & Fukui, M. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155585 · Cited by 124 · see citing works

Immunological and Metabolic Causes of Infertility in Polycystic Ovary Syndrome

Kicińska, A. M., Maksym, R., Zabielska-Kaczorowska, M. A., Stachowska, A., & Babińska, A. (2023) · Biomedicines · doi:10.3390/biomedicines11061567 · Cited by 98 · see citing works

Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue

Zhang, Z., Yang, D., Xiang, J., Zhou, J., Cao, H., Che, Q., Bai, Y., Guo, J., & Su, Z. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60354 · Cited by 80 · see citing works

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

Schüler‐Toprak, S., Ortmann, O., Buechler, C., & Treeck, O. (2022) · Biomedicines · doi:10.3390/biomedicines10102503 · Cited by 61 · see citing works

Astaxanthin Supplemented with High-Intensity Functional Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity

Saeidi, A., Habashi, A. N., Razi, O., Ataeinosrat, A., Rahmani, H., Mollabashi, S. S., Bagherzadeh-Rahmani, B., Aghdam, S. M., Khalajzadeh, L., Kiyumi, M. H. A., et al. (2023) · Nutrients · doi:10.3390/nu15020286 · Cited by 49 · see citing works

Cytokines and exosomal miRNAs in skeletal muscle–adipose crosstalk

Guo, L., Quan, M., Pang, W., Yin, Y., & Li, F. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.07.006 · Cited by 48 · see citing works

The effects of resistance training on myostatin and follistatin in adults: A systematic review and meta-analysis

Khalafi, M., Aria, B., Symonds, M. E., & Rosenkranz, S. K. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114272 · Cited by 48 · see citing works

Adipocyte-Specific Expression of PGC1α Promotes Adipocyte Browning and Alleviates Obesity-Induced Metabolic Dysfunction in an HO-1-Dependent Fashion

Shen, H., Singh, S. P., Raffaele, M., Waldman, M., Hochhauser, E., Ospino, J., Arad, M., & Peterson, S. J. (2022) · Antioxidants · doi:10.3390/antiox11061147 · Cited by 42 · see citing works

Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver

López-Bermudo, L., Luque‐Sierra, A., Maya‐Miles, D., Gallego‐Durán, R., Ampuero, J., Romero‐Gómez, M., Berná, G., & Martı́n, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.892672 · Cited by 32 · see citing works

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis

Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works

Mechanisms of Testosterone's Anabolic Effects on Muscle and Function: Controversies and New Insights

Bhasin, S., Wang, C., Chandra, M. R. G., Gagliano‐Jucá, T., & Jasuja, R. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf041 · Cited by 24 · see citing works

Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management

Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2025) · Metabolites · doi:10.3390/metabo15020085 · Cited by 19 · see citing works

The multifaceted regulation of white adipose tissue browning and their therapeutic potential

Satheesan, A., Kumar, J. S., Leela, K. V., Lathakumari, R. H., Angelin, M., Murugesan, R., & Chaithanya, V. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01117-3 · Cited by 13 · see citing works

The Concentration of Follistatin and Activin A in Serum and Selected Biochemical Parameters in Women with Polycystic Ovary Syndrome: Stratification by Tobacco Smoke Exposure, Insulin Resistance, and Overweight/Obesity

Niepsuj, J., Piwowar, A., Franik, G., & Bizoń, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175316 · Cited by 9 · see citing works

The Influence of Metabolic Syndrome on Potential Aging Biomarkers in Participants with Metabolic Syndrome Compared to Healthy Controls

Holmannová, D., Borský, P., Andrýs, C., Kremláček, J., Fiala, Z., Kovaříková, H., Řeháček, V., Esterková, M., Počtová, G., Maresova, T., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12010242 · Cited by 8 · see citing works

Molecular Mechanisms and Clinical Implications of Complex Prehabilitation in Colorectal Cancer Surgery: A Comprehensive Review

Włodarczyk, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157242 · Cited by 12 · see citing works

Identification of key modules in metabolic syndrome induced by second-generation antipsychotics based on co-expression network analysis

Sun, Y., Zhu, C., Huang, L., Luo, C., Ju, P., & Chen, J. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.01.003 · Cited by 8 · see citing works

Impact of spinach thylakoid extract-induced 12-week high-intensity functional training on specific adipokines in obese males

Saeidi, A., Motamedi, P., Hoteit, M., Sadek, Z., Ramadan, W., Dara, M. M., Almaqhawi, A., Shahrbanian, S., Abednatanzi, H., Escobar, K. A., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2398467 · Cited by 7 · see citing works

Insights into the bone morphogenetic protein signaling in musculoskeletal disorders: Mechanisms and crosstalk

Chen, B., Liu, X., Hu, M., & Liao, J. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.03.005 · Cited by 7 · see citing works

Myostatin in Obesity: A Molecular Link Between Metabolic Dysfunction and Musculotendinous Remodeling

Cesanelli, L., Minderis, P., Fokin, A., Ratkevičius, A., Satkunskienė, D., & Degens, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020967 · Cited by 7 · see citing works

Transforming Growth Factorβ1 Overexpression Is Associated with Insulin Resistance and Rapidly Progressive Kidney Fibrosis under Diabetic Conditions

D’Alessandro, V. F., Takeshita, A., Yasuma, T., Toda, M., D’Alessandro‐Gabazza, C. N., Okano, Y., Tharavecharak, S., Inoue, C., Nishihama, K., Fujimoto, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214265 · Cited by 7 · see citing works

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

Razi, O., Teixeira, A. M., Tartibian, B., Zamani, N., & Knechtle, B. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04610-1 · Cited by 7 · see citing works

Exploring myostatin’s role and potential applications in fisheries and aquaculture: a review

Priyanka, P., Kashyap, S., Umesh, Verma, K., Singh, M., & Yadav, N. (2024) · Aquaculture International · doi:10.1007/s10499-024-01700-3 · Cited by 6 · see citing works

Unraveling the interplay: exploring signaling pathways in pancreatic cancer in the context of pancreatic embryogenesis

Swain, S., Narayan, R. K., & Mishra, P. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1461278 · Cited by 5 · see citing works

Dietary perennial ryegrass improves meat quality through the gut–muscle axis in geese by regulating the ECM receptor complex/TGF-β signaling

Zulfiqar, Z., Asif, M. A., Li, Y., Al-Mitib, L., Han, Y., Shaukat, A., Zhu, X., Wang, Z., Sun, H., Cui, Y., et al. (2025) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2025.108247 · Cited by 6 · see citing works

The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat

Shao, H., Zhang, H., & Jia, D. (2024) · Metabolites · doi:10.3390/metabo14050287 · Cited by 4 · see citing works

Studying Myostatin as a Diagnostic Indicator in Sera of Iraqi Women with Metabolic Syndrome

Assaf, R. H., & Farhan, L. O. (2023) · Baghdad Science Journal · doi:10.21123/bsj.2023.8180 · Cited by 3 · see citing works

Glycosaminoglycan dermatan sulfate supplementation decreases diet‐induced obesity and metabolic dysfunction in mice

Stojnić, B., Galmés, S., Serrano, A., Sulli, M. M., Sušak, L., Seye, N., Palou, A., Diretto, G., Bonet, M. L., & Ribot, J. (2023) · BioFactors · doi:10.1002/biof.2022 · Cited by 3 · see citing works

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Su, Y., Liu, N., Liu, Y., Sun, Y., & Jiao, Y. (2025) · Experimental Physiology · doi:10.1113/ep093049 · Cited by 2 · see citing works

Comparative Transcriptome Analysis Reveals the Role of the FST Gene in Goose Muscle Development

Wang, C., Liu, Y., Li, M., Yang, Y., Dai, J., Chen, S., Wang, H., & He, D. (2025) · Animals · doi:10.3390/ani15203009 · Cited by 2 · see citing works

FST Polymorphisms Associate with Musculoskeletal Traits and Modulate Exercise Response Differentially by Sex and Modality in Northern Han Chinese Adults

Cao, W., Gu, Z., Fu, R. G., Chen, Y., He, Y., Rui, Y., Yang, X., & He, Z. (2025) · Genes · doi:10.3390/genes16070810 · Cited by 1 · see citing works

The effect of circuit resistance training with three different intensities on muscle growth factors in obese men: a randomized controlled trial

Niazi, S., Rajabi, H., & Amani-Shalamzari, S. (2025) · Sport Sciences for Health · doi:10.1007/s11332-025-01501-y · Cited by 1 · see citing works

TRPM8-driven thermogenesis by menthol: mechanisms of cold injury prevention

Li, Y., Song, Y., Yang, X., Zhu, H., Yu, H., & Kong, Y. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01120-8 · Cited by 1 · see citing works

Adipo-Myokine Modulation in Obesity: Integrative Effects of Spinach Thylakoids and Functional Training in Men with Obesity: A Randomized Controlled Clinical Trial

Razi, O., Shafei, A., Abdi, M., Saeidi, B., Farzanegi, P., Zamani, N., ALNasser, M. N., Hejazi, K., Almaqhawi, A., Saeidi, A., et al. (2026) · Nutrients · doi:10.3390/nu18030509 · Cited by 1 · see citing works

Myostatin Research: From Molecular Understanding to Clinical Translation for Musculoskeletal and Metabolic Disorders

Lei, C., Jiang, H., Yang, X., Ding, S., Yu, Y., Zhang, Z., Wang, L., Gao, C., Lü, A., Qin, L., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093836 · Cited by 1 · see citing works

Exercise Intensity and Circulating Exerkine Responses: A Narrative Review of Selected Molecules

Zhao, Y., Wang, T., Zhang, X., Wang, W., Fu, Y., Laher, I., & Li, S. (2026) · Biomolecules · doi:10.3390/biom16060852 · Cited by 1 · see citing works

Kardiyokinlerin Obezite ve Beslenme İle İlişkisi

Gerboğa, R., & Yılmaz, H. Ö. (2025) · Sağlık Bilimleri ve Klinik Araştırmaları Dergisi · doi:10.63695/jhscr.1601578

Follistatin Mitigates Atherosclerosis Through Activation of Arginine Metabolism and Adipose Browning

Dirakvand, G., Pervin, S., Villa, B., Le, C., Yohanna, K., Grijalva, V. R., Chattopadhyay, A., Sinha, S. K., Reddy, S. T., & Singh, R. (2026) · Cells · doi:10.3390/cells15131205

Molecular Protein Interactions and Predictive Pathways as Biomarkers for Enhancing Volleyball Performance: A Narrative Review

Cai, Y., Dai, J., Thirupathi, A., & Song, W. (2026) · Biomarker Insights · doi:10.1177/11772719261466285

Molecular linkages among exercise, obesity, MASLD, and adipose tissue metabolism: a bioinformatic analysis

Yang, M. J., Lyu, T., & Zhang, C. (2026) · The Journal of Precision Medicine Health and Disease · doi:10.1016/j.premed.2026.100052

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

Deng, X., Shen, Y., Sun, Y. H., Lu, L., & Sun, C. (2026) · MedComm · doi:10.1002/mco2.70976

Novel Aspects of Follistatin/Transforming Growth Factor-β (TGF-β) Signaling in Adipose Tissue Metabolism: Implications in Metabolic Health

Pervin, S., Wilson, N. Y. A. H., Reddy, S. T., & Singh, R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88294 · Cited by 3 · see citing works

Novel Aspects of Follistatin/Transforming Growth Factor-β (TGF-β) Signaling in Adipose Tissue Metabolism : Implications in Metabolic Health

Pervin, S. (2022) · BiblioBoard Library Catalog (Open Research Library)

Modulation of transforming growth factor-β/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders

Pervin, S., Singh, V., Tucker, A., Collazo, J., & Singh, R. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0036 · Cited by 13 · see citing works

Regulation of brown adipocyte metabolism by myostatin/follistatin signaling

Singh, R., Braga, M., & Pervin, S. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00060 · Cited by 70 · see citing works

Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice

Li, H., Zhang, C., Liu, J., Xie, W., Xu, W., Liang, F., Huang, K., & He, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220310 · Cited by 26 · see citing works