The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta
Open accessAbstract
Amyloid beta (Aβ) plays a critical role in the pathophysiology of Alzheimer’s disease. Increasing evidence indicates mitochondria as an important target of Aβ toxicity; however, the effects of Aβ toxicity on mitochondria have not yet been fully elucidated. Recent biochemical studies in vivo and in vitro implicate mitochondrial permeability transition pore (mPTP) formation involvement in Aβ mediated mitochondrial dysfunction. mPTP formation results in severe mitochondrial dysfunction such as reactive oxygen species (ROS) generation, mitochondrial membrane potential dissipation, intracellular calcium perturbation, decrease in mitochondrial respiration, release of pro-apoptotic factors and eventually cell death. Cyclophilin D (CypD) is one of the more well-known mPTP components and recent findings reveal that Aβ has significant impact on CypD-mediated mPTP formation. In this review, the role of Aβ in the formation of mPTP and the potential of mPTP inhibition as a therapeutic strategy in AD treatment are examined.
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Cites
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
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Cited by
Fricker, M., Tolkovsky, A. M., Borutaite, V., Coleman, M., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,108
Mechanism of Oxidative Stress in Neurodegeneration
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Neuroprotective strategies involving ROS in Alzheimer disease
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The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275
Mitochondrial Calcium: Effects of Its Imbalance in Disease
Matuz-Mares, D., González-Andrade, M., Araiza-Villanueva, M. G., Vilchis-Landeros, M. M., & Vázquez-Meza, H. (2022) · Antioxidants · doi:10.3390/antiox11050801 · Cited by 266
Metadata
- Authors
- Du, H., & Yan, S. S.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 1802
- Issue
- 1
- Pages
- 198-204
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2130508542
- Cited by
- 238
- References
- 18
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Du, H., & Yan, S. S. (2010). Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/j.bbadis.2009.07.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
