The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Mechanism of Oxidative Stress in Neurodegeneration
Open accessAbstract
Biological tissues require oxygen to meet their energetic demands. However, the consumption of oxygen also results in the generation of free radicals that may have damaging effects on cells. The brain is particularly vulnerable to the effects of reactive oxygen species due to its high demand for oxygen, and its abundance of highly peroxidisable substrates. Oxidative stress is caused by an imbalance in the redox state of the cell, either by overproduction of reactive oxygen species, or by dysfunction of the antioxidant systems. Oxidative stress has been detected in a range of neurodegenerative disease, and emerging evidence from in vitro and in vivo disease models suggests that oxidative stress may play a role in disease pathogenesis. However, the promise of antioxidants as novel therapies for neurodegenerative diseases has not been borne out in clinical studies. In this review, we critically assess the hypothesis that oxidative stress is a crucial player in common neurodegenerative disease and discuss the source of free radicals in such diseases. Furthermore, we examine the issues surrounding the failure to translate this hypothesis into an effective clinical treatment.
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Cites
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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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Oxidative stress and neurodegeneration: where are we now?
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Mitochondrial metabolism of reactive oxygen species
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Cited by
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971
“In the pathogenesis of neurodegeneration, many processes are included, such as protein misfolding and aggregation, abnormal kinase-signaling pathways, neuronal calcium dysregulation, and even impaired synaptic transmission (Gandhi and Abramov, 2012).”
BackgroundInfluentialZielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683
The role of oxidative stress in neurodegenerative diseases
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355
Oxidative Stress and the Central Nervous System
Salim, S. (2017) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,247
Metadata
- Authors
- Gandhi, S., & Abramov, A. Y.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-11
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2064004368
- Cited by
- 960
- References
- 102
- FWCI
- 28.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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