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An overview of molecular basis of iron metabolism regulation and the associated pathologies
Open accessAbstract
Iron is essential for several vital biological processes. Its deficiency or overload drives to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, such as the alternative splicing, microRNAs, the IRP/IRE system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.
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“Furthermore, the hypoxia inducible factor (HIF) and the nuclear factor-erythroid 2-related factor 2 (NRF2) pathways are related with anemia (Lee et al., 2004;Silva and Faustino, 2015).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Silva and Faustino, 2015
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Metadata
- Authors
- Silva, B., & Faustino, P.
- Affiliations
- National Institute of Health Dr. Ricardo Jorge (PT)
- Corresponding author
- Faustino, Paula
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 1852
- Issue
- 7
- Pages
- 1347-1359
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2076768785
- Cited by
- 300
- References
- 193
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 27 · 2023: 40 · 2022: 25 · 2021: 31 · 2020: 24 · 2019: 30 · 2018: 23 · 2017: 21 · 2016: 28 · 2015: 9
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron metabolism, iron homeostasis, hepcidin, iron absorption, enterocytes, inflammation, anemia, erythropoiesis, post-transcriptional regulation, alternative splicing, microRNA, proteolytic cleavage
- MeSH terms
- Animals, Humans, Iron, Iron Metabolism Disorders, Iron-Binding Proteins, Iron-Regulatory Proteins
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