Cited by 236Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsNuclear Receptors and Signaling

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Sirtuin regulation in aging and injury

Open access

Poulose, Ninu, Raju, Raghavan·2015·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2015.08.017PMC PMC4682052

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Abstract

Sirtuins or Sir2 family of proteins are a class of NAD(+) dependent protein deacetylases which are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP ribosyl transferase, demalonylation and desuccinylation activities. Originally identified in the yeast, these proteins regulate key cellular processes like cell cycle, apoptosis, metabolic regulation and inflammation. Humans encode seven sirtuin isoforms SIRT1-SIRT7 with varying intracellular distribution. Apart from their classic role as histone deacetylases regulating transcription, a number of cytoplasmic and mitochondrial targets of sirtuins have also been identified. Sirtuins have been implicated in longevity and accumulating evidence indicate their role in a spectrum of diseases like cancer, diabetes, obesity and neurodegenerative diseases. A number of studies have reported profound changes in SIRT1 expression and activity linked to mitochondrial functional alterations following hypoxic-ischemic conditions and following reoxygenation injury. The SIRT1 mediated deacetylation of targets such as PGC-1α, FOXO3, p53 and NF-κb has profound effect on mitochondrial function, apoptosis and inflammation. These biological processes and functions are critical in life-span determination and outcome following injury. Aging is reported to be characterized by declining SIRT1 activity, and its increased expression or activation demonstrated prolonged life-span in lower forms of animals. A pseudohypoxic state due to declining NAD(+) has also been implicated in aging. In this review we provide an overview of studies on the role of sirtuins in aging and injury.

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Authors: Poulose, N., & Raju, R.
Affiliations: Augusta University (US)
Corresponding author: Raju, Raghavan
ORCID: Poulose, Ninu
Raju, Raghavan
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2015-11
Volume: 1852
Issue: 11
Pages: 2442-2455
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2015.08.017
PMC: PMC4682052
OpenAlex: W2114556905
Cited by: 236
References: 314
Citations by year: 2026: 9 · 2025: 12 · 2024: 11 · 2023: 21 · 2022: 23 · 2021: 28 · 2020: 20 · 2019: 17 · 2018: 19 · 2017: 39 · 2016: 31 · 2015: 4
FWCI: 3.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01 GM 101927)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: sirtuins, SIRT1, aging, tissue damage, NAD+-dependent deacetylation, mitochondrial function, hypoxia-ischemia, reoxygenation injury, PGC-1α, FOXO3, p53, NF-κB, apoptosis, inflammation, longevity, pseudohypoxia, neurodegenerative diseases, cancer, diabetes mellitus, obesity

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