Endothelial cell senescence in aging-related vascular dysfunction
Open accessAbstract
Increased cardiovascular disease in aging is partly a consequence of the vascular endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC senescence is a pathophysiological process of structural and functional changes including dysregulation of vascular tone, increased endothelium permeability, arterial stiffness, impairment of angiogenesis and vascular repair, and a reduction of EC mitochondrial biogenesis. Dysregulation of cell cycle, oxidative stress, altered calcium signaling, hyperuricemia, and vascular inflammation have been implicated in the development and progression of EC senescence and vascular disease in aging. A number of abnormal molecular pathways are associated with these underlying pathophysiological changes including Sirtuin 1, Klotho, fibroblast growth factor 21, and activation of the renin angiotensin-aldosterone system. However, the molecular mechanisms of EC senescence and associated vascular impairment in aging are not completely understood. This review provides a contemporary update on molecular mechanisms, pathophysiological events, as well functional changes in EC senescence and age-associated cardiovascular disease. This article is part of a Special Issue entitled: Genetic and epigenetic regulation of aging and longevity edited by Jun Ren & Megan Yingmei Zhang.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Key clinical risk factors for developing severe COVID-19 such as advanced age, obesity, diabetes, and vascular disease are all characterized by activation or exacerbation of cellular senescence processes.
“Key clinical risk factors for developing severe COVID-19 such as advanced age, obesity, diabetes, and vascular disease are all characterized by the activation or exacerbation of cellular senescence processes (66).”
From Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 (2021) · cites this paper as [66]
This expression profile is indicative of an early cellular senescence phenotype.
“This profile is indicative of an early cellular senescence phenotype62–66.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes
Zhou, J., Wang, Q., Ding, Y., & Zou, M. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0213 · Cited by 18 · see citing works
RetractedOkano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239 · see citing works
Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study
Mitchell, G. F., Hwang, S.-J., Vasan, R. S., Larson, M. G., Pencina, M. J., Hamburg, N. M., Vita, J. A., Levy, D., & Benjamin, E. J. (2010) · Circulation · doi:10.1161/circulationaha.109.886655 · Cited by 2,225 · see citing works
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works
Senescence in Health and Disease
He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works
Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women
Mitchell, G. F., Parise, H., Benjamin, E. J., Larson, M. G., Keyes, M. J., Vita, J. A., Vasan, R. S., & Levy, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000128420.01881.aa · Cited by 1,507 · see citing works
Residual Lifetime Risk for Developing Hypertension in Middle-aged Women and Men
Vasan, R. S., Beiser, A., Seshadri, S. S., Larson, M. G., Kannel, W. B., D’Agostino, R. B., & Levy, D. A. (2002) · JAMA · doi:10.1001/jama.287.8.1003 · Cited by 1,399 · see citing works
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,192 · see citing works
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061 · see citing works
Tripathi, V., Shen, Z., Chakraborty, A., Giri, S., Freier, S. M., Wu, X., Zhang, Y., Gorospe, M., Prasanth, S. G., Lal, A., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003368 · Cited by 753 · see citing works
Telomere length and replicative aging in human vascular tissues.
Chang, E., & Harley, C. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11190 · Cited by 635 · see citing works
Impaired progenitor cell activity in age-related endothelial dysfunction
Heiss, C., Keymel, S., Niesler, U., Ziemann, J., Kelm, M., & Kalka, C. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.074 · Cited by 573 · see citing works
Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques
Martinet, W., Knaapen, M., Meyer, G. R. Y. D., Herman, A. G., & Kockx, M. M. (2002) · Circulation · doi:10.1161/01.cir.0000026393.47805.21 · Cited by 448 · see citing works
Wilkinson, I. B., Hall, I. R., MacCallum, H., Mackenzie, I. S., McEniery, C. M., van der Arend, B. J., Shu, Y.-E., Mackay, L., Webb, D. J., & Cockcroft, J. R. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.101770 · Cited by 371 · see citing works
MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
Boon, R. A., Seeger, T., Heydt, S., Fischer, A., Hergenreider, E., Horrevoets, A. J. G., Vinciguerra, M., Rosenthal, N. A., Sciacca, S., Pilato, M., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.255737 · Cited by 365 · see citing works
MicroRNA-34a regulation of endothelial senescence
Ito, T., Yagi, S., & Yamakuchi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.012 · Cited by 336 · see citing works
Elahy, M., Jackaman, C., Mamo, J. C., Lam, V., Dhaliwal, S. S., Giles, C., Nelson, D., & Takechi, R. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0029-9 · Cited by 300 · see citing works
Zhou, S., Chen, H., Wan, Y.-Z., Zhang, Q.-J., Wei, Y.-S., Huang, S., Liu, J., Lu, Y., Zhang, Z., Yang, R., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.243592 · Cited by 273 · see citing works
Lin, Z., Pan, X., Wu, F., Ye, D., Zhang, Y., Wang, Y., Jin, L., Lian, Q., Huang, Y., Ding, H., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.015308 · Cited by 271 · see citing works
Plasma Klotho and Cardiovascular Disease in Adults
Semba, R. D., Cappola, A. R., Sun, K., Bandinelli, S., Dalal, M., Crasto, C., Guralnik, J. M., & Ferrucci, L. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03558.x · Cited by 269 · see citing works
Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown
Yamazaki, Y., Baker, D. J., Tachibana, M., Liu, C.-C., van Deursen, J. M., Brott, T. G., Bu, G., & Kanekiyo, T. (2016) · Stroke · doi:10.1161/strokeaha.115.010835 · Cited by 263 · see citing works
HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells
Zeng, L., Xiao, Q., Margariti, A., Zhang, Z., Zampetaki, A., Patel, S. V., Capogrossi, M. C., Hu, Y., & Xu, Q. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605113 · Cited by 251 · see citing works
Uric Acid - Key Ingredient in the Recipe for Cardiorenal Metabolic Syndrome
Chaudhary, K. R., Malhotra, K., Sowers, J. R., & Aroor, A. R. (2013) · Cardiorenal Medicine · doi:10.1159/000355405 · Cited by 242 · see citing works
Self-citationPuddu, P., Puddu, G. M., Cravero, E., Vizioli, L., & Muscari, A. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.01.013 · Cited by 236 · see citing works
Rossman, M. J., Kaplon, R. E., Hill, S. D., McNamara, M. N., Santos-Parker, J. R., Pierce, G. L., Seals, D. R., & Donato, A. J. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00416.2017 · Cited by 232 · see citing works
Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases
Cencioni, C., Spallotta, F., Martelli, F., Valente, S., Mai, A., Zeiher, A., & Gaetano, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917643 · Cited by 218 · see citing works
Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis
Okuda, K., Khan, M. Y., Skurnick, J., Kimura, M., Aviv, H., & Aviv, A. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00482-7 · Cited by 217 · see citing works
Foltz, I. N., Hu, S., King, C., Wu, X., Yang, C., Wang, W., Weiszmann, J., Stevens, J., Chen, J. S., Nuanmanee, N., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004690 · Cited by 211 · see citing works
Arunachalam, G., Yao, H., Sundar, I. K., Caito, S. W., & Rahman, I. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.080 · Cited by 204 · see citing works
Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 202 · see citing works
Zarzuelo, M. J., López-Sepúlveda, R., Sánchez, M., Romero, M., Gómez-Guzmán, M., Ungvary, Z., Pérez-Vizcaíno, F., Jiménez, R., & Duarte, J. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.015 · Cited by 202 · see citing works
Kitagawa, M., Sugiyama, H., Morinaga, H., Inoue, T., Takiue, K., Ogawa‐Akiyama, A., Yamanari, T., Kikumoto, Y., Uchida, H. A., Kitamura, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056695 · Cited by 195 · see citing works
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., et al. (2013) · Aging Cell · doi:10.1111/acel.12039 · Cited by 190 · see citing works
Illi, B., Scopece, A., Nanni, S., Farsetti, A., Morgante, L., Biglioli, P., Capogrossi, M. C., & Gaetano, C. (2005) · Circulation Research · doi:10.1161/01.res.0000159181.06379.63 · Cited by 189 · see citing works
Enalapril and losartan attenuate mitochondrial dysfunction in aged rats
de Cavanagh, E. M. V., Piotrkowski, B., Basso, N., Stella, I., Inserra, F., Ferder, L., & Fraga, C. G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0063fje · Cited by 185 · see citing works
Vascular stiffness in insulin resistance and obesity
Jia, G., Aroor, A. R., DeMarco, V. G., Martinez‐Lemus, L. A., Meininger, G. A., & Sowers, J. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00231 · Cited by 170 · see citing works
Self-citationLower skeletal muscle capillarization and VEGF expression in aged vs. young men
Ryan, N. A., Zwetsloot, K. A., Westerkamp, L. M., Hickner, R. C., Pofahl, W. E., & Gavin, T. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00827.2005 · Cited by 165 · see citing works
Ageing induced vascular smooth muscle cell senescence in atherosclerosis
Uryga, A. K., & Bennett, M. R. (2016) · The Journal of Physiology · doi:10.1113/jp270923 · Cited by 160 · see citing works
Reduced Klotho is associated with the presence and severity of coronary artery disease
Navarro‐González, J. F., Donate‐Correa, J., de Fuentes, M. M., Pérez-Hernández, H., Martínez‐Sanz, R., & Fernández, C. M. (2013) · Heart · doi:10.1136/heartjnl-2013-304746 · Cited by 160 · see citing works
Khan, S. Y., Awad, E. M., Oszwald, A., Mayr, M., Yin, X., Waltenberger, B., Stuppner, H., Lipovac, M., Uhrín, P., & Breuss, J. M. (2017) · Scientific Reports · doi:10.1038/srep39501 · Cited by 155 · see citing works
PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα
Shao, D., Liu, Y., Liu, X., Zhu, L., Cui, Y., Cui, A., Qiao, A., Kong, X., Liu, Y. U., Chen, Q., et al. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.012 · Cited by 155 · see citing works
Protective effect of the inhibition of the renin–angiotensin system on aging
Basso, N., Paglia, N., Stella, I., de Cavanagh, E. M. V., Ferder, L., Arnaiz, M. D. R. L., & Inserra, F. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.027 · Cited by 153 · see citing works
Bianchessi, V., Badi, I., Bertolotti, M., Nigro, P., D’Alessandra, Y., Capogrossi, M. C., Zanobini, M., Pompilio, G., Raucci, A., & Lauri, A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.012 · Cited by 149 · see citing works
Abbas, M., Jesel, L., Auger, C., Amoura, L., Messas, N., Manin, G., Rumig, C., León‐González, A. J., Ribeiro, T. P., da Silva, G. C., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.017513 · Cited by 147 · see citing works
Expression of Chr9p21 genes CDKN2B (p15), CDKN2A (p16, p14) and MTAP in human atherosclerotic plaque
Holdt, L. M., Sass, K., Gäbel, G., Bergert, H., Thiery, J., & Teupser, D. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.06.029 · Cited by 143 · see citing works
Age‐Associated Changes in the Vascular Renin‐Angiotensin System in Mice
Yoon, H. E., Kim, E. N., Kim, M. Y., Lim, J. H., Jang, I. E., Ban, T. H., Shin, S. J., Park, C. W., Chang, Y. S., & Choi, B. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6731093 · Cited by 143 · see citing works
Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function
Lindberg, K., Olauson, H., Amin, R., Ponnusamy, A., Goetz, R. M., Taylor, R. F., Mohammadi, M., Canfield, A. E., Kublickiene, K. R., & Larsson, T. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060658 · Cited by 142 · see citing works
Uric Acid Promotes Left Ventricular Diastolic Dysfunction in Mice Fed a Western Diet
Jia, G., Habibi, J., Bostick, B. P., Ma, L., DeMarco, V. G., Aroor, A. R., Hayden, M. R., Whaley‐Connell, A. T., & Sowers, J. R. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04737 · Cited by 141 · see citing works
Self-citationChatterjee, S., Ganini, D., Tokar, E. J., Kumar, A., Das, S., Corbett, J. T., Kadiiska, M. B., Waalkes, M. P., Diehl, A. M., & Mason, R. P. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.11.035 · Cited by 134 · see citing works
Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction
Bhayadia, R., Schmidt, B. M. W., Melk, A., & Hömme, M. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv008 · Cited by 126 · see citing works
Baccarelli, A., Tarantini, L., Wright, R. O., Bollati, V., Litonjua, A. A., Zanobetti, A., Sparrow, D., Vokonas, P., & Schwartz, J. D. (2010) · Epigenetics · doi:10.4161/epi.5.3.11377 · Cited by 122 · see citing works
Morgan, R. G., Ives, S. J., Lesniewski, L. A., Cawthon, R. M., Andtbacka, R. H. I., Noyes, R. D., Richardson, R. S., & Donato, A. J. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00197.2013 · Cited by 115 · see citing works
Pedersen, E. M., Oyre, S., Agerbæk, M., Kristensen, I. B., Ringgaard, S., Boesiger, P., & Wp, P. (1999) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.1999.0913 · Cited by 111 · see citing works
MicroRegulators come of age in senescence
Gorospe, M., & Abdelmohsen, K. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.03.005 · Cited by 108 · see citing works
The role of the anti-ageing protein Klotho in vascular physiology and pathophysiology
Mencke, R., & Hillebrands, J. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.001 · Cited by 104 · see citing works
Gu, Y., Vorburger, R. S., Scarmeas, N., Luchsinger, J. A., Manly, J. J., Schupf, N., Mayeux, R. P., & Brickman, A. M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.04.022 · Cited by 99 · see citing works
Eitan, E., Tichon, A., Gazit, A., Gitler, D., Slavin, S., & Priel, E. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200212 · Cited by 96 · see citing works
Kurz, D. J., Kloeckener‐Gruissem, B., Akhmedov, A. T., Eberli, F. R., Bühler, I., Berger, W., Bertel, O., & Lüscher, T. F. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000222961.24912.69 · Cited by 93 · see citing works
Wan, Y.-Z., Gao, P., Zhou, S., Zhang, Z., Hao, D., Lian, L., Li, Y., Chen, H., & Liu, D. (2014) · Aging Cell · doi:10.1111/acel.12247 · Cited by 90 · see citing works
Vascular aging: implications for cardiovascular disease and therapy
Ghebre, Y. T., Yakubov, E., Wong, W. T., & Krishnamurthy, P. (2016) · Translational Medicine · doi:10.4172/2161-1025.1000183 · Cited by 87 · see citing works
Xiong, S., Salazar, G., Martín, A. S., Ahmad, M., Patrushev, N. A., Hilenski, L. L., Nazarewicz, R. R., Ma, M., Ushio‐Fukai, M., & Alexander, R. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.065235 · Cited by 83 · see citing works
Ishibazawa, A., Nagaoka, T., Takahashi, T., Yamamoto, K., Kamiya, A., Ando, J., & Yoshida, A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7686 · Cited by 78 · see citing works
Age-related difference of site-specific histone modifications in rat liver
Kawakami, K., Nakamura, A., Ishigami, A., Goto, S., & Takahashi, R. (2009) · Biogerontology (Dordrecht) · doi:10.1007/s10522-008-9176-0 · Cited by 78 · see citing works
Epigenetic regulation of endothelial‐cell‐mediated vascular repair
Fraineau, S., Palii, C. G., Allan, D., & Brand, M. (2014) · FEBS Journal · doi:10.1111/febs.13183 · Cited by 76 · see citing works
Kim, M. Y., Kang, E. S., Ham, S. A., Hwang, J. S., Yoo, T. S., Lee, H., Paek, K. S., Park, C., Lee, H. T., Kim, J., et al. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.09.008 · Cited by 71 · see citing works
Longitudinal Association Between Serum Uric Acid and Arterial Stiffness
Canepa, M., Viazzi, F. C., Strait, J. B., Ameri, P., Pontremoli, R., Brunelli, C., Studenski, S. A., Ferrucci, L., Lakatta, E. G., & AlGhatrif, M. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08114 · Cited by 71 · see citing works
Fructose and Uric Acid: Is There a Role in Endothelial Function?
Jia, G., Aroor, A. R., Whaley‐Connell, A. T., & Sowers, J. R. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0434-z · Cited by 69 · see citing works
Self-citationSung, J. Y., Lee, K. Y., Kim, J., & Choi, H. C. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.001 · Cited by 69 · see citing works
Age intrinsic loss of telomere protection via TRF1 reduction in endothelial cells
Hohensinner, P. J., Kaun, C., Buchberger, E., Ebenbauer, B., Demyanets, S., Huk, I., Eppel, W., Maurer, G., Huber, K., & Wojta, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.11.034 · Cited by 67 · see citing works
Effect of aging on expression of angiogenesis-related factors in mouse skeletal muscle
Wagatsuma, A. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.003 · Cited by 64 · see citing works
Pal, P. B., Sonowal, H., Shukla, K., Sk, S., & Ramana, K. V. (2017) · Endocrinology · doi:10.1210/en.2017-00294 · Cited by 63 · see citing works
Aroor, A. R., Jia, G., Habibi, J., Sun, Z., Ramirez‐Perez, F. I., Brady, B., Chen, D., Martinez‐Lemus, L. A., Manrique, C. M., Nistala, R., et al. (2017) · Metabolism · doi:10.1016/j.metabol.2017.06.006 · Cited by 61 · see citing works
Self-citationOlmos, G., Miguel, P. M., Alcalde‐Estévez, E., Medrano, D. R., Sosa, P., Rodríguez‐Mañas, L., Naves‐Díaz, M., Rodrı́guez-Puyol, D., Ruiz‐Torres, M. P., & López‐Ongil, S. (2017) · Aging Cell · doi:10.1111/acel.12664 · Cited by 59 · see citing works
Wang, X., Song, S., Xiao, H., Gao, P., Li, X.-J., & Si, L. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000363031 · Cited by 58 · see citing works
Telomere length in vascular tissues from patients with atherosclerotic disease
Nzietchueng, R., Elfarra, M., Nloga, J., Labat, C., Carteaux, J., Maureira, P., Lacolley, P. J., Villemot, J., & Benetos, A. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0029-1 · Cited by 58 · see citing works
Wang, X., Xiao, H., Ling-lin, L., Cheng, D., Li, X.-J., & Si, L. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.06.020 · Cited by 57 · see citing works
Jia, G., Habibi, J., Aroor, A. R., Hill, M. A., DeMarco, V. G., Lee, L. E., Ma, L., Barron, B. J., Whaley‐Connell, A. T., & Sowers, J. R. (2017) · Metabolism · doi:10.1016/j.metabol.2017.08.008 · Cited by 50 · see citing works
Self-citationGleyzer, N., & Scarpulla, R. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.291575 · Cited by 49 · see citing works
Markers of endothelial dysfunction and cerebral blood flow in older adults
Sabayan, B., Westendorp, R. G. J., van der Grond, J., Stott, D. J., Sattar, N. A., van Osch, M. J. P., van Buchem, M. A., & de Craen, A. J. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.020 · Cited by 48 · see citing works
Takahashi, M., Eda, A., Fukushima, T., & Hohjoh, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048974 · Cited by 44 · see citing works
Mun, G. I., Lee, S. J., An, S. M., Kim, I. K., & Boo, Y. C. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.032 · Cited by 41 · see citing works
Efficient differentiation of hESCs into endothelial cells in vitro is secured by epigenetic changes
Lagarkova, M. A., Volchkov, P., Philonenko, E. S., & Киселев, С. Л. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6700 · Cited by 38 · see citing works
Lin, Y., Zhen, Y., Wei, J., Liu, B., Zong-yuan, Y., & Hu, G. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.101 · Cited by 38 · see citing works
The influence of nitric oxide synthase 2 on cutaneous wound angiogenesis
Chin, L. C., Kumar, P., Palmer, J. A., Rophael, J. A., Dolderer, J. H., Thomas, G. P. L., Morrison, W. A., Penington, A., Stewart, A. G., & Mitchell, G. M. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10599.x · Cited by 35 · see citing works
Advanced age decreases local calcium signaling in endothelium of mouse mesenteric arteries in vivo
Boerman, E. M., Everhart, J. E., & Segal, S. S. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00038.2016 · Cited by 35 · see citing works
DAVIDGE, S., Hubel, C. A., & McLaughlin, M. K. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.6.r1625 · Cited by 30 · see citing works
Lastra, G., Manrique, C. M., Jia, G., Aroor, A. R., Hayden, M. R., Barron, B. J., Niles, B. J., Padilla, J., & Sowers, J. R. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00483.2016 · Cited by 29 · see citing works
Self-citationYue, Z., Rong, J., Ping, W., Bing, Y., Xin, Y., Feng, L., & Yaping, W. (2014) · Genetics and Molecular Research · doi:10.4238/2014.december.4.3 · Cited by 26 · see citing works
Ricottini, E., Madonna, R., Grieco, D., Zoccoli, A., Stampachiacchiere, B., Patti, G., Tonini, G., Caterina, R. D., & Sciascio, G. D. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.10.043 · Cited by 26 · see citing works
Werner syndrome: a model for sarcopenia due to accelerated aging
Yamaga, M., Takemoto, M., Shoji, M., Sakamoto, K., Yamamoto, M., Ishikawa, T., Koshizaka, M., Maezawa, Y., Kobayashi, K., & Yokote, K. (2017) · Aging · doi:10.18632/aging.101265 · Cited by 19 · see citing works
Is aortic wall shear stress affected by aging? An image-based numerical study with two age groups
Lantz, J., Renner, J., Länne, T., & Karlsson, M. (2015) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2014.12.011 · Cited by 18 · see citing works
Relation between endothelial progenitor cells and arterial stiffness in patients with psoriasis
Liu, J., Chen, Y., Zhen, Z., Yeung, C. K., Chan, J. C. Y., Chan, H. H. L., Tse, H., & Yiu, K. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.13235 · Cited by 16 · see citing works
Young endothelial cells revive aging blood
Chang, V. Y., Termini, C. M., & Chute, J. P. (2017) · Journal of Clinical Investigation · doi:10.1172/jci97707 · Cited by 6 · see citing works
de Andrade, C. R., Corrêa, F. M. D. A., & de Oliveira, A. M. (2009) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.45.307 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,834 · see citing works
Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00082-y · Cited by 572 · see citing works
Biology and therapeutic targeting of vascular endothelial growth factor A
Pérez, L., & Ferrara, N. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00631-w · Cited by 515 · see citing works
NLRP3 inflammasome in endothelial dysfunction
Bai, B., Yang, Y., Wang, Q., Li, M., Tian, C., Liu, Y., Aung, L. H. H., Li, P., Yu, T., & Chu, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02985-x · Cited by 492 · see citing works
Senescence mechanisms and targets in the heart
Chen, M. S., Lee, R. T., & Garbern, J. C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab161 · Cited by 336 · see citing works
D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237 · see citing works
The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy
Ricard, N., Bailly, S., Guignabert, C., & Simons, M. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00517-4 · Cited by 223 · see citing works
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy
Herzog, M. J., Müller, P., Lechner, K., Stiebler, M., Arndt, P., Kunz, M., Ahrens, D., Schmeißer, A., Schreiber, S., & Braun-Dullaeus, R. C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02346-0 · Cited by 246 · see citing works
Han, Y., & Kim, S. Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00906-w · Cited by 201 · see citing works
Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes
Bonafè, M., Prattichizzo, F., Giuliani, A., Storci, G., Sabbatinelli, J., & Olivieri, F. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.04.005 · Cited by 184 · see citing works
Zimmerman, B., Bart Rypma, A., Gratton, G., & Fabiani, M. (2021) · Psychophysiology · doi:10.1111/psyp.13796 · Cited by 173 · see citing works
Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases
de Almeida, A. J. P. O., Rezende, M. S. D. A., Dantas, S. H., Silva, S. D. L., de Oliveira, J. C. P. L., de Azevedo, F. D. L. A. A., Alves, R. M. F. R., de Menezes, G. M. S., dos Santos, P. F., Gonçalves, T. A. F., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1954398 · Cited by 167 · see citing works
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 169 · see citing works
Kaempferol: Paving the path for advanced treatments in aging-related diseases
Hussain, M. S., Altamimi, A. S. A., Afzal, M., Almalki, W. H., Kazmi, I. A., Alzarea, S. I., Gupta, G., Shahwan, M. J., Kukreti, N., Wong, L. S., et al. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112389 · Cited by 145 · see citing works
TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis
Ren, L.-L., Miao, H., Wang, Y.-N., Liu, F., Li, P., & Zhao, Y.-Y. (2023) · Aging and disease · doi:10.14336/ad.2023.0222 · Cited by 139 · see citing works
Bellut, M., Papp, L., Bieber, M., Kraft, P., Stoll, G., & Schuhmann, M. K. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04379-z · Cited by 135 · see citing works
Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging
Hwang, H. J., Kim, N., Herman, A. B., Gorospe, M., & Lee, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710135 · Cited by 135 · see citing works
Wolf, J., Rasmussen, D. K., Sun, Y. J., Vu, J. T., Wang, E., Espinosa, C. A., Bigini, F., Chang, R. T., Montague, A. A., Tang, P. H., et al. (2023) · Cell · doi:10.1016/j.cell.2023.09.012 · Cited by 125 · see citing works
Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke
Koutsaliaris, I. K., Moschonas, I. C., Pechlivani, L., Tsouka, A. N., & Tselepis, A. D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210921161711 · Cited by 120 · see citing works
Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain
Graves, S. I., & Baker, D. J. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13403 · Cited by 118 · see citing works
Wu, Y., Tang, L., Huang, H., Yu, Q., Hu, B., Wang, G., Ge, F., Yin, T., Li, S., & Yu, X. (2023) · Nature Communications · doi:10.1038/s41467-023-37094-8 · Cited by 118 · see citing works
Dagher, O., Mury, P., Thorin‐Trescases, N., Noly, P., Thorin, É., & Carrier, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.658400 · Cited by 113 · see citing works
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Suda, M., Paul, K. H., Minamino, T., Miller, J. D., Lerman, A., Ellison, G. M., Tchkonia, T., & Kirkland, J. L. (2023) · Cells · doi:10.3390/cells12091296 · Cited by 116 · see citing works
MicroRNA-34a: the bad guy in age-related vascular diseases
Raucci, A., Macrì, F., Castiglione, S., Badi, I., Vinci, M. C., & Zuccolo, E. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03979-4 · Cited by 114 · see citing works
Mahoney, S. A., Venkatasubramanian, R., Darrah, M. A., Ludwig, K. R., VanDongen, N. S., Greenberg, N., Longtine, A. G., Hutton, D. A., Brunt, V. E., Campisi, J., et al. (2023) · Aging Cell · doi:10.1111/acel.14060 · Cited by 107 · see citing works
Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Luan, Y., Zhu, X., Jiao, Y., Liu, H., Huang, Z., Pei, J., Xu, Y., Yang, Y., & Ren, K. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01792-5 · Cited by 106 · see citing works
Senescent cells and macrophages: key players for regeneration?
Elder, S. S., & Emmerson, E. (2020) · Open Biology · doi:10.1098/rsob.200309 · Cited by 109 · see citing works
Effects of polystyrene nanoplastics on endothelium senescence and its underlying mechanism
Shiwakoti, S., Ko, J.-Y., Gong, D.-S., Dhakal, B., Lee, J.-H., Adhikari, R., Gwak, Y.-H., Park, S., Choi, I. J., Schini‐Kerth, V. B., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107248 · Cited by 96 · see citing works
You, Y., Chen, X., Chen, Y., Pang, J., Chen, Q., Liu, Q., Xue, H., Zeng, Y., Xiao, J., Mi, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102828 · Cited by 92 · see citing works
Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells
Hansel, C., Jendrossek, V., & Klein, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093279 · Cited by 85 · see citing works
Zhu, H.-Y., Hong, F.-F., & Yang, S.-L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094540 · Cited by 84 · see citing works
Redox regulation of UPR signalling and mitochondrial ER contact sites
Casas-Martinez, J. C., Samali, A., & McDonagh, B. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05286-0 · Cited by 79 · see citing works
Khavinson, V., Linkova, N. S., Dyatlova, A., Кантемирова, Р. К., & Kozlov, K. L. (2022) · Cells · doi:10.3390/cells12010106 · Cited by 78 · see citing works
Marón, F. J. M., Ferder, L., Reiter, R. J., & Manucha, W. A. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105595 · Cited by 74 · see citing works
The role of FGF21 in the pathogenesis of cardiovascular disease
Zhang, Y., Liu, D., Long, X.-X., Fang, Q.-C., Jia, W.-P., & Li, H.-T. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001890 · Cited by 68 · see citing works
Sabe, S. A., Feng, J., Sellke, F. W., & Abid, M. R. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00603.2021 · Cited by 68 · see citing works
Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy
Ma, L., Li, K., Wei, W., Zhou, J., Li, Z., Zhang, T., Wangsun, Y., Tian, F., Dong, Q., Zhang, H., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102693 · Cited by 67 · see citing works
Matrix stiffness regulates macrophage polarization in atherosclerosis
Wang, Y., Shi, R., Zhai, R., Yang, S., Peng, T., Zheng, F., Shen, Y., Li, M., & Li, L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106236 · Cited by 66 · see citing works
Abdelgawad, I. Y., Agostinucci, K. J., Sadaf, B., Grant, M. K. O., & Zordoky, B. N. M. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1170434 · Cited by 70 · see citing works
Immunosenescence in atherosclerosis: A role for chronic viral infections
Talepoor, A. G., & Doroudchi, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945016 · Cited by 64 · see citing works
Endothelial Cell Dysfunction: Onset, Progression, and Consequences
Naderi‐Meshkin, H., & Setyaningsih, W. A. W. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906223 · Cited by 74 · see citing works
PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging
Liu, S., Wu, J., Stolarz, A. J., Zhang, H., Boerma, M., Byrum, S. D., Rusch, N. J., & Ding, Z. (2023) · Theranostics · doi:10.7150/thno.83914 · Cited by 63 · see citing works
SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?
Fernandes, I. G., de Brito, C. A., dos Reis, V. M. S., Sato, M. N., & Pereira, N. Z. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8844280 · Cited by 64 · see citing works
Marón, F. J. M., Camargo, A. B., & Manucha, W. A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117513 · Cited by 62 · see citing works
Vascular calcium signalling and ageing
Harraz, O. F., & Jensen, L. J. (2021) · The Journal of Physiology · doi:10.1113/jp280950 · Cited by 61 · see citing works
TFEB is a central regulator of the aging process and age-related diseases
Abokyi, S., Ghartey‐Kwansah, G., & Tse, D. Y. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101985 · Cited by 59 · see citing works
Oxidative Glucose Metabolism Promotes Senescence in Vascular Endothelial Cells
Stabenow, L. K., Zibrova, D., Ender, C., Helbing, D. L., Spengler, K., Marx, C., Wang, Z., & Heller, R. (2022) · Cells · doi:10.3390/cells11142213 · Cited by 59 · see citing works
Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke
Sharma, S., Nozohouri, S., Vaidya, B., & Abbruscato, T. J. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119343 · Cited by 60 · see citing works
Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis
Miller, B., & Sewell-Loftin, M. K. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.804934 · Cited by 56 · see citing works
Zhu, M., Min, S., Mao, X., Zhou, Y., Zhang, Y., Li, W., Li, L., Wu, L., Cong, X., & Yu, G. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00180-6 · Cited by 56 · see citing works
Sun, X., & Feinberg, M. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.693067 · Cited by 55 · see citing works
Nagane, M., Yasui, H., Kuppusamy, P., Yamashita, T., & Inanami, O. (2021) · Journal of Radiation Research · doi:10.1093/jrr/rrab032 · Cited by 55 · see citing works
Dong, Y., Wu, X., Han, L., Bian, J., He, C., El-Omar, E. M., Gong, L., & Wang, M. (2022) · Nutrients · doi:10.3390/nu14142836 · Cited by 55 · see citing works
Kato, M., Nihei, F., Hotta, K., Tsukamoto, T., Kurita, Y., Akira, K. U. B. O., & Takagi, H. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165643 · Cited by 53 · see citing works
The role of p53 in the alternation of vascular functions
Chan, G. H. H., Chan, E., Kwok, C. T., Leung, G., Lee, S. M., & Seto, S. W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.981152 · Cited by 53 · see citing works
Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy
Desai, N., Sahel, D. K., Sawant, B. K. S., Postwala, H. I., Shah, Y. B., Chavda, V. P., Fernandes, C., Khatri, D. K., & Vora, L. K. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202400370 · Cited by 53 · see citing works
The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update
Campagna, R., Mazzanti, L., Pompei, V., Alia, S., Vignini, A., & Emanuelli, M. (2024) · Cells · doi:10.3390/cells13171469 · Cited by 57 · see citing works
Lee, O.-H., Woo, Y. M., Moon, S., Lee, J., Park, H., Jang, H. S., Park, Y., Bae, S., Park, K., Heo, J. H., et al. (2020) · Aging · doi:10.18632/aging.202176 · Cited by 52 · see citing works
Sex Differences in Molecular Mechanisms of Cardiovascular Aging
Justina, V. D., Miguez, J. S., Priviero, F. B. M., Sullivan, J. C., Giachini, F. R. C., & Webb, R. C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.725884 · Cited by 52 · see citing works
Heparanase as active player in endothelial glycocalyx remodeling
Masola, V., Greco, N., Gambaro, G., Franchi, M., & Onisto, M. (2021) · Matrix Biology Plus · doi:10.1016/j.mbplus.2021.100097 · Cited by 51 · see citing works
You, Q., Yu, L., Li, G., He, H., & Lv, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.803102 · Cited by 48 · see citing works
SGLT2 inhibition ameliorates nano plastics-induced premature endothelial senescence and dysfunction
Dhakal, B., Shiwakoti, S., Park, E., Kang, K., Schini‐Kerth, V. B., Park, S., Ji, H., Park, J. S., Ko, J.-Y., & Oak, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-33086-2 · Cited by 48 · see citing works
Role of hydrogen sulfide in cardiovascular ageing
Testai, L., Citi, V., Martelli, A., Brogi, S., & Calderone, V. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105125 · Cited by 48 · see citing works
Lai, A., Zhou, Y., Thurgood, P., Chheang, C., Sekar, N. C., Nguyen, N., Peter, K., Khoshmanesh, K., & Baratchi, S. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c07756 · Cited by 47 · see citing works
Hay, M., Barnes, C. A., Huentelman, M. J., Brinton, R. D., & Ryan, L. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01090-w · Cited by 47 · see citing works
Pathogenic mitochondrial dysfunction and metabolic abnormalities
Moos, W. H., Faller, D. V., Glavas, I. P., Harpp, D. N., Kamperi, N., Kanara, I., Kodukula, K., Mavrakis, A. N., Pernokas, J., Pernokas, M., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114809 · Cited by 49 · see citing works
Roles and Mechanisms of DNA Methylation in Vascular Aging and Related Diseases
Xu, H., Li, S., & Liu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.699374 · Cited by 47 · see citing works
Valencia, I., Vallejo, S., Dongil, P., Romero, A., Hipólito‐Luengo, Á. S., Shamoon, L., Posada-Ayala, M., García‐Olmo, D., Carraro, R., Erusalimsky, J. D., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18477 · Cited by 46 · see citing works
Liang, X., Zhang, Y., Lin, F., Li, M., Li, X., Chen, Y., Liu, J., Meng, Q., Ma, X., Wang, E., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10365 · Cited by 47 · see citing works
The Role of SGLT2 Inhibitors in Vascular Aging
Liu, L., Ni, Y., Zhan, J., & Liu, Y. (2021) · Aging and Disease · doi:10.14336/ad.2020.1229 · Cited by 44 · see citing works
Roles and functions of antisense lncRNA in vascular aging
Cui, X.-Y., Zhan, J., & Liu, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101480 · Cited by 43 · see citing works
Systemic aging and aging‐related diseases
Li, Q., Xiao, N., Zhang, H., Liang, G., Lin, Y., Qian, Z., Yang, X. Y., Yang, J., Fu, Y., Zhang, C., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402479rrr · Cited by 43 · see citing works
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases
Knopp, R. C., Erickson, M. A., Rhea, E. M., Reed, M. J., & Banks, W. A. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231157917 · Cited by 44 · see citing works
de la Riva, P., Marta-Enguita, J., Rodríguez-Antigüedad, J., Bergareche, A., & de Munaín, A. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111631 · Cited by 47 · see citing works
Liu, I.-F., Lin, T.-C., Wang, S., Yen, C., Li, C., Kuo, H., Hsieh, C., Chang, C.-Y., Chang, C., Chen, Y., et al. (2023) · Biology Direct · doi:10.1186/s13062-023-00363-z · Cited by 41 · see citing works
Wong, G. C., & Chow, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220203 · Cited by 40 · see citing works
A Review of Radiation-Induced Vascular Injury and Clinical Impact
Kameni, L. E., Januszyk, M., Berry, C. E., Downer, M. A., Parker, J. B. L., Morgan, A. G., Valencia, C., Griffin, M., Li, D. J., Liang, N. E., et al. (2023) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000003723 · Cited by 40 · see citing works
Sun, H., Zhang, F., Xu, Y. M., Sun, S., Wang, H., Du, Q., Gu, C., Black, S. M., Han, Y., & Tang, H. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7723 · Cited by 40 · see citing works
Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake
Rysz, J., Franczyk, B., Rysz-Górzyńska, M., & Gluba-Brzózka, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010183 · Cited by 41 · see citing works
Anthocyanins and Vascular Health: A Matter of Metabolites
Festa, J., Hussain, A., Al-Hareth, Z., Singh, H., & Boit, M. D. (2023) · Foods · doi:10.3390/foods12091796 · Cited by 43 · see citing works
Emerging role of α-Klotho in energy metabolism and cardiometabolic diseases
Liu, Y., & Chen, M. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102854 · Cited by 39 · see citing works
Potential Benefits of Berry Anthocyanins on Vascular Function
Festa, J., Boit, M. D., Hussain, A., & Singh, H. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100170 · Cited by 40 · see citing works
Pro-Aging Effects of Xanthine Oxidoreductase Products
Battelli, M. G., Bortolotti, M., Bolognesi, A., & Polito, L. (2020) · Antioxidants · doi:10.3390/antiox9090839 · Cited by 38 · see citing works
Vascular Aging in Ischemic Stroke
Liu, L., Zhao, B., Yu, Y., Gao, W., Liu, W., Chen, L., Xia, Z., & Cao, Q. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033341 · Cited by 38 · see citing works
Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and Challenges
Begum, M. K., Konja, D., Singh, S., Chłopicki, S., & Wang, Y. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001154 · Cited by 40 · see citing works
Ya, J., Kadir, R. R. A., & Bayraktutan, U. (2022) · Tissue Barriers · doi:10.1080/21688370.2022.2103353 · Cited by 35 · see citing works
Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs
Moos, W. H., Faller, D. V., Glavas, I. P., Harpp, D. N., Kanara, I., Mavrakis, A. N., Pernokas, J., Pernokas, M., Pinkert, C. A., Powers, W. R., et al. (2020) · BioResearch open access · doi:10.1089/biores.2020.0004 · Cited by 36 · see citing works
Endothelial Glycocalyx as a Regulator of Fibrotic Processes
Masola, V., Zaza, G., Arduini, A., Onisto, M., & Gambaro, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062996 · Cited by 36 · see citing works
Liang, Z., Chen, Y., Gu, R., Guo, Q., & Nie, X. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666221024120825 · Cited by 35 · see citing works
Harries, L. W. (2022) · FEBS Journal · doi:10.1111/febs.16462 · Cited by 35 · see citing works
Diwan, B., & Sharma, R. (2022) · Food Science and Biotechnology · doi:10.1007/s10068-022-01114-y · Cited by 36 · see citing works
Lu, M., Lei, Z., Pan, J., Shi, H., Zhang, M., & Li, C. (2023) · Food & Function · doi:10.1039/d3fo01688a · Cited by 36 · see citing works
Gao, Z., Bravo, R., Rupert, J. E., Drunen, R. V., Yu, Y., Eckel‐Mahan, K. L., & Kolonin, M. G. (2024) · Aging Cell · doi:10.1111/acel.14138 · Cited by 34 · see citing works
Młynarska, E., Kowalik, A., Krajewska, A., Krupińska, N., Marcinkowska, W., Motor, J., Przybylak, A., Tłustochowicz, K., Rysz, J., & Franczyk, B. (2025) · Biomolecules · doi:10.3390/biom15101452 · Cited by 35 · see citing works
Effects of cellular senescence on metabolic pathways in non-immune and immune cells
Frasca, D., Saada, Y. B., Garcia, D., & Friguet, B. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111428 · Cited by 34 · see citing works
Vascular Aging and Atherosclerosis: A Perspective on Aging
Ma, S., Xie, X., Yuan, R., Xin, Q., Miao, Y., Leng, S. X., Chen, K., & Cong, W. (2024) · Aging and Disease · doi:10.14336/ad.2024.0201-1 · Cited by 33 · see citing works
Endothelium function dependence of acute changes in pulse wave velocity and flow-mediated slowing
Stoner, L. R., Stone, K. J., Zieff, G. H., Blackwell, J. A., Diana, J. C., Credeur, D. P., Paterson, C. A., & Fryer, S. M. (2020) · Vascular Medicine · doi:10.1177/1358863x20926588 · Cited by 33 · see citing works
Muraca, M., & Cappariello, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228682 · Cited by 34 · see citing works
SARS CoV2 infection _The longevity study perspectives
Lio, D., Scola, L., Giarratana, R. M., Candore, G., Colonna‐Romano, G., Caruso, C., & Balistreri, C. R. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101299 · Cited by 33 · see citing works
Probing the Interface of HIV and Inflammaging
Sieg, S. F., Shive, C. L., Panigrahi, S., & Freeman, M. L. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00547-0 · Cited by 33 · see citing works
- Authors
- Jia, G., Aroor, A. R., Jia, C., & Sowers, J. R.
- Affiliations
- University of Missouri Health System (US)
- Corresponding author
- Jia, Guanghong
- Sowers, James R.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 1865
- Issue
- 7
- Pages
- 1802-1809
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2885972205
- Cited by
- 454
- References
- 96
- Citations by year
- 2026: 52 · 2025: 88 · 2024: 67 · 2023: 83 · 2022: 76 · 2021: 48 · 2020: 33 · 2019: 6
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association (1-17-IBS-201)
- NIH (R01 HL73101-01A, R01 HL107910-01)
- Veterans Affairs Merit System (0018)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- endothelial cell senescence, vascular aging, vascular dysfunction, age-related cardiovascular disease, oxidative stress, calcium signaling, hyperuricemia, vascular inflammation, mitochondrial biogenesis, angiogenesis, arterial stiffness, endothelial permeability, SIRT1, Klotho, FGF21, renin-angiotensin-aldosterone system, cell cycle
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Endothelium, Vascular, Humans, Signal Transduction, Cellular Senescence, Oxidative Stress, Vascular Stiffness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
