Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex

FGF-21 as a novel metabolic regulator

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Fibroblast Growth Factor 21 Corrects Obesity in Mice

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Downstream processing of monoclonal antibodies--application of platform approaches.

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Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

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βKlotho is required for metabolic activity of fibroblast growth factor 21

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Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

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Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

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βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

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Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

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Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

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Antigen–specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

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βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

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FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho

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Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

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FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation

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Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

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FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to isthmic signals

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Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

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FGF21 N‐ and C‐termini play different roles in receptor interaction and activation

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FGF21 reloaded: challenges of a rapidly growing field

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Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

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Relevant use of Klotho in FGF19 subfamily signaling system in vivo

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FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice

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Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid

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Understanding the Physical Interactions in the FGF21/FGFR/β‐Klotho Complex: Structural Requirements and Implications in FGF21 Signaling

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Klotho-related Protein Is a Novel Cytosolic Neutral β-Glycosylceramidase

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Hormone-like fibroblast growth factors and metabolic regulation

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Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress

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Therapeutic utilities of fibroblast growth factor 19

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Understanding the Structure-Function Relationship between FGF19 and Its Mitogenic and Metabolic Activities

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Receptor Antibodies as Novel Therapeutics for Diabetes

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The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

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Adipose tissue in control of metabolism

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A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects

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FGF21 gene therapy as treatment for obesity and insulin resistance

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A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

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FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

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Adipose tissue plasticity from WAT to BAT and in between

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Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

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Inventing new medicines: The FGF21 story

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Going Back to the Biology of FGF21: New Insights

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FGF21-based pharmacotherapy – potential utility for metabolic disorders

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FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance

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FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

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Metabolic Targets in Nonalcoholic Fatty Liver Disease

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Latest approaches for the treatment of obesity

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Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance

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Selenium, Vanadium, and Chromium as Micronutrients to Improve Metabolic Syndrome

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Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine

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Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress

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FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

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Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

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FGF21 Protects the Blood–Brain Barrier by Upregulating PPARγ via FGFR1/β-klotho after Traumatic Brain Injury

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