Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway
Abstract
Background In the present study, we investigated the effects of pyridoxine on hippocampal functions and changes in protein profiles based on the proteomic approach.Methods Eight-week-old mice received intraperitoneal injections of physiological saline (vehicle) or 350mg/kg pyridoxine twice a day for 21days.Results Phosphoglycerate mutase 1 was up-regulated, while CB1 cannabinoid receptor-interacting protein 1 (CRIP1) was down-regulated, in the pyridoxine-treated group. Additionally, the serotonin and tyrosine hydroxylase was increased in the hippocampus of the pyridoxine-treated group than in that of the vehicle-treated group. Furthermore, discrimination indices based on the novel object recognition test were significantly higher in the pyridoxine-treated group than in the vehicle-treated group. Administration of CRIP1a siRNA significantly increases the discrimination index as well as cell proliferation and neuroblast differentiation in the dentate gyrus. In addition, the administration of rimonabant, a CB1 cannabinoid receptor antagonist, for 3weeks significantly decreased the novel object recognition memory, the tyrosine hydroxylase level, the amount of cell proliferation, and neuroblast differentiation in the dentate gyrus. Treatment with pyridoxine significantly increased novel object recognition memory, but slightly ameliorated rimonabant-induced reduction in serotonin, the tyrosine hydroxylase level, the amount of cell proliferation, and neuroblast differentiation in the dentate gyrus.Conclusion These results suggest that pyridoxine promotes hippocampal functions by increasing serotonin and tyrosine hydroylase immunoreactivity in the hippocampus. This positive effect may be associated with CRIP1a and CB1 cannabinoid receptor function.General significance Vitamin-B 6 enhances hippocampal functions and this is closely associated with CRIP1a and CB1 cannabinoid receptors.
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Knockdown of cannabinoid 1-R-interacting protein 1 in the mouse hippocampus increased cell proliferation and neuroblast differentiation in the dentate gyrus and improved NOP memory.
“knockdown of the cannabinoid 1-R-interacting protein 1 in the mouse hippocampus increased cell proliferation and neuroblast differentiation in the dentate gyrus and improved NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Jung et al., 2017
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258 · see citing works
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
Dopamine depletion impairs precursor cell proliferation in Parkinson disease
Höglinger, G. U., Rizk, P., Mp, M., Duyckaerts, C. J., Oertel, W. H., Caillé, I., & Hirsch, É. C. (2004) · Nature Neuroscience · doi:10.1038/nn1265 · Cited by 946 · see citing works
Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H. (2009) · Learning & Memory · doi:10.1101/lm.1172609 · Cited by 654 · see citing works
Banasr, M., Héry, M., Printemps, R., & Daszuta, A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300320 · Cited by 539 · see citing works
Riggs, K., Spiro, A., Tucker, K. L., & Rush, D. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.306 · Cited by 504 · see citing works
Celada, P., Puig, M. V., Casanovas, J. M., Guillazo, G., & Artigas, F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09917.2001 · Cited by 497 · see citing works
Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
Colombo, G., Agabio, R., Diaz, G., Lobina, C., Reali, R., & Gessa, G. L. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00322-1 · Cited by 486 · see citing works
Association Between Nutritional Status and Cognitive Functioning in a Healthy Elderly Population
Goodwin, J. S. (1983) · JAMA · doi:10.1001/jama.1983.03330450047024 · Cited by 481 · see citing works
Structure and Mechanism of Monoamine Oxidase
Edmondson, D. E., Mattevi, A., Binda, C., Li, M., & Hubálek, F. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364784 · Cited by 371 · see citing works
Amargos-Bosch, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg128 · Cited by 370 · see citing works
Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment
Rue, A. L., Koehler, K., Wayne, S., Chiulli, S. J., Haaland, K., & Garry, P. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.1.20 · Cited by 339 · see citing works
Rukhsana Sultana, A., Debra Boyd-kimball, A., Poon, H. F., Cai, J., Pierce, W. M. J., Klein, J. B., Merchant, M. L., Markesbery, W. R., & Butterfield, D. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.021 · Cited by 334 · see citing works
The endocannabinoid system drives neural progenitor proliferation
Aguado, T., Monory, K., Palazuelos, J., Stella, N., Cravatt, B. F., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M., & Galve‐Roperh, I. (2005) · The FASEB Journal · doi:10.1096/fj.05-3995fje · Cited by 327 · see citing works
Joosten, E., van den Berg, A., Riezler, R., Naurath, H., Lindenbaum, J., Stabler, S., & Allen, R. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.4.468 · Cited by 322 · see citing works
Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice
Jin, K., Xie, L., Kim, S. H., Parmentier‐Batteur, S., Sun, Y., Mao, X. O., Childs, J., & Greenberg, D. A. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.2.204 · Cited by 271 · see citing works
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh104 · Cited by 232 · see citing works
Proteomics Analysis of the Alzheimer's Disease Hippocampal Proteome
Rukhsana Sultana, A., Debra Boyd-kimball, A., Cai, J., Pierce, W. M. J., Klein, J. B., Merchant, M. L., & Butterfield, D. A. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11203 · Cited by 231 · see citing works
Puig, M. V. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.8.870 · Cited by 223 · see citing works
Monoamine Oxidases: Certainties and Uncertainties
Tipton, K. F., Boyce, S., O’Sullivan, J., Davey, G. P., & Healy, J. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364810 · Cited by 199 · see citing works
Jensen, P. K., Paša-Tolić, L., Anderson, G. A., Horner, J. A., Lipton, M., Bruce, J. E., & Smith, R. D. (1999) · Analytical Chemistry · doi:10.1021/ac990196p · Cited by 190 · see citing works
Goncalves, M. B. C. V., Suetterlin, P., Yip, P. K., Molina‐Holgado, F., Walker, D. J., Oudin, M. J., Zentar, M. P., Pollard, S. M., Yáñez‐Muñoz, R. J., Williams, G. H., et al. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.05.001 · Cited by 177 · see citing works
Debra Boyd-kimball, A., Rukhsana Sultana, A., Poon, H. F., Lynn, B. C., Casamenti, F., Pepeu, G., Klein, J. B., & Butterfield, D. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.022 · Cited by 166 · see citing works
Protein Detection Methods in Proteomics Research
Westermeier, R., & Marouga, R. (2005) · Bioscience Reports · doi:10.1007/s10540-005-2845-1 · Cited by 153 · see citing works
Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of Glioblastoma
Sanzey, M., Rahim, S. A. A., Oudin, A., Dirkse, A., Kaoma, T., Vallar, L., Herold‐Mende, C. C., Bjerkvig, R., Golebiewska, A., & Niclou, S. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123544 · Cited by 130 · see citing works
Niehaus, J. L., Liu, Y., Wallis, K. T., Egertová, M., Bhartur, S. G., Mukhopadhyay, S., Shi, S., He, H., Selley, D. E., Howlett, A. C., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.039263 · Cited by 121 · see citing works
Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma
Na, K., Lee, E., Lee, H., Kim, K., Lee, H., Jeong, S., Jeong, A., Cho, S. Y., Kim, S. A., Song, S. Y., et al. (2009) · PROTEOMICS · doi:10.1002/pmic.200900105 · Cited by 120 · see citing works
Bates, C. J., Pentieva, K. D., Prentice, A., Mansoor, M. A., & Finch, S. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599000380 · Cited by 108 · see citing works
Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort
Deijen, J. B., van der Beek, E. J., Orlebeke, J. F., & van den Berg, H. (1992) · Psychopharmacology · doi:10.1007/bf02247729 · Cited by 104 · see citing works
Age differences in vitamin B6 status of 617 men
Rose, C., György, P., Butler, M., Andres, R., Norris, A. H., Shock, N. W., Tobin, J. D., Brin, M., & Spiegel, H. E. (1976) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/29.8.847 · Cited by 101 · see citing works
Two distinct activity patterns of fast-spiking interneurons during neocortical UP states
Puig, M. V., Ushimaru, M., & Kawaguchi, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712219105 · Cited by 98 · see citing works
Endocannabinoids via CB 1 receptors act as neurogenic niche cues during cortical development
Díaz-Alonso, J., Guzmán, M., & Galve‐Roperh, I. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0385 · Cited by 94 · see citing works
Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine
Kuypers, K. P. C., & Ramaekers, J. G. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105056670 · Cited by 87 · see citing works
Liu, A., Jain, N. K., Vyas, A., & Lim, L. W. (2015) · eLife · doi:10.7554/elife.04803 · Cited by 78 · see citing works
Xapelli, S., Agasse, F., Sardà‐Arroyo, L., Bernardino, L. I., Santos, T., Ribeiro, F. F., Valero, J., Bragança, J., Schitine, C., Reis, R. A. D. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063529 · Cited by 77 · see citing works
Chiu, W., Depboylu, C., Hermanns, G., Maurer, L., Windolph, A., Oertel, W. H., Ries, V., & Höglinger, G. U. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.020 · Cited by 76 · see citing works
Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-Born Dentate Granule Cells
Mu, Y., Zhao, C., & Gage, F. H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4913-10.2011 · Cited by 75 · see citing works
Horder, J., Cowen, P. J., Di Simplicio, M., Browning, M., & Harmer, C. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1517-4 · Cited by 69 · see citing works
Basavarajappa, B. S., & Subbanna, S. (2013) · Hippocampus · doi:10.1002/hipo.22213 · Cited by 65 · see citing works
Vitamin B6 and Cognitive Development: Recent Research Findings from Human and Animal Studies
Guilarte, T. R. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1993.tb03102.x · Cited by 65 · see citing works
Bétry, C., Etiévant, A., Pehrson, A., Sánchez, C., & Haddjeri, N. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.12.002 · Cited by 59 · see citing works
Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice
Singh, C., Bortolato, M., Bali, N., Godar, S. C., Scott, A. L., Chen, K., Thompson, R. F., & Shih, J. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308037110 · Cited by 56 · see citing works
Cannabinoid Receptor–Interacting Protein 1a Modulates CB1 Receptor Signaling and Regulation
Smith, T. H., Blume, L. C., Straiker, A. J., Cox, J. O., David, B. G., McVoy, J. R. S., Sayers, K. W., Poklis, J. L., Abdullah, R. A., Egertová, M., et al. (2015) · Molecular Pharmacology · doi:10.1124/mol.114.096495 · Cited by 56 · see citing works
Wilson, K. E., Marouga, R., Prime, J. E., Pashby, D. P., Orange, P. R., Crosier, S., Keith, A. B., Lathe, R., Mullins, J. J., Estibeiro, P., et al. (2005) · PROTEOMICS · doi:10.1002/pmic.200401255 · Cited by 56 · see citing works
Hasanein, P., & Far, M. T. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.02.007 · Cited by 52 · see citing works
Proteomics identification of PGAM1 as a potential therapeutic target for urothelial bladder cancer
Peng, X., Gong, F. M., Chen, Y., Qiu, M., Cheng, K., Tang, J., Ge, J., Chen, N., Zeng, H., & Liu, J. Y. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.11.027 · Cited by 51 · see citing works
Origin of the dopaminergic innervation of adult neurogenic areas
Höglinger, G. U., Arias-Carrión, Ó., Ipach, B., & Oertel, W. H. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23537 · Cited by 46 · see citing works
Xu, J., Chen, R., Zhang, J., & Chen, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010306 · Cited by 44 · see citing works
Salvi, R., Steigleder, T., Schlachetzki, J. C. M., Waldmann, E., Schwab, S., Winner, B., Winkler, J., & Kohl, Z. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00077 · Cited by 44 · see citing works
The Influence of Protein Intake on Vitamin B-6 Metabolism Differs in Young and Elderly Humans
Pannemans, D. L. E., van den Berg, H., & Westerterp, K. R. (1994) · Journal of Nutrition · doi:10.1093/jn/124.8.1207 · Cited by 40 · see citing works
Sex-dependence of anxiety-like behavior in cannabinoid receptor 1 (Cnr1) knockout mice
Bowers, M. E., & Ressler, K. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.005 · Cited by 40 · see citing works
Schlachetzki, J. C. M., Grimm, T., Schlachetzki, Z., Abdallah, N. M. ‐. B., Ettle, B., Voehringer, P., Ferger, B., Winner, B., Nuber, S., & Winkler, J. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23677 · Cited by 38 · see citing works
Stenfors, C., & Ross, S. B. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02138-0 · Cited by 37 · see citing works
Abraham, P. M., Kuruvilla, K. P., Mathew, J., Malat, A., Joy, S., & Paulose, C. S. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-78 · Cited by 33 · see citing works
Lee, S., Kim, D. H., Yoon, S., & Ryu, J. H. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.017 · Cited by 31 · see citing works
Yoo, D. Y., Kim, W., Kim, D. W., Yoo, K., Chung, J. Y., Youn, H. Y., Yoon, Y. S., Choi, S. Y., Won, M., & Hwang, I. K. (2011) · Neurochemical Research · doi:10.1007/s11064-010-0385-y · Cited by 30 · see citing works
Jung, H. Y., Yoo, D. Y., Nam, S. M., Kim, J. W., Choi, J. H., Yoo, M., Lee, S., Yoon, Y. S., & Hwang, I. K. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3412 · Cited by 26 · see citing works
Yoo, D. Y., Kim, W., Kim, I. H., Nam, S. M., Chung, J. Y., Choi, J. H., Yoon, Y. S., Won, M., & Hwang, I. K. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0597-9 · Cited by 25 · see citing works
Gordon, N., & Goelman, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.09.013 · Cited by 21 · see citing works
Effect of dexfenfluramine on metabolic and neurochemical measures in restraint-stressed ob/ob mice
Rowland, N. E., & DUNN, A. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00105-r · Cited by 13 · see citing works
Ádám, Á., Wenger, T., & Csillag, A. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.02.004 · Cited by 12 · see citing works
Yoo, D. Y., Kim, W., Yoo, K., Nam, S. M., Chung, J. Y., Yoon, Y. S., Won, M., & Hwang, I. K. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23035 · Cited by 11 · see citing works
Effect of pyridoxine deficiency on the structural and functional development of hippocampus.
Krishna, A., & Ramakrishna, T. (2004) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
Shah, H., Dehghani, F., Ramezan, M., Gannaban, R. B., Haque, Z. F., Rahimi, F. C., Abbasi, S., & Shin, A. C. (2023) · Antioxidants · doi:10.3390/antiox12020415 · Cited by 46 · see citing works
Alesci, A., Fumia, A., Cascio, P. L., Miller, A., & Cicero, N. (2021) · Journal of the American Nutrition Association · doi:10.1080/07315724.2021.1965503 · Cited by 28 · see citing works
Systemic vitamin intake impacting tissue proteomes
Jeong, H., & Vacanti, N. M. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00491-7 · Cited by 27 · see citing works
Cruz-Martínez, A. M., Tejas-Juárez, J. G., Díaz, J. M. M., Florán, B., López-Alonso, V. E., & Escartín-Pérez, R. E. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.08.002 · Cited by 24 · see citing works
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease
Oliver, E. E., Hughes, E. K., Puckett, M., Chen, R., Lowther, W. T., & Howlett, A. C. (2020) · Biomolecules · doi:10.3390/biom10121609 · Cited by 24 · see citing works
Kim, W., Kwon, H. J., Jung, H. Y., Yoo, D. Y., Kim, D. W., & Hwang, I. K. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104631 · Cited by 20 · see citing works
Jung, H. Y., Kwon, H. J., Kim, W., Nam, S. M., Kim, J. W., Hahn, K. R., Yoo, D. Y., Won, M., Yoon, Y. S., Kim, D. W., et al. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2678-5 · Cited by 20 · see citing works
Jung, H. Y., Kim, W., Hahn, K. R., Kwon, H. J., Nam, S. M., Chung, J. Y., Yoon, Y. S., Kim, D. W., Yoo, D. Y., & Hwang, I. K. (2020) · Cells · doi:10.3390/cells9051067 · Cited by 19 · see citing works
Role of pyridoxine in GABA synthesis and degradation in the hippocampus
Jung, H. Y., Kwon, H. J., Kim, W., Nam, S. M., Kim, J. W., Hahn, K. R., Yoo, D. Y., Yoon, Y. S., Choi, S. Y., Kim, D. W., et al. (2019) · Tissue and Cell · doi:10.1016/j.tice.2019.09.005 · Cited by 17 · see citing works
Vitamins: a nutritional intervention to modulate the Alzheimer’s disease progression
Alam, J. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1826762 · Cited by 18 · see citing works
Kwon, H. J., Kim, W., Jung, H. Y., Kang, M. S., Kim, J. W., Hahn, K. R., Yoo, D. Y., Yoon, Y. S., Hwang, I. K., & Kim, D. W. (2019) · Laboratory Animal Research · doi:10.1186/s42826-019-0020-2 · Cited by 15 · see citing works
Kwon, H. J., Jung, H. Y., Hahn, K. R., Kim, W., Kim, J. W., Yoo, D. Y., Yoon, Y. S., Hwang, I. K., & Kim, D. W. (2018) · Laboratory Animal Research · doi:10.5625/lar.2018.34.4.239 · Cited by 14 · see citing works
Yoo, D. Y., Cho, S. B., Jung, H. Y., Kim, W., Nam, S. M., Kim, J. W., Moon, S. M., Yoon, Y. S., Kim, D. W., Choi, S. Y., et al. (2020) · Brain and Behavior · doi:10.1002/brb3.1534 · Cited by 10 · see citing works
Entacapone promotes hippocampal neurogenesis in mice
Hwang, I., Yoo, D., Jung, H. Y., Kim, W., Hahn, K. R., Kwon, H., Nam, S. M., Chung, J., Yoon, Y., & Kim, D. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.300447 · Cited by 10 · see citing works
Yu, Y. H., Park, D., Yoo, D. Y., & Kim, D. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.4.002 · Cited by 7 · see citing works
Kamel, S. A., & Abdoon, F. M. (2022) · AIP conference proceedings · doi:10.1063/5.0094172 · Cited by 7 · see citing works
Shirokova, O. M., Kuzmina, D. M., Zaborskaya, O. G., Щелчкова, Н. А., Kozliaeva, E. V., Александровна, К. С., Pershin, V. I., Vasilchikov, P. I., & Mukhina, I. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031251 · Cited by 6 · see citing works
Jafari‐Sabet, M., Amiri, S., Aghamiri, H., & Fatahi, N. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107638 · Cited by 4 · see citing works
Janthakhin, Y., Juntapremjit, S., Hummel, K., Razzazi‐Fazeli, E., & Kingtong, S. (2024) · Bioinformatics and Biology Insights · doi:10.1177/11779322241306290 · Cited by 3 · see citing works
Kim, D., Li, M., Nguyen, T. H., Choi, Y., Jang, S., Kim, M., Kim, Y. W., Shin, M., de Guzman, A. C. V., & Park, S. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2695485 · Cited by 1 · see citing works
Xue, C., Li, X., Ding, H., Qian, X., Zhang, M., Chen, K., Wei, Z., Li, Y., Jia, J., & Zhang, W. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01505-6 · Cited by 1 · see citing works
Громова, О. А., Sorokina, M. A., Rachteenko, A. V., & Владимирович, Р. К. (2018) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2018-13-142-154
- Authors
- Jung, H. Y., Kim, D. W., Nam, S. M., Kim, J. W., Chung, J. Y., Won, M.-H., Seong, J. K., Yoon, Y. S., Yoo, D. Y., & Hwang, I. K.
- Affiliations
- Seoul National University (KR)
- Gangneung–Wonju National University (KR)
- Kangwon National University (KR)
- Corresponding author
- Yoo, Dae Young
- Hwang, In Koo
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 1861
- Issue
- 12
- Pages
- 3142-3153
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W2754495124
- Cited by
- 23
- References
- 68
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 8 · 2019: 3 · 2018: 4
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Seoul National University
- National Research Foundation of Korea (NRF-2013R1A1A2059364, NRF-2016R1A2B4009156, NRF-2015M3A9D5A01076747)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Keywords
- pyridoxine, hippocampus, cognitive function, serotonin turnover, tyrosine hydroxylase, CB1 receptor, CRIP1, rimonabant, novel object recognition memory, dentate gyrus, neuroblast differentiation, cell proliferation, phosphoglycerate mutase 1, siRNA knockdown
- MeSH terms
- Animals, Carrier Proteins, Cognition, Hippocampus, Immunohistochemistry, Male, Memory, Mice, Inbred C57BL, Pyridoxine, Serotonin, Tyrosine 3-Monooxygenase, Receptor, Cannabinoid, CB1, Mice, LIM Domain Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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