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The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis
Abstract
Leukotrienes (LTs) are powerful inflammatory lipid mediators derived from the 5-lipoxygenase (5-LO) cascade of arachidonic acid. Recent clinical, population genetic, cell biological, and mouse studies indicate participation of the 5-LO pathway in atherogenesis and arterial wall remodeling. 5-LO is expressed by leukocytes including blood monocytes, tissue macrophages, dendritic cells, neutrophils, and mast cells. LTB4 and the cysteinyl LTs LTC4, LTD4, and LTE4, act through two BLT and two cysLT receptors that are differentially expressed on hematopoietic and arterial wall cells. The precise roles of LTs or the LT receptors in cardiovascular physiology remain largely to be explored. In this review, we will discuss what is currently known about the 5-LO atherosclerosis connection. We will attempt to propose strategies to further explore potential links between the 5-LO pathway and blood vessel physiology and disease progression.
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“In a final note, it should be also considered that although NOX4 activity has been shown to reduce fibrosis in atherosclerosis (230), it can also promote fibrosis, particularly in the lung, but also in kidney and other tissues (110, 201, 416, 596, 820).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [596]
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Metadata
- Authors
- LOTZER, K., FUNK, C., & HABENICHT, A.
- Affiliations
- Queen's University (CA)
- Friedrich Schiller University Jena (DE)
- Corresponding author
- HABENICHT, A
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2005-07-21
- Volume
- 1736
- Issue
- 1
- Pages
- 30-7
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2132989642
- Cited by
- 108
- References
- 51
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 10
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (2r01hl058464-04)
- National Heart, Lung, and Blood Institute (HL 58464)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- 5-lipoxygenase, leukotrienes, atherosclerosis, atherogenesis, arterial remodeling, leukotriene B4, cysteinyl leukotrienes, cysteinyl leukotriene receptor, arachidonic acid metabolism, leukocytes, inflammation
- MeSH terms
- Animals, Arachidonate 5-Lipoxygenase, Arteries, Arteriosclerosis, Signal Transduction, Mice
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