The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis
Abstract
Leukotrienes (LTs) are powerful inflammatory lipid mediators derived from the 5-lipoxygenase (5-LO) cascade of arachidonic acid. Recent clinical, population genetic, cell biological, and mouse studies indicate participation of the 5-LO pathway in atherogenesis and arterial wall remodeling. 5-LO is expressed by leukocytes including blood monocytes, tissue macrophages, dendritic cells, neutrophils, and mast cells. LTB4 and the cysteinyl LTs LTC4, LTD4, and LTE4, act through two BLT and two cysLT receptors that are differentially expressed on hematopoietic and arterial wall cells. The precise roles of LTs or the LT receptors in cardiovascular physiology remain largely to be explored. In this review, we will discuss what is currently known about the 5-LO atherosclerosis connection. We will attempt to propose strategies to further explore potential links between the 5-LO pathway and blood vessel physiology and disease progression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In a final note, it should be also considered that although NOX4 activity has been shown to reduce fibrosis in atherosclerosis (230), it can also promote fibrosis, particularly in the lung, but also in kidney and other tissues (110, 201, 416, 596, 820).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [596]
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817
Self-citationLeukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
Samuelsson, B. O. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,839
Dahlén, S., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. O. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3887 · Cited by 1,019
A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., & Shimizu, T. (1997) · Nature · doi:10.1038/42506 · Cited by 975
Characterization of the human cysteinyl leukotriene CysLT1 receptor
Lynch, K. R., O’Neill, G. P., Liu, Q., Im, D., Sawyer, N., Metters, K. M., Coulombe, N., Abramovitz, M., Figueroa, D. J., Zeng, Z., et al. (1999) · Nature · doi:10.1038/21658 · Cited by 965
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
Helgadóttir, A., Manolescu, A. R., Þorleifsson, G., Grétarsdóttir, S., Jonsdottir, H., Þorsteinsdóttir, U., Samani, N. J., Gudmundsson, G. H., Grant, S. F. A., Þorgeirsson, G., et al. (2004) · Nature Genetics · doi:10.1038/ng1311 · Cited by 923
Characterization of the Human Cysteinyl Leukotriene 2 Receptor
Heise, C. E., O’Dowd, B. F., Figueroa, D. J., Sawyer, N., Nguyen, T., Im, D., Stocco, R., Bellefeuille, J. N., Abramovitz, M., Cheng, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003490200 · Cited by 660
Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis
Dwyer, J. H., Allayee, H., Dwyer, K. M., Fan, J., Wu, H., Mar, R., Lusis, A. J., & Mehrabian, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025079 · Cited by 623
Drazen, J. M., Yandava, C., Dubé, L. M., Szczerbak, N., Hippensteel, R., Pillari, A., Israel, E., Schork, N. J., Silverman, E. S., Katz, D. A., et al. (1999) · Nature Genetics · doi:10.1038/9680 · Cited by 561
Cited by
Sorted by citations
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
Wang, B., Wu, L., Chen, J., Dong, L., Chen, C., Zheng, W., Hu, J., Fleming, I., & Wang, D. W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00443-w · Cited by 1,538
Reactive oxygen species in cardiovascular disease
Sugamura, K., & Keaney (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.004 · Cited by 769
Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
Fialkow, L., Wang, Y., & Downey, G. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.030 · Cited by 723
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Inflammatory networks in ageing, age-related diseases and longevity
Vasto, S., Candore, G., Balistreri, C. R., Caruso, M., Colonna‐Romano, G., Grimaldi, M. P., Listı̀, F., Nuzzo, D., Lio, D., & Caruso, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.015 · Cited by 481
Metadata
- Authors
- LOTZER, K., FUNK, C., & HABENICHT, A.
- Affiliations
- Queen's University (CA)
- Friedrich Schiller University Jena (DE)
- Corresponding author
- HABENICHT, A
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2005-07-21
- Volume
- 1736
- Issue
- 1
- Pages
- 30-7
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2132989642
- Cited by
- 108
- References
- 51
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 10
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (2r01hl058464-04)
- National Heart, Lung, and Blood Institute (HL 58464)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- 5-lipoxygenase, leukotrienes, atherosclerosis, atherogenesis, arterial remodeling, leukotriene B4, cysteinyl leukotrienes, cysteinyl leukotriene receptor, arachidonic acid metabolism, leukocytes, inflammation
- MeSH terms
- Animals, Arachidonate 5-Lipoxygenase, Arteries, Arteriosclerosis, Signal Transduction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
