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Activation of the hepatic LDL receptor promoter by thyroid hormone.

Lopez, Dayami, Abisambra Socarrás, Jose F., Bedi, Mohini, Ness, Gene C.·2007·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2007.05.001
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Abstract

The question of whether mature sterol regulatory element binding protein-2 (SREBP-2) mediates transcriptional activation of the hepatic low density lipoprotein (LDL) receptor by thyroid hormone was investigated. Western blotting analysis and electrophoretic mobility shift assays demonstrated that mature nuclear SREBP-2 protein could be detected in liver nuclear extracts prepared from normal animals but not in extracts prepared from rats rendered hypothyroid either by hypophysectomy (Hx) or thyroidectomy (Tx). Treatment of Hx rats with T3 restored LDL receptor mRNA levels in about 1 h and caused a 6-fold increase 2.5 h after T3 administration. However, no detectable mature SREBP-2 was seen in this time period despite a substantial reduction in serum cholesterol levels caused by the T3 treatment. Deletion of the SRE region from the LDL receptor promoter did not decrease the T3 response. Thus, the possibility that T3 may be mediating LDL receptor induction directly via a thyroid response element (TRE) was investigated. Reporter gene analysis and electrophoretic mobility shift assays demonstrated that the rat LDL receptor promoter contains two functional TREs (US-TRE and 2H-TRE). Either one of these elements could support T3 induction. However, the stronger of these elements is US-TRE at-612 which binds TRbeta1 more tightly and when mutated results in a diminished T3 response. These results indicate that the rapid induction of the hepatic LDL receptor by thyroid hormone is likely…

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Research works printed but not linked: 52

  1. Walton, 1965, The significance of alterations in serum lipids in thyroid dysfunction, I. The relation between serum lipoproteins, carotenoids and vitamin A in hypothyroidism and thyrotoxicosis, Clin. Sci., 29, 199
  2. Illingworth, 1981, Familial hypercholesterolaemia and primary hypothyroidism: coexistence of both disorders in a young woman with severe hypercholesterolaemia, Clin. Endocrinol., 14, 145, 10.1111/j.1365-2265.1981.tb00609.x · DOI
  3. Ness, 1990, Effect of thyroid hormone on hepatic cholesterol 7α hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthase and apolipoprotein A-I mRNA levels in hypophysectomized rats, Biochem. Biophys. Res. Commun., 172, 1150, 10.1016/0006-291X(90)91568-D · DOI
  4. Cappola, 2003, Hypothyroidism and atherosclerosis, J. Clin. Endocrinol. Metab., 88, 2438, 10.1210/jc.2003-030398 · DOI
  5. Hansson, 1983, Experimental hyperthyroidism in man. Effects on plasma lipoproteins, lipoprotein lipase and hepatic lipase, Horm. Metab. Res., 15, 449, 10.1055/s-2007-1018751 · DOI
  6. Ness, 1991, Thyroid hormone: basis for its hypocholesterolemic effect, J. Fla. Med. Assoc., 78, 383
  7. Underwood, 1986, A thyromimetics that decreases plasma cholesterol levels without increasing cardiac activity, Nature, 324, 425, 10.1038/324425a0 · DOI
  8. Stephan, 1992, Reduction of cardiovascular and thyroxine-suppressing activities of L-T3 by liver targeting with cholic acid, Biochem. Pharmacol., 43, 1969, 10.1016/0006-2952(92)90640-5 · DOI
  9. Engelken, 1981, The effects of altered thyroid status on lipid metabolism in the genetic hyperlipemic Zucker rat, Atherosclerosis, 38, 177, 10.1016/0021-9150(81)90114-3 · DOI
  10. Aviram, 1982, Lipid and lipoprotein patterns in thyroid dysfunction and the effect of therapy, Clin. Biochem., 15, 62, 10.1016/S0009-9120(82)90529-X · DOI
  11. Thompson, 1981, Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo, Proc. Natl. Acad. Sci. U. S. A., 78, 2591, 10.1073/pnas.78.4.2591 · DOI
  12. Leeson, 1989, Selective thyromimetics. Cardiac-sparing thyroid hormone analogues containing 3′-arylmethyl substituents, J. Med. Chem., 32, 320, 10.1021/jm00122a009 · DOI
  13. Walton, 1965, The significance of alterations in serum lipids in thyroid dysfunction, II. Alterations of the metabolism and turnover of 131-I-low-density lipoproteins in hypothyroidism and thyrotoxicosis, Clin. Sci., 29, 217
  14. Morkin, 2004, Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects, J. Mol. Cell. Cardiol., 37, 1137
  15. Ness, 1998, Effects of l-triiodothyronine and the thyromimetric L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression, Biochem. Pharmacol., 56, 121, 10.1016/S0006-2952(98)00119-1 · DOI
  16. Salter, 1991, Effects of hypothyroidism and high-fat feeding on mRNA concentrations for the low-density lipoprotein receptor and on acyl-CoA:cholesterol acyltransferase activities in rat liver, Biochem. J., 276, 825, 10.1042/bj2760825 · DOI
  17. Ness, 1994, Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats, Arch. Biochem. Biophys., 315, 199, 10.1006/abbi.1994.1490 · DOI
  18. Staels, 1990, Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats, Endocrinology, 127, 1144, 10.1210/endo-127-3-1144 · DOI
  19. Hudig, 1997, Triiodothyronine prevents the amiodarone-induced decrease in the expression of the liver low-density lipoprotein receptor gene, J. Endocrinol., 152, 413, 10.1677/joe.0.1520413 · DOI
  20. Ness, 1995, Transcriptional regulation of rat hepatic low-density lipoprotein receptor and cholesterol 7α hydroxylase by thyroid hormone, Arch. Biochem. Biophys., 323, 404, 10.1006/abbi.1995.0061 · DOI
  21. Dueland, 1993, Effect of dietary cholesterol and taurocholate on cholesterol 7α-hydroxylase and hepatic LDL receptors in inbred mice, J. Lipid Res., 34, 923, 10.1016/S0022-2275(20)39679-6 · DOI
  22. Mistry, 1981, Individual variation in the effects of dietary cholesterol on plasma lipoproteins and cellular cholesterol homeostasis in man. Studies of low density lipoprotein receptor activity and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in blood mononuclear cells, J. Clin. Invest., 67, 493, 10.1172/JCI110058 · DOI
  23. Applebaum-Bowden, 1984, Down-regulation of the low-density lipoprotein receptor by dietary cholesterol, Am. J. Clin. Nutr., 39, 360, 10.1093/ajcn/39.3.360 · DOI · Paper page
  24. Hennessy, 1992, Effects of dietary fats and cholesterol on liver lipid content and hepatic apolipoproteins A-I, B, and E and LDL receptor mRNA levels in cebus monkeys, J. Lipid Res., 33, 351, 10.1016/S0022-2275(20)41525-1 · DOI
  25. Kovanen, 1981, Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits, Proc. Natl. Acad. Sci. U. S. A., 78, 1396, 10.1073/pnas.78.3.1396 · DOI
  26. Rudling, 1993, Loss of resistance to dietary cholesterol in the rat after hypophysectomy: importance of the presence of growth hormone for hepatic low density lipoprotein-receptor expression, Proc. Natl. Acad. Sci. U. S. A., 90, 8851, 10.1073/pnas.90.19.8851 · DOI
  27. Südhof, 1987, 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter, Cell, 48, 1061, 10.1016/0092-8674(87)90713-6 · DOI · Paper page
  28. Bishop, 1992, Structure of the hamster low density lipoprotein receptor gene, J. Lipid Res., 33, 549, 10.1016/S0022-2275(20)41620-7 · DOI
  29. Hoffer, 1993, The mouse low density lipoprotein receptor gene: cDNA sequence and exon–intron structure, Biochem. Biophys. Res. Commun., 191, 880, 10.1006/bbrc.1993.1299 · DOI
  30. Mehta, 1991, The low density lipoprotein receptor in Xenopus laevis, II. Feedback repression mediated by conserved sterol regulatory element, J. Biol. Chem., 266, 10415, 10.1016/S0021-9258(18)99241-0 · DOI
  31. Osborne, 1995, Transcriptional control mechanisms in the regulation of cholesterol balance, Crit. Rev. Euk. Gene Exp., 5, 317, 10.1615/CritRevEukarGeneExpr.v5.i3-4.50 · DOI
  32. Magana, 1996, Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter, J. Biol. Chem., 271, 32689, 10.1074/jbc.271.51.32689 · DOI
  33. Ericsson, 1996, Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene, Proc. Natl. Acad. Sci. U. S. A., 93, 945, 10.1073/pnas.93.2.945 · DOI
  34. Sato, 1996, Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2, J. Biol. Chem., 271, 26461, 10.1074/jbc.271.43.26461 · DOI
  35. Hua, 1993, SREBP-2, a second basic-helix–loop–helix–leucine zipper protein that stimulates transcription by binding to a sterol regulatory element, Proc. Natl. Acad. Sci. U. S. A., 90, 11603, 10.1073/pnas.90.24.11603 · DOI · Paper page
  36. Yokoyama, 1993, SREBP-1, a basic helix–loop–helix–leucine zipper protein that controls transcription of the low density lipoprotein receptor gene, Cell, 75, 187, 10.1016/S0092-8674(05)80095-9 · DOI
  37. Briggs, 1993, Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter, I. Identification of the protein and delineation of its target nucleotide sequence, J. Biol. Chem., 268, 14490, 10.1016/S0021-9258(19)85265-1 · DOI · Paper page
  38. Wang, 1994, SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis, Cell, 77, 53, 10.1016/0092-8674(94)90234-8 · DOI
  39. Sato, 1994, Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element binding protein-1 (SREBP-1), J. Biol. Chem., 269, 17267, 10.1016/S0021-9258(17)32550-4 · DOI
  40. Shimano, 2001, Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes, Prog. Lipid Res., 40, 439, 10.1016/S0163-7827(01)00010-8 · DOI
  41. Hua, 1995, Hairpin orientation of sterol regulatory element binding protein-2 in cell membranes as determined by protease protection, J. Biol. Chem., 270, 29422, 10.1074/jbc.270.49.29422 · DOI
  42. Shin, 2003, Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2), J. Biol. Chem., 278, 34114, 10.1074/jbc.M305417200 · DOI
  43. Yu, 1995, Enhanced DNA-binding activity of Stat3-related protein in cells transformed by the Src oncoprotein, Science, 269, 81, 10.1126/science.7541555 · DOI · Paper page
  44. Lopez, 2006, Characterization of the rat LDL receptor 5′-flanking region, Biochim. Biophys. Acta, 1761, 492, 10.1016/j.bbalip.2006.03.012 · DOI
  45. Petty, 1990, Identification of a thyroid hormone response element in the malic enzyme gene, J. Biol. Chem., 265, 7395, 10.1016/S0021-9258(19)39126-4 · DOI
  46. Samuels, 1979, Depletion of l-3,5,3′-triiodothyronine and l-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone, Endocrinology, 105, 80, 10.1210/endo-105-1-80 · DOI
  47. Lopez, 2003, Peroxisome proliferator-activated receptor α induces rat sterol carrier protein X promoter activity through two peroxisome proliferator-response elements, Mol. Cell. Endocrinol., 205, 169, 10.1016/S0303-7207(02)00300-3 · DOI
  48. Lopez, 1999, Steroidogenic factor-1 mediates cyclic 3′,5′-adenosine monophosphate regulation of the high density lipoprotein receptor, Endocrinology, 140, 3034, 10.1210/endo.140.7.6846 · DOI
  49. Bakker, 1998, Effects of triiodothyronine and amiodarone on the human LDL receptor gene, Biochem. Biophys. Res. Commun., 249, 517, 10.1006/bbrc.1998.9174 · DOI
  50. Zandieh Doulabi, 2002, TRb1 protein is preferentially expressed in the pericentral zone of rat liver and exhibits marked diurnal variation, Endocrinology, 143, 979, 10.1210/endo.143.3.8706 · DOI
  51. Flamant, 2003, Thyroid hormone receptors: lessons from knockout and knock-in mutant mice, Trends Endocrinol. Metab., 14, 85, 10.1016/S1043-2760(02)00043-7 · DOI · Paper page
  52. Murray, 1988, Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors, J. Biol. Chem., 263, 12770, 10.1016/S0021-9258(18)37820-7 · DOI

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Metadata

Authors
Lopez, D., Abisambra Socarrás, J. F., Bedi, M., & Ness, G. C.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2007-09
Volume
1771
Issue
9
Pages
1216-1225
ISSN
1388-1981
DOI
10.1016/j.bbalip.2007.05.001
Cited by
109
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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