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Cited by 92Cellular transport and secretionLipid metabolism and biosynthesisLipid Membrane Structure and Behavior

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Phospholipase D in endocytosis and endosomal recycling pathways

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Donaldson, Julie G.·2009·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2009.05.011PMC PMC2731818
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Abstract

The discovery that Arf GTPases, mediators of membrane traffic, activate phospholipase D (PLD) raised the possibility that Arfs could facilitate membrane traffic by altering membrane lipid composition. PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways.

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Cited by

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Metadata

Authors
Donaldson, J. G.
Affiliations
National Institutes of Health (US)
Corresponding author
Donaldson, Julie G.
ORCID
Donaldson, Julie G.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2009-09
Volume
1791
Issue
9
Pages
845-849
ISSN
1388-1981 (ISSN-L)
DOI
10.1016/j.bbalip.2009.05.011
PMC
PMC2731818
OpenAlex
W2048825955
Cited by
92
References
2
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 16 · 2013: 5 · 2012: 7
FWCI
0.58
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (Z01HL000517)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
phospholipase D, endocytosis, endosomal recycling, Arf GTPases, phosphatidic acid, membrane curvature, membrane trafficking, phosphatidylcholine hydrolysis, membrane fission, membrane fusion
MeSH terms
Animals, Cell Membrane, Endocytosis, Humans, Phospholipase D, Receptors, Cell Surface, Endosomes, Signal Transduction

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CoChat. (2026). Citation check: Phospholipase D in endocytosis and endosomal recycling pathways. https://app.cochat.ai/papers/10.1016/j.bbalip.2009.05.011
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Donaldson, J. G. (2009). Phospholipase D in endocytosis and endosomal recycling pathways. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. https://doi.org/10.1016/j.bbalip.2009.05.011

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