Cited by 247

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Membrane rafts in Alzheimer's disease beta-amyloid production

Vetrivel, Kulandaivelu S., Thinakaran, Gopal·2010·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.bbalip.2010.03.007

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Cholesterol regulates the formation of lipid clusters and the affinity of proteins to lipid clusters, including β-secretase and γ-secretase.

    “In cellular membranes, cholesterol regulates the formation of lipid clusters (also known as lipid rafts) and the affinity of proteins to lipid clusters (7), including β-secretase and γ-secretase (8–10).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 90

  1. [2]Thinakaran G Koo EH Amyloid precursor protein trafficking, processing, and function J Biol Chem 283 2008 29615 29619 18650430 PMC2573065
  2. [3]Vassar R BACE1: the beta-secretase enzyme in Alzheimer’s disease J Mol Neurosci 23 2004 105 114 15126696
  3. [4]Allinson TM Parkin ET Turner AJ Hooper NM ADAMs family members as amyloid precursor protein alpha-secretases J Neurosci Res 74 2003 342 352 14598310
  4. [5]Iwatsubo T The g-secretase complex: machinery for intramembrane proteolysis Curr Opin Neurobiol 14 2004 379 383 15194119
  5. [6]Kitazume S Tachida Y Oka R Shirotani K Saido TC Hashimoto Y Alzheimer’s beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase Proc Natl Acad Sci U S A 98 2001 13554 13559 11698669 PMC61079
  6. [7]Li Q Sudhof TC Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1 J Biol Chem 279 2004 10542 10550 14699153
  7. [8]Lichtenthaler SF Dominguez DI Westmeyer GG Reiss K Haass C Saftig P De Strooper B Seed B The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1 J Biol Chem 278 2003 48713 48719 14507929
  8. [10]Wong HK Sakurai T Oyama F Kaneko K Wada K Miyazaki H Kurosawa M De Strooper B Saftig P Nukina N beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase J Biol Chem 280 2005 23009 23017 15824102
  9. [11]Hu X Hicks CW He W Wong P Macklin WB Trapp BD Yan R Bace1 modulates myelination in the central and peripheral nervous system Nat Neurosci 9 2006 1520 1525 17099708
  10. [13]Kuhn PH Marjaux E Imhof A De Strooper B Haass C Lichtenthaler SF Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase J Biol Chem 282 2007 11982 11995 17307738
  11. [14]Hemming ML Elias JE Gygi SP Selkoe DJ Identification of beta-secretase (BACE1) substrates using quantitative proteomics PLoS One 4 2009 e8477 20041192 PMC2793532
  12. [15]Lazarov O Lee M Peterson DA Sisodia SS Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice J Neurosci 22 2002 9785 9793 12427834 PMC6757836
  13. [16]Hemming ML Elias JE Gygi SP Selkoe DJ Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements PLoS Biol 6 2008 e257 18942891 PMC2570425
  14. [17]Schubert D LaCorbiere M Saitoh T Cole G Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate Proc Natl Acad Sci U S A 86 1989 2066 2069 2494659 PMC286848
  15. [18]Weidemann A Konig G Bunke D Fischer P Salbaum JM Masters CL Beyreuther K Identification, biogenesis, and localization of precursors of Alzheimer’s disease A4 amyloid protein Cell 57 1989 115 126 2649245
  16. [19]Oltersdorf T Ward PJ Henriksson T Beattie EC Neve R Lieberburg I Fritz LC The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway J Biol Chem 265 1990 4492 4497 1968460
  17. [20]Suzuki T Nairn AC Gandy SE Greengard P Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C Neuroscience 48 1992 755 761 1630623
  18. [21]Knops J Gandy S Greengard P Lieberburg I Sinha S Serine phosphorylation of the secreted extracellular domain of APP Biochem Biophys Res Commun 197 1993 380 385 8267571
  19. [22]Oishi M Nairn AC Czernik AJ Lim GS Isohara T Gandy SE Greengard P Suzuki T The cytoplasmic domain of Alzheimer’s amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells Mol Med 3 1997 111 123 9085254 PMC2230054
  20. [23]Sisodia SS Beta-amyloid precursor protein cleavage by a membrane-bound protease Proc Natl Acad Sci U S A 89 1992 6075 6079 1631093 PMC49440
  21. [24]Golde TE Estus S Younkin LH Selkoe DJ Younkin SG Processing of the amyloid protein precursor to potentially amyloidogenic derivatives Science 255 1992 728 730 1738847
  22. [25]Miller CC McLoughlin DM Lau KF Tennant ME Rogelj B The X11 proteins, Abeta production and Alzheimer’s disease Trends Neurosci 29 2006 280 285 16545469
  23. [26]Borg JP Ooi J Levy E Margolis B The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein Mol Cell Biol 16 1996 6229 6241 8887653 PMC231626
  24. [27]Morris SM Cooper JA Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 Traffic 2 2001 111 123 11247302
  25. [28]Wang B Hu Q Hearn MG Shimizu K Ware CB Liggitt DH Jin LW Cool BH Storm DR Martin GM Isoform-specific knockout of FE65 leads to impaired learning and memory J Neurosci Res 75 2004 12 24 14689444
  26. [30]Ho A Liu X Sudhof TC Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer’s disease J Neurosci 28 2008 14392 14400 19118172 PMC2693334
  27. [31]Cam JA Zerbinatti CV Knisely JM Hecimovic S Li Y Bu G The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production J Biol Chem 279 2004 29639 29646 15126508
  28. [32]Cam JA Zerbinatti CV Li Y Bu G Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein J Biol Chem 280 2005 15464 15470 15705569
  29. [33]Andersen OM Reiche J Schmidt V Gotthardt M Spoelgen R Behlke J von Arnim CA Breiderhoff T Jansen P Wu X Bales KR Cappai R Masters CL Gliemann J Mufson EJ Hyman BT Paul SM Nykjaer A Willnow TE Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein Proc Natl Acad Sci U S A 102 2005 13461 13466 16174740 PMC1224625
  30. [34]Koo EH Sisodia SS Archer DR Martin LJ Weidemann A Beyreuther K Fischer P Masters CL Price DL Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport Proc Natl Acad Sci U S A 87 1990 1561 1565 1689489 PMC53515
  31. [35]Huse JT Pijak DS Leslie GJ Lee VM Doms RW Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer’s disease beta-secretase J Biol Chem 275 2000 33729 33737 10924510
  32. [36]Walter J Fluhrer R Hartung B Willem M Kaether C Capell A Lammich S Multhaup G Haass C Phosphorylation regulates intracellular trafficking of beta-secretase J Biol Chem 276 2001 14634 14641 11278841
  33. [37]Pastorino L Ikin AF Nairn AC Pursnani A Buxbaum JD The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta) Mol Cell Neurosci 19 2002 175 185 11860271
  34. [38]Koo EH Squazzo SL Evidence that production and release of amyloid beta-protein involves the endocytic pathway J Biol Chem 269 1994 17386 17389 8021238
  35. [39]Cirrito JR Kang JE Lee J Stewart FR Verges DK Silverio LM Bu G Mennerick S Holtzman DM Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo Neuron 58 2008 42 51 18400162 PMC2390913
  36. [40]Thinakaran G Teplow DB Siman R Greenberg B Sisodia SS Metabolism of the “Swedish” amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the “beta-secretase” site occurs in the golgi apparatus J Biol Chem 271 1996 9390 9397 8621605
  37. [41]De Strooper B Saftig P Craessaerts K Vanderstichele H Guhde G Annaert W Von Figura K Van Leuven F Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein Nature 391 1998 387 390 9450754
  38. [42]De Strooper B Annaert W Cupers P Saftig P Craessaerts K Mumm JS Schroeter EH Schrijvers V Wolfe MS Ray WJ Goate A Kopan R A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain Nature 398 1999 518 522 10206645
  39. [43]Wolfe MS Xia W Ostaszewski BL Diehl TS Kimberly WT Selkoe DJ Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity Nature 398 1999 513 517 10206644
  40. [44]Vetrivel KS Cheng H Lin W Sakurai T Li T Nukina N Wong PC Xu H Thinakaran G Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes J Biol Chem 279 2004 44945 44954 15322084 PMC1201506
  41. [45]Dietschy JM Turley SD Cholesterol metabolism in the brain Current Opinion in Lipidology 12 2001 105 112 11264981
  42. [46]Dietschy JM Turley SD Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal J Lipid Res 45 2004 1375 1397 15254070
  43. [47]Paratcha G Ib·Òez CF Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme Current Opinion in Neurobiology 12 2002 542 549 12367633
  44. [48]Golub T Wacha S Caroni P Spatial and temporal control of signaling through lipid rafts Current Opinion in Neurobiology 14 2004 542 550 15464886
  45. [49]Kamiguchi H The region-specific activities of lipid rafts during axon growth and guidance Journal of Neurochemistry 98 2006 330 335 16805828
  46. [50]Kuo YM Emmerling MR Bisgaier CL Essenburg AD Lampert HC Drumm D Roher AE Elevated low-density lipoprotein in Alzheimer’s disease correlates with brain abeta 1–42 levels Biochem Biophys Res Commun 252 1998 711 715 9837771
  47. [51]Kivipelto M Helkala EL Laakso MP Hanninen T Hallikainen M Alhainen K Soininen H Tuomilehto J Nissinen A Midlife vascular risk factors and Alzheimer’s disease in later life: longitudinal, population based study Bmj 322 2001 1447 1451 11408299 PMC32306
  48. [52]Jick H Zornberg GL Jick SS Seshadri S Drachman DA Statins and the risk of dementia Lancet 356 2000 1627 1631 11089820
  49. [53]Wolozin B Kellman W Ruosseau P Celesia GG Siegel G Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors Arch Neurol 57 2000 1439 1443 11030795
  50. [54]Sparks DL Scheff SW Hunsaker JC 3rd Liu H Landers T Gross DR Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol Exp Neurol 126 1994 88 94 8157129
  51. [55]Miida T Takahashi A Tanabe N Ikeuchi T Can statin therapy really reduce the risk of Alzheimer’s disease and slow its progression? Curr Opin Lipidol 16 2005 619 623 16276238
  52. [56]Canevari L Clark JB Alzheimer’s disease and cholesterol: the fat connection Neurochem Res 32 2007 739 750 17191138
  53. [57]Hoyer S Riederer P Alzheimer disease-no target for statin treatment. A mini review Neurochem Res 32 2007 695 706 17063393
  54. [58]Xiu J Nordberg A Shan KR Yu WF Olsson JM Nordman T Mousavi M Guan ZZ Lovastatin stimulates up-regulation of alpha7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the alpha-form of secreted amyloid precursor protein J Neurosci Res 82 2005 531 541 16240392
  55. [59]Won JS Im YB Khan M Contreras M Singh AK Singh I Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts J Neurochem 105 2008 1536 1549 18266936 PMC2707757
  56. [60]Simons M Keller P De Strooper B Beyreuther K Dotti CG Simons K Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons Proc Natl Acad Sci U S A 95 1998 6460 6464 9600988 PMC27798
  57. [61]Fassbender K Simons M Bergmann C Stroick M Lutjohann D Keller P Runz H Kuhl S Bertsch T von Bergmann K Hennerici M Beyreuther K Hartmann T Simvastatin strongly reduces levels of Alzheimer’s disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo Proc Natl Acad Sci U S A 98 2001 5856 5861 11296263 PMC33303
  58. [62]Refolo LM Malester B LaFrancois J Bryant-Thomas T Wang R Tint GS Sambamurti K Duff K Pappolla MA Hypercholesterolemia accelerates the Alzheimer’s amyloid pathology in a transgenic mouse model Neurobiol Dis 7 2000 321 331 10964604
  59. [63]Refolo LM Pappolla MA LaFrancois J Malester B Schmidt SD Thomas-Bryant T Tint GS Wang R Mercken M Petanceska SS Duff KE A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer’s disease Neurobiol Dis 8 2001 890 899 11592856
  60. [64]Hartmann T Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance Neurodegener Dis 3 2006 305 311 17047372
  61. [65]Porter FD Smith-Lemli-Opitz syndrome: pathogenesis, diagnosis and management Eur J Hum Genet 16 2008 535 541 18285838
  62. [66]Katsuno M Adachi H Sobue G Getting a handle on Huntington’s disease: the case for cholesterol Nat Med 15 2009 253 254 19265827
  63. [67]Runz H Rietdorf J Tomic I de Bernard M Beyreuther K Pepperkok R Hartmann T Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells J Neurosci 22 2002 1679 1689 11880497 PMC6758870
  64. [69]Puglielli L Konopka G Pack-Chung E Ingano LA Berezovska O Hyman BT Chang TY Tanzi RE Kovacs DM Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide Nat Cell Biol 3 2001 905 912 11584272
  65. [70]Cole SL Grudzien A Manhart IO Kelly BL Oakley H Vassar R Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism J Biol Chem 280 2005 18755 18770 15718241
  66. [71]Sawamura N Ko M Yu W Zou K Hanada K Suzuki T Gong JS Yanagisawa K Michikawa M Modulation of amyloid precursor protein cleavage by cellular sphingolipids J Biol Chem 279 2004 11984 11991 14715666
  67. [72]Simons K Toomre D Lipid rafts and signal transduction Nat Rev Mol Cell Biol 1 2000 31 39 11413487
  68. [73]Hancock JF Lipid rafts: contentious only from simplistic standpoints Nat Rev Mol Cell Biol 7 2006 456 462 16625153 PMC2782566
  69. [74]Helms JB Zurzolo C Lipids as targeting signals: lipid rafts and intracellular trafficking Traffic 5 2004 247 254 15030566
  70. [75]Brown DA London E Functions of lipid rafts in biological membranes Annu Rev Cell Dev Biol 14 1998 111 136 9891780
  71. [76]Lichtenberg D Goni FM Heerklotz H Detergent-resistant membranes should not be identified with membrane rafts Trends Biochem Sci 30 2005 430 436 15996869
  72. [77]Pike LJ Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function J Lipid Res 47 2006 1597 1598 16645198
  73. [78]Brugger B Sandhoff R Wegehingel S Gorgas K Malsam J Helms JB Lehmann WD Nickel W Wieland FT Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles J Cell Biol 151 2000 507 518 11062253 PMC2185577
  74. [79]Mukherjee S Maxfield FR Role of membrane organization and membrane domains in endocytic lipid trafficking Traffic 1 2000 203 211 11208103
  75. [80]Puri V Watanabe R Dominguez M Sun X Wheatley CL Marks DL Pagano RE Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases Nat Cell Biol 1 1999 386 388 10559968
  76. [81]Riddell DR Christie G Hussain I Dingwall C Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts Curr Biol 11 2001 1288 1293 11525745
  77. [82]Vetrivel KS Cheng H Kim SH Chen Y Barnes NY Parent AT Sisodia SS Thinakaran G Spatial segregation of g-secretase and substrates in distinct membrane domains J Biol Chem 280 2005 25892 25900 15886206 PMC1201532
  78. [84]Ehehalt R Keller P Haass C Thiele C Simons K Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts J Cell Biol 160 2003 113 123 12515826 PMC2172747
  79. [85]Abad-Rodriguez J Ledesma MD Craessaerts K Perga S Medina M Delacourte A Dingwall C De Strooper B Dotti CG Neuronal membrane cholesterol loss enhances amyloid peptide generation J Cell Biol 167 2004 953 960 15583033 PMC2172459
  80. [86]Kojro E Gimpl G Lammich S Marz W Fahrenholz F Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10 Proc Natl Acad Sci U S A 98 2001 5815 5820 11309494 PMC33296
  81. [87]Hansen GH Niels-Christiansen LL Thorsen E Immerdal L Danielsen EM Cholesterol depletion of enterocytes. Effect on the Golgi complex and apical membrane trafficking J Biol Chem 275 2000 5136 5142 10671559
  82. [88]Hao M Mukherjee S Sun Y Maxfield FR Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes J Biol Chem 279 2004 14171 14178 14734557
  83. [89]Kirsch C Eckert GP Mueller WE Statin effects on cholesterol micro-domains in brain plasma membranes Biochem Pharmacol 65 2003 843 856 12628479
  84. [90]Melkonian KA Ostermeyer AG Chen JZ Roth MG Brown DA Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated J Biol Chem 274 1999 3910 3917 9920947
  85. [91]Benjannet S Elagoz A Wickham L Mamarbachi M Munzer JS Basak A Lazure C Cromlish JA Sisodia S Checler F Chretien M Seidah NG Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production J Biol Chem 276 2001 10879 10887 11152688
  86. [93]Wahrle S Das P Nyborg AC McLendon C Shoji M Kawarabayashi T Younkin LH Younkin SG Golde TE Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains Neurobiol Dis 9 2002 11 23 11848681
  87. [94]Cheng H Vetrivel KS Drisdel RC Meckler X Gong P Leem JY Li T Carter M Chen Y Nguyen P Iwatsubo T Tomita T Wong PC Green WN Kounnas MZ Thinakaran G S-palmitoylation of gamma-secretase subunits nicastrin and APH-1 J Biol Chem 284 2009 1373 1384 19028695 PMC2615504
  88. [95]Scheiffele P Roth MG Simons K Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain Embo J 16 1997 5501 5508 9312009 PMC1170182
  89. [96]Bruckner K Pablo Labrador J Scheiffele P Herb A Seeburg PH Klein R EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains Neuron 22 1999 511 524 10197531
  90. [97]Yoon IS Chen E Busse T Repetto E Lakshmana MK Koo EH Kang DE Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway FASEB J 21 2007 2742 2752 17463224

Cited by

Sorted by citations

Metadata

Authors
Vetrivel, K. S., & Thinakaran, G.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2010-08
Volume
1801
Issue
8
Pages
860-867
ISSN
1388-1981
Cited by
247
References
6
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review