Characterization and purification of β−secretase inhibitory peptides fraction from sea cucumber (Holothuria spinifera) enzymatic hydrolysates
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Aβ peptide production is regulated through enzyme inhibition associated with the amyloidogenic cascade, mainly β-secretase.
“Recent reports point to the Aβ peptides production regulation, through enzyme inhibition associated with the amyloidogenic cascade, mainly β-secretase [162,163,164].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [162]
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- Authors
- Rathnayake, A. U., Abuine, R., Palanisamy, S., Lee, J. K., & Byun, H.-G.
- Affiliations
- Gangneung–Wonju National University (KR)
- Corresponding author
- Byun, Hee-Guk
- ORCID
- Venue
- Process Biochemistry
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 111
- Pages
- 86-96
- ISSN
- 0032-9592 (ISSN-L)
- 1359-5113
- OpenAlex
- W3204942313
- Cited by
- 11
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Process Biochemistry (publishedVersion)
- Funders
- Ministry of Oceans and Fisheries (20140441)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Keywords
- sea cucumbers, enzymatic hydrolysate, trypsin hydrolysate, Alzheimer's disease, amyloid-beta, amyloid precursor protein, amyloid hypothesis, SH-SY5Y cells, oxidative stress, c-Jun N-terminal kinase, p38 MAPK, functional food ingredients
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