Cited by 492Fatty Acid Research and HealthInflammatory mediators and NSAID effectsEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 159 of the 166 references it cites were found in a registry or an index.

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

Open access

Serhan, Charles N., Dalli, Jesmond, Colas, Romain A., Winkler, Jeremy W., Chiang, Nan·2015·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2014.08.006PMC PMC4324013

Open this paper in CoChat — free account

Abstract

Acute inflammatory responses are protective, yet without timely resolution can lead to chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self-resolving) inflammatory exudates in mice and structural elucidation uncovered novel resolution phase mediators in vivo that stimulate endogenous resolution mechanisms in inflammation. Resolving inflammatory exudates and human leukocytes utilize DHA and other n-3 EFA to produce three structurally distinct families of potent di- and trihydroxy-containing products, with several stereospecific potent mediators in each family. Given their potent and stereoselective picogram actions, specific members of these new families of mediators from the DHA metabolome were named D-series resolvins (Resolvin D1 to Resolvin D6), protectins (including protectin D1-neuroprotectin D1), and maresins (MaR1 and MaR2). In this review, we focus on a) biosynthesis of protectins and maresins as anti-inflammatory-pro-resolving mediators; b) their complete stereochemical assignments and actions in vivo in disease models. Each pathway involves the biosynthesis of epoxide-containing intermediates produced from hydroperoxy-containing precursors from human leukocytes and within exudates. Also, aspirin triggers an endogenous DHA metabolome that biosynthesizes potent products in inflammatory exudates and human leukocytes, namely aspirin-triggered Neuroprotectin D1/Protectin D1 [AT-(NPD1/PD1)]. Identification and structural elucidation of these new families of bioactive mediators in resolution has opened the possibility of diverse patho-physiologic actions in several processes including infection, inflammatory pain, tissue regeneration, neuroprotection-neurodegenerative disorders, wound healing, and others. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance".

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbalip.2014.08.006

Cites

159 of 159 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
Samuelsson, B. O. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,839
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
Self-citation
Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
Samuelsson, B. O., Dahlén, S., LINDGREN, J. Å., Rouzer, C. A., & Serhan, C. N. (1987) · Science · doi:10.1126/science.2820055 · Cited by 2,233
Resolvins
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453
Self-citation

Show all 166 references

Research works printed but not linked: 9

Bazan, 1990, Supply of n−3 polyunsaturated fatty acids and their significance in the central nervous system, vol. 8, 1
Van Dyke, 2006, A novel approach to resolving inflammation, Sci. Am., 42
Stables, 2011, Transcriptomic analyses of murine resolution-phase macrophages, Blood, 118, e192, 10.1182/blood-2011-04-345330 · DOI
Serhan, 2009, Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions, J. Exp. Med., 206, 15, 10.1084/jem.20081880 · DOI · Paper page
Serhan, 2012, Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain, FASEB J., 26, 1755, 10.1096/fj.11-201442 · DOI
Samuelsson, 2012, Role of basic science in the development of new medicines: examples from the eicosanoid field, J. Biol. Chem., 287, 10070, 10.1074/jbc.X112.351437 · DOI
Spite, 2009, Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis, Nature, 461, 1287, 10.1038/nature08541 · DOI · Paper page
Chiang, 2012, Infection regulates pro-resolving mediators that lower antibiotic requirements, Nature, 484, 524, 10.1038/nature11042 · DOI · Paper page
Yanes, 2010, Metabolic oxidation regulates embryonic stem cell differentiation, Nat. Chem. Biol., 6, 411, 10.1038/nchembio.364 · DOI

Sorted by citations

Items 301–400 of 489

Evaluation of anti-inflammatory, analgesic and TNF-α inhibition (upon RAW 264.7 cell line) followed by the selection of extract (leaf and stem) with respect to potency to introduce anti-oral-ulcer model obtained from Olax psittacorum (Lam.) Vahl in addition to GC-MS illustration
Majumder, R., Adhikari, L., Dhara, M., & Sahu, J. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113146 · Cited by 12
Beneficial Effects of Enteral Docosahexaenoic Acid on the Markers of Inflammation and Clinical Outcomes of Neonates Undergoing Cardiovascular Surgery: An Intervention Study
Bernabé-García, M., López‐Alarcón, M., Villegas‐Silva, R., Mancilla-Ramı́rez, J., Rodríguez‐Cruz, M., Maldonado‐Hernández, J., Chávez-Rueda, A. K., Blanco-Favela, F. A., Espinoza-Garcia, L., & Lagunes-Salazar, S. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000447498 · Cited by 12
Omega-3 fatty acids in cause, prevention and management of violence in schizophrenia: Conceptualization and application
Ouyang, W., Sun, G., & Hsu, M. (2019) · Aggression and Violent Behavior · doi:10.1016/j.avb.2019.101347 · Cited by 12
Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1
Olsen, M. V., Lyngstadaas, A. V., Bair, J. A., Hodges, R. R., Utheim, T. P., Serhan, C. N., & Dartt, D. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116233 · Cited by 11
The biosynthetic pathways of the protectins
Haatveit, Å. S., & Hansen, T. V. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106787 · Cited by 12
Leishmania mexicana promotes pain-reducing metabolomic reprogramming in cutaneous lesions
Volpedo, G., Oljuskin, T., Cox, B., Mercado, Y., Askwith, C. C., Azodi, N., Bernier, M. C., Nakhasi, H. L., Gannavaram, S., & Satoskar, A. R. (2023) · iScience · doi:10.1016/j.isci.2023.108502 · Cited by 11
Exploring the unique role of specialized pro-resolving mediators in cancer therapeutics
Quinlivan, K. M., Howard, I. V., Southan, F., Bayer, R. L., Torres, K. L., Serhan, C. N., & Panigrahy, D. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106944 · Cited by 12
Microalgae as an emerging alternative raw material of docosahexaenoic acid and eicosapentaenoic acid – a review
Sharma, T., Das, N., Kakkar, P. M., Mohapatra, R. K., Pamidimarri, S. D. V. N., Singh, R. K., Kumar, M., Guldhe, A., & Nayak, M. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2486267 · Cited by 14
The association of plasma inflammatory markers with omega-3 fatty acids and their mediating role in psychotic symptoms and functioning: An analysis of the NEURAPRO clinical trial
Susai, S. R., Mongan, D., Healy, C., Cannon, M. D., Nelson, B., Markulev, C., Schäfer, M. R., Berger, M., Mossaheb, N., Schlögelhofer, M., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.018 · Cited by 11
[Retracted] The Role of 12/15‐Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
Tan, R., Yan, B., Wang, C., & Zhang, L. (2022) · BioMed Research International · doi:10.1155/2022/4589191 · Cited by 12
Retracted
Omega-3/omega-6 fatty acid ratios in different phospholipid classes and depressive symptoms in coronary artery disease patients
Mazereeuw, G., Herrmann, N., David, W. L., Hillyer, L. M., OH, P. I., & Lanctôt, K. L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.009 · Cited by 11
Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers
Tiwari, S., Yang, J., Morisseau, C. H. P., Durbin-Johnson, B. P., Hammock, B. D., & Gomes, A. V. (2021) · Scientific Reports · doi:10.1038/s41598-021-86284-1 · Cited by 11
Salivary levels of last generation specific pro‐resolving lipid mediators (SPMs) (protectin and maresin) in patients with cardiovascular and periodontal disease: A case‐control study
Önal, M. A., Fentoğlu, Ö., Aksoy, F., Calapoğlu, M., Varol, E., & Orhan, H. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12861 · Cited by 11
COVID-19, Coenzyme Q10 and Selenium
Hargreaves, I. P., & Mantle, D. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-71697-4_13 · Cited by 12
Pro-Resolving Inflammatory Effects of a Marine Oil Enriched in Specialized Pro-Resolving Mediators (SPMs) Supplement and Its Implication in Patients with Post-COVID Syndrome (PCS)
Aznar, A. G., Egea, F. M., Banzo, R. G., Gutiérrez, R., Rizo, J. M., Ledo, P. R., Nerín, I., & Regidor, P. (2024) · Biomedicines · doi:10.3390/biomedicines12102221 · Cited by 10
The Analgesic and Anxiolytic Effect of Souvenaid, a Novel Nutraceutical, Is Mediated by Alox15 Activity in the Prefrontal Cortex
Shalini, S.-M., Herr, D. R., & Ong, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0138-2 · Cited by 10
Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models
Schäfer, M., Reisch, F., Łabuz, D., Machelska, H., Stehling, S., Püschel, G. P., Rothe, M., Heydeck, D., & Kühn, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311034 · Cited by 10
Myocardial Cell Signaling During the Transition to Heart Failure
Zeglinski, M. R., Moghadam, A. R., Ande, S. R., Sheikholeslami, K., Mokarram, P., Sepehri, Z., Rokni, H., Mohtaram, N. K., Poorebrahim, M., Masoom, A., et al. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170053 · Cited by 13
Interface between Resolvins and Efferocytosis in Health and Disease
Mohammad‐Rafiei, F., Negahdari, S., Tahershamsi, Z., & Hayat, S. M. G. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01187-4 · Cited by 8
Molecular Mechanisms Associated with the Inhibitory Role of Long Chain n-3 PUFA in Colorectal Cancer
Jayathilake, A. G., Luwor, R. B., Nurgali, K., & Su, X. Q. (2024) · Integrative Cancer Therapies · doi:10.1177/15347354241243024 · Cited by 10
Emerging mechanisms of organ crosstalk: The role of oxylipins
Fisk, H. L., & Shaikh, S. R. (2024) · Nutrition Bulletin · doi:10.1111/nbu.12726 · Cited by 9
Linking Lipid Metabolism and Immune Function: New Insights into Chronic Respiratory Diseases
Kotlyarov, S. N. (2025) · Pathophysiology · doi:10.3390/pathophysiology32020026 · Cited by 9
Eosinophils in inflammatory bowel disease pathogenesis: an ROS-centric view
Tomii, T., & Kano, G. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1608202 · Cited by 11
Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial
Dreßler, M., Fußbroich, D., Böhler, L., Herrmann, E. M., Benker, N., Tytyk, M., Schulze, J., Schubert, R., Beermann, C., & Zielen, S. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01343-2 · Cited by 9
Supplementation with Silybum marianum Extract, Synbiotics, Omega-3 Fatty Acids, Vitamins, and Minerals: Impact on Biochemical Markers and Fecal Microbiome in Overweight Dogs
Balouei, F., Stefanon, B., Martello, E., Atuahene, D., Sandri, M., & Meineri, G. (2024) · Animals · doi:10.3390/ani14040579 · Cited by 9
Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases
Liu, H., Xiaoyi, L. I. U., Xie, J., & Shuai, C. H. E. N. (2023) · Food Science and Technology · doi:10.1590/fst.111022 · Cited by 8
Modifications of Blood Molecular Components after Treatment with Low Ozone Concentrations
Inguscio, C. R., Cisterna, B., Carton, F., Barberis, E., Manfredi, M., & Malatesta, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417175 · Cited by 8
Harnessing Oxylipins and Inflammation Modulation for Prevention and Treatment of Colorectal Cancer
Gretschel, J., Hage, R. E., Wang, R., Chen, Y., Pietzner, A., Loew, A., Leineweber, C. G., Wördemann, J., Rohwer, N., Weylandt, K. H., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105408 · Cited by 8
Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?
Croft, D. P., Block, R., Cameron, S. J., Evans, K. A., Lowenstein, C. J., Ling, F. S. K., Zaręba, W., Hopke, P. K., Utell, M. J., Thurston, S. W., et al. (2018) · Air Quality Atmosphere & Health · doi:10.1007/s11869-018-0586-0 · Cited by 8
Omega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the “Brazilian Omega Study” (BROS)—a randomized controlled trial
Batista, E. S., Rios, T. D. S., Muñoz, V. R., de Jesus, J. S., Vasconcelos, M. M., da Cunha, D. T., Marques-Rocha, J. L., Nakandakari, S. C. B. R., Lara, R., da Silva, A. S. R., et al. (2021) · Trials · doi:10.1186/s13063-021-05702-x · Cited by 8
Validation of a Liquid–Liquid Extraction Method to Study the Temporal Production of D-Series Resolvins by Head Kidney Cells from Atlantic Salmon (Salmon salar) Exposed to Docosahexaenoic Acid
Araujo, P. W., Iqbal, S., Arnø, A., Espe, M., & Holen, E. (2023) · Molecules · doi:10.3390/molecules28124728 · Cited by 8
Biotransformation of C20- and C22-polyunsaturated fatty acids and fish oil hydrolyzates to R , R -dihydroxy fatty acids as lipid mediators using double-oxygenating 15 R -lipoxygenase
Lee, J., Ko, Y., Park, J., & Oh, D. (2024) · Green Chemistry · doi:10.1039/d4gc00308j · Cited by 8
Role of Toll-like receptor 4/oxidant-coupled activation in regulating the biosynthesis of omega-3 polyunsaturated fatty acid derivative resolvin D1 in primary murine peritoneal macrophage
Zhang, Y., & Igwe, O. J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.021 · Cited by 8
Dietary Oat Bran Increases Some Proinflammatory Polyunsaturated Fatty‐Acid Oxidation Products and Reduces Anti‐Inflammatory Products in Apolipoprotein E−/− Mice
Lee, J. C., AlGhawas, D. S., Poutanen, K. S., Leung, K. S., Oger, C., Galano, J., Durand, T., & El-Nezami, H. S. (2018) · Lipids · doi:10.1002/lipd.12090 · Cited by 8
Long-chain polyunsaturated fatty acids improve airway pathological features and gut microbial imbalances in BALB/c mice with ovalbumin-induced asthma
Jiang, T., Li, P.-F., Zhao, J.-W., Dai, L.-L., Sun, D., Liu, M., An, L., Jia, L.-Q., Jing, X.-G., Wang, H., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104465 · Cited by 5
Protectin DX as a therapeutic strategy against frailty in mice
Perazza, L. R., Gower, A. C., Brown‐Borg, H. M., Pajevic, P. D., & Thompson, L. V. (2023) · GeroScience · doi:10.1007/s11357-023-00789-3 · Cited by 7
Bioactive Compounds for Customized Brain Health: What Are We and Where Should We Be Heading?
Begdache, L., & Marhaba, R. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20156518 · Cited by 8
Long-term substitution of fish oil with alternative sources in Atlantic salmon (Salmo salar): Performance, health, and consumer appeal
leyton, T. P., Marín, S. L., Castillo, S., Sánchez, R., Collipal, R., Madrid, J., & Farı́as, A. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741073 · Cited by 9
The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure
Chen, Z., Lu, Q., Wang, J., Cao, X., Wang, K., Wang, Y., Wu, Y., & Yang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1023999 · Cited by 7
Effect of n-3 long-chain polyunsaturated fatty acids on wound healing using animal models – a review
Komprda, T. (2018) · Acta Veterinaria Brno · doi:10.2754/avb201887040309 · Cited by 8
Fatty acid metabolism in the placentae of gestational diabetes mellitus
Joshi, N. P., & Joshi, S. (2025) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2025.102682 · Cited by 6
The effect of perinatal supplementation of DHA on specialized pro-resolving lipid mediators in the brain of offspring
Dubrof, S., Zukaitis, J. G., Ahmed, I., Sun, W., Zhao, Q., & Park, H. J. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2025.159629 · Cited by 6
A review of perioperative immune‐modulating and metabolic‐modulating nutrition strategies for bowel resection surgery
Walsh, M., & Martindale, R. G. (2024) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2634 · Cited by 7
Protective Role of Eicosapentaenoic and Docosahexaenoic and Their N-Ethanolamide Derivatives in Olfactory Glial Cells Affected by Lipopolysaccharide-Induced Neuroinflammation
Pellitteri, R., Cognata, V. L., Russo, C., Patti, A., & Sanfilippo, C. (2024) · Molecules · doi:10.3390/molecules29204821 · Cited by 6
Anti-inflammatory, Analgesic, and Antipyretic Potential of Azadirachta indica: A Review
Oktavia, S. N., Ifora, I., & Fauziah, F. (2022) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v12i3-s.5502 · Cited by 6
Periodontal and cardiovascular therapies modify specialized pro-resolving lipid mediator (sPRLM) (LPXA4, PD1, RvE1, RvD1, and MaR1)-mediated pathway: the first pilot clinical study
Güvenç, K. K., Fentoğlu, Ö., Calapoğlu, M., Aksoy, F., & Orhan, H. (2023) · Clinical Oral Investigations · doi:10.1007/s00784-023-05174-0 · Cited by 6
Epoxy Fatty Acids
Kuksis, A., & Pruzanski, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809521-8.00003-9 · Cited by 6
Absorption of Polyunsaturated Fatty Acid (PUFA) Is Related to IgG Blood Levels of Neonatal Pigs during the First 48 Hours Postpartum
Pierzynowska, K. G., Woliński, J., Weström, B. R., Jaźwiec, R., Shmigel, H., & Pierzynowski, S. G. (2020) · Journal of Immunology Research · doi:10.1155/2020/3813250 · Cited by 6
The potential anti-inflammatory effect of Omega-3 polyunsaturated fatty acids on experimentally induced ulcerative colitis in rats
Hussein, S. A., Elazem, M. B. A., & Ali, H. M. (2019) · Benha Veterinary Medical Journal · doi:10.21608/bvmj.2019.13806.1022 · Cited by 6
Purposeful Review to Identify the Benefits, Mechanism of Action and Practical Considerations of Omega-3 Polyunsaturated Fatty Acid Supplementation for the Management of Diabetes Mellitus
Abdissa, D. (2021) · Nutrition and Dietary Supplements · doi:10.2147/nds.s298870 · Cited by 6
Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment
Shichiri, M., Suzuki, H., Isegawa, Y., & Tamai, H. (2022) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-61 · Cited by 6
Omega-3 Fatty Acids and Epilepsy
Tejada, S., Martorell, M., Capó, X., Tur, J. A., Pons, A., & Sureda, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811297-7.00020-2 · Cited by 6
The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew
Schäfer, M., Fan, Y., Gu, T., Heydeck, D., Stehling, S., Ivanov, I., Yao, Y., & Kühn, H. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158550 · Cited by 6
First total synthesis of the anti-inflammatory and pro-resolving lipid mediator 16(R),17(S)-diHDHA
Rodrı́guez, A. R., & Spur, B. W. (2018) · Tetrahedron Letters · doi:10.1016/j.tetlet.2018.02.029 · Cited by 6
Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties
Kanwal, M., Nadeem, H., Malik, S., & Maqsood, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41152 · Cited by 5
The profile of oxidative stress markers (arachidonic and linoleic acid derivatives) in patients with benign prostatic hyperplasia in relation to metabolic syndrome
Ratajczak, W., Walczakiewicz, K., Laszczyńska, M., Chmielowiec, K., Palma, J., Drozd, A., Lubkowska, A., & Sipak‐Szmigiel, O. (2025) · Aging · doi:10.18632/aging.206187 · Cited by 7
Dysregulation of Arachidonic Acid Metabolism Drives Inflammatory Lipid Production in Localized Provoked Vulvodynia
Fischer, S. A., Oladele, O., Mahamed, Z., Chrysilla, E., Baumer, A., Bekauri, T., Maddipati, K. R., Love, T., Linder, M. A., & Falsetta, M. L. (2025) · Nutrients · doi:10.3390/nu17132233 · Cited by 5
Potential Role of Bioactive Lipids in Rheumatoid Arthritis
Torres, W., Chávez-Castillo, M., Peréz-Vicuña, J. L., Carrasquero, R., Diaz, M. P., Gómez, Y., Ramírez, P., Cano, C., Rojas, J., Chacín, M., et al. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210525164734 · Cited by 5
Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
Zhao, D., Yang, B. K., Ye, C., Zhang, S., Lv, X., & Chen, Q. (2021) · Innate Immunity · doi:10.1177/17534259211057038 · Cited by 5
Biotransformation of docosahexaenoic acid into 10R,17S-dihydroxydocosahexaenoic acid as protectin DX 10-epimer by serial reactions of arachidonate 8R- and 15S-lipoxygenases
Lee, T., Ko, Y., Shin, K., & Oh, D. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-04032-9 · Cited by 6
Software-aided quality control of parallel reaction monitoring based quantitation of lipid mediators
Wutkowski, A., Krajewski, M. P., Bagwan, N., Schäfer, M., Paudyal, B. R., Schaible, U. E., & Schwudke, D. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.01.044 · Cited by 5
Biological relevance of double lipoxygenase products of polyunsaturated fatty acids, especially within blood vessels and brain
Guichardant, M., Véricel, E., & Lagarde, M. (2018) · Biochimie · doi:10.1016/j.biochi.2018.08.009 · Cited by 6
Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme
Marbach-Breitrück, E., Kutzner, L., Rothe, M., Gurke, R., Schreiber, Y., Reddanna, P., Schebb, N. H., Stehling, S., Wieler, L. H., Heydeck, D., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7751 · Cited by 5
Synthesis of 13R,20-dihydroxy-docosahexaenoic acid by site-directed mutagenesis of lipoxygenase derived from Oscillatoria nigro-viridis PCC 7112
Yi, J.-J., Heo, S.-Y., Ju, J., Oh, B.-R., Son, W. S., & Seo, J. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.09.079 · Cited by 5
Biocatalytic regio- and stereoselective access to ω-3 endocannabinoid epoxides with peroxygenase from oat flour
Sanfilippo, C., & Patti, A. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105014 · Cited by 5
Pro-resolving and pro-inflammatory fatty acid-derived mediators in sputum of stable state bronchiectasis patients
Terranova, L., Risé, P., Gramegna, A., Pinna, C., Agostoni, C. V., Syrén, M., Turolo, S., Marchisio, P., Amati, F., Aliberti, S., et al. (2022) · Respiratory Research · doi:10.1186/s12931-022-02301-5 · Cited by 5
Combined Therapy With Avastin, a PAF Receptor Antagonist and a Lipid Mediator Inhibited Glioblastoma Tumor Growth
Flores, V. A. C., Menghani, H., Mukherjee, P. K., Marrero, L., Obenaus, A., Dang, Q., Khoutorova, L., Reid, M. M., Belayev, L., & Bazan, N. G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.746470 · Cited by 5
Linseed as a Functional Food for the Management of Obesity
Shafie, S. R., Poudyal, H., Panchal, S. K., & Brown, L. (2016) · Springer eBooks · doi:10.1007/978-3-319-40458-5_13 · Cited by 5
Immune Response and Tissue Damage
Arnhold, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816388-7.00006-1 · Cited by 5
Evidence for the presence and diagnostic utility of SPM in human peripheral bloodPreprint
Dalli, J., Gómez, E. A., & Serhan, C. N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.28.489064 · Cited by 5
Effects of Docosahexaenoic Acid on Prostate Cancer
Tamarindo, G. H., Amaro, G. M., da Silva, A. D. T., & Góes, R. M. (2025) · Journal of Xenobiotics · doi:10.3390/jox15040111 · Cited by 5
From Strain to Repair: A Targeted Review of Lipid Mediators Driving the Inflammatory Cascade Following Exercise
Satija, S., Mitchell, T. W., Anthony, R., Peoples, G. E., & Sampson, J. A. (2025) · Sports Medicine · doi:10.1007/s40279-025-02347-7 · Cited by 5
Integrating downstream mediators of Omega-3 fatty acids into enteral nutrition for improved patient care: An expert panel consensus
Martindale, R. G., Mundi, M. S., Waitzberg, D. L., Waele, E. D., Scarcella, M., Umbrello, M., Calder, P. C., Dalli, J., Puthucheary, Z., & van Zanten, A. R. H. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.11.014 · Cited by 4
Resolving lipoxin A4: Endogenous mediator or exogenous anti-inflammatory agent?
McGuffee, R. M., Luetzen, M. A., & Ford, D. A. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100734 · Cited by 4
Formulation of Entandrophragma utile into an Herbal Emulgel for the Management of Inflammation
Kola-Mustapha, A. T., Ibraheem, H. F., Taiwo, S. O., Ishola, I. O., Usman, S. O., & Ghazali, Y. O. (2023) · Gels · doi:10.3390/gels9120956 · Cited by 4
Vagus nerve stimulation: Potential for treating chronic wounds
Budhiraja, A., Mehta, A., Alhamo, M. A., Swedarsky, R., Dahle, S. E., & Isseroff, R. R. (2024) · Wound Repair and Regeneration · doi:10.1111/wrr.13151 · Cited by 4
Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis
Yildiz, Ö., Hunt, G. P., Schroth, J., Dhillon, G., Spargo, T. P., Al‐Chalabi, A., Kõks, S., Turner, M. R., Shaw, P. J., Henson, S. M., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae402 · Cited by 4
Immunology of atherosclerosis: problems and prospects of immunotherapy
Kotlyarov, S. N. (2025) · Vessel Plus · doi:10.20517/2574-1209.2025.40 · Cited by 5
Alterations in eicosanoid composition during embryonic development in the chorioallantoic membrane of the American alligator (Alligator mississippiensis) and domestic chicken (Gallus gallus)
Cantu, T. M., Bowden, J. A., Scott, J., Pérez-Viscasillas, J. B., Huncik, K. M., Guillette, M. P., & Guillette, L. J. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.07.006 · Cited by 4
Authorised EU health claims for the essential fatty acids
Wahle, K. W. J., Heys, S. D., & Rotondo, D. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-382-9.00012-8 · Cited by 4
A Review on the Anti-inflammatory activity of Hesperidin, A Bioflavonoid Synthesized by Citrus fruits
Jagetia, G. C. (2018) · Immunology and Inflammation Diseases Therapy · doi:10.31579/2637-8876/007 · Cited by 4
Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund’s adjuvant-induced paw inflammation model
Heydeck, D., Kakularam, K. R., Łabuz, D., Machelska, H., Rohwer, N., Weylandt, K. H., & Kühn, H. (2023) · Inflammation Research · doi:10.1007/s00011-023-01770-8 · Cited by 5
Dynamic changes in proresolving lipid mediators and their receptors following acute vascular injury in male rats
Kagaya, H., Kim, A. S., Chen, M., Lin, P., Yin, X., Spite, M. R., & Conte, M. S. (2024) · Physiological Reports · doi:10.14814/phy2.16178 · Cited by 3
The 12th World Congress on Inflammation
Yagnik, D. (2015) · Inflammation Research · doi:10.1007/s00011-015-0839-4 · Cited by 4
Omega-3 Fatty Acid Supplementation—A Possible Dietary Adjunct to Enhance Immune Therapy in Cancer?Preprint
Wachtel, N., Rohwer, N., Pietzner, A., Loew, A., & Weylandt, K. H. (2018) · Preprints.org · doi:10.20944/preprints201804.0115.v1 · Cited by 4
Functional humanization of 15-lipoxygenase-1 (Alox15) protects mice from dextran sodium sulfate induced intestinal inflammation
Reisch, F., Schäfer, M., Łabuz, D., Machelska, H., Stehling, S., Püschel, G. P., Rothe, M., Heydeck, D., & Kühn, H. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00756-0 · Cited by 3
Unwinding the Threads of Mesoporous Silica Nanoparticles as Cutting-edge for the Management of Inflammation: An Updated Review
Dhiman, P., Singh, S., Arora, S., Sharma, N., Gulia, R., & Kishore, L. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010310578240926051158 · Cited by 3
Neuroprotectin D1 Attenuates Blast Overpressure Induced Reactive Microglial Cells in the Cochlea
Ríos, J. D., Hughes, C. K., Lally, J., Wienandt, N., Esquivel, C. R., Serhan, C. N., & Weitzel, E. K. (2021) · The Laryngoscope · doi:10.1002/lary.29337 · Cited by 4
The role of modified Mediterranean neuroprotective diet on emotion, cognition, and depression
Singh, R. B., Horiuchi, R., Wilczyńska, A., Suchday, S., Tyagi, G., Magomedova, A. G., Fatima, G., Smail, M. M. A., Isaza, A., Jain, M., et al. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819815-5.00030-6 · Cited by 4
In vivo inhibitory effect of hydro-ethanol extract of xylopia aethiopica fruits on mediators of acute inflammation
Osafo, N., & Yeboah, K. O. (2022) · ACTA Pharmaceutica Sciencia · doi:10.23893/1307-2080.aps.6006 · Cited by 3
Protective Effects of 7S,15R-Dihydroxy-16S,17S-Epoxy-Docosapentaenoic Acid (diHEP-DPA) against Blue Light-Induced Retinal Damages in A2E-Laden ARPE-19 Cells
Song, S.-Y., Park, D.-H., Lee, S.-H., Lim, H.-K., Park, J. W., Seo, J., & Cho, S. (2024) · Antioxidants · doi:10.3390/antiox13080982 · Cited by 4
Role of n-3 (Omega-3) Polyunsaturated Fatty Acids in Postpartum Depression: Mechanisms and Implications for Prevention and Treatment
Levant, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-40458-5_22 · Cited by 4
Dynamic associations between daily alternate healthy eating index, exercise, sleep, seasonal change and mental distress among young and mature men and women
Begdache, L., Chen, M., McKenna, C. E., & Witt, D. F. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100157 · Cited by 3
Cognitive Decline and Mental Distress: A Potential Mismatch between the Contemporary Diet and the Evolved Brain
Begdache, L. (2018) · Anthropology and Ethnology Open Access Journal · doi:10.23880/aeoaj-16000105 · Cited by 2
In vitro assessment of cytotoxicity and anti-inflammatory properties of shilajit nutraceutical: A preliminary study
Balasubramanian, S. K., Ezhilarasi, S., Rajkumar, K., Ravikumar, N., & Mahalaxmi, S. (2020) · Journal of Interdisciplinary Dentistry · doi:10.4103/jid.jid_2_20 · Cited by 3
Identification of a novel enzyme from E. pacifica that acts as an eicosapentaenoic 8R-LOX and docosahexaenoic 10R-LOX
Yuki, S., Uemura, A., Hakozaki, M., Yano, A., Abe, M., Misawa, Y., Baba, N., & Yamada, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-77386-3 · Cited by 3
Effect of omega-3 on painful symptoms of patients with osteoarthritis of the synovial joints. Systematic review and meta-analysis.
Bahamondes, M. A., Valdés, C., & Moncada, G. (2021) · Oral surgery, oral medicine, oral pathology and oral radiology · doi:10.1016/j.oooo.2021.01.020 · Cited by 3
Nutritional support for intensive care patients: the role of lipid component
Пасечник, И. Н., Talyzin, P. A., & Skobelev, E. I. (2024) · Russian Journal of Anesthesiology and Reanimatology · doi:10.17116/anaesthesiology202403158 · Cited by 2
Zein nanocarriers for controlled maresin-1 delivery: A novel approach in biomaterial-based immunomodulation
Sousa, A. B., Martins, C., Sarmento, B. F. C. C., Barbosa, M. A., & Barbosa, J. N. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214238 · Cited by 2
Arachidonoyl-carnitine and arachidonoyl-coenzyme A are suitable substrates for mammalian ALOX isoforms
Chen, X., Parvez, S., Wiegand, H. F., Wu, L., Stehling, S., Borchert, A., Yang, J., Aparoy, P., & Kühn, H. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100861 · Cited by 2

Authors: Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Serhan, Charles N.
ORCID: Serhan, Charles N.
Dalli, Jesmond
Chiang, Nan
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2015-04
Volume: 1851
Issue: 4
Pages: 397-413
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2014.08.006
PMC: PMC4324013
OpenAlex: W2049424212
Cited by: 492
References: 166
Citations by year: 2026: 19 · 2025: 32 · 2024: 35 · 2023: 38 · 2022: 52 · 2021: 56 · 2020: 55 · 2019: 34 · 2018: 57 · 2017: 52 · 2016: 32 · 2015: 28
FWCI: 4.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Mérieux Foundation (R01GM038765)
NIH (P01GM095467)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: protectins, maresins, resolvins, neuroprotectin D1, protectin D1, omega-3 fatty acids, acute inflammation, inflammation resolution, epoxide intermediate, hydroperoxides, leukocytes, aspirin, neuroprotection, wound healing, inflammatory pain
MeSH terms: Animals, Anti-Inflammatory Agents, Aspirin, Docosahexaenoic Acids, Humans, Inflammation, Structure-Activity Relationship, Molecular Structure, Signal Transduction, Metabolome, Lipoxygenases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks