The DOI matches its Crossref record; 159 of the 166 references it cites were found in a registry or an index.
Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome
Open accessAbstract
Acute inflammatory responses are protective, yet without timely resolution can lead to chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self-resolving) inflammatory exudates in mice and structural elucidation uncovered novel resolution phase mediators in vivo that stimulate endogenous resolution mechanisms in inflammation. Resolving inflammatory exudates and human leukocytes utilize DHA and other n-3 EFA to produce three structurally distinct families of potent di- and trihydroxy-containing products, with several stereospecific potent mediators in each family. Given their potent and stereoselective picogram actions, specific members of these new families of mediators from the DHA metabolome were named D-series resolvins (Resolvin D1 to Resolvin D6), protectins (including protectin D1-neuroprotectin D1), and maresins (MaR1 and MaR2). In this review, we focus on a) biosynthesis of protectins and maresins as anti-inflammatory-pro-resolving mediators; b) their complete stereochemical assignments and actions in vivo in disease models. Each pathway involves the biosynthesis of epoxide-containing intermediates produced from hydroperoxy-containing precursors from human leukocytes and within exudates. Also, aspirin triggers an endogenous DHA metabolome that biosynthesizes potent products in inflammatory exudates and human leukocytes, namely aspirin-triggered Neuroprotectin D1/Protectin D1 [AT-(NPD1/PD1)]. Identification and structural elucidation of these new families of bioactive mediators in resolution has opened the possibility of diverse patho-physiologic actions in several processes including infection, inflammatory pain, tissue regeneration, neuroprotection-neurodegenerative disorders, wound healing, and others. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance".
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“NPD1 is highlighted here as a neuroprotective mediator in ischemic stroke, as defined by cellular and molecular targets, and demonstrated that the pathway that leads to its formation was enhanced in its neuroprotective bioactivity by the presence of aspirin (Marcheselli et al., 2003) by aspirin-triggered NPD1 (Bazan et al., 2012; Serhan et al., 2015; Serhan and Petasis, 2011).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Serhan et al., 2015
In the citing paper
“NPD1 is highlighted here as a neuroprotective mediator in ischemic stroke, as defined by cellular and molecular targets, and demonstrated that the pathway that leads to its formation was enhanced in its neuroprotective bioactivity by the presence of aspirin (Marcheselli et al., 2003) by aspirin-triggered NPD1 (Bazan et al., 2012; Serhan et al., 2015; Serhan and Petasis, 2011).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Serhan et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
Samuelsson, B. O. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,839
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
Self-citationLeukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
Samuelsson, B. O., Dahlén, S., LINDGREN, J. Å., Rouzer, C. A., & Serhan, C. N. (1987) · Science · doi:10.1126/science.2820055 · Cited by 2,233
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453
Self-citation
Flagged first, then by citations
7 of the 166 references couldn’t be matched to a known paper.
Research works printed but not linked: 9
- Bazan, 1990, Supply of n−3 polyunsaturated fatty acids and their significance in the central nervous system, vol. 8, 1
- Van Dyke, 2006, A novel approach to resolving inflammation, Sci. Am., 42
- Stables, 2011, Transcriptomic analyses of murine resolution-phase macrophages, Blood, 118, e192, 10.1182/blood-2011-04-345330 · DOI
- Serhan, 2009, Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions, J. Exp. Med., 206, 15, 10.1084/jem.20081880 · DOI · Paper page
- Serhan, 2012, Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain, FASEB J., 26, 1755, 10.1096/fj.11-201442 · DOI
- Samuelsson, 2012, Role of basic science in the development of new medicines: examples from the eicosanoid field, J. Biol. Chem., 287, 10070, 10.1074/jbc.X112.351437 · DOI
- Spite, 2009, Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis, Nature, 461, 1287, 10.1038/nature08541 · DOI · Paper page
- Chiang, 2012, Infection regulates pro-resolving mediators that lower antibiotic requirements, Nature, 484, 524, 10.1038/nature11042 · DOI · Paper page
- Yanes, 2010, Metabolic oxidation regulates embryonic stem cell differentiation, Nat. Chem. Biol., 6, 411, 10.1038/nchembio.364 · DOI
Cited by
Sorted by citations
Items 101–200 of 489
Kim, H., Huang, B. X., & Spector, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094635 · Cited by 75
Vik, A., Dalli, J., & Hansen, T. V. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.03.079 · Cited by 68
Dalli, J. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.007 · Cited by 67
Serhan, C. N., de la Rosa, X., & Jouvene, C. C. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12871 · Cited by 63
Estrada, J. A., & Contreras, I. (2019) · Nutrients · doi:10.3390/nu11051076 · Cited by 65
Protectins: Their biosynthesis, metabolism and structure-functions
Hansen, T. V., & Serhan, C. N. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115330 · Cited by 64
Moffett, J., Kubat, N. J., & Fray, L. M. (2015) · Journal of Inflammation Research · doi:10.2147/jir.s78631 · Cited by 62
Jannas-Vela, S., Espinosa, A., Candia, A. A., Flores‐Opazo, M., Peñailillo, L., & Valenzuela, R. (2023) · Nutrients · doi:10.3390/nu15040871 · Cited by 67
Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection
Imai, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.01.006 · Cited by 63
Involvement of Inflammation and Its Resolution in Disease and Therapeutics
Alfaro, S., Acuña, V., Ceriani, R., Cavieres, M. F., Oppenheimer, C. W., & Campos‐Estrada, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810719 · Cited by 68
Thomas, M. H., Pelleïeux, S., Vitale, N., & Olivier, J. L. (2016) · Biochimie · doi:10.1016/j.biochi.2016.07.013 · Cited by 60
Inflammation, Lipid (Per)oxidation, and Redox Regulation
Dias, I. H. K., Milic, I., Heiß, C., Ademowo, O. S., Polidori, M. C., Devitt, A., & Griffiths, H. R. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8022 · Cited by 57
Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
Tremblay, M.-E., Zhang, I., Bisht, K., Savage, J. C., Lecours, C., Parent, M., Titorenko, V., & Maysinger, D. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0580-0 · Cited by 66
Kotlyarov, S. N., & Котлярова, А. А. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312803 · Cited by 59
Martindale, R. G., Berlana, D., Boullata, J. I., Cai, W., Calder, P. C., Deshpande, G., Evans, D. C., García‐de‐Lorenzo, A., Goulet, O., Li, A., et al. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1746 · Cited by 58
Bhattacharjee, S., Jun, B., Belayev, L., Heap, J., Kautzmann, M.-A., Obenaus, A., Menghani, H., Marcell, S. J., Khoutorova, L., Yang, R., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700735 · Cited by 57
Serhan, C. N., de la Rosa, X., & Jouvene, C. C. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800806 · Cited by 55
Vella, L. D., Markworth, J. F., Farnfield, M. M., Maddipati, K. R., Russell, A. P., & Cameron‐Smith, D. (2019) · Physiological Reports · doi:10.14814/phy2.14108 · Cited by 55
Yang, A., Wu, Y., Yu, G., & Wang, H. (2021) · Respiratory Research · doi:10.1186/s12931-021-01792-y · Cited by 57
Sánchez‐Fernández, A., Zandee, S., Mastrogiovanni, M., Charabati, M., Rubbo, H., Prat, A., & López‐Vales, R. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02386-1 · Cited by 58
Biological Roles of Resolvins and Related Substances in the Resolution of Pain
Lim, J. Y., Park, C., & Hwang, S. W. (2015) · BioMed Research International · doi:10.1155/2015/830930 · Cited by 57
Campos, A. M., Maciel, E. A., Moreira, A. S. P., Sousa, B. C., Melo, T., Domingues, P. M., Curado, L., Antunes, B., Domingues, M. R., & dos Santos, F. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25191 · Cited by 57
Mouse strains and sexual divergence in corneal innervation and nerve regeneration
Pham, T. L., Kakazu, A. H., He, J., & Bazán, H. E. P. (2018) · The FASEB Journal · doi:10.1096/fj.201801957r · Cited by 54
Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids
Ramsden, C. E., Ringel, A., Majchrzak‐Hong, S. F., Yang, J., Blanchard, H. C., Zamora, D., Loewke, J., Rapoport, S. I., Hibbeln, J. R., Davis, J. M., et al. (2016) · Molecular Pain · doi:10.1177/1744806916636386 · Cited by 53
Panossian, A., Seo, E., & Efferth, T. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152881 · Cited by 64
Videla, L. A., Valenzuela, R., del Campo, A., & Zúñiga‐Hernández, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115528 · Cited by 53
Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease
Sun, X., Li, Y., Deng, Q., Hu, Y., Dong, J., Wang, W., Wang, Y., & Li, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934040 · Cited by 54
Serhan, C. N., & Chiang, N. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106718 · Cited by 56
Hansen, T. V., Dalli, J., & Serhan, C. N. (2017) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2017.06.003 · Cited by 51
Omega-3 fatty acids in prevention of diabetic retinopathy
Behl, T., & Kotwani, A. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12744 · Cited by 49
Pro-resolving lipid mediators: Agents of anti-ageing?
Doyle, R., Sadlier, D. M., & Godson, C. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.002 · Cited by 52
Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid
Beyer, M. P., Videla, L. A., Farías, C., & Valenzuela, R. (2023) · Nutrients · doi:10.3390/nu15153317 · Cited by 54
Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis
Eickmeier, O., Fußbroich, D., Mueller, K., Serve, F., Smaczny, C., Zielen, S., & Schubert, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171249 · Cited by 49
Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators
An, J.-U., Kim, S., & Oh, D. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101110 · Cited by 49
Fonteh, A. N., Cipolla, M., Chiang, A. J., Edminster, S. P., Arakaki, X., & Harrington, M. G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00083 · Cited by 47
Maresin 1 resolves aged‐associated macrophage inflammation to improve bone regeneration
Huang, R., Vi, L., Zong, X., & Baht, G. S. (2020) · The FASEB Journal · doi:10.1096/fj.202001145r · Cited by 47
Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies
Zhou, T., Lee, A., Lo, A., & Kwok, J. S. W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.816062 · Cited by 49
Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
Chávez-Castillo, M., Ortega, Á., Cudris–Torres, L., Durán, P., Rojas, M., Manzano, A., Garrido, B., Salazar, J. J., Silva, A., Rojas-Gómez, D. M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910370 · Cited by 49
Ariyoshi, T., Hagihara, M., Eguchi, S., Fukuda, A., Iwasaki, K., Oka, K., Takahashi, M., Yamagishi, Y., & Mikamo, H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.587725 · Cited by 45
Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance
Balas, L., & Durand, T. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.10.002 · Cited by 47
Valenzuela, R., Espinosa, A., Llanos, P., Hernández‐Rodas, M. C., Barrera, C. R., Vergara, D., Romero, N., Pérez, F., Manuel Ruz, O., & Videla, L. A. (2015) · Food & Function · doi:10.1039/c5fo01086a · Cited by 45
Ammann, E. M., Pottala, J. V., Robinson, J. G., Espeland, M. A., & Harris, W. S. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.06.006 · Cited by 48
Modulation of innate immunity of patients with Alzheimer's disease by omega‐3 fatty acids
Fiala, M., Kooij, G., Wagner, K. M., Hammock, B. D., & Pellegrini, M. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700065r · Cited by 44
Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer
Aljawadi, A., Moussa, H. M., Ramalingam, L., Dharmawardhane, S., Gollahon, L., Gunaratne, P. H., Rahman, R. L., & Moustaïd‐Moussa, N. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.09.018 · Cited by 43
Use of Lipids in Neonates Requiring Parenteral Nutrition
Deshpande, G. C., & Cai, W. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1759 · Cited by 50
Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects
Falsaperla, R., Lombardo, F., Filosco, F., Romano, C., Saporito, M. A. N., Puglisi, F., Piro, E., Ruggieri, M., & Pavone, P. (2020) · Pharmaceuticals · doi:10.3390/ph13070145 · Cited by 44
Wang, Y., Li, Y., Wang, J.-N., Zhao, Q.-X., Jin, J., Wen, S., Wang, S.-C., & Sun, T. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00831 · Cited by 45
Perucci, L. O., Sugimoto, M. A., Gomes, K. B., Dusse, L. M. S., Teixeira, M. M., & Sousa, L. P. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1364363 · Cited by 45
Insight into the mechanism of steroidal and non-steroidal anti-inflammatory drugs
Ali, K. A., Maity, A., Roy, S. D., Pramanik, S. D., Das, P. P., & Shaharyar, M. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99855-0.00004-x · Cited by 48
Aursnes, M., Tungen, J. E., Colas, R. A., Vlasakov, I., Dalli, J., Serhan, C. N., & Hansen, T. V. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00574 · Cited by 43
Resolvins as proresolving inflammatory mediators in cardiovascular disease
Capó, X., Martorell, M., Busquets-Cortés, C., Tejada, S., Tur, J. A., Pons, A., & Sureda, A. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.018 · Cited by 46
Wang, W., Xu, R., He, P., & Chen, R. (2021) · Journal of Inflammation · doi:10.1186/s12950-021-00271-x · Cited by 43
Bioactive lipids and pathological retinal angiogenesis
Elmasry, K., Ibrahim, A. S., Abdulmoneim, S., & Al‐Shabrawey, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14507 · Cited by 39
Wang, Q., Yan, S.-F., Yu, H., & Jin, S. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.229890 · Cited by 42
Differential Mobility Separation of Leukotrienes and Protectins
Jónasdóttir, H. S., Papan, C., Fabritz, S., Balas, L., Durand, T., Harðardóttir, I., Freysdóttir, J., & Giera, M. A. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00786 · Cited by 41
Fiala, M., Terrando, N., & Dalli, J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150367 · Cited by 43
Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells
Pace, S., & Werz, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01356 · Cited by 39
Pawełczyk, T., Piątkowska-Janko, E., Bogorodzki, P., Gębski, P., Grancow-Grabka, M., Trafalska, E., Żurner, N., & Pawełczyk, A. M. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.013 · Cited by 40
PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV-1 infection
He, J., Neumann, D. M., Kakazu, A. H., Pham, T. L., Musarrat, F., Cortina, M. S., & Bazán, H. E. P. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.06.015 · Cited by 39
Parisi, G. F., Carota, G., Castruccio Castracani, C., Spampinato, M., Manti, S., Papale, M., Di Rosa, M., Barbagallo, I., & Leonardi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052465 · Cited by 43
Schmitt, A., Martins‐de‐Souza, D., Akbarian, S., Cassoli, J. S., Ehrenreich, H., Fischer, A., Fonteh, A. N., Gattaz, W. F., Gawlik, M., Gerlach, M., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224929 · Cited by 43
Miyazawa, K., Fukunaga, H., Tatewaki, Y., Takano, Y., Yamamoto, S., Mutoh, T., & Taki, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165783 · Cited by 37
Blaauw, R., Calder, P. C., Martindale, R. G., & Berger, M. M. (2024) · Critical Care · doi:10.1186/s13054-024-04803-8 · Cited by 43
Proresolving Lipid Mediators in the Respiratory System
Serhan, C. N., & Levy, B. D. (2024) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020924-033209 · Cited by 44
Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37
Qu, L., & Caterina, M. J. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122203 · Cited by 38
Magalhães, K. G., Luna-Gomes, T., Mesquita-Santos, F. P., Corrêa, R., Assunção, L. S., Atella, G. C., Weller, P. F., Bandeira‐Melo, C., & Bozza, P. T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03161 · Cited by 37
Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond
Sánchez‐García, S., Jaén, R. I., Fernández‐Velasco, M., Delgado, C., Boscá, L., & Prieto, P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106982 · Cited by 40
Oxylipin Response to Acute and Chronic Exercise: A Systematic Review
Signini, É. D. F., Nieman, D. C., da Silva, C. D., Sakaguchi, C. A., & Catai, A. M. (2020) · Metabolites · doi:10.3390/metabo10060264 · Cited by 39
Qiao, N., Lin, Y., Wang, Z., Chen, J., Ge, Y.-Y., Yao, S., & Gong, J. (2020) · Journal of Surgical Research · doi:10.1016/j.jss.2020.06.062 · Cited by 38
Lee, M., Park, J. C., Yoon, D.-S., Han, J., Kang, S., Kamizono, S., Om, A., Shin, K., Hagiwara, A., & Lee, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-20108-7 · Cited by 36
Nutritional Intervention as an Essential Part of Multiple Sclerosis Treatment?
Penesová, A., Dean, Z., Kollár, B., Havranová, A., Imrich, R., Vlček, M., & Rádiková, Ž. (2018) · Physiological Research · doi:10.33549/physiolres.933694 · Cited by 35
Vital, S. A., Senchenkova, E. Y., Ansari, J., & Gavins, F. N. E. (2020) · Cells · doi:10.3390/cells9112473 · Cited by 35
Chataigner, M., Martin, M., Lucas, C., Pallet, V., Layé, S., Mehaignerie, A., Bouvret, E., Dinel, A., & Joffre, C. (2021) · Nutrients · doi:10.3390/nu13030824 · Cited by 36
McBurney, M. I., Tintle, N., Vasan, R. S., Sala‐Vila, A., & Harris, W. S. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab195 · Cited by 34
Eynard, A. R., & Repossi, G. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1049-9 · Cited by 34
Primdahl, K. G., Aursnes, M., Walker, M. E., Colas, R. A., Serhan, C. N., Dalli, J., Hansen, T. V., & Vik, A. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00634 · Cited by 33
Aspirin as a COX inhibitor and anti-inflammatory drug in human skeletal muscle
Ratchford, S. M., Lavin, K. M., Perkins, R. K., Jemioło, B., Trappe, S. W., & Trappe, T. A. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01119.2016 · Cited by 33
Mouton, A. J., Gonzalez, O. J. R., Kaminski, A. R., Moore, E. T., & Lindsey, M. L. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.026 · Cited by 33
Specialized Pro-Resolving Lipid Mediators: Emerging Therapeutic Candidates for Multiple Sclerosis
Zahoor, I., & Giri, S. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08796-4 · Cited by 37
Regidor, P., Santos, F. G., Rizo, J. M., & Egea, F. M. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110340 · Cited by 35
Valenzuela, R., & Videla, L. A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.013 · Cited by 32
Atopic Dermatitis: The Fate of the Fat
Pavel, P., Blunder, S., Moosbrugger‐Martinz, V., Elias, P. M., & Dubrac, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042121 · Cited by 32
Druggable Lipid GPCRs: Past, Present, and Prospects
Mizuno, H., & Kihara, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-50621-6_10 · Cited by 31
Zirpoli, H., Sosunov, S. A., Niatsetskaya, Z. V., Mayurasakorn, K., Kollareth, D. J. M., Serhan, C. N., Ten, V. S., & Deckelbaum, R. J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113495 · Cited by 32
Begdache, L., Kianmehr, H., Sabounchi, N. S., Chaar, M., & Marhaba, J. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1500198 · Cited by 33
Fonseca, F. C. D. S., Orlando, R. M., Turchetti-Maia, R. M. M., & Francischi, J. N. (2017) · Journal of Inflammation Research · doi:10.2147/jir.s142424 · Cited by 30
Melo, D. M., Roseno, T. F., de Barros, W. M., de Faria, R. A. P. G., Paglarini, C. D. S., Faria, P. B., Mariotto, S., & de Souza, X. R. (2019) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2019.103283 · Cited by 31
Ecovio®-based nanofibers as a potential fast transdermal releaser of aceclofenac
Carvalho, B. M., Pellá, M. C. G., Hardt, J. C., Rossin, A. R. D. S., Tonet, A., Ilipronti, T., Caetano, J., & Dragunski, D. C. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.115206 · Cited by 30
Fatty Acids and Oxylipins as Antifungal and Anti-Mycotoxin Agents in Food: A Review
Qiu, M., Wang, Y., Sun, L., Deng, Q., & Zhao, J. (2021) · Toxins · doi:10.3390/toxins13120852 · Cited by 30
Williams, J. P., Calvi, L. M., Chakkalakal, J. V., Finkelstein, J. N., O’Banion, M. K., & Puzas, E. J. (2016) · Radiation Research · doi:10.1667/rr14473.1 · Cited by 30
Classes of Lipid Mediators and Their Effects on Vascular Inflammation in Atherosclerosis
Lubrano, V., Ndreu, R., & Balzan, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021637 · Cited by 33
Pawełczyk, T., Grancow-Grabka, M., Trafalska, E., Szemraj, J., Żurner, N., & Pawełczyk, A. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.12.008 · Cited by 29
Resolving inflammation by using nutrition therapy
Norling, L. V., Ly, L., & Dalli, J. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000353 · Cited by 28
Penkert, H., Bertrand, A., Tiwari, V., Breimann, S., Müller, S. A., Jordan, P. M., Gerl, M. J., Klose, C. D., Cantuti‐Castelvetri, L., Bosch-Queralt, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109898 · Cited by 31
Role and mechanism of specialized pro-resolving mediators in obesity-associated insulin resistance
Liu, X., Tang, Y., Luo, Y., Gao, Y., & He, L. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02207-9 · Cited by 29
Sidorkiewicz, M. (2024) · Nutrients · doi:10.3390/nu16223937 · Cited by 30
Immunoresolvents signaling molecules at intersection between the brain and immune system
Dalli, J., & Serhan, C. N. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.10.007 · Cited by 27
Fish, n-3 fatty acids, cognition and dementia risk: not just a fishy tale
Saleh, R. N. M., & Minihane, A. M. (2021) · Proceedings of The Nutrition Society · doi:10.1017/s0029665121003700 · Cited by 28
Molecular Pharmacology of Inflammation Resolution in Atherosclerosis
Kotlyarov, S. N., & Котлярова, А. А. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094808 · Cited by 31
Metadata
- Authors
- Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Serhan, Charles N.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 1851
- Issue
- 4
- Pages
- 397-413
- ISSN
- 1388-1981 (ISSN-L)
- PMC
- PMC4324013
- OpenAlex
- W2049424212
- Cited by
- 492
- References
- 166
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 35 · 2023: 38 · 2022: 52 · 2021: 56 · 2020: 55 · 2019: 34 · 2018: 57 · 2017: 52 · 2016: 32 · 2015: 28
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mérieux Foundation (R01GM038765)
- NIH (P01GM095467)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- protectins, maresins, resolvins, neuroprotectin D1, protectin D1, omega-3 fatty acids, acute inflammation, inflammation resolution, epoxide intermediate, hydroperoxides, leukocytes, aspirin, neuroprotection, wound healing, inflammatory pain
- MeSH terms
- Animals, Anti-Inflammatory Agents, Aspirin, Docosahexaenoic Acids, Humans, Inflammation, Structure-Activity Relationship, Molecular Structure, Signal Transduction, Metabolome, Lipoxygenases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
