The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Focal adhesion regulation of cell behavior
Open accessAbstract
Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin cytoskeleton. Cells modify focal adhesions in response to changes in the molecular composition, two-dimensional (2D) vs. three-dimensional (3D) structure, and physical forces present in their extracellular matrix environment. We consider here how cells use focal adhesions to regulate signaling complexes and integrin function. Furthermore, we examine how this regulation controls complex cellular behaviors in response to matrices of diverse physical and biochemical properties. One event regulated by the physical structure of the ECM is phosphorylation of focal adhesion kinase (FAK) at Y397, which couples FAK to several signaling pathways that regulate cell proliferation, survival, migration, and invasion.
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Cites
Taking Cell-Matrix Adhesions to the Third Dimension
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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
Schlaepfer, D. D., Hanks, S. K., Hunter, T., & Geer, P. V. D. (1994) · Nature · doi:10.1038/372786a0 · Cited by 1,595
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Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A.-C., Macara, I. G., Madhani, H., Fink, G. R., & Ravichandran, K. S. (2002) · Nature Cell Biology · doi:10.1038/ncb824 · Cited by 576
Integrin Dynamics and Matrix Assembly
Pankov, R., Cukierman, E., Katz, B.-Z., Matsumoto, K., Lin, D. C., Lin, S., Hahn, C., & Yamada, K. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.1075 · Cited by 482
Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions
Ling, K., Doughman, R. L., Firestone, A. J., Bunce, M. W., & Anderson, R. A. (2002) · Nature · doi:10.1038/nature01082 · Cited by 443
Di Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R., & De Camilli, P. (2002) · Nature · doi:10.1038/nature01147 · Cited by 441
Regulation of Cell Migration by the Calcium-dependent Protease Calpain
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“Calpain is important for both focal adhesion remodeling and cell migration [124–126].”
BackgroundBarsukov, I. L., Prescot, A., Bate, N., Patel, B., Floyd, D. N., Bhanji, N., Bagshaw, C. R., Letinic, K., Di Paolo, G., De Camilli, P., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303850200 · Cited by 95
Cited by
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues
Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760
Berrier, A. L., & Yamada, K. M. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21237 · Cited by 957
Honczarenko, M., Le, Y., Swierkowski, M., Ghiran, I., Glodek, A. M., & Silberstein, L. E. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0319 · Cited by 722
General functionalization route for cell adhesion on non-wetting surfaces
Ku, S. H., Ryu, J., Hong, S. K., Lee, H., & Park, C. B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.020 · Cited by 687
Lillis, A. P., Van Duyn, L. B., Murphy-Ullrich, J. E., & Strickland, D. K. (2008) · Physiological Reviews · doi:10.1152/physrev.00033.2007 · Cited by 669
Metadata
- Authors
- Wozniak, M. A., Modzelewska, K., Kwong, L., & Keely, P. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 1692
- Issue
- 2-3
- Pages
- 103-119
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2085412371
- Cited by
- 999
- References
- 9
- FWCI
- 19.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wozniak, M. A., Modzelewska, K., Kwong, L., & Keely, P. J. (2004). Focal adhesion regulation of cell behavior. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2004.04.007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
